AiPD: Autoinhibited Protein Database

Q9UJX5

Gene name	ANAPC4 (APC4)
Protein name	Anaphase-promoting complex subunit 4
Names	APC4, Cyclosome subunit 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:29945
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

721-808 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

721-808 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

20 structures for Q9UJX5

Entry ID	Method	Resolution	Chain	Position	Source
4UI9	EM	360 A	I	1-808	PDB
5A31	EM	430 A	I	1-808	PDB
5BPW	X-ray	340 A	A	1-808	PDB
5G04	EM	400 A	I	1-808	PDB
5G05	EM	340 A	I	1-808	PDB
5KHR	EM	610 A	I	1-808	PDB
5KHU	EM	480 A	I	1-808	PDB
5L9T	EM	640 A	I	1-808	PDB
5L9U	EM	640 A	I	1-808	PDB
5LCW	EM	400 A	I	1-808	PDB
6Q6G	EM	320 A	I	1-808	PDB
6Q6H	EM	320 A	I	1-808	PDB
6TLJ	EM	380 A	I	1-808	PDB
6TM5	EM	390 A	I	1-808	PDB
6TNT	EM	378 A	I	1-808	PDB
7QE7	EM	290 A	I	1-808	PDB
8PKP	EM	320 A	I	1-808	PDB
8TAR	EM	400 A	I	1-808	PDB
8TAU	EM	350 A	I	1-808	PDB
AF-Q9UJX5-F1	Predicted				AlphaFoldDB

483 variants for Q9UJX5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA2878530 rs748685739	3	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1577363842 CA356561757	5	P>A		No	ClinGen Ensembl
TCGA novel	5	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1447136815 CA356561797	7	C>W		No	ClinGen gnomAD
CA2878531 rs772072500	8	F>I		No	ClinGen ExAC gnomAD
CA2878534 rs543616759	10	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA2878533 rs747148002	10	S>P		No	ClinGen ExAC gnomAD
rs1454552042 CA356561841	12	R>Q		No	ClinGen gnomAD
CA356561849 rs1577363877	13	V>M		No	ClinGen Ensembl
rs1027340582 CA93646524	19	L>F		No	ClinGen Ensembl
rs374595036 CA93646533	21	Q>E		No	ClinGen ESP
CA356561952 rs1379844841	21	Q>L		No	ClinGen gnomAD
CA356561954 rs1379844841	21	Q>R		No	ClinGen gnomAD
rs774367060 CA2878538	22	E>K		No	ClinGen ExAC gnomAD
rs1051893863 CA93646540	23	I>V		No	ClinGen TOPMed
rs761858918 CA2878539	24	I>T		No	ClinGen ExAC TOPMed gnomAD
rs767625635 CA2878540	25	F>C		No	ClinGen ExAC gnomAD
rs1215981197 CA356562008	25	F>L		No	ClinGen gnomAD
rs1463126778 CA356562093	32	R>W		No	ClinGen gnomAD
rs1471332002 CA356562141	35	I>T		No	ClinGen TOPMed
rs755691767 CA2878542	37	L>F		No	ClinGen ExAC gnomAD
CA2878543 rs563308193	38	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771587730 CA93646636	39	N>S		No	ClinGen TOPMed
CA2878544 rs529390900	40	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1420051565 CA356562205	41	A>T		No	ClinGen gnomAD
TCGA novel	41	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2878545 rs755259219	43	E>V		No	ClinGen ExAC gnomAD
rs1348230950 CA356562430	46	L>I		No	ClinGen gnomAD
CA2878568 rs754670587	47	H>Q		No	ClinGen ExAC gnomAD
CA356562444 rs1275075458	48	R>*		No	ClinGen gnomAD
CA356562460 rs1216988496	51	S>G		No	ClinGen gnomAD
CA2878570 rs753054846	51	S>T		No	ClinGen ExAC gnomAD
rs1020974687 CA93648756	54	R>*		No	ClinGen Ensembl
CA356562485 rs1376848629	54	R>Q		No	ClinGen TOPMed
CA356562519 rs1204859333	59	P>S		No	ClinGen gnomAD
CA356562525 rs1273005048	60	P>S		No	ClinGen gnomAD
rs540483057 CA2878573 COSM587051	61	N>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA93648800 rs890009718	64	T>I		No	ClinGen TOPMed gnomAD
rs781348727 CA2878575	66	K>N		No	ClinGen ExAC TOPMed gnomAD
CA2878577 rs770140408	69	T>M		No	ClinGen ExAC gnomAD
rs200503614 CA2878576	69	T>P		No	ClinGen 1000Genomes ExAC
rs747934614 CA2878579	72	A>S		No	ClinGen ExAC TOPMed gnomAD
CA356562601 rs747934614	72	A>T		No	ClinGen ExAC TOPMed gnomAD
rs772985175 COSM3767830 CA2878581	75	P>S	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1180476805 CA356562651	79	L>F		No	ClinGen TOPMed
CA356562678 rs1187299443	81	A>V		No	ClinGen gnomAD
CA356562692 rs1416243950	83	A>V		No	ClinGen gnomAD
CA356562693 COSM3428446 rs1354497748	84	L>F	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs374830999 CA93651417	85	A>V		No	ClinGen ESP TOPMed gnomAD
CA2878605 rs776473600	87	T>N		No	ClinGen ExAC TOPMed gnomAD
rs201839196 CA93651424	88	K>N		No	ClinGen Ensembl
