AiPD: Autoinhibited Protein Database

Q15311

Gene name	RALBP1
Protein name	RalA-binding protein 1
Names	RalBP1, 76 kDa Ral-interacting protein, Dinitrophenyl S-glutathione ATPase, DNP-SG ATPase, Ral-interacting protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10928
EC number	7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-154 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-154 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for Q15311

Entry ID	Method	Resolution	Chain	Position	Source
2KWH	NMR	-	A	393-446	PDB
2KWI	NMR	-	B	393-446	PDB
2MBG	NMR	-	A	184-446	PDB
6ZQT	X-ray	151 A	C/D	393-446	PDB
6ZRN	X-ray	148 A	C/D	393-446	PDB
AF-Q15311-F1	Predicted				AlphaFoldDB

403 variants for Q15311

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA296501974 rs1043762986	7	P>A		No	ClinGen TOPMed
CA8888816 rs758096977	10	S>G		No	ClinGen ExAC gnomAD
rs1419724435 CA402026746	11	S>G		No	ClinGen TOPMed gnomAD
rs1476747366 CA402026758	12	P>L		No	ClinGen gnomAD
CA296501975 rs200050154	13	S>I		No	ClinGen 1000Genomes
CA296501976 rs902526740	14	E>K		No	ClinGen TOPMed
CA8888820 rs781728639	15	H>Q		No	ClinGen ExAC gnomAD
CA8888821 rs147413500	16	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8888823 rs780034442	16	R>H	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs780034442 CA8888824	16	R>L		No	ClinGen ExAC gnomAD
CA8888822 rs147413500	16	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs757096143 CA296501977	17	R>G		No	ClinGen Ensembl
CA8888825 rs769017781	19	E>K		No	ClinGen ExAC gnomAD
CA402026815 rs1397873355	21	G>V		No	ClinGen gnomAD
CA402026824 rs1218477238	23	G>R		No	ClinGen gnomAD
CA402026839 rs1342108463	25	T>N		No	ClinGen gnomAD
CA402026845 rs1275937007	26	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8888828 rs770691521	26	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8888829 rs776629059	27	T>I		No	ClinGen ExAC gnomAD
rs1568066988 CA402026848	27	T>S		No	ClinGen Ensembl
CA8888830 rs759433095	28	P>A		No	ClinGen ExAC
rs764783166 CA8888831	34	S>N		No	ClinGen ExAC gnomAD
rs1437621789 CA402026911	36	T>I		No	ClinGen TOPMed
CA8888832 rs775003296	37	K>E		No	ClinGen ExAC gnomAD
rs1315759219 CA402026944	41	L>F		No	ClinGen TOPMed
CA8888834 rs763740122	43	R>C		No	ClinGen ExAC TOPMed gnomAD
CA402026955 rs763740122	43	R>G		No	ClinGen ExAC TOPMed gnomAD
rs371220710 CA8888835	43	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8888836 rs371220710	43	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs767833937 CA8888837	44	T>I		No	ClinGen ExAC gnomAD
CA402026967 rs1598866888	45	G>V		No	ClinGen Ensembl
rs756625374 CA8888839	46	E>D		No	ClinGen ExAC gnomAD
CA402026968 rs1175748978	46	E>K		No	ClinGen gnomAD
rs1159933902 CA402026977	47	P>S		No	ClinGen TOPMed
rs1299219768 CA402026984	48	S>*		No	ClinGen gnomAD
rs1299219768 CA402026986	48	S>L		No	ClinGen gnomAD
CA8888840 rs780128985	49	P>S		No	ClinGen ExAC gnomAD
CA402027015 rs1274828993	53	I>V		No	ClinGen gnomAD
rs1424359754 CA402027030	55	H>R		No	ClinGen TOPMed
rs902011808 CA296501981	55	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	56	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402027046 rs779267531	57	P>H		No	ClinGen ExAC TOPMed gnomAD
rs779267531 CA8888843	57	P>L		No	ClinGen ExAC TOPMed gnomAD
rs748451387 CA8888844	58	P>S		No	ClinGen ExAC TOPMed gnomAD
CA402027063 rs1598866928	60	V>A		No	ClinGen Ensembl
CA8888845 rs770730661	60	V>I		No	ClinGen ExAC gnomAD
CA402027061 rs770730661	60	V>L		No	ClinGen ExAC gnomAD
CA402027069 rs1598866930	61	V>A		No	ClinGen Ensembl
rs774913295 CA8888849	62	S>F		No	ClinGen ExAC gnomAD
