AiPD: Autoinhibited Protein Database

Q9UKN8

Gene name	GTF3C4
Protein name	General transcription factor 3C polypeptide 4
Names	TF3C-delta, Transcription factor IIIC 90 kDa subunit, TFIIIC 90 kDa subunit, TFIIIC90, Transcription factor IIIC subunit delta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9329
EC number	2.3.1.48: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

569-688 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

569-688 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9UKN8

Entry ID	Method	Resolution	Chain	Position	Source
8CLI	EM	320 A	B	1-822	PDB
8CLJ	EM	320 A	B/G	1-822	PDB
8CLL	EM	340 A	B/G	1-822	PDB
AF-Q9UKN8-F1	Predicted				AlphaFoldDB

499 variants for Q9UKN8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1001047248 CA200870740	2	N>D		No	ClinGen TOPMed gnomAD
rs1022128165 CA200870757	2	N>K		No	ClinGen TOPMed
rs774493926 CA5300548	3	T>A		No	ClinGen ExAC TOPMed gnomAD
CA375364240 rs1311171799	3	T>M		No	ClinGen TOPMed gnomAD
rs143172300 COSM3699498 CA5300549	4	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1367488266 CA375364256	4	A>V		No	ClinGen TOPMed
CA375364265 rs1315194724	5	D>G		No	ClinGen gnomAD
rs977905479 CA200870765	7	A>T		No	ClinGen Ensembl
rs551059877 CA5300550	7	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1418573317 CA375364331	8	R>Q		No	ClinGen TOPMed
CA375364323 rs1237487155	8	R>W		No	ClinGen TOPMed gnomAD
rs199984441 CA5300551	9	V>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA375364347 rs199984441	9	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA200870769 rs960462253	9	V>M		No	ClinGen Ensembl
rs537208639 CA5300552	10	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1482850396 CA375364382	12	A>T		No	ClinGen gnomAD
rs1258001041 CA375364405	13	D>H		No	ClinGen gnomAD
rs757913856 CA5300556	14	D>N		No	ClinGen ExAC TOPMed gnomAD
rs757913856 CA5300555	14	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1020110450 CA200870799	15	G>R		No	ClinGen TOPMed
CA5300558 rs756998341	16	P>R		No	ClinGen ExAC gnomAD
rs751203468 CA375364465	16	P>S		No	ClinGen ExAC TOPMed gnomAD
rs751203468 CA5300557	16	P>T		No	ClinGen ExAC TOPMed gnomAD
CA375364481 rs746264187	17	A>E		No	ClinGen ExAC TOPMed gnomAD
rs781585893 CA5300559	17	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5300560 rs746264187	17	A>V		No	ClinGen ExAC TOPMed gnomAD
CA375364524 rs1305170068	20	G>R		No	ClinGen gnomAD
CA375364554 rs1590128046	21	E>G		No	ClinGen Ensembl
rs1394599703 CA375364543	21	E>K		No	ClinGen TOPMed
rs1471588953 CA375364598	23	E>G		No	ClinGen TOPMed
rs1446455850 CA375364616	24	G>A		No	ClinGen gnomAD
CA375364621 rs1446455850	24	G>E		No	ClinGen gnomAD
CA375364645 rs1332490798	25	E>D		No	ClinGen gnomAD
CA375364639 rs1365437491	25	E>G		No	ClinGen TOPMed
rs1028873172 CA200870818	26	G>A		No	ClinGen TOPMed gnomAD
CA375364653 rs1377109871	26	G>R		No	ClinGen gnomAD
rs1028873172 CA375364659	26	G>V		No	ClinGen TOPMed gnomAD
CA375364678 rs1298556322	27	G>D		No	ClinGen gnomAD
rs951933277 CA200870822	27	G>S		No	ClinGen TOPMed gnomAD
CA5300562 rs770323812	28	G>S		No	ClinGen ExAC TOPMed gnomAD
rs13287671 CA200870832	29	E>*		No	ClinGen gnomAD
rs13287671 CA375364710	29	E>K		No	ClinGen gnomAD
CA375364741 rs1257726069	30	A>V		No	ClinGen gnomAD
CA200870843 rs984605635	31	G>D		No	ClinGen TOPMed
CA375364748 rs780496217	31	G>R		No	ClinGen ExAC gnomAD
rs780496217 CA5300563	31	G>S		No	ClinGen ExAC gnomAD
CA5300565 rs768668818	35	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1459204243 CA375364854	37	A>T		No	ClinGen TOPMed gnomAD
CA375364868 rs1266744744	38	D>Y		No	ClinGen gnomAD
CA375364896 rs1433893626	39	A>V		No	ClinGen gnomAD
CA375364899 rs1178362880	40	A>S		No	ClinGen gnomAD
rs1178362880 CA375364901	40	A>T		No	ClinGen gnomAD
rs1564351676 CA375364916	41	P>A		No	ClinGen Ensembl
rs1465576302 CA375364927	41	P>L		No	ClinGen gnomAD
CA375364943 rs1402994928	42	G>E		No	ClinGen gnomAD
rs1291484338 CA375364963	43	P>L		No	ClinGen gnomAD
CA375364947 rs1443911202	43	P>T		No	ClinGen gnomAD
rs1047261559 CA200870866	44	S>N		No	ClinGen gnomAD
CA200870870 rs867158126	45	A>S		No	ClinGen gnomAD