rs769312617 CA2878607	90	I>V		No	ClinGen ExAC gnomAD
CA356562753 rs1560429099	93	C>R		No	ClinGen Ensembl
rs575797971 CA2878610	95	V>A		No	ClinGen ExAC gnomAD
CA356562769 rs1412317501	95	V>I		No	ClinGen TOPMed
rs13127336 CA93651456	100	S>N		No	ClinGen Ensembl
CA356562819 rs1471695779	102	H>P		No	ClinGen gnomAD
CA356562828 rs147243013	103	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2878611 rs147243013	103	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA356562841 rs1456218604	105	S>C		No	ClinGen gnomAD
CA2878613 rs371805695	106	V>M		No	ClinGen ESP ExAC gnomAD
CA2878614 rs750916286	107	E>A		No	ClinGen ExAC TOPMed gnomAD
CA356562856 rs1397187616	108	A>P		No	ClinGen TOPMed gnomAD
CA356562868 rs1334084689	110	V>I		No	ClinGen gnomAD
TCGA novel	113	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2878615 rs756223606	113	M>V		No	ClinGen ExAC gnomAD
CA356562921 rs1289180822	114	H>L		No	ClinGen gnomAD
rs1560429172 CA356562919	114	H>Y		No	ClinGen Ensembl
CA2878616 rs780287319	116	M>L		No	ClinGen ExAC gnomAD
rs376010530 CA2878617	116	M>T		No	ClinGen ESP ExAC gnomAD
CA356562965 rs1347032204	117	E>G		No	ClinGen gnomAD
rs755236879 COSM1054666 CA2878618	117	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA356562980 rs1577370386	118	V>G		No	ClinGen Ensembl
rs200778308 CA93627489	131	A>T		No	ClinGen TOPMed gnomAD
rs1577375553 CA356552482	135	S>*		No	ClinGen Ensembl
rs1195667849 CA356552498	136	N>I		No	ClinGen TOPMed
rs767053276 CA2878638	138	L>F		No	ClinGen ExAC gnomAD
rs574552618 CA2878639	138	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765475845 CA2878641	143	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765475845 CA356552566	143	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1319973982 CA356552598	146	P>L		No	ClinGen TOPMed
CA93627545 rs942648852	149	Y>C		No	ClinGen TOPMed gnomAD
CA2878654 rs142209344	153	S>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	155	I>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_035792	155	I>V	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
CA2878667 rs779920658	159	E>A		No	ClinGen ExAC gnomAD
CA356552945 rs1304521303	161	S>C		No	ClinGen gnomAD
CA356552938 rs1314890906 COSM1054667	161	S>P	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1379989257 CA356552988	163	E>D		No	ClinGen TOPMed
rs1008728942 CA93627600	165	I>S		No	ClinGen Ensembl
CA2878670 rs778301350	171	V>I		No	ClinGen ExAC TOPMed gnomAD
CA356553936 rs1312175477	174	N>S		No	ClinGen gnomAD
CA356553982 rs1208447595	176	L>F		No	ClinGen gnomAD
rs752115448 COSM673928 CA2878688	177	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA93628199 rs988848095	181	S>R		No	ClinGen Ensembl
CA2878689 rs535218219	185	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs201642475 CA93628206	188	Y>F		No	ClinGen 1000Genomes gnomAD
CA356554283 rs1432586361	192	M>R		No	ClinGen gnomAD
CA356554332 rs1171686476	194	K>N		No	ClinGen gnomAD
rs771350520 CA356554370	197	R>*		No	ClinGen ExAC gnomAD
rs771350520 CA2878692	197	R>G		No	ClinGen ExAC gnomAD
CA2878694 rs377456652	197	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2878693 rs377456652	197	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs979290652 CA93628225	198	V>L		No	ClinGen TOPMed
rs1359796485 CA356554407	200	G>E		No	ClinGen gnomAD
CA2878696 rs776116087	200	G>R		No	ClinGen ExAC gnomAD
CA356554538 rs1348735915	201	I>T		No	ClinGen gnomAD
rs1438109540 CA356554555	202	A>G		No	ClinGen gnomAD
CA356554558 rs1438109540	202	A>V		No	ClinGen gnomAD
CA2878710 rs780962676	203	G>S		No	ClinGen ExAC gnomAD
rs746184414 CA2878711	204	T>I		No	ClinGen ExAC TOPMed gnomAD
CA2878713 rs780388156	209	C>R		No	ClinGen ExAC
CA356554720 rs1489472145	212	S>R		No	ClinGen gnomAD
CA2878714 rs749809902	213	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2878716 rs774402467 COSM1429258	220	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA93628502 rs148735249	224	S>C		No	ClinGen 1000Genomes
rs972551396 CA93628505	225	T>I		No	ClinGen Ensembl
rs377096625 CA2878717	226	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2878719 rs773529954	234	F>I		No	ClinGen ExAC TOPMed gnomAD
