Q9D0I8

PR
Gene name
Mrto4 (Mrt4)
Protein name
mRNA turnover protein 4 homolog
Names
Ribosome assembly factor Mrto4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69902
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D0I8

Entry ID Method Resolution Chain Position Source
AF-Q9D0I8-F1 Predicted AlphaFoldDB

15 variants for Q9D0I8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388722303 26 L>P No EVA
rs3388725998 40 L>I No EVA
rs3388723237 83 D>V No EVA
rs3388723229 110 E>* No EVA
rs238132731 113 N>D No EVA
rs3388728420 135 V>E No EVA
rs3388709541 138 D>G No EVA
rs3388731675 139 P>R No EVA
rs3388725549 147 H>Y No EVA
rs3388725991 176 C>S No EVA
rs3388731697 189 I>F No EVA
rs236267758 203 I>T No EVA
rs3388723213 205 K>E No EVA
rs3388726391 205 K>N No EVA
rs3388722241 210 A>T No EVA

No associated diseases with Q9D0I8

1 regional properties for Q9D0I8

Type Name Position InterPro Accession
domain 60S ribosomal protein L10P, insertion domain 125 - 194 IPR040637

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Cytoplasm
  • Shuttles between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UKD2 MRTO4 mRNA turnover protein 4 homolog Homo sapiens (Human) PR
10 20 30 40 50 60
MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN SKLKDIRNAW
70 80 90 100 110 120
KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKKLRGEV GLLFTNRTKE EVNEWFTKYT
130 140 150 160 170 180
EMDFARAGNK ATLTVSLDPG PLKQFPHSME PQLRQLGLPT ALKKGVVTLL SDYEVCKEGD
190 200 210 220 230
VLTPEQARIL KLFGYEMAEF KVIIKYMWDA QSGRFQQMDD DLPESAPESE GESEEEDDS