rs867158126 CA375364996	45	A>T		No	ClinGen gnomAD
CA375365008 rs1302791120	45	A>V		No	ClinGen gnomAD
CA200870872 rs867444042	46	A>S		No	ClinGen gnomAD
rs1217938706 CA375365041	47	F>Y		No	ClinGen gnomAD
CA5300571 rs765083568	48	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5300570 rs759314281	48	R>S		No	ClinGen ExAC gnomAD
rs1488942502 CA375365074	49	L>F		No	ClinGen gnomAD
rs752623629 CA5300572	49	L>R		No	ClinGen ExAC TOPMed gnomAD
CA375365096 rs1261132986	50	M>I		No	ClinGen gnomAD
rs866689535 CA200870902	50	M>K		No	ClinGen Ensembl
CA5300575 rs763652907	50	M>V		No	ClinGen ExAC
rs751151981 CA200870906	52	T>I		No	ClinGen ExAC TOPMed gnomAD
CA5300576 rs751151981	52	T>S		No	ClinGen ExAC TOPMed gnomAD
rs756908231 CA5300577	53	R>P		No	ClinGen ExAC gnomAD
rs756908231 CA375365122	53	R>Q		No	ClinGen ExAC gnomAD
rs369871890 CA200870914	53	R>W		No	ClinGen ESP TOPMed gnomAD
CA375365137 rs1489321984	54	R>Q		No	ClinGen gnomAD
CA375365156 rs1164551248	55	E>D		No	ClinGen gnomAD
rs1348885489 CA375365163	56	P>L		No	ClinGen gnomAD
rs756370178 CA5300580	58	V>L		No	ClinGen ExAC gnomAD
rs553661991 CA5300581	59	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs577948269 CA375365203	60	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1044725141 CA200870938	61	Q>H		No	ClinGen TOPMed
rs1278819638 CA375365230	62	Y>C		No	ClinGen gnomAD
CA375365241 rs1342107757	63	A>S		No	ClinGen TOPMed gnomAD
CA375365237 rs1342107757	63	A>T		No	ClinGen TOPMed gnomAD
rs866919383 CA200870940	63	A>V		No	ClinGen gnomAD
CA375365256 rs1445349926	65	S>G		No	ClinGen TOPMed
CA375365263 rs1286353466	65	S>T		No	ClinGen TOPMed
CA5300584 rs778934641	66	G>C		No	ClinGen ExAC TOPMed gnomAD
CA375365277 rs1224145377	66	G>D		No	ClinGen gnomAD
CA5300585 rs748278700	69	P>L		No	ClinGen ExAC gnomAD
TCGA novel	71	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5300587 rs773240454	74	E>Q		No	ClinGen ExAC gnomAD
CA375365374 rs1371346471	75	D>N		No	ClinGen TOPMed
rs1296395892 CA375365395	76	H>R		No	ClinGen TOPMed
CA375365406 rs1428121056	77	R>H		No	ClinGen TOPMed
CA375365416 rs1590128601	78	V>G		No	ClinGen Ensembl
rs769426206 CA5300589	79	S>C		No	ClinGen ExAC gnomAD
CA5300590 rs775452875	80	V>A		No	ClinGen ExAC gnomAD
rs762948791 CA5300591	81	S>P		No	ClinGen ExAC gnomAD
CA375365457 rs1298313864	82	T>A		No	ClinGen gnomAD
CA5300593 rs373168131	83	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs373168131 CA5300594	83	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs767061987 CA5300595	84	R>C		No	ClinGen ExAC gnomAD
rs1008328067 CA200870981	84	R>P		No	ClinGen Ensembl
rs1379696323 CA375365489	85	S>C		No	ClinGen gnomAD
rs1399928880 CA375365520	87	A>G		No	ClinGen TOPMed
CA375365582 rs375081797	92	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1441120710 CA375365626	96	H>Y		No	ClinGen gnomAD
rs996102613 CA200871005	97	N>D		No	ClinGen Ensembl
rs1008810586 CA200871008	97	N>S		No	ClinGen TOPMed gnomAD
rs199967299 CA375365648	98	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5300600 rs199967299	98	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1243940632 CA375365652	99	G>S		No	ClinGen TOPMed
CA375365666 rs1442395106	101	D>N		No	ClinGen TOPMed
rs1590128759 CA375365680	103	V>L		No	ClinGen Ensembl
CA375365699 rs1213542339	104	I>V		No	ClinGen TOPMed
CA5300602 rs748691331	105	H>Q		No	ClinGen ExAC gnomAD
rs144693888 CA5300604	110	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA375365789 rs144693888	110	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1333486710 CA375365811	111	A>T		No	ClinGen gnomAD
TCGA novel	112	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA200871020 rs370720484	112	P>R		No	ClinGen ESP
CA375365824 rs1454344173	112	P>S		No	ClinGen gnomAD
CA5300606 rs771315466	113	L>V		No	ClinGen ExAC gnomAD
CA5300608 rs749149752	114	N>D		No	ClinGen ExAC TOPMed gnomAD
CA375365869 rs1343035516	115	S>N		No	ClinGen gnomAD
CA375365871 CA375365873 rs1219136683	115	S>R		No	ClinGen gnomAD
rs1458699397 CA375365897	117	L>F		No	ClinGen TOPMed gnomAD
rs147937684 CA200878164	126	V>I		No	ClinGen ESP gnomAD
CA5300639 rs764715859	127	A>T		No	ClinGen ExAC TOPMed gnomAD