rs1163429815 CA356554947	235	Q>E		No	ClinGen gnomAD
TCGA novel	236	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2878748 rs761368684	236	L>P		No	ClinGen ExAC TOPMed gnomAD
rs767060078 CA2878749	237	E>G		No	ClinGen ExAC gnomAD
TCGA novel	240	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA93628994 rs367748788	241	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1298024035 CA356555033	246	P>S		No	ClinGen TOPMed
CA356555058 rs371711389	250	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371711389 CA2878753 COSM1540101	250	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1054668 CA2878752 rs766016624	250	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1049504668 CA93629007	252	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA356555105 rs1322310720	257	H>Y		No	ClinGen TOPMed
TCGA novel	263	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2878772 rs765587767	266	N>H		No	ClinGen ExAC TOPMed gnomAD
CA2878773 rs753140651	268	S>L		No	ClinGen ExAC gnomAD
CA2878776 rs377127273	271	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA356555254 rs1460720264	276	W>*		No	ClinGen gnomAD
rs267600133 CA93629614	278	E>K		No	ClinGen Ensembl
CA2878777 rs757328988	283	M>R		No	ClinGen ExAC gnomAD
CA356555313 TCGA novel rs1325119738	284	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
rs1265674693 CA356555320	285	S>C		No	ClinGen TOPMed
rs369536329 CA93629625	286	R>H		No	ClinGen ESP gnomAD
rs1247847863 CA356555330	287	L>P		No	ClinGen TOPMed gnomAD
CA356555327 rs1560435855	287	L>V		No	ClinGen Ensembl
rs781513756 CA2878778	289	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1325102164 CA356555351	290	F>L		No	ClinGen gnomAD
COSM481184 rs867835372 CA93629634	292	Q>*	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
CA356555382 rs1217489442	293	E>G		No	ClinGen TOPMed
rs775827422 CA2878794	294	K>E		No	ClinGen ExAC gnomAD
TCGA novel	294	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs920870053 CA93629832	295	N>K		No	ClinGen gnomAD
CA356555409 rs1340750478	297	T>N		No	ClinGen gnomAD
rs371912148 CA2878796	300	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs777104091 CA93629848	301	Q>*		No	ClinGen Ensembl
CA93629852 rs180856282	302	D>N		No	ClinGen 1000Genomes TOPMed gnomAD
rs1485079315 CA356555443	303	E>K		No	ClinGen gnomAD
rs1257103121 CA356555470	306	H>Y		No	ClinGen gnomAD
CA356555481 rs1186076673	307	L>F		No	ClinGen gnomAD
rs965368473 CA93629861	309	L>S		No	ClinGen TOPMed gnomAD
rs1451335119 CA356555499	310	W>*		No	ClinGen gnomAD
CA2878801 rs756401452	310	W>R		No	ClinGen ExAC gnomAD
CA356555505 rs1297384175	311	G>E		No	ClinGen TOPMed
rs1304431943 CA356555526	314	S>I		No	ClinGen gnomAD
rs79451053 CA93629981	316	E>K		No	ClinGen Ensembl
rs966049485 CA93629982	317	L>F		No	ClinGen TOPMed
CA356555610 rs1206002425	324	Q>H		No	ClinGen TOPMed
CA356555607 rs1277014882	324	Q>R		No	ClinGen gnomAD
rs374531860 CA2878827	327	V>G		No	ClinGen ESP ExAC gnomAD
CA356555653 rs1191670003	329	G>V		No	ClinGen gnomAD
CA356555661 rs1338668672	331	K>Q		No	ClinGen TOPMed
rs1475629937 CA356555665	331	K>R		No	ClinGen gnomAD
rs751278190 CA2878850	332	K>N		No	ClinGen ExAC gnomAD
rs1406580859 CA356555690	335	Q>*		No	ClinGen TOPMed gnomAD
rs757091654 CA2878851	339	S>L		No	ClinGen ExAC
rs773986195 CA93630102	342	S>A		No	ClinGen TOPMed
CA356555738 rs781057647	342	S>C		No	ClinGen ExAC TOPMed gnomAD
rs781057647 CA2878852	342	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1323155650 CA356555749	344	I>L		No	ClinGen gnomAD
rs1323155650 CA356555750	344	I>V		No	ClinGen gnomAD
rs1230888096 CA356555759	345	Q>R		No	ClinGen TOPMed gnomAD
CA356555764 rs1327343512	346	K>Q		No	ClinGen gnomAD
CA93630111 rs1046045943	346	K>R		No	ClinGen TOPMed
rs779418488 CA2878855	347	L>F		No	ClinGen ExAC gnomAD
rs144625033 CA2878856	348	V>I		No	ClinGen ESP ExAC
rs144625033 CA356555777	348	V>L		No	ClinGen ESP ExAC
CA356555782 rs1233968211	349	I>V		No	ClinGen gnomAD
CA356555800 rs1272551903	351	H>R		No	ClinGen gnomAD
