Q8BMQ2

PR
Gene name
Gtf3c4
Protein name
General transcription factor 3C polypeptide 4
Names
TF3C-delta, Transcription factor IIIC 90 kDa subunit, TFIIIC 90 kDa subunit, TFIIIC90, Transcription factor IIIC subunit delta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:269252
EC number
2.3.1.48: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

575-684 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BMQ2

Entry ID Method Resolution Chain Position Source
AF-Q8BMQ2-F1 Predicted AlphaFoldDB

34 variants for Q8BMQ2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388539584 52 P>L No EVA
rs3388540128 74 V>M No EVA
rs3388539555 81 S>G No EVA
rs3388540285 85 L>Q No EVA
rs3388539557 157 M>L No EVA
rs3388537479 159 G>D No EVA
rs3391388902 208 Y>* No EVA
rs3388543311 225 P>H No EVA
rs107962447 239 H>P No EVA
rs3411829590 255 T>I No EVA
rs3391420892 262 N>K No EVA
rs3388537644 285 Q>H No EVA
rs3388537667 293 K>N No EVA
rs3388541579 296 I>S No EVA
rs3388542763 357 V>L No EVA
rs3388543327 394 Y>F No EVA
rs3388539926 403 S>T No EVA
rs3388538385 455 L>F No EVA
rs3388538448 456 K>R No EVA
rs3388537405 458 E>D No EVA
rs3388539941 537 D>V No EVA
rs3388541566 619 E>G No EVA
rs3388541325 625 Q>* No EVA
rs3388543386 644 P>T No EVA
rs3388532940 647 S>L No EVA
rs3388543383 649 T>N No EVA
rs3388537449 659 P>A No EVA
rs3388539966 676 M>V No EVA
rs3388539548 678 L>M No EVA
rs3388541567 709 N>K No EVA
rs3388540835 753 D>E No EVA
rs3388540219 758 V>D No EVA
rs3388540209 761 N>I No EVA
rs3388540186 766 L>F No EVA

No associated diseases with Q8BMQ2

3 regional properties for Q8BMQ2

Type Name Position InterPro Accession
domain Transcription factor IIIC, 90kDa subunit, N-terminal 60 - 250 IPR024761
domain Transcription factor IIIC, putative zinc-finger 734 - 785 IPR024764
domain Domain of unknown function DUF5921 261 - 715 IPR045803

Functions

Description
EC Number 2.3.1.48 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
transcription factor TFIIIC complex A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
RNA polymerase III general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.

1 GO annotations of biological process

Name Definition
transcription initiation at RNA polymerase III promoter A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 Homo sapiens (Human) PR
10 20 30 40 50 60
MSEADQALVG PKADEPSPPA EEKDEGGGKE AAADAAPGPS ASFRLMVTRR EPAVKLQYAV
70 80 90 100 110 120
SGLEPLSWSE DHRVSVSTAR SVAVLELICD VHNPGQDLVI HRTSVPAPLN SCLLKVGSKT
130 140 150 160 170 180
EVAECKEKFA SSKDPTISQT FMLDRMFNPE GKALPPMRGF KYTSWSPMGC DANGRCLLAA
190 200 210 220 230 240
LTMDNRLTVQ VNLNRLQWVQ LVDLTEIYGD RLYETSYRLS KNEAPEGNLG DFAEFQRRHS
250 260 270 280 290 300
MQTPVRMEWS SICTTQQVKH NNECRDVSSV LLAVLFENGN IAVWQFQLPF VGKESISSCN
310 320 330 340 350 360
TIESGISSPS VLFWWEYEHN NRKMSGLIVG SAFGPVKILP VNLKAVKGYF TLRQPVVLWK
370 380 390 400 410 420
EMDKLPVHSI KCVPLYHPYQ KCSCSLVVAA RGSYVFWCLL LISKAGLNVH NSHVTGLHSL
430 440 450 460 470 480
PIVSITADKQ NGTVYTCSSD GKVRQLIPIF TDVALKFEHQ LIKLSDVFGS VRTHGIAVSP
490 500 510 520 530 540
CGAYLAIITT EGMMNGLHPV NKNYQVQFVT LKTFEEAAAQ LLESSVQNLF KQVDLIDLVR
550 560 570 580 590 600
WKILKDKHIP QFLHEALEKK IESSGVTYFW RFKLFLLRIL YQSMQKSPSE ALWKPTHEDS
610 620 630 640 650 660
KILLVDSPGM GDGEDEQQEE GTSKQGTKAG LQEKSKEGDT EETPEDSLTA GGDTGGREPV
670 680 690 700 710 720
EEKLLEIQGK IEAVEMHLTR EHMKRVLGEV YLHTWITENT SIPTRGLCNF LMSDEDYDDR
730 740 750 760 770 780
TAQVLIGHIS KKMNKQTFPE RCSLCKEILP FTDRKQAVCS NGHIWLRCFL TYQSCQSLIY
790 800 810
RRCLLHDSIA RHPVPEDPDW IKRLLQSPCP FCDSPVF