AiPD: Autoinhibited Protein Database

Q9UKD2

Gene name	MRTO4 (C1orf33, MRT4)
Protein name	mRNA turnover protein 4 homolog
Names	Ribosome assembly factor MRTO4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51154
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-239 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

192-239 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

34 structures for Q9UKD2

Entry ID	Method	Resolution	Chain	Position	Source
8FKR	EM	289 A	SQ	1-239	PDB
8FKS	EM	288 A	SQ	1-239	PDB
8FKT	EM	281 A	SQ	1-239	PDB
8FKU	EM	282 A	SQ	1-239	PDB
8FKV	EM	247 A	SQ	1-239	PDB
8FKW	EM	250 A	SQ	1-239	PDB
8FKX	EM	259 A	SQ	1-239	PDB
8FKY	EM	267 A	SQ	1-239	PDB
8FKZ	EM	304 A	SQ	1-239	PDB
8FL0	EM	291 A	SQ	1-239	PDB
8FL2	EM	267 A	SQ	1-239	PDB
8FL3	EM	253 A	SQ	1-239	PDB
8FL4	EM	289 A	SQ	1-239	PDB
8FL6	EM	262 A	SQ	1-239	PDB
8FL7	EM	255 A	SQ	1-239	PDB
8FL9	EM	275 A	SQ	1-239	PDB
8FLA	EM	263 A	SQ	1-239	PDB
8FLB	EM	255 A	SQ	1-239	PDB
8FLC	EM	276 A	SQ	1-239	PDB
8FLD	EM	258 A	SQ	1-239	PDB
8FLE	EM	248 A	SQ	1-239	PDB
8FLF	EM	265 A	SQ	1-239	PDB
8IDT	EM	280 A	J	1-239	PDB
8IDY	EM	300 A	J	1-239	PDB
8IE3	EM	330 A	J	1-239	PDB
8INE	EM	320 A	J	1-239	PDB
8INF	EM	300 A	J	1-239	PDB
8INK	EM	320 A	v	1-239	PDB
8IPD	EM	320 A	v	1-239	PDB
8IPX	EM	430 A	v	1-239	PDB
8IPY	EM	320 A	v	1-239	PDB
8IR1	EM	330 A	v	1-239	PDB
8IR3	EM	350 A	v	1-239	PDB
AF-Q9UKD2-F1	Predicted				AlphaFoldDB