CA356555823 rs1332783729	354	S>I		No	ClinGen gnomAD
CA2878871 rs370638458	356	S>L	Variant assessed as Somatic; 4.673e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs754543457 CA356556409	357	E>A		No	ClinGen ExAC gnomAD
CA2878875 rs754543457	357	E>G		No	ClinGen ExAC gnomAD
rs539027600 CA2878874	357	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA2878876 rs754543457	357	E>V		No	ClinGen ExAC gnomAD
CA2878878 rs758781711	358	S>A		No	ClinGen ExAC gnomAD
rs1183426749 CA356556421	358	S>F		No	ClinGen gnomAD
rs778265945 CA2878879	359	L>F		No	ClinGen ExAC gnomAD
CA93630976 rs34239612	362	H>R		No	ClinGen Ensembl
CA93630981 rs750225132	365	E>*		No	ClinGen Ensembl
rs777241058 CA2878882	366	L>M		No	ClinGen ExAC gnomAD
rs745886178 CA2878883	367	K>R		No	ClinGen ExAC gnomAD
CA356556555 rs1312465353	369	M>T		No	ClinGen gnomAD
rs769947767 CA2878884	371	S>A		No	ClinGen ExAC gnomAD
CA356556588 rs1328433850	372	W>R		No	ClinGen TOPMed gnomAD
CA356556619 rs1243396920	374	Q>E		No	ClinGen TOPMed
TCGA novel	375	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148354654 CA2878887	382	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA356556724 rs148354654	382	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2878888 rs772961792	384	A>V		No	ClinGen ExAC gnomAD
COSM3428447 rs535292691 CA2878891	387	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1194790053 CA356556822	388	E>G		No	ClinGen gnomAD
rs368949185 CA2878902	390	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs368232198 CA93631077	391	T>I		No	ClinGen Ensembl
CA356556965 rs1209113976	396	F>L		No	ClinGen TOPMed
rs775545101 CA2878903	396	F>S		No	ClinGen ExAC gnomAD
CA356556974 rs1488528534	397	I>V		No	ClinGen TOPMed
TCGA novel	399	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2878905 rs768844433	400	A>T		No	ClinGen ExAC
rs1266625680 CA356557048	401	N>D		No	ClinGen TOPMed
CA356557067 rs1469359787	401	N>K		No	ClinGen gnomAD
CA356557654 rs1487038233	406	V>I		No	ClinGen gnomAD
rs930612972 CA93634240	407	I>T		No	ClinGen TOPMed
CA356557677 rs1261284181	409	S>N		No	ClinGen gnomAD
rs371588814 CA2878925	410	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2878926 rs772244461	411	M>V		No	ClinGen ExAC
CA356557708 rs1419938666	413	N>T		No	ClinGen TOPMed
rs1190344827 CA356557717	414	F>C		No	ClinGen gnomAD
rs1418599842 CA356557720	414	F>L		No	ClinGen gnomAD
CA2878927 rs368929028	417	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs759287571 CA2878928	418	F>L		No	ClinGen ExAC gnomAD
CA2878930 rs141506541	419	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	419	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201488708 COSM167017 CA2878929	419	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1335416675 CA356557772	420	W>C		No	ClinGen Ensembl
rs762511291 CA2878931	422	Y>F		No	ClinGen ExAC gnomAD
TCGA novel	424	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1452542401 CA356558047	425	M>T		No	ClinGen TOPMed
CA356558062 rs1362960440	427	R>T		No	ClinGen gnomAD
TCGA novel	428	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356558070 rs1577393127	428	M>T		No	ClinGen Ensembl
rs747424967 CA93638091	430	E>K		No	ClinGen Ensembl
CA93638097 rs1046757731	432	H>R		No	ClinGen gnomAD
rs754997067 CA2878943	435	P>L		No	ClinGen ExAC gnomAD
CA93638098 rs927879684	435	P>S		No	ClinGen Ensembl
rs748246714 CA2878945	436	E>K		No	ClinGen ExAC gnomAD
CA356558164 rs1217641870 COSM481185	440	M>V	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA356558187 rs1577394249	443	K>E		No	ClinGen Ensembl
CA93638876 rs766746362	445	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1308122425 CA356558206	445	I>T		No	ClinGen gnomAD
rs542616693 CA2878962	446	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA2878963 rs755475334	446	T>I		No	ClinGen ExAC TOPMed gnomAD
rs762557146 CA93638892	449	A>D		No	ClinGen Ensembl
CA356558260 rs1216810411	454	E>Q		No	ClinGen TOPMed
rs1421266508 CA356558271	455	H>R		No	ClinGen gnomAD
CA93638900 rs570649808	457	N>S		No	ClinGen TOPMed gnomAD
CA93639216 rs377024564	463	Y>H		No	ClinGen ESP TOPMed gnomAD
