Q5SSI6
Gene name |
Utp18 (Wdr50) |
Protein name |
U3 small nucleolar RNA-associated protein 18 homolog |
Names |
WD repeat-containing protein 50 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217109 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5SSI6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5SSI6-F1 | Predicted | AlphaFoldDB |
19 variants for Q5SSI6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs237753095 | 39 | Q>H | No | EVA | |
| rs232672008 | 117 | E>D | No | EVA | |
| rs241339988 | 134 | Q>K | No | EVA | |
| rs3389195994 | 152 | N>Y | No | EVA | |
| rs251346446 | 166 | S>T | No | EVA | |
| rs3389194836 | 175 | K>R | No | EVA | |
| rs49199013 | 198 | R>Q | No | EVA | |
| rs265216020 | 206 | S>T | No | EVA | |
| rs3389194822 | 207 | E>D | No | EVA | |
| rs245661900 | 213 | L>W | No | EVA | |
| rs3389155791 | 229 | R>* | No | EVA | |
| rs3389194870 | 240 | A>D | No | EVA | |
| rs3389180990 | 314 | K>R | No | EVA | |
| rs3410819157 | 330 | H>Y | No | EVA | |
| rs46664395 | 355 | S>G | No | EVA | |
| rs247704501 | 396 | Y>S | No | EVA | |
| rs220457328 | 417 | L>P | No | EVA | |
| rs3389205994 | 527 | P>S | No | EVA | |
| rs3402934265 | 551 | D>Y | No | EVA |
No associated diseases with Q5SSI6
1 regional properties for Q5SSI6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | von Willebrand factor, type A | 319 - 483 | IPR002035 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Pwp2p-containing subcomplex of 90S preribosome | A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9V7P1 | wcd | U3 small nucleolar RNA-associated protein 18 homolog | Drosophila melanogaster (Fruit fly) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPERKSRTR | RDRRAGATPG | RKARPGSGST | PAKAARSSQR | TQPAEPRAAP | SAGSAAAAAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEESRLRQRN | RLTLEDDKPA | AERCLEQLVF | GDVEDDEDAL | LQRLRSSRGQ | LHGSSDESEV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENEAKDIFSQ | KKKQPVWVDE | DDEDEEIVDM | SNNRFRKDIM | KNASESKLSK | DKLQKRLKEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FQHAMGGVPD | WAEAGSKRRT | SSDDESEEDE | DDLLQRTGNF | ISTSTSLPRG | ILKMKNCRPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NAERPTTARI | SSVQFHPGAQ | VVMVSGVDNA | ISLFQVDGKT | NPKIQSIYLE | KFPIFKACFS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ANGEEVLATS | MHSKVLYVYD | MLAGKLIPVH | QVRGLKEKTV | KQFEVSPDGS | FLLISGIAGF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SHLLSMKTKE | LIGSMKINGR | IAASTFSSDS | KRIYTYSENG | EVYVWDVNSR | KCMNRFLDEG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLCGLSIAAS | KNGQYVACGS | KSGVVNIYNQ | DSCLQQTNPK | PIKAIMNLVT | GVTSLAFNPT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TEILAVASRK | MKEAVRLVHL | PSCTVFSNFP | VFKKSTLSRV | QTMDFSPRGG | YFALGNEKGR |
| 550 | |||||
| ALMYRLHHYS | DF |