CA375367557 rs1353734836	128	E>D		No	ClinGen gnomAD
rs1476543075 CA375367560	129	C>G		No	ClinGen TOPMed
rs1490712147 COSM1106289 CA375367710	134	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5300641 rs757337001	134	A>V		No	ClinGen ExAC gnomAD
rs141734420 CA5300644	135	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs150072883 CA5300645	137	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA200878178 rs983358572	138	D>N		No	ClinGen Ensembl
CA5300646 rs142424490	140	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777836863 CA5300648	144	T>I		No	ClinGen ExAC gnomAD
rs1417893808 CA375368142	152	N>D		No	ClinGen gnomAD
CA375368147 rs1297679561	152	N>S		No	ClinGen gnomAD
rs965874077 CA200878184	153	P>S		No	ClinGen TOPMed gnomAD
rs937807375 CA200878195	154	E>G		No	ClinGen TOPMed
TCGA novel	154	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5300651 rs776146272	157	A>S		No	ClinGen ExAC gnomAD
rs1340310794 CA375368308	159	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5300652 rs762953768	161	M>V		No	ClinGen ExAC TOPMed gnomAD
CA375368373 rs1271089183	162	R>G		No	ClinGen TOPMed
CA5300653 rs769535681	162	R>K		No	ClinGen ExAC gnomAD
CA5300654 rs775703703	163	G>E		No	ClinGen ExAC gnomAD
CA375368410 rs775703703	163	G>V		No	ClinGen ExAC gnomAD
CA5300655 rs763441059	165	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1237266027 CA375368451	165	K>R		No	ClinGen TOPMed gnomAD
CA200878212 rs764369501	168	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	168	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375369768 rs1564355300	172	M>L		No	ClinGen Ensembl
CA375369789 rs1184003543	175	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs762433623 CA375369803	177	N>D		No	ClinGen ExAC gnomAD
CA5300658 rs762433623	177	N>H		No	ClinGen ExAC gnomAD
CA375369818 rs1158050028	178	G>D		No	ClinGen gnomAD
rs767666438 CA5300659	178	G>S		No	ClinGen ExAC gnomAD
TCGA novel	179	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5300660 rs750571235	180	C>G		No	ClinGen ExAC gnomAD
rs756387215 CA5300661	180	C>W		No	ClinGen ExAC gnomAD
CA5300663 rs376003896	189	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5300664 rs758147814	190	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA200878236 rs925192356	190	R>H		No	ClinGen gnomAD
CA5300665 rs777448372	191	L>V		No	ClinGen ExAC gnomAD
CA375370009 rs1420517846	192	T>I		No	ClinGen TOPMed
CA200878241 rs763759650	193	I>M		No	ClinGen TOPMed
CA5300667 rs770891234	194	Q>L		No	ClinGen ExAC gnomAD
CA200878242 rs935152452	195	A>S		No	ClinGen Ensembl
CA375370078 rs1474103338	198	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1564355332 CA375370074	198	N>Y		No	ClinGen Ensembl
rs145407571 CA5300668	200	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA200878251 rs1052714753	201	Q>R		No	ClinGen Ensembl
CA5300669 rs745440647	203	V>A		No	ClinGen ExAC TOPMed gnomAD
rs149206327 CA200878266	204	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA375370183 rs1206041122	206	V>G		No	ClinGen TOPMed
CA5300673 rs573535287	210	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1380072606 CA375370243	211	I>F		No	ClinGen gnomAD
CA5300674 rs774888300	211	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1380072606 CA375370241	211	I>V		No	ClinGen gnomAD
CA5300677 rs773416400	215	R>C		No	ClinGen ExAC gnomAD
CA200878289 rs760878207	216	L>F		No	ClinGen ExAC TOPMed gnomAD
CA5300678 rs760878207	216	L>V		No	ClinGen ExAC TOPMed gnomAD
rs766376449 CA5300679	220	S>N		No	ClinGen ExAC TOPMed gnomAD
CA200878297 rs200907339	224	S>F		No	ClinGen Ensembl
rs540918126 CA375370404	225	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA375370410 rs1470597962	225	K>N		No	ClinGen TOPMed gnomAD
CA5300681 rs540918126	225	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1350449583 CA375370412	226	N>D		No	ClinGen TOPMed
rs1178947969 CA375370419	227	E>K		No	ClinGen gnomAD
CA5300683 rs143033367	229	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs143033367 CA375370437	229	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5300687 rs146657712	234	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779455330 CA5300688	235	D>E		No	ClinGen ExAC gnomAD