COSM1054670 CA93639222 rs866765051	465	R>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs34811474 CA356558351	465	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs34811474 VAR_054044 CA2878992	465	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA93639223 rs989857847	468	K>E		No	ClinGen Ensembl
rs781603844 CA2878994	472	V>I		No	ClinGen ExAC TOPMed gnomAD
rs143912823 CA2878995	474	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs754761160 CA2878996	474	R>K		No	ClinGen ExAC gnomAD
CA356558416 rs1260646143	475	V>I		No	ClinGen gnomAD
rs939008810 CA93641016	478	Y>C		No	ClinGen TOPMed
rs762006568 CA2879011	483	D>N		No	ClinGen ExAC gnomAD
CA2879012 rs767807827	485	D>G		No	ClinGen ExAC gnomAD
CA356558719 rs1440221923	485	D>N		No	ClinGen gnomAD
CA93641060 rs910318665	486	L>H		No	ClinGen Ensembl
rs750681301 CA2879013	488	S>L		No	ClinGen ExAC TOPMed gnomAD
CA93641063 rs944460543	489	P>S		No	ClinGen Ensembl
CA356558767 rs944460543	489	P>T		No	ClinGen Ensembl
rs372887745 CA2879015	490	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs372887745 CA93641070	490	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA93641074 rs774328664	491	N>T		No	ClinGen Ensembl
CA2879016 rs752606525	491	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs758241289 CA2879018	492	T>I		No	ClinGen ExAC gnomAD
CA2879019 rs758241289	492	T>R		No	ClinGen ExAC gnomAD
CA93641102 rs914072841	493	E>G		No	ClinGen Ensembl
CA93641105 rs945614092	494	G>V		No	ClinGen Ensembl
CA93641109 rs1043968057	496	Q>L		No	ClinGen Ensembl
TCGA novel	500	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2879022 rs371172862	501	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA2879023 rs745516525	503	N>H		No	ClinGen ExAC gnomAD
CA356558990 rs1294365651	505	S>R		No	ClinGen TOPMed
CA356558994 rs1269452535	506	H>Y		No	ClinGen TOPMed gnomAD
CA356559008 rs1445772382	507	L>R		No	ClinGen gnomAD
rs751498293 CA2879039	509	E>G		No	ClinGen ExAC gnomAD
rs756697299 CA2879040	510	S>G		No	ClinGen ExAC gnomAD
rs1316775792 CA356559218	511	P>S		No	ClinGen gnomAD
CA356559226 rs1175694524	512	L>S		No	ClinGen TOPMed
CA356559233 rs1197259782	513	L>P		No	ClinGen gnomAD
COSM109115 rs139520407 CA93644385	515	P>S	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA93644395 rs559716705	517	Y>F		No	ClinGen TOPMed gnomAD
CA2879041 rs780664822	518	P>S		No	ClinGen ExAC gnomAD
CA2879042 rs745448023	519	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2879043 rs769299350	519	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs779804823 CA2879044	521	S>P		No	ClinGen ExAC gnomAD
rs914854704 CA93644407	523	H>D		No	ClinGen Ensembl
rs796307790 CA356559329	528	R>L		No	ClinGen gnomAD
rs796307790 CA93644418	528	R>Q		No	ClinGen gnomAD
rs780628587 CA2879045	528	R>W		No	ClinGen ExAC gnomAD
CA356559330 rs1180057789	529	M>L		No	ClinGen TOPMed
CA2879046 rs140699299	531	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1459413710 CA356559349	531	N>Y		No	ClinGen TOPMed
rs774943244 CA2879047	533	I>T		No	ClinGen ExAC gnomAD
rs980164466 CA93644441	534	D>G		No	ClinGen Ensembl
rs762398520 CA2879048	535	Q>H		No	ClinGen ExAC
rs1420004005 CA356559400	538	Q>R		No	ClinGen gnomAD
rs1448502355 CA356559853	542	D>N		No	ClinGen gnomAD
rs748983730 CA2879062	546	K>R		No	ClinGen ExAC gnomAD
rs950879201 CA93645035	549	N>T		No	ClinGen TOPMed gnomAD
CA2879064 rs779417519	549	N>Y		No	ClinGen ExAC gnomAD
rs1379284529 CA356559966	550	Q>E		No	ClinGen TOPMed gnomAD
CA2879065 rs748565993	553	C>S		No	ClinGen ExAC TOPMed gnomAD
CA93645056 rs748565993	553	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA356559994 rs1226997563	554	I>T		No	ClinGen TOPMed
rs201363321 CA2879066	554	I>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	555	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356560009 rs1267082995	556	L>F		No	ClinGen TOPMed gnomAD
CA2879069 rs771043324	557	Y>C		No	ClinGen ExAC gnomAD
CA2879071 rs759738029	560	T>S		No	ClinGen ExAC gnomAD
rs557083298 CA2879072	561	R>S		No	ClinGen 1000Genomes ExAC gnomAD