219 variants for Q9UKD2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA338776374 rs1160530911	2	P>R		No	ClinGen TOPMed
CA338776382 rs1422332166	3	K>R		No	ClinGen TOPMed gnomAD
rs779138446 CA338776393	5	K>E		No	ClinGen ExAC TOPMed gnomAD
rs779138446 CA653110	5	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA338776395 rs1391039766	5	K>T		No	ClinGen gnomAD
CA18828216 rs979175180	7	D>E		No	ClinGen TOPMed gnomAD
rs1447507876 CA338776416	7	D>G		No	ClinGen gnomAD
CA338776413 rs916892028	7	D>N		No	ClinGen TOPMed gnomAD
CA18828205 rs916892028	7	D>Y		No	ClinGen TOPMed gnomAD
rs1380357457 CA338776447	8	K>T		No	ClinGen gnomAD
CA653148 rs761677032	11	S>F		No	ClinGen ExAC TOPMed gnomAD
rs374329034 CA653149	13	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA18829446 rs746457921	15	T>I		No	ClinGen Ensembl
CA653151 rs762753214	16	A>G		No	ClinGen ExAC gnomAD
CA338777373 rs750418059	16	A>S		No	ClinGen ExAC gnomAD
CA653150 rs750418059	16	A>T		No	ClinGen ExAC gnomAD
CA338777381 rs762753214	16	A>V		No	ClinGen ExAC gnomAD
rs368212058 CA18829459	17	K>E		No	ClinGen ESP TOPMed
CA653152 rs766494076	19	G>A		No	ClinGen ExAC TOPMed gnomAD
rs779067703 CA18829464	22	L>W		No	ClinGen Ensembl
rs1480058757 CA338777554	25	N>K		No	ClinGen gnomAD
CA653153 rs751527839	25	N>T		No	ClinGen ExAC gnomAD
rs755298774 CA653154	26	L>P		No	ClinGen ExAC gnomAD
rs1379327066 CA338777577	27	I>M		No	ClinGen gnomAD
rs1394965112 CA338778162	30	L>V		No	ClinGen gnomAD
CA653181 rs369921635	31	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs369921635 CA653180	31	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA653179 rs201223173	31	R>W	Variant assessed as Somatic; 0.0006007 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA338778179 rs1337023388	32	K>E		No	ClinGen gnomAD
CA653182 rs780800623	33	C>Y		No	ClinGen ExAC gnomAD
CA338778222 rs1217104097	34	V>A		No	ClinGen TOPMed gnomAD
CA653183 rs747817190	37	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs747817190 CA338778287	37	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs141316973 CA653185	38	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA653186 rs749025613	39	Y>C		No	ClinGen ExAC gnomAD
CA338778315 rs1479611126	39	Y>H		No	ClinGen gnomAD
rs201687442 CA18830050	40	L>F		No	ClinGen gnomAD
rs201687442 CA338778326	40	L>I		No	ClinGen gnomAD
rs1157333956 CA338778390	42	I>S		No	ClinGen TOPMed
CA18830053 rs1028286295	42	I>V		No	ClinGen TOPMed
TCGA novel	43	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA653190 rs767594490	48	M>I		No	ClinGen ExAC gnomAD
rs759481436 CA653189	48	M>K		No	ClinGen ExAC gnomAD
CA653188 rs774128439	48	M>V		No	ClinGen ExAC gnomAD
rs371062022 CA653191	51	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	54	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1484618390 CA338778663	55	D>G		No	ClinGen gnomAD
rs757528147 CA653195	57	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA653194 rs769660709	57	R>W		No	ClinGen ExAC TOPMed gnomAD
rs551210514 CA338778761	59	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs551210514 CA653197	59	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA653198 rs758917550	59	A>V		No	ClinGen ExAC
rs1569597832 CA338778779	60	W>*		No	ClinGen Ensembl
rs1258567835 CA338778783	60	W>C		No	ClinGen gnomAD
CA338778797 rs1459036603	61	K>N		No	ClinGen gnomAD
CA653200 rs747658479	62	H>P		No	ClinGen ExAC gnomAD
rs375388657 CA653199	62	H>Y		No	ClinGen ESP ExAC gnomAD
CA653202 rs138723852	64	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs563261309 CA653201 COSM901474	64	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs753458499 CA653221	65	M>I		No	ClinGen ExAC gnomAD
CA338779147 rs1314016345	65	M>T		No	ClinGen gnomAD
CA338779163 rs1195893828	66	F>L		No	ClinGen TOPMed
TCGA novel	70	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA653223 rs778636679	73	M>T		No	ClinGen ExAC gnomAD
CA653222 rs756863283	73	M>V		No	ClinGen ExAC gnomAD
rs1050053534 CA18830429	74	M>V		No	ClinGen TOPMed
rs745660047 CA653224	75	V>A		No	ClinGen ExAC gnomAD
rs1558122326 CA338779328	75	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA338779370 rs1342875575	76	A>S		No	ClinGen TOPMed
TCGA novel	76	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA653227 rs746907275	77	L>F		No	ClinGen ExAC TOPMed gnomAD
CA338779396 rs1489869148	78	G>D		No	ClinGen gnomAD
rs139632622 CA653229	79	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs137874394 CA653228	79	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA18830438 rs11542047	80	S>I		No	ClinGen Ensembl
CA18830441 rs778546078	83	D>H		No	ClinGen Ensembl
rs1479328776 CA338779507	85	Y>H		No	ClinGen gnomAD
rs200319651 CA18830448	88	N>K		No	ClinGen 1000Genomes
rs1044299901 CA18830445	88	N>S		No	ClinGen Ensembl
CA338779589 rs1380128120	90	H>Y		No	ClinGen gnomAD
