Q04601
PR
Gene name |
APC4 (YDR118W) |
Protein name |
Anaphase-promoting complex subunit 4 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR118W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q04601
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8A3T | EM | 350 A | Q | 1-652 | PDB |
| 8A5Y | EM | 490 A | Q | 1-652 | PDB |
| 8A61 | EM | 540 A | Q | 1-652 | PDB |
| AF-Q04601-F1 | Predicted | AlphaFoldDB |
24 variants for Q04601
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-685912 | 12 | Y>N | No | SGRP | |
| s04-686035 | 53 | D>N | No | SGRP | |
| s04-686149 | 91 | T>S | No | SGRP | |
| s04-686171 | 98 | W>L | No | SGRP | |
| s04-686342 | 155 | S>N | No | SGRP | |
| s04-686416 | 180 | Y>H | No | SGRP | |
| s04-686557 | 227 | K>E | No | SGRP | |
| s04-686791 | 305 | E>K | No | SGRP | |
| s04-686807 | 310 | R>K | No | SGRP | |
| s04-686807 | 310 | R>M | No | SGRP | |
| s04-687003 | 375 | K>N | No | SGRP | |
| s04-687166 | 430 | L>V | No | SGRP | |
| s04-687233 | 452 | L>P | No | SGRP | |
| s04-687276 | 466 | D>E | No | SGRP | |
| s04-687421 | 515 | L>V | No | SGRP | |
| s04-687424 | 516 | I>V | No | SGRP | |
| s04-687530 | 551 | K>R | No | SGRP | |
| s04-687629 | 584 | G>E | No | SGRP | |
| s04-687633 | 585 | L>F | No | SGRP | |
| s04-687640 | 588 | S>G | No | SGRP | |
| s04-687688 | 604 | E>K | No | SGRP | |
| s04-687742 | 622 | R>G | No | SGRP | |
| s04-687743 | 622 | R>K | No | SGRP | |
| s04-687827 | 650 | Q>R | No | SGRP |
No associated diseases with Q04601
1 regional properties for Q04601
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Olfactomedin-like domain | 230 - 489 | IPR003112 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anaphase-promoting complex | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear periphery | The portion of the nuclear lumen proximal to the inner nuclear membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| anaphase-promoting complex-dependent catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| protein K11-linked ubiquitination | A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of meiotic cell cycle | Any process that modulates the rate or extent of progression through the meiotic cell cycle. |
| regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
| regulation of mitotic metaphase/anaphase transition | Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSPINDYFI | DYNPLFPIFA | TRIAKGLAIY | RVSDHARLAV | IPIRNINLVA | NYDWDTTTGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLSIFFKDGT | IRIHDIFKDG | RLVSFLRIPS | TKISKGIWDR | IPLRYEPNNR | DFACNIIDDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKLIRFVKDS | KRINIVPYTQ | PNSLWRGPDE | DDLDSNEKLD | VHVVFNEGND | KITVFFNGDY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVFLSVDNIE | NENSLKSIIK | VQDGFYQCFY | EDGTVQTLNL | GPLLQSKSSV | NLLNYIMVIK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELIGYMLTHL | EFINRELATP | YLDFVKRLCD | EAYGYGKLKS | ELEALFLLGE | ISCDLEDWLC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSVGEKNFKR | WKYLGCEAYQ | KTVQILTLIF | VPACERIIIY | VEKLRAILQA | FSIQNKLSYT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDLTAVEVLL | KSSQKLLTMT | LNSIIGLGRD | ETLFEKFFIW | FNDRLHEALD | EDYKLKFQFE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DDLYFGYDLL | SYFDRILSKK | GTEPSSIIDV | KLYRDLINSM | SDMEKDIAQS | NVNSHIQQHI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LVDLKTDVFA | QKYPSSQINL | LDAIKLPKHN | YIVYLIQVTK | HNSAQEPFSE | ENKKKLYIGT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKDENLGIIS | KESSVKIPAL | FKSYRLSSTR | FVPNRVHSLL | RDIGLSDSNY | HSSHVTDYRG |
| 610 | 620 | 630 | 640 | 650 | |
| ENYENEEDDG | TIAIPAYIRE | NRENDDFIAC | TAKVSVDGRS | ASLVFPKEKQ | NV |