rs772938316 CA2879093	564	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1237290917 CA356560083	565	S>F		No	ClinGen gnomAD
CA2879094 rs760658281	566	T>I		No	ClinGen ExAC gnomAD
CA2879095 rs149749991	567	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs573056698 CA2879097	567	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs573056698 CA2879096	567	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA93645275 rs149749991	567	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173255117 CA356560102	569	L>*		No	ClinGen gnomAD
rs1432083276 CA356560099	569	L>V		No	ClinGen gnomAD
rs764947097 CA2879098	571	K>R		No	ClinGen ExAC gnomAD
rs752407065 CA2879099	572	F>C		No	ClinGen ExAC gnomAD
TCGA novel	573	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	573	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2879116 rs760438589	576	W>C		No	ClinGen ExAC gnomAD
CA93645468 rs867834394	578	N>D		No	ClinGen Ensembl
CA356560190 rs1218149779	580	T>A		No	ClinGen gnomAD
CA356560203 rs1316402356	582	N>T		No	ClinGen TOPMed
CA2879117 rs770855476	582	N>Y		No	ClinGen ExAC gnomAD
CA356560217 rs1315911506	584	H>R		No	ClinGen gnomAD
CA356560230 rs1450849952	586	L>V		No	ClinGen gnomAD
rs759054546 CA2879120	587	L>I		No	ClinGen ExAC
TCGA novel	588	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2879121 rs764848895	589	T>I		No	ClinGen ExAC gnomAD
TCGA novel	589	T>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs973863059 CA93645480	591	L>P		No	ClinGen Ensembl
CA356560265 rs1258001693	592	E>Q		No	ClinGen TOPMed
rs1328315594 CA356560276	593	D>G		No	ClinGen TOPMed
CA2879123 rs762659013	594	S>A		No	ClinGen ExAC TOPMed gnomAD
CA2879124 COSM733654 rs763691964	594	S>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA356560289 rs1260415474	595	L>R		No	ClinGen gnomAD
rs1476440537 CA550664363	596	Y>*		No	ClinGen gnomAD
rs1164366275 CA356560302	597	K>R		No	ClinGen gnomAD
rs1413476892 CA356560313	598	M>I		No	ClinGen gnomAD
CA356560347 rs1161579146	603	R>T		No	ClinGen gnomAD
rs751928386 CA2879125	604	H>R		No	ClinGen ExAC gnomAD
rs1399479281 CA356560359	605	T>S		No	ClinGen gnomAD
CA356560367 rs1577402815	606	D>G		No	ClinGen Ensembl
CA356560365 rs1296491893	606	D>H		No	ClinGen TOPMed gnomAD
rs370276115 CA2879126	607	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2879142 rs533672504	609	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1278537389 CA356560447	616	I>T		No	ClinGen gnomAD
CA2879145 rs575771639	618	I>V		No	ClinGen ExAC TOPMed gnomAD
CA356560490 rs750853941	622	S>R		No	ClinGen ExAC gnomAD
TCGA novel	623	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA93646063 rs753556884	624	T>A		No	ClinGen gnomAD
rs201954140 CA2879149	625	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2879150 rs753903477	626	A>T		No	ClinGen ExAC TOPMed gnomAD
CA356560523 rs1333249594	628	T>A		No	ClinGen gnomAD
CA356560527 rs1577403620	628	T>I		No	ClinGen Ensembl
CA356560530 rs1441376048	629	E>K		No	ClinGen TOPMed
rs1416408190 CA356560565	633	R>K		No	ClinGen gnomAD
rs906712896 CA356560578	634	S>G		No	ClinGen TOPMed gnomAD
CA356560580 rs1170538986	634	S>N		No	ClinGen gnomAD
rs906712896 CA93646117	634	S>R		No	ClinGen TOPMed gnomAD
rs1194392220 CA356560905	635	I>F		No	ClinGen TOPMed gnomAD
CA356560904 rs1194392220	635	I>V		No	ClinGen TOPMed gnomAD
CA2879171 rs758665567	644	Y>F		No	ClinGen ExAC gnomAD
CA2879170 rs752892651	644	Y>H		No	ClinGen ExAC gnomAD
rs758665567 CA356560973	644	Y>S		No	ClinGen ExAC gnomAD
CA2879172 rs778192398	646	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1458179881 CA356560992	647	E>K		No	ClinGen TOPMed gnomAD
CA356560993 rs1458179881	647	E>Q		No	ClinGen TOPMed gnomAD
CA356561023 rs1363258678	651	V>A		No	ClinGen gnomAD
rs892433801 CA356561051	655	D>E		No	ClinGen TOPMed
rs1401460027 CA356561054	656	T>A		No	ClinGen gnomAD
CA356561059 rs1339250471	657	V>I		No	ClinGen TOPMed gnomAD
CA2879175 rs779976609	659	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2879176 rs749197099	659	R>H		No	ClinGen ExAC TOPMed gnomAD
CA356561071 rs779976609	659	R>S		No	ClinGen ExAC TOPMed gnomAD