rs201602095 CA8888848	62	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs762462985 CA8888850	65	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	67	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA296501982 rs866604250	68	H>R		No	ClinGen gnomAD
TCGA novel	69	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8888852 rs780587928	73	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1159408634	73	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	76	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382621246 CA402027202	79	E>D		No	ClinGen gnomAD
rs1276616875 CA402027248	84	G>D		No	ClinGen TOPMed
CA402027254 rs1163064366	85	Y>S		No	ClinGen gnomAD
CA8888872 rs769713781	87	A>G		No	ClinGen ExAC gnomAD
rs779952908 CA8888873	89	Q>E		No	ClinGen ExAC gnomAD
CA8888874 rs375010086	91	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8888875 rs768120613	92	S>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	98	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402027358 rs1381571725	100	P>S		No	ClinGen TOPMed
CA402027365 rs1377282463	101	S>A		No	ClinGen TOPMed gnomAD
rs773896430 CA8888876	101	S>F		No	ClinGen ExAC gnomAD
rs773896430 CA402027366	101	S>Y		No	ClinGen ExAC gnomAD
CA402027382 rs1242280667	103	M>I		No	ClinGen gnomAD
CA8888878 rs372081924	106	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs773572577 CA8888879	107	K>R		No	ClinGen ExAC gnomAD
rs1256144543 CA402027424	109	I>M		No	ClinGen gnomAD
rs1423321580 CA402027427	110	H>Y		No	ClinGen TOPMed
TCGA novel	111	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402027495 rs1252858294	119	K>R		No	ClinGen gnomAD
CA402027516 rs1187155046	122	E>Q		No	ClinGen gnomAD
TCGA novel	123	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754367555 CA402027587	131	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8888882 rs754367555	131	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1313625410 CA402027595	132	K>R		No	ClinGen TOPMed gnomAD
CA296502283 rs74838839	136	H>P		No	ClinGen ExAC gnomAD
rs765360108 CA8888885	136	H>Q		No	ClinGen ExAC
CA8888884 rs74838839	136	H>R		No	ClinGen ExAC gnomAD
CA402027648 rs1253381444	139	E>G		No	ClinGen TOPMed
rs1298277625	139	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1393902407 CA402027673	142	K>T		No	ClinGen gnomAD
rs752752885 CA8888887	144	E>G		No	ClinGen ExAC TOPMed gnomAD
rs758579995 CA8888888	147	K>E		No	ClinGen ExAC gnomAD
rs11559053 CA296502284	149	K>E		No	ClinGen Ensembl
CA402027739 rs1416462334	151	S>A		No	ClinGen gnomAD
rs1276152269 CA402027745	152	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	152	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	153	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8888889 rs139161232	155	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1598868095 CA402027888	171	K>R		No	ClinGen Ensembl
CA402027895 rs1253119951	172	P>Q		No	ClinGen gnomAD
rs1228193650 CA402027894	172	P>S		No	ClinGen gnomAD
rs117752793 CA402027898	173	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs117752793 CA8888891	173	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA296502285 rs778373139	174	Q>R		No	ClinGen Ensembl
CA402027923 rs1486818576	176	P>L		No	ClinGen gnomAD
CA8888892 rs149502553	176	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs768599467 CA8888894	178	V>M		No	ClinGen ExAC gnomAD
rs1197226444 CA402027938	179	P>A		No	ClinGen TOPMed gnomAD
CA8888895 rs375158770	179	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs771674965 CA8888897	180	Q>E		No	ClinGen ExAC gnomAD
rs530667248 CA296502286	180	Q>P		No	ClinGen 1000Genomes gnomAD
