AiPD: Autoinhibited Protein Database

Gene name	Pccb
Protein name	Propionyl-CoA carboxylase beta chain, mitochondrial
Names	PCCase subunit beta, Propanoyl-CoA:carbon dioxide ligase subunit beta
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:66904
EC number	6.4.1.3: Forming carbon-carbon bonds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-51 (Predicted disordered autoinhibitory region) PR

1-51 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q99MN9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs219459016	17	S>G	No	EVA
rs260077887	27	T>A	No	EVA
rs3389054688	40	R>H	No	EVA
rs260648302	73	S>R	No	EVA
rs3389064908	78	P>S	No	EVA
rs13469050	82	M>V	No	EVA
rs3389045597	139	H>Y	No	EVA
rs3389067672	142	K>R	No	EVA
rs3389045549	151	I>V	No	EVA
rs3400040395	162	D>E	No	EVA
rs3400650227	163	S>P	No	EVA
rs3389062009	172	V>M	No	EVA
rs3389068625	205	G>E	No	EVA
rs3400818785	218	M>I	No	EVA
rs3400818822	218	M>T	No	EVA
rs3400664913	219	V>M	No	EVA
rs3400818103	295	D>V	No	EVA
rs3389067705	310	L>F	No	EVA
rs3389059079	327	D>N	No	EVA
rs3389034136	345	G>D	No	EVA
rs3389034220	348	R>SE*	No	EVA
rs3389059118	349	M>V	No	EVA
rs3389064727	363	V>G	No	EVA
rs3389053358	375	K>N	No	EVA
rs3389032767	389	P>S	No	EVA
rs3389066590	428	K>Q	No	EVA
rs3389053414	441	Y>*	No	EVA
rs3389068623	446	S>F	No	EVA
rs3389032760	483	A>V	No	EVA
rs3389010693	497	P>R	No	EVA
rs3389045587	499	A>T	No	EVA
rs3389068703	510	P>S	No	EVA
rs3389068690	511	S>F	No	EVA

Type	Name	Position	InterPro Accession
domain	Acetyl-coenzyme A carboxyltransferase, N-terminal	34 - 292	IPR011762
domain	Acetyl-coenzyme A carboxyltransferase, C-terminal	296 - 535	IPR011763
domain	Acetyl-CoA carboxylase	60 - 539	IPR034733

		Description
EC Number	6.4.1.3	Forming carbon-carbon bonds
Subcellular Localization	Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
catalytic complex	A protein complex which is capable of catalytic activity.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
propionyl-CoA carboxylase activity	Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9V9A7	Mccc2	Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	Drosophila melanogaster (Fruit fly)	PR
P34385	F02A9.10	Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	Caenorhabditis elegans	PR