Q9V7P1
Gene name |
wcd (l(2)k07824, CG7989) |
Protein name |
U3 small nucleolar RNA-associated protein 18 homolog |
Names |
Protein wicked, WD repeat protein l(2)k07824 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG7989 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9V7P1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9V7P1-F1 | Predicted | AlphaFoldDB |
No variants for Q9V7P1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9V7P1 | |||||
No associated diseases with Q9V7P1
4 regional properties for Q9V7P1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 196 - 233 | IPR001680-1 |
| repeat | WD40 repeat | 323 - 361 | IPR001680-2 |
| repeat | WD40 repeat | 364 - 404 | IPR001680-3 |
| repeat | WD40 repeat | 457 - 499 | IPR001680-4 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| germinal vesicle | The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Pwp2p-containing subcomplex of 90S preribosome | A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. |
| small nuclear ribonucleoprotein complex | A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| female germ-line stem cell asymmetric division | The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. |
| neuroblast proliferation | The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5SSI6 | Utp18 | U3 small nucleolar RNA-associated protein 18 homolog | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSDESSDGL | EELQSLKALY | GQQEQEKPAK | IKRERYIPKA | SQAKELNYVE | VPMEKVLFGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RQRLLTNLAK | SVGQKLPNDD | EDEQEENPGQ | AKPGDKRKAA | WSDSDDEDLQ | VGDVKKATKH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGPLNHLRKD | KSYKEYLTAR | FQRTLNQPKW | AEKKVKNEDD | EDVSSDEELL | RTVGFIDRKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNSDLPQKTL | NFKRVKDLNR | ATYAEGNATS | IQFHPTSTAA | LVAGMNGLAT | IYAVDGQKNE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLHNMRFKKF | PLACSRIAPC | GTRAFFGSVK | PFYYSYDLLE | AKESKLKLPG | AMEFMHRFEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPCGKFIVTA | GKFGAIHLLT | AKTNELLHSF | KQEGKVKGFT | WSSDSKRILV | CGSTSNVSVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLRQNLIEHI | FMDDGCIHGE | SIQLSPNQRL | LATGSQEGVV | NIYDYESIFA | SKAPQPEKRF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MNLRTAITDL | QFNHSSELLA | MCSSEAPNAF | KLAHFPSATV | YSNFPAQNEK | VGFVTSMAFS |
| 490 | 500 | ||||
| PHSSFLAFAT | KGKQVPLFRL | KYFKGY |