Q9V3R6

PR
Gene name
Adat1
Protein name
tRNA-specific adenosine deaminase 1
Names
dADAT1, tRNA-specific adenosine-37 deaminase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG16889
EC number
3.5.4.34: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

106-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9V3R6

Entry ID Method Resolution Chain Position Source
AF-Q9V3R6-F1 Predicted AlphaFoldDB

No variants for Q9V3R6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V3R6

No associated diseases with Q9V3R6

1 regional properties for Q9V3R6

Type Name Position InterPro Accession
domain Adenosine deaminase/editase 7 - 389 IPR002466

Functions

Description
EC Number 3.5.4.34 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

5 GO annotations of molecular function

Name Definition
double-stranded RNA adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
double-stranded RNA binding Binding to double-stranded RNA.
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA-specific adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.

4 GO annotations of biological process

Name Definition
adenosine to inosine editing The conversion of an adenosine residue to inosine in an RNA molecule by deamination.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q22618 adr-2 Double-stranded RNA-specific adenosine deaminase adr-2 Caenorhabditis elegans PR
10 20 30 40 50 60
MCDNKKPTVK EIAELCLKKF ESLPKTGKPT ANQWTILAGI VEFNRNTEAC QLVSLGCGTK
70 80 90 100 110 120
CIGESKLCPN GLILNDSHAE VLARRGFLRF LYQELKQDRI FHWNSTLSTY DMDEHVEFHF
130 140 150 160 170 180
LSTQTPCGDA CILEEEQPAA RAKRQRLDED SEMVYTGAKL ISDLSDDPML QTPGALRTKP
190 200 210 220 230 240
GRGERTLSMS CSDKIARWNV IGVQGALLDV LISKPIYFSS LNFCCDDAQL ESLERAIFKR
250 260 270 280 290 300
FDCRTFKHTR FQPQRPQINI DPGIRFEFSQ RSDWQPSPNG LIWSQVPEEL RPYEISVNGK
310 320 330 340 350 360
RQGVTKKKMK TSQAALAISK YKLFLTFLEL VKFNPKLSEM FDQQLSDPER IAYASCKDLA
370 380 390
RDYQFAWREI KEKYFLQWTK KPHELLDFNP MSNK