CA402027959 rs1375685239	182	D>G		No	ClinGen TOPMed gnomAD
CA8888898 rs772740129	183	V>F		No	ClinGen ExAC gnomAD
CA402027963 rs772740129	183	V>I		No	ClinGen ExAC gnomAD
rs552330033 CA8888899	186	L>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	187	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8888900 rs771403375	187	K>R		No	ClinGen ExAC gnomAD
CA402027996 rs1470689129	188	P>S		No	ClinGen TOPMed gnomAD
CA402028011 rs1438981187	190	F>S		No	ClinGen TOPMed
TCGA novel	192	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382689067 CA402028030	193	P>A		No	ClinGen gnomAD
rs1297707280 CA402028044	195	A>D		No	ClinGen TOPMed gnomAD
rs1297707280 CA402028045	195	A>G		No	ClinGen TOPMed gnomAD
CA402028061 rs1435183098	198	V>I		No	ClinGen gnomAD
CA8888901 rs368559132	203	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA402028101 rs1329412459	203	M>T		No	ClinGen gnomAD
CA8888902 rs760082264	204	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1457460691 CA402028105	204	Y>D		No	ClinGen TOPMed
CA8888903 rs765845733 CA402028118	205	D>E		No	ClinGen ExAC gnomAD
rs28552921 CA402028135	208	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8888904 rs28552921 RCV000966253	208	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1214857225 CA402028133	208	R>W		No	ClinGen gnomAD
CA8888907 rs751698054	212	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1192859734 CA402028169	214	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8888909 rs114518459	217	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1484750520 CA402028196	218	D>H		No	ClinGen TOPMed
CA8888910 rs546659926	219	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
rs372077609 CA8888912	220	V>I		No	ClinGen ESP ExAC gnomAD
CA402028221 rs748188211	221	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1290487914 CA402028224	222	K>E		No	ClinGen gnomAD
rs1388504084 CA402028232	223	Y>H		No	ClinGen gnomAD
CA402028242 rs1465489508	224	G>V		No	ClinGen TOPMed
rs777394300 CA8888915	227	C>Y		No	ClinGen ExAC gnomAD
rs746612146 CA8888916	233	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8888930 rs753568672	239	K>E		No	ClinGen ExAC
rs1374344857 CA401882501	240	V>L		No	ClinGen gnomAD
CA401882515 rs1225784950	241	D>G		No	ClinGen gnomAD
rs754767040 CA8888931	246	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758550291 CA401882609	249	R>P		No	ClinGen TOPMed gnomAD
rs758550291 CA295903039	249	R>Q		No	ClinGen TOPMed gnomAD
CA401882606 rs1469364485	249	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA401882620 rs1231901344	250	E>V		No	ClinGen gnomAD
CA401882636 rs1178614066	251	E>G		No	ClinGen TOPMed gnomAD
rs777989427 CA8888934	251	E>K		No	ClinGen ExAC TOPMed gnomAD
CA401882654 rs1415370507	253	T>A		No	ClinGen gnomAD
CA401882655 rs1415370507	253	T>S		No	ClinGen gnomAD
rs368700058 CA8888935	254	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1165562491 CA401882675	254	N>K		No	ClinGen gnomAD
CA8888936 rs368845774	258	Y>C		No	ClinGen ESP ExAC gnomAD
rs1568069104 CA401882729	259	E>K		No	ClinGen Ensembl
CA401882750 rs1464077445	260	P>L		No	ClinGen gnomAD
CA8888937 rs756912606	261	N>S		No	ClinGen ExAC gnomAD
rs1415788098 CA401882869	270	Y>C		No	ClinGen gnomAD
rs770022126 COSM1471110 CA8888940	272	R>*	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs770022126 CA401882889	272	R>G		No	ClinGen ExAC TOPMed gnomAD
CA401882892 rs1598869758	272	R>Q		No	ClinGen Ensembl
rs775970990 CA8888941	275	P>R		No	ClinGen ExAC gnomAD