CA338779619 rs773508998	91	Q>H		No	ClinGen ExAC gnomAD
CA338779616 rs1223102992	91	Q>L		No	ClinGen TOPMed
rs771448710 CA653251	92	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1244400261 CA338780178	93	S>G		No	ClinGen gnomAD
rs774802300 CA653252	93	S>N		No	ClinGen ExAC gnomAD
rs760184427 CA653253	93	S>R		No	ClinGen ExAC gnomAD
CA653254 rs768051757	95	R>K		No	ClinGen ExAC gnomAD
CA653255 rs753335630	96	L>F		No	ClinGen ExAC gnomAD
rs1241750912 CA338780227	97	R>M		No	ClinGen gnomAD
CA653256 rs761353023	98	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1186454375 CA338780244	99	E>K		No	ClinGen gnomAD
COSM3930560 CA653257 rs764610980	100	V>A	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1278680122 CA338780259	100	V>L		No	ClinGen TOPMed
rs1473466891 CA338780274	101	G>C		No	ClinGen gnomAD
rs375190321 CA653259	104	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs766166805 CA653260	105	T>I		No	ClinGen ExAC gnomAD
CA338780320 rs1395270865	106	N>K		No	ClinGen gnomAD
CA653262 rs140930864	106	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781169715 CA338780323	107	R>C		No	ClinGen ExAC TOPMed gnomAD
CA653264 rs114437725	107	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114437725 CA338780324	107	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA653263 rs781169715	107	R>S		No	ClinGen ExAC TOPMed gnomAD
rs756251022 CA653265	108	T>P		No	ClinGen ExAC gnomAD
CA338780332 rs1558122535	109	K>E		No	ClinGen Ensembl
rs1384283226 CA338780336	109	K>N		No	ClinGen TOPMed
CA653267 rs749539725	109	K>R		No	ClinGen ExAC TOPMed gnomAD
CA338780353 rs1254600737	111	E>D		No	ClinGen TOPMed gnomAD
rs1344707001 CA338780358	112	V>A		No	ClinGen gnomAD
CA338780361 rs1377742026	113	N>D		No	ClinGen gnomAD
CA338780368 rs1256354677	114	E>K		No	ClinGen gnomAD
CA653292 rs184192373	115	W>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772766675 CA653293	117	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1387920064 CA338780484	120	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	121	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338780502 rs1569601180	122	M>V		No	ClinGen Ensembl
CA338780528 rs1239902326	124	Y>D		No	ClinGen gnomAD
CA653298 rs756091401	125	A>T		No	ClinGen ExAC TOPMed gnomAD
rs760719301 CA653301	126	R>L		No	ClinGen ExAC TOPMed gnomAD
rs760719301 COSM216994 CA653300	126	R>Q	liver urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs754007838 CA653302	128	G>C		No	ClinGen ExAC TOPMed gnomAD
rs757441207 CA653303	128	G>V		No	ClinGen ExAC gnomAD
CA338780594 rs1159015683	130	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	130	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338780616 rs1254853567	132	A>T		No	ClinGen gnomAD
rs1177788230 CA338780643	133	F>L		No	ClinGen gnomAD
rs1569601304 CA338780631	133	F>L		No	ClinGen Ensembl
rs1569601325 CA338780659	134	T>I		No	ClinGen Ensembl
rs758482846 CA653306	136	S>I		No	ClinGen ExAC gnomAD
rs758482846 CA653307	136	S>N		No	ClinGen ExAC gnomAD
CA338780702 rs1455395038	137	L>P		No	ClinGen gnomAD
CA653309 rs769202061	138	D>N		No	ClinGen ExAC gnomAD
CA653310 rs781643335	140	G>E		No	ClinGen ExAC gnomAD
CA653312 rs770453544	141	P>L		No	ClinGen ExAC gnomAD
CA653311 rs186851379	141	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186851379 CA338780762	141	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA653314 rs759235950	145	F>L		No	ClinGen ExAC TOPMed gnomAD
CA338780830 rs759235950	145	F>V		No	ClinGen ExAC TOPMed gnomAD
CA338780855 rs1320959440	146	P>L		No	ClinGen TOPMed
CA653319 rs760511737	147	H>D		No	ClinGen ExAC TOPMed gnomAD
rs760511737 CA653317	147	H>N		No	ClinGen ExAC TOPMed gnomAD
rs760511737 CA653318	147	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs918402669 CA18830815	148	S>C		No	ClinGen TOPMed
rs150086843 CA653320	150	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs558244885 CA653321	152	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
CA653322 rs558244885	152	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA653324 rs777341550	156	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1209649256 CA338781091	157	G>S		No	ClinGen TOPMed
rs1252707109 CA338781143	158	L>R		No	ClinGen TOPMed
CA338781186 rs1569601565	160	T>P		No	ClinGen Ensembl
rs748671029 CA653328 COSM424899	161	A>T	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1424413099 CA338781234	162	L>F		No	ClinGen gnomAD
CA18830840 rs199783929	162	L>P		No	ClinGen 1000Genomes
CA653332 rs771793428	165	G>S		No	ClinGen ExAC gnomAD
rs1284181041 CA338781549	166	V>A		No	ClinGen gnomAD
rs1213336995 CA338781543	166	V>M		No	ClinGen TOPMed gnomAD
rs1428936348 CA338781575	167	V>A		No	ClinGen TOPMed
CA653353 rs746662867	169	L>V		No	ClinGen ExAC gnomAD
CA653356 rs747934332	173	Y>N		No	ClinGen ExAC gnomAD
