Q9V8K2
PR
Gene name |
Sec6 |
Protein name |
Exocyst complex component 3 |
Names |
Exocyst complex component Sec6 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG5341 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9V8K2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9V8K2-F1 | Predicted | AlphaFoldDB |
No variants for Q9V8K2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9V8K2 | |||||
No associated diseases with Q9V8K2
1 regional properties for Q9V8K2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M20, dimerisation domain | 242 - 334 | IPR011650 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| exocyst | A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| rhabdomere | The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction. |
| zonula adherens | A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| border follicle cell migration | The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster. |
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| exocyst localization | Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| Golgi to plasma membrane protein transport | The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. |
| neurotransmitter secretion | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. |
| ovarian follicle cell development | The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster. |
| plasma membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. |
| protein localization to cell cortex | A process in which a protein is transported to, or maintained in, the cell cortex. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| rhabdomere membrane biogenesis | A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane. |
| synaptic vesicle docking | The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. |
| synaptic vesicle targeting | The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q19262 | sec-6 | Exocyst complex component 3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLQQLEEQA | RQAALKDIQN | MLQRPGQLEK | VEQYRHRIAR | KKASVEALLK | TGMQGQLDGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVGLKQLETC | MQDVREVRRR | MDEVERLLRG | VPEVYDALEV | VREENTKHSQ | YATAMENLKH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IFNVDASVQK | TMALIEDDKL | LNAHQCLADL | ENSRDDLLYE | LHKQPKQHAS | DKITLKRHFE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVDTVSQELE | KKLRLILSRT | LNTLRKKPTI | IVTALRIIER | EEKNDQFALQ | QQKVTGFLPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRPKAWRRMI | MDVLQQSVIT | RIEGSKLEER | ADNKMWLVRD | LEILRQIILE | DLRVVKSLCV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PCFPPHYDIF | GEYVKFYHEG | LSSYLDNIVR | SGLEGNEYVS | MMAWVTHTYP | GVELMSHPDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVDVHRQIGT | LLRPEHLKAL | EDEYLQNMQR | NFQEWMTKAA | ETEKQEWFTE | TVPDQDEEYY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HTSAPVIIFQ | MIDQHLQVTN | TIHQELTFKA | LVMSIQQVEI | FGQTYLKNVI | ELKEHHFRNR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DQIKYFTHYI | ITIVNNSQQM | VELAQQMKQL | YWPKSRTEHY | EDFERLLATF | QRIRAHAASY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLEEAFLDME | CHFNDLFTAK | WLASNIAVDT | ICVTLDDYFQ | DYNHLRPNNF | EMVINEAQKL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LAKRYIRALL | SKRLSKPRAE | CDAITRKIKT | EAKRFKLFFE | KIAPKISLSD | SPLDLISTLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ALLSSDIELL | VLDLHTLLGS | YPSLNEDHLV | RLFYIRNDVK | AAEVREKVQD | AMKSKKAMVS |
| 730 | |||||
| IAKQDCIFKE | IVFSDKLW |