TCGA novel	276	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373416081 CA8888942	277	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA401882948 rs1271638332	277	N>T		No	ClinGen gnomAD
CA401882992 rs375926697	281	K>E		No	ClinGen ESP TOPMed gnomAD
rs375926697 CA295903112	281	K>Q		No	ClinGen ESP TOPMed gnomAD
TCGA novel	282	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8888943 rs769235242	283	L>F		No	ClinGen ExAC TOPMed gnomAD
rs761890562 CA8888945	284	M>T		No	ClinGen ExAC gnomAD
rs142799309 CA8888944	284	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA401883043 rs1259466417	285	P>L		No	ClinGen gnomAD
rs537083100 CA8888946	285	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1358619096 CA401883077	288	E>Q		No	ClinGen TOPMed
CA401883146 rs1476856297	293	R>T		No	ClinGen TOPMed gnomAD
rs1420298267 CA401883161	294	T>I		No	ClinGen gnomAD
CA401883160 rs1420298267	294	T>S		No	ClinGen gnomAD
rs1568069145 CA401883164	295	T>A		No	ClinGen Ensembl
CA8888947 RCV000924577 rs528466267	295	T>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs558924426 CA8888949	297	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401883294 COSM180379 rs1430612464	305	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1321348484 CA401883295	305	R>H		No	ClinGen TOPMed gnomAD
rs1321348484 CA8888951	305	R>L		No	ClinGen TOPMed gnomAD
rs1271347527 CA401883317	307	L>F		No	ClinGen gnomAD
rs1351473594 CA401883327	308	K>E		No	ClinGen TOPMed gnomAD
rs764106578 CA8888954	308	K>R		No	ClinGen ExAC TOPMed gnomAD
CA401883401 rs1346731444	313	C>*		No	ClinGen gnomAD
CA8888956 rs756822703	315	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA401883439 rs1198988746	316	L>P		No	ClinGen TOPMed
rs146856822 CA8888961	322	I>M		No	ClinGen ESP ExAC gnomAD
CA8888960 rs143680866	322	I>T		No	ClinGen ESP ExAC gnomAD
CA8888959 rs140099378	322	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA401883541 rs1226820232	325	M>V		No	ClinGen TOPMed
CA8888964 rs779376569	326	D>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	326	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401883558 rs1598869858	326	D>N		No	ClinGen Ensembl
CA295903205 rs779376569	326	D>V		No	ClinGen ExAC TOPMed gnomAD
CA401883598 rs1175810598	329	I>T		No	ClinGen gnomAD
rs772121543 CA401883839	342	I>L		No	ClinGen ExAC gnomAD
rs772121543 CA8888966	342	I>V		No	ClinGen ExAC gnomAD
CA8888967 rs577133248	344	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA401883983 rs1369662473	349	T>A		No	ClinGen gnomAD
rs1234544776 CA401883994	349	T>I		No	ClinGen gnomAD
rs1305259774 CA401884017	351	Q>E		No	ClinGen gnomAD
CA401884350 rs1323936112	352	I>T		No	ClinGen TOPMed gnomAD
rs747127902 CA8888988	354	N>D		No	ClinGen ExAC
rs754419518 CA8888989	354	N>S		No	ClinGen ExAC gnomAD
CA295904976 rs755389699	355	R>L		No	ClinGen ExAC gnomAD
CA8888990 rs755389699	355	R>Q		No	ClinGen ExAC gnomAD
rs970821047 CA295904983	357	L>V		No	ClinGen TOPMed
TCGA novel	363	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401884600 rs1393737858	364	V>A		No	ClinGen gnomAD
rs982045952 CA295904999	367	L>V		No	ClinGen TOPMed
CA401884765 rs1353159348	372	V>L		No	ClinGen TOPMed
rs1568069690 CA401884786	373	L>P		No	ClinGen Ensembl
rs201125287 CA295905004	376	V>A		No	ClinGen 1000Genomes
CA401884884 rs1598870600	377	M>I		No	ClinGen Ensembl
rs772536201 CA8888996	377	M>T		No	ClinGen ExAC gnomAD
CA401884864 rs1430069798	377	M>V		No	ClinGen TOPMed
rs1598870605 CA401884893	378	K>Q		No	ClinGen Ensembl
CA8888998 rs765869242	387	T>M		No	ClinGen ExAC TOPMed gnomAD
COSM288297 rs1598870614 CA401885109	388	M>L	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs989252022 CA295905039	389	P>A		No	ClinGen TOPMed
