Q9V9A7

PR
Gene name
Mccc2
Protein name
Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Names
MCCase subunit beta, 3-methylcrotonyl-CoA carboxylase 2, 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit, 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3267
EC number
6.4.1.4: Forming carbon-carbon bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9V9A7

Entry ID Method Resolution Chain Position Source
AF-Q9V9A7-F1 Predicted AlphaFoldDB

No variants for Q9V9A7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V9A7

No associated diseases with Q9V9A7

3 regional properties for Q9V9A7

Type Name Position InterPro Accession
domain Acetyl-coenzyme A carboxyltransferase, N-terminal 48 - 305 IPR011762
domain Acetyl-coenzyme A carboxyltransferase, C-terminal 321 - 570 IPR011763
domain Acetyl-CoA carboxylase 74 - 568 IPR034733

Functions

Description
EC Number 6.4.1.4 Forming carbon-carbon bonds
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
methylcrotonoyl-CoA carboxylase complex A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
methylcrotonoyl-CoA carboxylase activity Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.

3 GO annotations of biological process

Name Definition
coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
leucine catabolic process The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
regulation of eclosion Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99MN9 Pccb Propionyl-CoA carboxylase beta chain, mitochondrial Mus musculus (Mouse) PR
P34385 F02A9.10 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Caenorhabditis elegans PR
10 20 30 40 50 60
MIRLNWLFRS SSVLLRSQVR LLHVGDANVL HSEVDKQSAE YKENAREMAS LVGDLRNFTS
70 80 90 100 110 120
QVLKGGGQKA IERHTSRGKL LARERINLLL DKGSPFLELS ALAGHELYGE EVVNSGGIVT
130 140 150 160 170 180
GVGRVCGTEC LVVANDATVK GGSYYPITVK KHLRAQEIAQ ENRLPCIYLV DSGGANLPRQ
190 200 210 220 230 240
ADVFPDKLHF GRIFYNQANM SAQGIPQIAV VMGSCTAGGA YVPAMADESI IVKKQGTIFL
250 260 270 280 290 300
AGPPLVKAAT GEEVSAEDLG GADLHCKTSG VTDHYALDDE HALYLARQIV SNLNLSATNS
310 320 330 340 350 360
YNDQLMHSSQ VNFQTATPPS AVEEPRYDAE ELYGIVGPNL TKSFDVREVI ARIVDGSRFT
370 380 390 400 410 420
EFKKLYGETL VCGFAKLYGH TVGIVGNNGV LFSESALKGA HFIQLCAQRK IPLVFLQNIT
430 440 450 460 470 480
GFMVGRDAEA NGIAKNGAKM VTAVACANVP KFTVIIGGSY GAGNYGMCGR AYSPRFLYMW
490 500 510 520 530 540
PNSRISVMGG TQAANVMAQI TEDQRKRAGK EFSEEEAQKL KAPIVEMFEA EGSPYYSTAR
550 560 570
LWDDGIIDPA NTRQILGLSL KAALNNAGQE TKFGVFRM