Q9VBX1

PR
Gene name
Clbn
Protein name
Ribosome quality control complex subunit NEMF homolog
Names
Protein Caliban
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG11847
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-402 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VBX1

Entry ID Method Resolution Chain Position Source
AF-Q9VBX1-F1 Predicted AlphaFoldDB

No variants for Q9VBX1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VBX1

No associated diseases with Q9VBX1

2 regional properties for Q9VBX1

Type Name Position InterPro Accession
domain NFACT, RNA-binding domain 528 - 638 IPR008532
domain NFACT protein, C-terminal 893 - 982 IPR021846

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic side of mitochondrial outer membrane The external (cytoplasmic) face of the mitochondrial outer membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RQC complex A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.

2 GO annotations of molecular function

Name Definition
ribosomal large subunit binding Binding to a large ribosomal subunit.
tRNA binding Binding to a transfer RNA.

6 GO annotations of biological process

Name Definition
CAT tailing The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control sytem.
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
rescue of stalled ribosome A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.
ribosome-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60524 NEMF Ribosome quality control complex subunit NEMF Homo sapiens (Human) PR
Q8CCP0 Nemf Ribosome quality control complex subunit NEMF Mus musculus (Mouse) PR
10 20 30 40 50 60
MKTRFNTFDI ICGVAELQKL VGWRVNQIYD VDNKTYLFRM QGTGAVEKVT LLIESGTRFH
70 80 90 100 110 120
TTRFEWPKNM APSGFSMKLR KHLKNKRLEK VQQMGSDRIV DFQFGTGDAA YHVILELYDR
130 140 150 160 170 180
GNVILTDYEL TTLYILRPHT EGENLRFAMR EKYPVERAKQ PTKELELEAL VKLLENARNG
190 200 210 220 230 240
DYLRQILTPN LDCGPAVIEH VLLSHGLDNH VIKKETTEET PEAEDKPEKG GKKQRKKQQN
250 260 270 280 290 300
TKLEQKPFDM VNDLPILQQA VKDAQELIAE GNSGKSKGYI IQVKEEKPTE NGTVEFFFRN
310 320 330 340 350 360
IEFHPYLFIQ FKNFEKATFE SFMEAVDEFY STQESQKIDM KTLQQEREAL KKLSNVKNDH
370 380 390 400 410 420
AKRLEELTKV QDVDRKKAEL ITSNQSLVDN AIRAVQSAIA SQLSWPDIHE LVKEAQANGD
430 440 450 460 470 480
AVASSIKQLK LETNHISLML SDPYDNDEDD DLKDPEVTVV DVDLALSAWA NARRYYDMKR
490 500 510 520 530 540
SAAQKEKKTV DASQKALKSA ERKTQQTLKE VRTISNIVKA RKVFWFEKFY WFISSENYLV
550 560 570 580 590 600
IGGRDAQQNE LIVKRYMRPK DIYVHAEIQG ASSVIIQNPT GEEIPPKTLL EAGSMAISYS
610 620 630 640 650 660
VAWDAKVVTN SYWVTSDQVS KTAPTGEYLA TGSFMIRGKK NFLPSCHLTM GLSLLFKLED
670 680 690 700 710 720
SFIERHLGER KVRSLEDDQI DPNVKENEVE HDLLSDNEDA DSNINLSEPS SNTEITAFPN
730 740 750 760 770 780
TEVKIEHDTG RIIVRSDSVN PEIEETKESE VVLDKILKKT DDEETTIILA GPSRKKQVSA
790 800 810 820 830 840
KKTKEDKARA KQEAAKQEVP PVSSEPKNPS QVKRGQKGKL KKMKQKYKDQ DDEEREIRMM
850 860 870 880 890 900
ILKSSGKEKP QASADKVVEK SESTKEYVKP EKSAAPKNPV ELDDADEVPV GGDVDVLNSL
910 920 930 940 950 960
TGQPHEGDEL LFAIPVVAPY QALQNYKFKV KLTPGTGKRG KAAKLALNIF AKEKSCSARE
970 980 990
KDLLKSIKEE SLARNIPGKV KLSAPQLQKY HK