CA401885158 rs374235427	390	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8889000 rs374235427	390	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs747537272 CA401885282	396	A>E		No	ClinGen ExAC TOPMed gnomAD
rs747537272 CA8889005 COSM1287529	396	A>V	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA401885308 rs1370825389	397	G>A		No	ClinGen gnomAD
CA401885297 rs781177570	397	G>C		No	ClinGen ExAC gnomAD
rs781177570 CA8889007	397	G>S		No	ClinGen ExAC gnomAD
CA401885315 rs1168066329	398	I>V		No	ClinGen gnomAD
rs770170835 CA8889010	399	K>R		No	ClinGen ExAC gnomAD
TCGA novel	401	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747966913 CA8889012	403	R>S		No	ClinGen ExAC gnomAD
rs200197423 CA295906069	412	L>S		No	ClinGen 1000Genomes
CA401885858 COSM1710983 rs1368932788	414	R>*	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs777454415 CA8889032	414	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1304525167 CA401885880	415	D>A		No	ClinGen gnomAD
CA401885923 rs1237348970	417	Q>H		No	ClinGen TOPMed gnomAD
rs770783042 CA8889034	418	G>A		No	ClinGen ExAC gnomAD
TCGA novel	421	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776152794 CA401885991	423	L>F		No	ClinGen ExAC TOPMed gnomAD
rs759034779 CA401885995	424	S>A		No	ClinGen ExAC gnomAD
rs759034779 CA8889036	424	S>P		No	ClinGen ExAC gnomAD
TCGA novel	432	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775094966 CA8889038	432	V>G		No	ClinGen ExAC gnomAD
CA401886158 rs1351792982	437	T>A		No	ClinGen TOPMed gnomAD
rs1395314774 CA401886223	442	K>R		No	ClinGen gnomAD
TCGA novel	450	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401887721 rs1351728725	453	T>I		No	ClinGen gnomAD
CA8889051 rs755284343	454	K>N		No	ClinGen ExAC gnomAD
rs954020920 CA401887753	455	I>M		No	ClinGen TOPMed gnomAD
rs1412072913 CA401887812	459	I>M		No	ClinGen gnomAD
CA401887821 rs1291918282	460	A>D		No	ClinGen TOPMed gnomAD
CA401887824 rs1291918282	460	A>V		No	ClinGen TOPMed gnomAD
rs542878133 CA295910022	461	S>C		No	ClinGen TOPMed
CA295910014 rs542878133	461	S>G		No	ClinGen TOPMed
rs777561304 CA8889053	461	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1323055131 CA401887901	466	D>A		No	ClinGen gnomAD
CA401887899 rs1289940958	466	D>N		No	ClinGen gnomAD
CA8889054 rs746797343	469	K>E		No	ClinGen ExAC TOPMed
rs1250417991 CA401887954	470	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs745848757 CA8889057	471	E>G		No	ClinGen ExAC gnomAD
rs780988700 CA401887967	471	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8889056 rs780988700	471	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8889058 rs769273667	472	M>T		No	ClinGen ExAC gnomAD
CA401888040 rs1182426816	475	N>S		No	ClinGen gnomAD
rs775002893 CA8889059	479	I>T		No	ClinGen ExAC gnomAD
rs762551080 CA8889060	484	A>V		No	ClinGen ExAC gnomAD
CA8889061 rs372277773	485	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1311405593 CA401888190	485	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	486	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781091746 CA8889080	493	Q>K		No	ClinGen ExAC gnomAD
rs1287752693 CA401888625	498	A>T		No	ClinGen gnomAD
rs1598873558 CA401888631	499	M>L		No	ClinGen Ensembl
rs779470358 CA8889083	502	F>C		No	ClinGen ExAC
CA8889084 rs748810192	504	R>C		No	ClinGen ExAC gnomAD
rs768270450 CA8889085	504	R>H		No	ClinGen ExAC gnomAD
rs1482376876 CA401888673	505	R>Q		No	ClinGen TOPMed
CA8889086 rs773866824	505	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1023764049 CA295912443	507	I>T		No	ClinGen TOPMed gnomAD