rs748932249 CA5300689	237	A>S		No	ClinGen ExAC TOPMed gnomAD
rs768234250 CA5300690	237	A>V		No	ClinGen ExAC gnomAD
TCGA novel	241	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1248346415 CA375370535	243	H>Q		No	ClinGen TOPMed
rs1178365341 CA375370568	248	P>A		No	ClinGen TOPMed
rs1564355394 CA375370574	249	V>L		No	ClinGen Ensembl
CA200878414 rs1004371797	256	I>F		No	ClinGen Ensembl
rs145321049 CA5300694	256	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1481048356 CA375370674	263	K>R		No	ClinGen TOPMed gnomAD
rs761102419 CA5300695	264	H>L		No	ClinGen ExAC gnomAD
rs1421896895 CA375370688	265	N>D		No	ClinGen gnomAD
CA375370702 rs1354693164	267	E>K		No	ClinGen TOPMed gnomAD
CA375370711 rs759779139	268	C>G		No	ClinGen ExAC gnomAD
CA5300698 rs759779139	268	C>R		No	ClinGen ExAC gnomAD
rs749918154 CA200878459	269	R>Q		No	ClinGen gnomAD
rs754499700 CA5300699	269	R>W		No	ClinGen ExAC gnomAD
TCGA novel	270	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375370720 rs1405463664	270	D>N		No	ClinGen gnomAD
CA5300700 rs201546911	271	V>I		No	ClinGen ExAC TOPMed gnomAD
rs756979020 CA5300701	273	S>C		No	ClinGen ExAC gnomAD
rs767312396 CA5300702	273	S>N		No	ClinGen ExAC gnomAD
CA375370762 rs1293065225	277	A>T		No	ClinGen TOPMed
rs1224858006 CA375370806	283	G>D		No	ClinGen gnomAD
rs779585989 CA5300705	283	G>S		No	ClinGen ExAC TOPMed gnomAD
CA375370819 rs1396996828	285	I>V		No	ClinGen TOPMed
rs778778757 CA5300709	287	V>L		No	ClinGen ExAC gnomAD
rs778778757 CA5300708	287	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1422174670 CA375370854	290	F>C		No	ClinGen gnomAD
CA375370853 rs1422174670	290	F>S		No	ClinGen gnomAD
rs201207420 CA200878522	290	F>V		No	ClinGen Ensembl
CA5300711 rs773741291	295	V>L		No	ClinGen ExAC gnomAD
CA375370890 rs1304455556	296	G>R		No	ClinGen gnomAD
CA375370898 rs1358485963	297	K>E		No	ClinGen gnomAD
rs771386434 CA375370903	297	K>N		No	ClinGen ExAC TOPMed
CA5300715 rs759600640	304	N>S		No	ClinGen ExAC gnomAD
rs776754367 CA5300714	304	N>Y		No	ClinGen ExAC gnomAD
CA5300717 rs376721373	306	I>V		No	ClinGen ExAC TOPMed
rs763182669 CA5300718	307	E>A		No	ClinGen ExAC gnomAD
CA375370963 rs1455269072	307	E>K		No	ClinGen TOPMed
CA5300719 rs150601105	312	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA375371009 rs1248189045	314	S>N		No	ClinGen TOPMed gnomAD
rs1485741709 CA375371014	315	V>I		No	ClinGen TOPMed
rs1283975422 CA375371021	316	L>V		No	ClinGen gnomAD
CA375371072 rs1244169119	322	E>G		No	ClinGen gnomAD
rs750226686 CA5300720	322	E>K		No	ClinGen ExAC gnomAD
CA5300721 rs138645157	323	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1318090338 CA375371118	328	M>I		No	ClinGen TOPMed
CA375371126 rs1176255946	329	S>T		No	ClinGen gnomAD
CA5300723 rs753389105	336	A>T		No	ClinGen ExAC gnomAD
CA375371179 rs1302712779	337	F>S		No	ClinGen TOPMed
CA375371197 rs1232207652	339	P>R		No	ClinGen TOPMed
rs754475496 CA5300724	339	P>T		No	ClinGen ExAC gnomAD
CA200878597 rs373209760	340	I>M		No	ClinGen ESP TOPMed
TCGA novel	342	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378021066 CA375371277	346	N>S		No	ClinGen TOPMed gnomAD
CA375371291 rs1400028180	347	L>P		No	ClinGen gnomAD
rs1159806850 CA375371310	349	A>T		No	ClinGen gnomAD
CA5300725 rs778582706	350	V>I		No	ClinGen ExAC
TCGA novel	351	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346925659 CA375371336	351	K>R		No	ClinGen gnomAD
rs1290459438 CA375371464	361	I>T		No	ClinGen TOPMed
rs1454841578 CA375371511	364	K>N		No	ClinGen gnomAD
rs201188354 CA5300728	366	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5300731 rs781484748	373	S>I		No	ClinGen ExAC TOPMed gnomAD
CA375371609 rs1310983974	374	I>V		No	ClinGen TOPMed gnomAD
rs1455193844 CA375371634	376	C>R		No	ClinGen TOPMed
rs1053550791 CA200878627	378	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA200878646 rs377330805	382	P>S		No	ClinGen ESP
rs769815686 CA5300733	383	Y>S		No	ClinGen ExAC gnomAD
CA375371726 rs1469145911	384	Q>H		No	ClinGen gnomAD
rs1409996696 CA375371739	386	C>Y		No	ClinGen gnomAD
