AiPD: Autoinhibited Protein Database

Gene name	Nemf
Protein name	Ribosome quality control complex subunit NEMF
Names	Nuclear export mediator factor, Serologically defined colon cancer antigen 1 homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:66244
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

693-778 (Predicted disordered autoinhibitory region) PR

693-778 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8CCP0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389244876	96	D>V	No	EVA
rs3389240861	110	Y>H	No	EVA
rs3389252159	118	D>V	No	EVA
rs3389249866	129	Y>C	No	EVA
rs247809682	176	A>T	No	EVA
rs235052160	182	V>L	No	EVA
rs3389200904	187	L>H	No	EVA
rs3389209499	236	L>F	No	EVA
rs3389173017	237	R>M	No	EVA
rs214664071	279	S>A	No	EVA
rs3389240888	311	K>Q	No	EVA
rs259918628	457	L>M	No	EVA
rs3389215915	479	R>G	No	EVA
rs3403520664	483	K>R	No	EVA
rs3389239779	500	E>*	No	EVA
rs3402693904	516	I>M	No	EVA
rs3403716648	516	I>S	No	EVA
rs3403316681	517	Q>H	No	EVA
rs3403316698	518	K>*	No	EVA
rs3403007751	518	K>R	No	EVA
rs3389209473	521	K>*	No	EVA
rs3389239785	541	G>V	No	EVA
rs3389238694	553	K>*	No	EVA
rs3389235127	673	V>L	No	EVA
rs3389240891	683	S>N	No	EVA
rs258753457	702	S>T	No	EVA
rs246211417	719	M>R	No	EVA
rs3389237034	753	I>N	No	EVA
rs227120078	755	E>G	No	EVA
rs3402746833	773	L>V	No	EVA
rs3389209456	807	A>V	No	EVA
rs3389243710	821	E>V	No	EVA
rs3389238622	876	D>V	No	EVA
rs238915090	906	P>T	No	EVA
rs3403500976	909	E>Q	No	EVA
rs3389236992	910	P>H	No	EVA
rs3389227623	918	P>S	No	EVA
rs3389215977	923	R>L	No	EVA
rs3389236990	936	V>I	No	EVA
rs3389249881	951	D>E	No	EVA
rs232878031	961	Q>R	No	EVA
rs3402746683	975	P>S	No	EVA
rs37998688	1001	V>E	No	EVA
rs3389215994	1010	K>R	No	EVA
rs3389215959	1017	A>P	No	EVA
rs3389200936	1021	F>I	No	EVA
rs3389173079	1023	H>Y	No	EVA
rs3389240923	1039	K>E	No	EVA

Type	Name	Position	InterPro Accession
domain	NFACT, RNA-binding domain	527 - 637	IPR008532
domain	NFACT protein, C-terminal	963 - 1054	IPR021846

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RQC complex	A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.

Name	Definition
ribosomal large subunit binding	Binding to a large ribosomal subunit.
tRNA binding	Binding to a transfer RNA.

Name	Definition
CAT tailing	The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control sytem.
nuclear export	The directed movement of substances out of the nucleus.
protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
rescue of stalled ribosome	A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.
ribosome-associated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VBX1	Clbn	Ribosome quality control complex subunit NEMF homolog	Drosophila melanogaster (Fruit fly)	PR
O60524	NEMF	Ribosome quality control complex subunit NEMF	Homo sapiens (Human)	PR