rs995182157 CA295912471	511	K>E		No	ClinGen TOPMed
rs867322343 CA401888734	514	I>L		No	ClinGen TOPMed
CA295912492 rs867322343	514	I>V		No	ClinGen TOPMed
rs1445245154 CA401888751	516	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8889088 rs772299698	517	L>V		No	ClinGen ExAC gnomAD
CA401888759 rs1248704887	518	R>G		No	ClinGen gnomAD
TCGA novel	518	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149216756 CA8889089	519	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs767010644 CA8889091	521	I>M		No	ClinGen ExAC gnomAD
CA8889092 rs777338950	522	A>V		No	ClinGen ExAC gnomAD
rs773655777 CA8889108	527	R>C		No	ClinGen ExAC TOPMed gnomAD
CA295912760 rs911945497	527	R>H		No	ClinGen TOPMed
CA401888958 rs1389441948	529	Q>H		No	ClinGen gnomAD
rs1325190793 CA401888983	531	G>S		No	ClinGen TOPMed gnomAD
rs1233704649 CA401888998	532	R>*		No	ClinGen TOPMed
CA8889110 rs771493471	532	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1305964767 CA401889112	538	Y>*		No	ClinGen TOPMed
CA8889112 rs760138997	539	S>P		No	ClinGen ExAC gnomAD
CA295912784 rs866817365	540	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs763017977 CA8889116	541	E>A		No	ClinGen ExAC gnomAD
rs1384362354 CA401889146	541	E>K		No	ClinGen TOPMed
CA401889171 rs1271152384	542	S>N		No	ClinGen gnomAD
CA401889182 rs1172355625	543	E>K		No	ClinGen TOPMed
TCGA novel	544	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8889118 rs368804758	544	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760614753 CA295912810	553	Q>H		No	ClinGen gnomAD
rs1187939238 CA401889361	554	I>T		No	ClinGen gnomAD
rs1474496719 CA401889355	554	I>V		No	ClinGen gnomAD
rs766197922 CA8889120	560	Q>R		No	ClinGen ExAC gnomAD
rs753692835 CA8889121	564	E>K	Variant assessed as Somatic; 4.634e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1346089334 CA401890224	568	I>V		No	ClinGen gnomAD
TCGA novel	571	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401890258 rs1257059622	572	H>R		No	ClinGen gnomAD
rs753695857 CA8889142	573	L>S		No	ClinGen ExAC TOPMed gnomAD
CA401890282 rs1231252289	575	Q>H		No	ClinGen TOPMed gnomAD
rs144964228 CA8889143	576	A>V		No	ClinGen 1000Genomes ExAC
rs752646969 CA8889145	577	I>N		No	ClinGen ExAC gnomAD
rs765210331 CA8889144	577	I>V		No	ClinGen ExAC TOPMed gnomAD
rs374024426 CA8889146	581	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA401890327 rs1378035062	581	R>H		No	ClinGen TOPMed gnomAD
CA401890318 rs374024426	581	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1156806829 CA401890332	582	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1156806829 CA401890334	582	E>Q		No	ClinGen gnomAD
CA8889148 rs751209223	583	A>V		No	ClinGen ExAC gnomAD
CA401890383 rs1322746831	585	I>L		No	ClinGen gnomAD
rs367939064 CA401890397	585	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1322746831 CA401890386	585	I>V		No	ClinGen gnomAD
CA401890436 rs1386462500	588	R>C		No	ClinGen TOPMed gnomAD
CA8889151 rs746254893	588	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780605304 CA8889153	589	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8889155 rs768695459	592	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs749833901 CA8889154	592	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1249461065 CA401890512	593	L>P		No	ClinGen gnomAD
rs761980244 CA8889157	595	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA401890545 rs772297398	595	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1190325047 CA401890537	595	Q>P		No	ClinGen gnomAD
rs1598874351 CA401890560	596	M>R		No	ClinGen Ensembl
CA401890577 rs1434688599	597	Q>P		No	ClinGen TOPMed gnomAD
