Q9VEN1
Gene name |
cher (cheerio, sko, CG3937) |
Protein name |
Filamin-A |
Names |
FLN-A , Actin-binding protein 280 , ABP-280 , Filamin-1 , Filamin1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
dme:Dmel_CG3937 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
1655-1752 (IgFLNa19 domain) |
Relief mechanism |
PTM, Others |
Assay |
|
Target domain |
1847-1940 (IgFLNa21 domain) |
Relief mechanism |
PTM, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VEN1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VEN1-F1 | Predicted | AlphaFoldDB |
No variants for Q9VEN1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VEN1 | |||||
No associated diseases with Q9VEN1
5 regional properties for Q9VEN1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 456 - 580 | IPR000595 |
| domain | Ion transport domain | 144 - 383 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 483 - 499 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 521 - 544 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 572 - 640 | IPR032406 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| apical cortex | The region that lies just beneath the plasma membrane on the apical edge of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| female germline ring canal | An intercellular bridge that connects the germline cells of a female cyst. |
| female germline ring canal inner rim | A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins. |
| female germline ring canal outer rim | An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| actin crosslink formation | The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. |
| behavioral response to ethanol | Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| female germline ring canal formation | Assembly of the intercellular bridges that connect the germ-line cells of a female cyst. |
| female germline ring canal formation, actin assembly | Recruitment and organization of actin filaments in female germline ring canals. |
| germarium-derived female germ-line cyst encapsulation | Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster. |
| germline ring canal formation | Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts. |
| long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| negative regulation of lamellocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. |
| positive regulation of cytoskeleton organization | Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| sarcomere organization | The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| syncytial embryo cellularization | The separation of a syncytial embryo into individual cells. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMTEKSNGVK | SSPANNHNHH | PPPSIKANGK | DDHRAGSRPQ | SVAADDDTSS | ELQRLAEMDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRRGRGGFRR | IVRLVGIIRD | WANKNFREEE | PRPDSFLERF | RGPELQTVTT | HQGDGKGDKD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEGKGTKKKF | ELFVLDPAGD | WYYRWLFVIA | MPVLYNWCLL | VARACFSDLQ | RNYFVVWLVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYFSDTVYIA | DLIIRLRTGF | LEQGLLVKDP | KKLRDNYIHT | LQFKLDVASI | IPTDLIYFAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GIHSPEVRFN | RLLHFARMFE | FFDRTETRTS | YPNIFRISNL | VLYILVIIHW | NACIYYAISK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIGFGVDTWV | YPNITDPEYG | YLAREYIYCL | YWSTLTLTTI | GETPPPVKDE | EYLFVIFDFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGVLIFATIV | GNVGSMISNM | NATRAEFQAK | IDAVKHYMQF | RKVSKDMEAK | VIKWFDYLWT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NKKTVDEREV | LKNLPAKLRA | EIAINVHLST | LKKVRIFQDC | EAGLLVELVL | KLRPQVFSPG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DYICRKGDIG | KEMYIIKEGK | LAVVADDGVT | QYALLSAGSC | FGEISILNIK | GSKMGNRRTA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NIRSLGYSDL | FCLSKDDLME | AVTEYPDAKK | VLEERGREIL | MKEGLLDENE | VAASMEVDVQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKLEQLETNM | ETLYTRFARL | LAEYTGAQQK | LKQRITVLET | KMKQNHEDDY | LSDGINTPEP |
| AVAE |