CA375371756 rs1412690859	388	C>S		No	ClinGen gnomAD
rs773046935 CA5300737	391	V>L		No	ClinGen ExAC gnomAD
CA375371782 rs1329604663	392	V>L		No	ClinGen TOPMed gnomAD
CA5300739 rs766205680	394	A>G		No	ClinGen ExAC gnomAD
rs760454849 CA5300738	394	A>S		No	ClinGen ExAC gnomAD
rs753664038 CA5300740	398	Y>F		No	ClinGen ExAC gnomAD
rs1004910585 CA200878705	399	V>I		No	ClinGen Ensembl
CA375371828 rs1441626006	400	F>L		No	ClinGen gnomAD
rs764806134 CA5300742	401	W>C		No	ClinGen ExAC gnomAD
rs1590134757 CA375371840	401	W>L		No	ClinGen Ensembl
rs752302758 CA5300744	402	C>W		No	ClinGen ExAC gnomAD
rs200074482 CA200878719	403	L>R		No	ClinGen Ensembl
rs1205141984 CA375371862	405	L>V		No	ClinGen gnomAD
rs1281192676 CA375371882	408	K>T		No	ClinGen TOPMed
rs140693132 CA5300748	413	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA375371922 rs1324943035	414	H>L		No	ClinGen TOPMed
CA5300751 rs770327028	420	G>D		No	ClinGen ExAC gnomAD
rs749428116 CA5300753	426	I>M		No	ClinGen ExAC gnomAD
rs780087553 CA5300752	426	I>V		No	ClinGen ExAC gnomAD
rs768862853 CA5300754	429	M>I		No	ClinGen ExAC gnomAD
rs528734639 CA5300755	430	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA375372086 rs1404854210	435	N>K		No	ClinGen gnomAD
CA375372110 rs1284532197	439	Y>C		No	ClinGen gnomAD
CA5300756 rs748419455	442	S>F		No	ClinGen ExAC gnomAD
rs770585023 CA5300757	443	S>G		No	ClinGen ExAC gnomAD
rs759521618 CA5300759	447	V>M		No	ClinGen ExAC gnomAD
TCGA novel	449	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA200878769 rs900835851	453	I>V		No	ClinGen TOPMed gnomAD
CA5300760 rs765321046	456	D>E		No	ClinGen ExAC gnomAD
rs1372359443 CA375372273	463	H>P		No	ClinGen gnomAD
CA200878780 rs978774425	464	Q>R		No	ClinGen Ensembl
rs1167459551 CA375372315	469	S>P		No	ClinGen TOPMed
rs1411684024 CA375372353	472	F>I		No	ClinGen TOPMed gnomAD
rs1172913383 CA375372376	473	G>A		No	ClinGen TOPMed
CA375372409 rs1303849289	476	R>M		No	ClinGen gnomAD
rs751123154 CA5300764	477	T>I		No	ClinGen ExAC gnomAD
CA200878788 rs956649378	479	G>R		No	ClinGen Ensembl
rs767741207 CA5300766	482	V>M		No	ClinGen ExAC gnomAD
CA375372510 rs1271530140	485	C>Y		No	ClinGen gnomAD
rs755530765 CA200878808	486	G>S		No	ClinGen gnomAD
rs917849815 CA200878810	487	A>V		No	ClinGen gnomAD
CA375372578 rs1203382261	491	I>M		No	ClinGen TOPMed gnomAD
rs1258273070 CA375372588	492	I>T		No	ClinGen TOPMed
rs780605582 CA5300769	494	T>A		No	ClinGen ExAC gnomAD
CA375372625 rs1447405361	495	E>D		No	ClinGen gnomAD
rs1195102253 CA375372634	496	G>D		No	ClinGen gnomAD
rs1564355784 CA375372641	497	M>V		No	ClinGen Ensembl
rs749801864 CA5300770	499	N>D		No	ClinGen ExAC TOPMed gnomAD
CA375372670 rs1444240476	499	N>S		No	ClinGen TOPMed gnomAD
CA375372678 rs1387221677	500	G>R		No	ClinGen TOPMed gnomAD
rs1387221677 CA375372676	500	G>S		No	ClinGen TOPMed gnomAD
rs1228512422 CA375372721	504	V>I		No	ClinGen TOPMed
rs142926692 CA5300773	505	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5300774 rs142926692	505	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5300775 rs776274426	511	Q>*		No	ClinGen ExAC gnomAD
rs769713214 CA5300777	512	F>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1451556358 CA375372833	512	F>L		No	ClinGen gnomAD
CA375372829 rs769713214	512	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1161798476 CA375372859	515	L>F		No	ClinGen Ensembl
CA5300779 rs763007178	515	L>P		No	ClinGen ExAC gnomAD
CA200878861 rs868547019	516	K>E		No	ClinGen Ensembl
rs1426530867 CA375372902	518	F>L		No	ClinGen gnomAD
TCGA novel	522	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1389189391 CA375372955	523	A>S		No	ClinGen TOPMed
CA5300783 rs767260308	524	Q>*		No	ClinGen ExAC gnomAD
rs1206604536 CA375372973	524	Q>H		No	ClinGen TOPMed gnomAD
rs1168125401 CA375372998	528	S>C		No	ClinGen TOPMed
rs1024343600 CA200878866	529	S>L		No	ClinGen TOPMed
CA5300784 rs750782237	530	V>I		No	ClinGen ExAC gnomAD
CA375373018 rs1166822372	532	N>H		No	ClinGen gnomAD
TCGA novel	534	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	534	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5300786 rs766746512	535	K>R		No	ClinGen ExAC TOPMed