CA356561075 rs1263904236	660	E>K		No	ClinGen gnomAD
rs778254664 CA2879178	662	R>K		No	ClinGen ExAC gnomAD
CA356561108 rs1043795148	664	R>S		No	ClinGen gnomAD
CA356561131 rs1577404730	668	Q>*		No	ClinGen Ensembl
CA356561144 rs771661752	670	P>S		No	ClinGen ExAC gnomAD
CA2879180 rs771661752	670	P>T		No	ClinGen ExAC gnomAD
CA2879181 rs772880730	672	S>F		No	ClinGen ExAC gnomAD
TCGA novel	674	V>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2879183 rs771295630	676	N>S		No	ClinGen ExAC gnomAD
rs199902077 CA2879184	677	S>G		No	ClinGen ExAC TOPMed gnomAD
CA356561207 rs1560450795	679	D>A		No	ClinGen Ensembl
TCGA novel	679	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA93647061 rs552682704	682	E>G		No	ClinGen Ensembl
rs1421191636 CA356561235	683	Y>C		No	ClinGen gnomAD
CA2879185 rs759960371	684	Q>H		No	ClinGen ExAC gnomAD
rs1577404794 CA356561244	684	Q>L		No	ClinGen Ensembl
rs368537806 CA2879186	686	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA2879188 rs763150398	689	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA2879189 rs764373002	690	S>F		No	ClinGen ExAC gnomAD
rs1395949687 CA356561278	690	S>T		No	ClinGen gnomAD
CA93647095 rs1014089483	692	R>G		No	ClinGen Ensembl
CA2879213 rs753525889	693	L>P		No	ClinGen ExAC gnomAD
CA356561312 rs1170487023	694	D>N		No	ClinGen gnomAD
TCGA novel	695	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1560451525 CA356561321	695	E>Q		No	ClinGen Ensembl
rs1027953561 CA93648300	696	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	699	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766411258 CA2879216 COSM3661040	703	R>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2879217 rs202221095	703	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1294299591 CA356561381	704	T>A		No	ClinGen gnomAD
CA356561383 rs1367024976	704	T>N		No	ClinGen gnomAD
rs1403119082 CA356561392	705	M>I		No	ClinGen gnomAD
CA356561399 rs1281300426	706	H>R		No	ClinGen gnomAD
rs9174 CA356561409	707	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756841584 CA93648371	709	K>N		No	ClinGen ExAC gnomAD
rs746566068 CA2879219	709	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1223352074 CA356561466	715	E>G		No	ClinGen gnomAD
TCGA novel	717	M>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356561504 rs1196744690	720	Q>R		No	ClinGen gnomAD
rs367659041 CA2879222	725	N>S		No	ClinGen ESP ExAC gnomAD
COSM3775775 CA356561555 rs1170556411	728	R>*	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA356561620 rs1303626129	736	S>A		No	ClinGen TOPMed
CA356561642 rs1450004796	739	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	740	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1343214608 CA356561650	740	H>R		No	ClinGen TOPMed
rs755782244 CA2879241	741	V>L		No	ClinGen ExAC TOPMed gnomAD
rs755782244 CA356561654	741	V>M		No	ClinGen ExAC TOPMed gnomAD
rs376460606 CA2879242	747	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA356561723 rs973214830	748	I>M		No	ClinGen gnomAD
CA2879244 rs769236592	755	D>G		No	ClinGen ExAC gnomAD
CA93648837 rs919120354	755	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs17855710 CA93648862	756	E>G		No	ClinGen gnomAD
CA356561854 rs17855710	756	E>V		No	ClinGen gnomAD
CA2879246 rs775029120	759	D>H		No	ClinGen ExAC gnomAD
CA356561887 rs775029120	759	D>N		No	ClinGen ExAC gnomAD
rs1444691794 CA356561922	761	E>A		No	ClinGen gnomAD
CA93648889 rs1019400309	762	E>Q		No	ClinGen TOPMed
rs1560451984 CA356561935	762	E>V		No	ClinGen Ensembl
CA2879247 rs748109493	763	E>A		No	ClinGen ExAC gnomAD
CA2879248 CA93648904 rs772204215	763	E>D		No	ClinGen ExAC TOPMed gnomAD
rs748109493 CA356561950	763	E>G		No	ClinGen ExAC gnomAD
CA2879249 rs561331536	764	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1233968815 CA356561966	765	S>G		No	ClinGen gnomAD
rs1381085831 CA356562011	767	K>N		No	ClinGen gnomAD
CA356562006 rs1180767428	767	K>R		No	ClinGen gnomAD
TCGA novel	770	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1156964264 CA356562057	771	I>V		No	ClinGen gnomAD