CA401890581 rs1434688599	597	Q>R		No	ClinGen TOPMed gnomAD
CA295914707 rs376577692	598	R>*		No	ClinGen ESP gnomAD
CA8889159 rs773367882	598	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8889160 rs773367882	598	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA401890600 rs1449653918	599	A>T		No	ClinGen gnomAD
rs1457796369 CA401890607	599	A>V		No	ClinGen gnomAD
CA401890635 rs1161422048	601	A>T		No	ClinGen TOPMed gnomAD
rs1216693010 CA401890645	601	A>V		No	ClinGen TOPMed
CA401890656 rs1233734978	602	E>G		No	ClinGen TOPMed
rs369532344 CA8889162	602	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA401890686 rs1370101476	604	Q>*		No	ClinGen TOPMed gnomAD
rs763007442 CA8889163	605	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8889164 rs372929952	605	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA401890742 rs1230818746	607	E>G		No	ClinGen TOPMed gnomAD
rs1319464221 CA401890756	609	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8889166 rs756910572	610	E>*		No	ClinGen ExAC gnomAD
CA401890768 rs1265672931	610	E>D		No	ClinGen TOPMed gnomAD
rs767184648 CA8889167	611	P>A		No	ClinGen ExAC TOPMed gnomAD
rs767184648 CA401890770	611	P>S		No	ClinGen ExAC TOPMed gnomAD
CA401890769 rs767184648	611	P>T		No	ClinGen ExAC TOPMed gnomAD
CA401890774 rs1202797075	612	E>K		No	ClinGen gnomAD
CA401890785 rs1372189310	613	W>*		No	ClinGen TOPMed
COSM1389956 CA8889168 rs750108400	614	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs756469650 CA8889169	614	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8889170 rs756469650	614	R>L		No	ClinGen ExAC TOPMed gnomAD
rs755507371 CA8889172	615	G>R		No	ClinGen ExAC gnomAD
rs755507371 CA401890795	615	G>W		No	ClinGen ExAC gnomAD
CA8889173 rs35867116 VAR_049147	617	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA401890842 rs1598874411	618	V>G		No	ClinGen Ensembl
CA8889175 rs772113798	618	V>I	Variant assessed as Somatic; 4.822e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8889177 rs137976679	620	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8889178 rs137976679	620	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1348623941 CA401890873	620	P>S		No	ClinGen TOPMed
rs141739854 CA295914854	624	G>S		No	ClinGen ESP TOPMed gnomAD
CA8889182 rs200994399	625	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401890980 rs1202647055	627	E>K		No	ClinGen gnomAD
rs761401980 CA8889183	628	P>A		No	ClinGen ExAC gnomAD
rs1434969596 CA401891004	629	K>*		No	ClinGen TOPMed
rs1207128432 CA401891019	630	A>T		No	ClinGen gnomAD
rs750067012 CA8889185	631	A>S		No	ClinGen ExAC gnomAD
CA401891047 rs1182553371	632	K>E		No	ClinGen gnomAD
TCGA novel	633	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401891084 rs1447868828	633	E>D		No	ClinGen gnomAD
CA401891075 rs1416105372	633	E>K		No	ClinGen gnomAD
rs150549954 CA8889186	634	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs994935898 CA295914932	635	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	635	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766722779 CA8889187	636	K>E		No	ClinGen ExAC gnomAD
CA401891138 rs1311537270	637	A>T		No	ClinGen gnomAD
CA401891149 rs1359122396	637	A>V		No	ClinGen gnomAD
CA401891171 rs1195034782	639	K>T		No	ClinGen TOPMed
rs755417867 CA8889189	640	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8889190 rs368834573	641	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8889192 rs373024496	644	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs530173610 CA8889193 COSM1740444	645	S>L	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs771063506 CA8889195	646	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1210792656 CA401891306	647	S>T		No	ClinGen gnomAD