rs1184490654 CA375373062	538	D>H		No	ClinGen gnomAD
CA5300788 rs536735702 COSM1106296	539	L>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs754298365 CA5300787	539	L>V		No	ClinGen ExAC gnomAD
rs1181205272 CA375373096	542	L>V		No	ClinGen gnomAD
CA5300791 rs748315051	544	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5300790 rs748315051	544	R>P		No	ClinGen ExAC TOPMed gnomAD
rs778071444 CA5300792	545	W>R		No	ClinGen ExAC gnomAD
TCGA novel	550	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747243764 CA5300793	552	H>Y		No	ClinGen ExAC
rs1405888496 CA375373244	553	I>M		No	ClinGen gnomAD
CA375373250 rs1468950956	554	P>S		No	ClinGen gnomAD
rs1436146810 CA375373281	556	F>C		No	ClinGen TOPMed
CA5300795 rs780026999	556	F>V		No	ClinGen ExAC gnomAD
CA5300796 rs749147104	558	Q>R		No	ClinGen ExAC gnomAD
rs146673001 CA375373338	561	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1241168444	564	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA5300798 rs145764040	565	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA375373400 rs1270994884	565	I>T		No	ClinGen TOPMed
rs1413805272 CA375373436	568	S>G		No	ClinGen Ensembl
CA375373457 rs1335329586	569	G>A		No	ClinGen TOPMed
rs1479787005 CA375373491	572	Y>C		No	ClinGen gnomAD
CA375373508 rs1195238522	573	F>L		No	ClinGen TOPMed gnomAD
CA5300801 rs772794978	574	W>*		No	ClinGen ExAC TOPMed gnomAD
CA375373524 rs772794978	574	W>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	574	W>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	574	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5300803 rs766693428	581	L>R		No	ClinGen ExAC gnomAD
rs765836358 CA5300806	588	M>I		No	ClinGen ExAC TOPMed gnomAD
CA5300805 rs759943928	588	M>V		No	ClinGen ExAC gnomAD
rs758442546 CA5300808	591	T>S		No	ClinGen ExAC TOPMed gnomAD
rs751790621 CA5300810	597	W>*		No	ClinGen ExAC gnomAD
CA375373813 rs1223832809	600	T>A		No	ClinGen gnomAD
rs1391983802 CA375373815	600	T>I		No	ClinGen TOPMed
rs1294771949 CA375373830	602	E>A		No	ClinGen TOPMed gnomAD
rs757590948 CA5300811	602	E>K		No	ClinGen ExAC gnomAD
rs534512256 CA5300812	603	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs534512256 CA200879012	603	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA5300813 rs370378462	604	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA375373872 rs577534312	609	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5300815 rs577534312	609	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1209177 CA200879018 rs1050022135	611	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	613	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375373907 rs1201962438	614	M>I		No	ClinGen gnomAD
rs1417883643 CA375373913	615	G>D		No	ClinGen gnomAD
TCGA novel	615	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375373918 rs1426345087	616	N>D		No	ClinGen gnomAD
rs1169355939 CA375373919	616	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	618	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564356001 CA375373938	619	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs771524922 CA5300817	628	S>F		No	ClinGen ExAC gnomAD
rs1405555555 CA375374011	629	K>E		No	ClinGen gnomAD
rs956202694 CA375374024	630	Q>H		No	ClinGen TOPMed gnomAD
rs1359671198 CA375374046	634	Q>E		No	ClinGen gnomAD
CA5300819 rs760291993	634	Q>H		No	ClinGen ExAC gnomAD
rs1359671198 CA375374045	634	Q>K		No	ClinGen gnomAD
CA375374049 rs1381836918	634	Q>R		No	ClinGen gnomAD
rs143136226 CA5300821	637	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs143136226 CA5300822	637	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs556897264 CA5300824	640	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs200585752 CA5300825	641	K>Q		No	ClinGen ExAC gnomAD
CA375374109 rs1187490676	643	G>E		No	ClinGen gnomAD
rs1332016605 CA375374106	643	G>R		No	ClinGen TOPMed
CA5300826 rs763400777	645	V>A		No	ClinGen ExAC gnomAD
rs1261921431 CA375374120	645	V>I		No	ClinGen TOPMed gnomAD
rs368103877 CA200879094	646	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs368103877 CA5300827	646	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs757539474 CA5300829	648	P>L		No	ClinGen ExAC gnomAD