rs1577406744 CA356562105	774	E>A		No	ClinGen Ensembl
CA2879252 rs775248115	777	S>L		No	ClinGen ExAC TOPMed gnomAD
rs751523068 CA2879255	779	S>*		No	ClinGen ExAC gnomAD
CA356562169 rs1360056234	779	S>P		No	ClinGen TOPMed
rs756665756 CA2879256	780	E>K		No	ClinGen ExAC gnomAD
rs943226343 CA93648959	781	A>G		No	ClinGen Ensembl
CA356562192 rs1484600842	781	A>S		No	ClinGen TOPMed gnomAD
CA2879257 rs767043531	782	E>G		No	ClinGen ExAC TOPMed gnomAD
CA356562220 rs1577406825	783	N>T		No	ClinGen Ensembl
rs749967876 CA2879258	784	Q>P		No	ClinGen ExAC gnomAD
CA356562244 rs146675413	785	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2879260 rs146675413	785	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356562259 rs1346462953	786	A>G		No	ClinGen gnomAD
CA356562260 rs1346462953	786	A>V		No	ClinGen gnomAD
rs1220343203 CA356562278	789	A>V		No	ClinGen gnomAD
CA2879262 rs755396618	790	A>T		No	ClinGen ExAC gnomAD
rs1200993284 CA356562296	792	A>V		No	ClinGen gnomAD
CA356562298 rs779503444	793	P>A		No	ClinGen ExAC gnomAD
rs779503444 CA2879263	793	P>S		No	ClinGen ExAC gnomAD
rs980364248 CA93649055	800	E>D		No	ClinGen TOPMed
CA93649053 VAR_054045 rs11550697	800	E>G		No	ClinGen UniProt Ensembl dbSNP
TCGA novel	802	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2879264 CA93649057 rs748672674	803	D>E		No	ClinGen ExAC gnomAD
CA356562371 rs1191466541	804	P>A		No	ClinGen gnomAD
rs1418303797 CA356562390	807	D>H		No	ClinGen TOPMed
CA356562402 rs1188355683	808	S>F		No	ClinGen TOPMed

No associated diseases with Q9UJX5

2 regional properties for Q9UJX5

Type	Name	Position	InterPro Accession
domain	Anaphase-promoting complex subunit 4, long domain	234 - 430	IPR024790
domain	Anaphase-promoting complex subunit 4-like, WD40 domain	27 - 117	IPR024977

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
anaphase-promoting complex	A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear periphery	The portion of the nuclear lumen proximal to the inner nuclear membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
protein phosphatase binding	Binding to a protein phosphatase.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

7 GO annotations of biological process

Name	Definition
anaphase-promoting complex-dependent catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
protein K11-linked ubiquitination	A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
regulation of meiotic cell cycle	Any process that modulates the rate or extent of progression through the meiotic cell cycle.
regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of mitotic metaphase/anaphase transition	Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04601	APC4	Anaphase-promoting complex subunit 4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q91W96	Anapc4	Anaphase-promoting complex subunit 4	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MLRFPTCFPS	FRVVGEKQLP	QEIIFLVWSP	KRDLIALANT	AGEVLLHRLA	SFHRVWSFPP
70	80	90	100	110	120
NENTGKEVTC	LAWRPDGKLL	AFALADTKKI	VLCDVEKPES	LHSFSVEAPV	SCMHWMEVTV
130	140	150	160	170	180
ESSVLTSFYN	AEDESNLLLP	KLPTLPKNYS	NTSKIFSEEN	SDEIIKLLGD	VRLNILVLGG
190	200	210	220	230	240
SSGFIELYAY	GMFKIARVTG	IAGTCLALCL	SSDLKSLSVV	TEVSTNGASE	VSYFQLETNL
250	260	270	280	290	300
LYSFLPEVTR	MARKFTHISA	LLQYINLSLT	CMCEAWEEIL	MQMDSRLTKF	VQEKNTTTSV
310	320	330	340	350	360
QDEFMHLLLW	GKASAELQTL	LMNQLTVKGL	KKLGQSIESS	YSSIQKLVIS	HLQSGSESLL
370	380	390	400	410	420
YHLSELKGMA	SWKQKYEPLG	LDAAGIEEAI	TAVGSFILKA	NELLQVIDSS	MKNFKAFFRW
430	440	450	460	470	480
LYVAMLRMTE	DHVLPELNKM	TQKDITFVAE	FLTEHFNEAP	DLYNRKGKYF	NVERVGQYLK
490	500	510	520	530	540
DEDDDLVSPP	NTEGNQWYDF	LQNSSHLKES	PLLFPYYPRK	SLHFVKRRME	NIIDQCLQKP
550	560	570	580	590	600
ADVIGKSMNQ	AICIPLYRDT	RSEDSTRRLF	KFPFLWNNKT	SNLHYLLFTI	LEDSLYKMCI
610	620	630	640	650	660
LRRHTDISQS	VSNGLIAIKF	GSFTYATTEK	VRRSIYSCLD	AQFYDDETVT	VVLKDTVGRE
670	680	690	700	710	720
GRDRLLVQLP	LSLVYNSEDS	AEYQFTGTYS	TRLDEQCSAI	PTRTMHFEKH	WRLLESMKAQ
730	740	750	760	770	780
YVAGNGFRKV	SCVLSSNLRH	VRVFEMDIDD	EWELDESSDE	EEEASNKPVK	IKEEVLSESE
790	800
AENQQAGAAA	LAPEIVIKVE	KLDPELDS