Q9VDG2

PR
Gene name
Rlip
Protein name
RalA-binding protein 1
Names
RalBP1, Ral-interacting protein 1
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG11622
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VDG2

Entry ID Method Resolution Chain Position Source
AF-Q9VDG2-F1 Predicted AlphaFoldDB

5 variants for Q9VDG2

Variant ID(s) Position Change Description Diseaes Association Provenance
229 I>V RNA edited version [UniProt] No
230 E>G RNA edited version [UniProt] No
233 K>E RNA edited version [UniProt] No
254 E>G RNA edited version [UniProt] No
265 K>R RNA edited version [UniProt] No

No associated diseases with Q9VDG2

1 regional properties for Q9VDG2

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 191 - 385 IPR000198

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding Binding to a small monomeric GTPase.

4 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
regulation of Ras protein signal transduction Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15311 RALBP1 RalA-binding protein 1 Homo sapiens (Human) PR
Q62172 Ralbp1 RalA-binding protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MDFDSPEEKE FPGLYASEAA DAKSRKSKEE SDFSEDHDHS KKDLLIGRRK DKKEKGKDRG
70 80 90 100 110 120
YAALEGESSP EEELDTKSPS KSKKSKTFKF TSSKSKEKRE KSRDKSEKDS KHAEEEPSVS
130 140 150 160 170 180
HKVKEKERDK EKDRDEPKKK DKEEKRKEKD KKADKKDKKD KKSKQLSQQQ DDVSAAEEVL
190 200 210 220 230 240
ALGYPVFGVS VSLATERSRC HDGVDIPLVV RDCIDFLQDH LKCEQIYKIE PIKTRLMHFK
250 260 270 280 290 300
RLYNNREHDS AVDELNLPTA CSLLKLFLRE LPEPLLTTDL VARFEEVASH PKVTTQQAEL
310 320 330 340 350 360
QQLLEQLPKC NRTLLAWVLL HFDAVIQQER HNKLNAQSLA MLLSPTLQMS HRLMVALLCH
370 380 390 400 410 420
CNNLFADVQL IKYVPPLTST SPKLPDTPED IQTELRKQDS LLSQIHSEMN AGFITKKREE
430 440 450 460 470 480
QLWEVQRIIT QLKRKLRTFE KKQEKTAEEV DNSSSAPPAV ASEDTTDSKP AGTPAVSTNN
490 500 510 520 530 540
SISQEEPKTD TLTPKDAPND FTIDPSTGFI LLPKSNPHRE NLLRLQIEYD ELMEWQNELK
550 560 570 580 590 600
ARIVAERNEV YRLKQLYEQQ SINSQMASLA SGSQAPPESD YERIIEHYTR ENALLEHKKN
610 620
MLGMELKEER RACIALQVEL RLQQF