rs1239275917 CA401891322	648	R>S		No	ClinGen gnomAD
rs749079878 CA8889197	650	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8889198 rs548196845	653	T>A		No	ClinGen 1000Genomes ExAC
rs201564046 CA401891356	653	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8889199 rs201564046	653	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with Q15311

1 regional properties for Q15311

Type	Name	Position	InterPro Accession
domain	Rho GTPase-activating protein domain	192 - 380	IPR000198

Functions

		Description
EC Number	7.6.2.2	Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization	Cell membrane ; Peripheral membrane protein Cytoplasm, cytosol Cytoplasm, cytoskeleton, spindle pole Nucleus Mitochondrion	Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity) Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling Docking on the membrane is required to transduce the Ral signal (By similarity) Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277) Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010) The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (Probable)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
spindle pole	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

8 GO annotations of molecular function

Name	Definition
ABC-type glutathione S-conjugate transporter activity	Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out).
ABC-type xenobiotic transporter activity	Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity	Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding	Binding to a small monomeric GTPase.
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
xenobiotic transmembrane transporter activity	Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

12 GO annotations of biological process

Name	Definition
chemotaxis	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
doxorubicin transport	The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
positive regulation of mitochondrial fission	Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of Cdc42 protein signal transduction	Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.
transmembrane transport	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
xenobiotic detoxification by transmembrane export across the plasma membrane	A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VDG2	Rlip	RalA-binding protein 1	Drosophila melanogaster (Fruit fly)	PR
Q62172	Ralbp1	RalA-binding protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MTECFLPPTS	SPSEHRRVEH	GSGLTRTPSS	EEISPTKFPG	LYRTGEPSPP	HDILHEPPDV
70	80	90	100	110	120
VSDDEKDHGK	KKGKFKKKEK	RTEGYAAFQE	DSSGDEAESP	SKMKRSKGIH	VFKKPSFSKK
130	140	150	160	170	180
KEKDFKIKEK	PKEEKHKEEK	HKEEKHKEKK	SKDLTAADVV	KQWKEKKKKK	KPIQEPEVPQ
190	200	210	220	230	240
IDVPNLKPIF	GIPLADAVER	TMMYDGIRLP	AVFRECIDYV	EKYGMKCEGI	YRVSGIKSKV
250	260	270	280	290	300
DELKAAYDRE	ESTNLEDYEP	NTVASLLKQY	LRDLPENLLT	KELMPRFEEA	CGRTTETEKV
310	320	330	340	350	360
QEFQRLLKEL	PECNYLLISW	LIVHMDHVIA	KELETKMNIQ	NISIVLSPTV	QISNRVLYVF
370	380	390	400	410	420
FTHVQELFGN	VVLKQVMKPL	RWSNMATMPT	LPETQAGIKE	EIRRQEFLLN	CLHRDLQGGI
430	440	450	460	470	480
KDLSKEERLW	EVQRILTALK	RKLREAKRQE	CETKIAQEIA	SLSKEDVSKE	EMNENEEVIN
490	500	510	520	530	540
ILLAQENEIL	TEQEELLAME	QFLRRQIASE	KEEIERLRAE	IAEIQSRQQH	GRSETEEYSS
550	560	570	580	590	600
ESESESEDEE	ELQIILEDLQ	RQNEELEIKN	NHLNQAIHEE	REAIIELRVQ	LRLLQMQRAK
610	620	630	640	650
AEQQAQEDEE	PEWRGGAVQP	PRDGVLEPKA	AKEQPKAGKE	PAKPSPSRDR	KETSI