rs757687002 CA5300830	650	D>E		No	ClinGen ExAC gnomAD
rs1452722959 CA375374160	651	D>A		No	ClinGen gnomAD
CA375374161 rs1452722959	651	D>G		No	ClinGen gnomAD
rs1343400741 CA375374157	651	D>N		No	ClinGen gnomAD
rs1343400741 CA375374158	651	D>Y		No	ClinGen gnomAD
rs201972228 CA5300831	652	S>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5300832 rs371993706	652	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5300836 rs777246101	655	T>M		No	ClinGen ExAC gnomAD
rs758374926 CA5300835	655	T>P		No	ClinGen ExAC TOPMed gnomAD
rs970646182 CA200879147	656	T>I		No	ClinGen Ensembl
rs1216865325 CA375374201	658	D>G		No	ClinGen gnomAD
CA200879149 rs926481315	659	A>G		No	ClinGen Ensembl
rs781306541 CA5300838	662	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5300839 rs375701353	662	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA375374245 rs1444675937	665	M>T		No	ClinGen gnomAD
CA200879155 rs1001914710	665	M>V		No	ClinGen TOPMed gnomAD
CA375374275 rs1345097639	669	L>F		No	ClinGen TOPMed
rs368435345 CA5300841	671	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1564356112 CA375374329	673	Q>*		No	ClinGen Ensembl
rs1360870586 CA375374348	674	G>R		No	ClinGen TOPMed
rs763532468 CA5300843	676	I>V		No	ClinGen ExAC gnomAD
rs764755045 CA5300844	678	A>V		No	ClinGen ExAC gnomAD
rs1407142092 CA375374471	682	H>R		No	ClinGen gnomAD
rs1336275955 CA375374462	682	H>Y		No	ClinGen TOPMed gnomAD
CA200879184 rs984241478	684	T>A		No	ClinGen TOPMed gnomAD
CA375374507 rs1373238019	685	R>G		No	ClinGen gnomAD
rs749134726 CA200879196	688	M>T		No	ClinGen Ensembl
CA5300846 rs761918283	698	H>R		No	ClinGen ExAC gnomAD
CA5300847 rs767720022	701	I>N		No	ClinGen ExAC gnomAD
CA375374792 rs1414770370	704	N>K		No	ClinGen TOPMed
CA5300848 rs750611452	706	S>G		No	ClinGen ExAC gnomAD
TCGA novel	707	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262074025 CA375374820	707	I>V		No	ClinGen gnomAD
CA375374853 rs1211535883	709	T>I		No	ClinGen gnomAD
CA5300850 rs528646416	710	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA200879215 rs528646416	710	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752487633 CA5300851 COSM1460732	710	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1414129888 CA375374898	714	N>Y		No	ClinGen gnomAD
TCGA novel	718	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1590135380 CA375374956	721	E>G		No	ClinGen Ensembl
CA375374954 rs1430165350	721	E>Q		No	ClinGen gnomAD
rs1564356176 CA375374985	725	R>G		No	ClinGen Ensembl
CA375374998 rs1443524221	727	A>T		No	ClinGen gnomAD
TCGA novel	727	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368128146 CA5300857	728	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs780594678 CA5300856	728	R>W		No	ClinGen ExAC TOPMed gnomAD
rs879073909 CA200881189	729	V>M		No	ClinGen Ensembl
CA5300878 rs767870216	731	I>T		No	ClinGen ExAC TOPMed gnomAD
CA200881216 rs994665926	733	H>Y		No	ClinGen TOPMed
rs1177977828 CA375375517	734	I>V		No	ClinGen TOPMed
rs1480518398 CA375375527	735	S>L		No	ClinGen TOPMed
CA5300880 rs748962520	738	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1290291502 CA375375587	743	F>S		No	ClinGen gnomAD
CA375375607 rs1453076741	746	H>Y		No	ClinGen TOPMed gnomAD
CA375375622 rs1190789296	748	S>G		No	ClinGen TOPMed gnomAD
CA375375630 rs1241685567	749	L>V		No	ClinGen gnomAD
rs773496457 CA200881257	751	K>E		No	ClinGen Ensembl
rs779452492 CA5300882	753	I>M		No	ClinGen ExAC gnomAD
rs867559745 CA200881263	755	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs775529469 CA5300884	758	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1164727629 CA375375700	759	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1393540102 COSM177083 CA375375701	759	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs773331846 CA5300885	760	K>R		No	ClinGen ExAC TOPMed gnomAD
CA5300886 rs760736129	763	V>I		No	ClinGen ExAC gnomAD
CA375375735 rs1325484456	764	C>F		No	ClinGen gnomAD
CA5300888 rs776781321	765	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1299149215 CA375375739	765	S>P		No	ClinGen gnomAD
