Q22618

PR
Gene name
adr-2 (T20H4.4)
Protein name
Double-stranded RNA-specific adenosine deaminase adr-2
Names
DRADA
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T20H4.4
EC number
3.5.4.37: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

224-319 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q22618

Entry ID Method Resolution Chain Position Source
AF-Q22618-F1 Predicted AlphaFoldDB

No variants for Q22618

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q22618

No associated diseases with Q22618

2 regional properties for Q22618

Type Name Position InterPro Accession
domain Adenosine deaminase/editase 122 - 493 IPR002466
domain Double-stranded RNA-binding domain 36 - 105 IPR014720

Functions

Description
EC Number 3.5.4.37 In cyclic amidines
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
double-stranded RNA adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
double-stranded RNA binding Binding to double-stranded RNA.
metal ion binding Binding to a metal ion.
tRNA-specific adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.

6 GO annotations of biological process

Name Definition
adenosine to inosine editing The conversion of an adenosine residue to inosine in an RNA molecule by deamination.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V3R6 Adat1 tRNA-specific adenosine deaminase 1 Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MSVEEGMEVE LKSEKMDLDD NIPDFVKETV ERSGKNPMSL FSELYVHMTG NTPVFDFYNR
70 80 90 100 110 120
NQPNGSMKFI CVVILNGERI EGNVKSKKKE AKVSCSLKGL EVVLKHVSEY VVPAVKFEEK
130 140 150 160 170 180
TTFFEMLREH TYAKFYELCK NNALIYGFEK VIASVFLKIN GNLQIIALST GNKGLRGDKI
190 200 210 220 230 240
VNDGTALIDC HAEILARRGL LRFLYSEVLK FSTEPPNSIF TKGKNALVLK PGISFHLFIN
250 260 270 280 290 300
TAPCGVARID KKLKPGTSDD LQNSSRLRFK IDKGMGTVLG GASEFEAPQT FDGIMMGERM
310 320 330 340 350 360
RTMSCSDKLL RANVLGVQGA ILSHFIDPIY YSSIAVAELN NADRLRKAVY SRAATFKPPA
370 380 390 400 410 420
PFHVQDVEIG ECQVEDTEQS TSAAARSTIS SMNWNLADGN TEVVRTSDGM VHDKDMSGAD
430 440 450 460 470 480
ITTPSRLCKK NMAELMITIC TLTKTSVDYP ISYEELKAGS QEYAAAKKSF ITWLRQKDLG
490
IWQRKPREFQ MFTIN