rs139714257 CA653358	174	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA653359 rs762900630	177	K>Q		No	ClinGen ExAC gnomAD
rs766384607 CA653361	177	K>R		No	ClinGen ExAC gnomAD
rs766384607 CA653360	177	K>T		No	ClinGen ExAC gnomAD
rs759809381 CA653362	178	E>G		No	ClinGen ExAC gnomAD
CA338781944 rs1318484134	180	D>N		No	ClinGen TOPMed gnomAD
CA338782059 rs1346876109	183	T>I		No	ClinGen gnomAD
CA338782072 rs753113915	184	P>S		No	ClinGen ExAC TOPMed gnomAD
rs753113915 CA653364	184	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1278791844 CA338782096	185	E>Q		No	ClinGen TOPMed
rs1292698255 CA338782192	187	A>D		No	ClinGen gnomAD
CA338782185 rs1206484226	187	A>T		No	ClinGen TOPMed
CA653365 rs756461838	188	R>C		No	ClinGen ExAC gnomAD
CA338782213 rs756461838	188	R>G		No	ClinGen ExAC gnomAD
CA653366 rs764483401	188	R>H		No	ClinGen ExAC TOPMed gnomAD
CA338782216 rs764483401	188	R>P		No	ClinGen ExAC TOPMed gnomAD
CA653367 rs754307809	189	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs553525688 CA338782426	192	L>H		No	ClinGen 1000Genomes TOPMed
CA18831190 rs553525688	192	L>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed
CA18831186 rs373656332	192	L>V		No	ClinGen Ensembl
rs1232352913 CA338782465	195	Y>C		No	ClinGen TOPMed
rs752295280 CA653395	195	Y>N		No	ClinGen ExAC gnomAD
CA653397 rs200351822	196	E>K		No	ClinGen ExAC TOPMed gnomAD
CA653396 rs200351822	196	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA653398 rs749101180	198	A>V		No	ClinGen ExAC gnomAD
rs770809976 CA653399	200	F>L		No	ClinGen ExAC gnomAD
CA653401 rs545850657	202	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs772146307 CA653402	204	I>F		No	ClinGen ExAC gnomAD
CA18831211 rs150343927	206	Y>H		No	ClinGen ESP TOPMed gnomAD
CA18831222 rs1001198351	207	M>T		No	ClinGen TOPMed gnomAD
CA653405 rs768920517	207	M>V		No	ClinGen ExAC gnomAD
CA18831225 rs1017132707	209	D>N		No	ClinGen Ensembl
CA18831228 rs564605284	212	S>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs564605284 CA653406	212	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA653408 rs181723825	213	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs750997503 CA653409	214	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA338782786 CA653411 rs763485730	214	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1197937743 CA338782800	215	F>C		No	ClinGen gnomAD
CA18831249 rs200028582	216	Q>R		No	ClinGen 1000Genomes
rs752234709 CA653412	217	Q>*		No	ClinGen ExAC gnomAD
rs377289167 CA653413	217	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs777446790 CA653414	218	M>T		No	ClinGen ExAC TOPMed gnomAD
CA338782862 rs1257667468	219	G>E		No	ClinGen gnomAD
CA653417 rs757079218	220	D>E		No	ClinGen ExAC TOPMed gnomAD
rs753620362 CA653415	220	D>G		No	ClinGen ExAC gnomAD
rs745822391 CA653418	221	D>N		No	ClinGen ExAC TOPMed gnomAD
rs950844805 CA18831267	222	L>F		No	ClinGen Ensembl
TCGA novel	223	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143190389 CA653419	224	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA653420 rs780177305	225	S>G		No	ClinGen ExAC gnomAD
rs146948534 CA653421	226	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA653422 rs768810763	227	S>Y		No	ClinGen ExAC gnomAD
rs369837947 CA338783023	229	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs369837947 CA653423	229	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1269446772 CA338783044	231	E>A		No	ClinGen TOPMed
rs1398251265 CA338783053	232	E>Q		No	ClinGen TOPMed gnomAD
rs770287349 CA653425	235	S>L		No	ClinGen ExAC TOPMed gnomAD
rs773651738 CA653426 CA18831288	236	E>D		No	ClinGen ExAC gnomAD
rs1374375671 CA338783147	237	D>G		No	ClinGen TOPMed gnomAD
rs1198873971 CA338783141	237	D>H		No	ClinGen TOPMed
CA653427 rs763611622	238	D>G		No	ClinGen ExAC gnomAD

No associated diseases with Q9UKD2

1 regional properties for Q9UKD2

Type	Name	Position	InterPro Accession
domain	60S ribosomal protein L10P, insertion domain	125 - 194	IPR040637

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus Cytoplasm	Shuttles between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor	A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name	Definition
nuclear-transcribed mRNA catabolic process	The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
ribosomal large subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9D0I8	Mrto4	mRNA turnover protein 4 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MPKSKRDKKV	SLTKTAKKGL	ELKQNLIEEL	RKCVDTYKYL	FIFSVANMRN	SKLKDIRNAW
70	80	90	100	110	120
KHSRMFFGKN	KVMMVALGRS	PSDEYKDNLH	QVSKRLRGEV	GLLFTNRTKE	EVNEWFTKYT
130	140	150	160	170	180
EMDYARAGNK	AAFTVSLDPG	PLEQFPHSME	PQLRQLGLPT	ALKRGVVTLL	SDYEVCKEGD
190	200	210	220	230
VLTPEQARVL	KLFGYEMAEF	KVTIKYMWDS	QSGRFQQMGD	DLPESASEST	EESDSEDDD