rs763842441 CA5300890	766	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1358398099 CA375375788	772	R>Q		No	ClinGen TOPMed gnomAD
CA375375787 rs1225561862	772	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs770057207 CA5300911	775	L>V		No	ClinGen ExAC gnomAD
CA5300913 rs761447650	776	T>P		No	ClinGen ExAC gnomAD
CA375375832 rs1268581248	777	Y>H		No	ClinGen TOPMed
CA375375892 rs1426692041	785	Y>F		No	ClinGen TOPMed gnomAD
rs1033266842 CA200882768	785	Y>H		No	ClinGen TOPMed gnomAD
CA5300915 rs139312188	791	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5300916 rs760699737	791	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA375375936 rs139312188	791	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5300917 rs765957834	796	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1389576766 CA375375968	796	R>W		No	ClinGen TOPMed gnomAD
rs958787310 CA200882798	797	H>Q		No	ClinGen TOPMed
rs1351045720 CA375375978	798	P>S		No	ClinGen gnomAD
rs1416785968 CA375375993	800	P>L		No	ClinGen TOPMed
CA375376026 rs1431515716	803	P>S		No	ClinGen gnomAD
rs538028488 CA5300958 COSM1209178	804	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA375376054 rs1458168319	807	K>E		No	ClinGen gnomAD
rs1295077631 CA375376064	808	R>K		No	ClinGen gnomAD
rs770857932 CA5300959	808	R>S		No	ClinGen ExAC gnomAD
TCGA novel	810	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759573114 CA5300961	821	V>I		No	ClinGen ExAC gnomAD

No associated diseases with Q9UKN8

4 regional properties for Q9UKN8

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	56 - 340	IPR000719
active_site	Serine/threonine-protein kinase, active site	177 - 189	IPR008271
binding_site	Protein kinase, ATP binding site	62 - 86	IPR017441
domain	Glycogen synthase kinase 3, catalytic domain	51 - 343	IPR039192

Functions

		Description
EC Number	2.3.1.48	Transferring groups other than amino-acyl groups
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
transcription factor TFIIIC complex	A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.

4 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
enzyme activator activity	Binds to and increases the activity of an enzyme.
histone acetyltransferase activity	Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
RNA polymerase III general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.

4 GO annotations of biological process

Name	Definition
5S class rRNA transcription by RNA polymerase III	The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter.
transcription by RNA polymerase III	The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
transcription initiation at RNA polymerase III promoter	A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.
tRNA transcription by RNA polymerase III	The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BMQ2	Gtf3c4	General transcription factor 3C polypeptide 4	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MNTADQARVG	PADDGPAPSG	EEEGEGGGEA	GGKEPAADAA	PGPSAAFRLM	VTRREPAVKL
70	80	90	100	110	120
QYAVSGLEPL	AWSEDHRVSV	STARSIAVLE	LICDVHNPGQ	DLVIHRTSVP	APLNSCLLKV
130	140	150	160	170	180
GSKTEVAECK	EKFAASKDPT	VSQTFMLDRV	FNPEGKALPP	MRGFKYTSWS	PMGCDANGRC
190	200	210	220	230	240
LLAALTMDNR	LTIQANLNRL	QWVQLVDLTE	IYGERLYETS	YRLSKNEAPE	GNLGDFAEFQ
250	260	270	280	290	300
RRHSMQTPVR	MEWSGICTTQ	QVKHNNECRD	VGSVLLAVLF	ENGNIAVWQF	QLPFVGKESI
310	320	330	340	350	360
SSCNTIESGI	TSPSVLFWWE	YEHNNRKMSG	LIVGSAFGPI	KILPVNLKAV	KGYFTLRQPV
370	380	390	400	410	420
ILWKEMDQLP	VHSIKCVPLY	HPYQKCSCSL	VVAARGSYVF	WCLLLISKAG	LNVHNSHVTG
430	440	450	460	470	480
LHSLPIVSMT	ADKQNGTVYT	CSSDGKVRQL	IPIFTDVALK	FEHQLIKLSD	VFGSVRTHGI
490	500	510	520	530	540
AVSPCGAYLA	IITTEGMING	LHPVNKNYQV	QFVTLKTFEE	AAAQLLESSV	QNLFKQVDLI
550	560	570	580	590	600
DLVRWKILKD	KHIPQFLQEA	LEKKIESSGV	TYFWRFKLFL	LRILYQSMQK	TPSEALWKPT
610	620	630	640	650	660
HEDSKILLVD	SPGMGNADDE	QQEEGTSSKQ	VVKQGLQERS	KEGDVEEPTD	DSLPTTGDAG
670	680	690	700	710	720
GREPMEEKLL	EIQGKIEAVE	MHLTREHMKR	VLGEVYLHTW	ITENTSIPTR	GLCNFLMSDE
730	740	750	760	770	780
EYDDRTARVL	IGHISKKMNK	QTFPEHCSLC	KEILPFTDRK	QAVCSNGHIW	LRCFLTYQSC
790	800	810	820
QSLIYRRCLL	HDSIARHPAP	EDPDWIKRLL	QSPCPFCDSP	VF