AiPD: Autoinhibited Protein Database

Q9UH92

Gene name	MLX (BHLHD13, TCFL4)
Protein name	Max-like protein X
Names	Class D basic helix-loop-helix protein 13, bHLHd13, Max-like bHLHZip protein, Protein BigMax, Transcription factor-like protein 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6945
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

36-160 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

36-160 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UH92

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UH92-F1	Predicted				AlphaFoldDB

240 variants for Q9UH92

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs935353558 CA290773529	2	T>M		No	ClinGen TOPMed
CA290773528 rs920415713	2	T>S		No	ClinGen Ensembl
CA399600449 rs1236755728	3	E>K		No	ClinGen gnomAD
rs1329020400 CA399600460	4	P>Q		No	ClinGen TOPMed
CA290773532 rs929144048	6	A>T		No	ClinGen gnomAD
rs182950482 CA8578462	6	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754191585 CA399600477	8	P>A		No	ClinGen ExAC TOPMed gnomAD
rs868532594 CA290773546	8	P>H		No	ClinGen Ensembl
rs754191585 CA8578463	8	P>T		No	ClinGen ExAC TOPMed gnomAD
CA399600495 rs1402770868	10	D>E		No	ClinGen TOPMed
CA8578465 rs754712752	10	D>G		No	ClinGen ExAC TOPMed
rs548524602 CA8578466	11	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757883517 CA8578468	15	A>T		No	ClinGen ExAC gnomAD
rs746975126 CA399600539	17	P>H		No	ClinGen ExAC TOPMed gnomAD
CA8578470 rs746975126	17	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399600538 rs868376287	17	P>S		No	ClinGen TOPMed gnomAD
rs868376287 CA290773595	17	P>T		No	ClinGen TOPMed gnomAD
CA399600548 rs1299521243	19	G>R		No	ClinGen gnomAD
rs537756330 CA290773599	20	A>S		No	ClinGen 1000Genomes
rs768887679 CA8578474	20	A>V		No	ClinGen ExAC gnomAD
rs1443531017 CA399600566	22	A>S		No	ClinGen TOPMed
rs1460998986 CA399600588	25	G>E		No	ClinGen TOPMed gnomAD
rs1460998986 CA399600590	25	G>V		No	ClinGen TOPMed gnomAD
CA399600587 rs1244005398	25	G>W		No	ClinGen gnomAD
CA399600595 rs1219558691	26	R>M		No	ClinGen Ensembl
CA290773616 rs368562422	29	R>Q		No	ClinGen TOPMed gnomAD
rs767553265 CA8578477	31	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8578478 rs773287221	33	R>C		No	ClinGen ExAC gnomAD
CA290773627 rs371378892	33	R>H		No	ClinGen Ensembl
TCGA novel	34	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA290773630 rs75782551	37	G>R		No	ClinGen Ensembl
rs761094176 CA8578480	39	R>L		No	ClinGen ExAC TOPMed gnomAD
rs766957141 CA8578481	40	G>R		No	ClinGen ExAC TOPMed gnomAD
rs754281479 CA8578482	42	S>F		No	ClinGen ExAC TOPMed gnomAD
rs755439287 CA8578483	43	L>F		No	ClinGen ExAC TOPMed gnomAD
CA290773636 rs765662123	44	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1313248506 CA399600694	44	L>R		No	ClinGen TOPMed gnomAD
CA8578484 rs765662123	44	L>V		No	ClinGen ExAC TOPMed gnomAD
CA8578485 rs752356404	45	S>P		No	ClinGen ExAC TOPMed gnomAD
CA399600697 rs1322373773	45	S>Y		No	ClinGen gnomAD
CA290773649 rs1029915076	46	P>R		No	ClinGen Ensembl
CA290773664 rs559253696	48	S>A		No	ClinGen 1000Genomes TOPMed gnomAD
rs1256171510 CA399600732	51	L>F		No	ClinGen TOPMed
CA399600740 rs1205197323	52	S>F		No	ClinGen TOPMed
CA399600750 rs1225448950	54	P>H		No	ClinGen gnomAD
CA8578487 rs534650646	54	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399600754 rs1256482096	55	R>Q		No	ClinGen gnomAD
CA8578488 rs746460209	55	R>W		No	ClinGen ExAC gnomAD
CA399600760 rs1323140727	56	G>D		No	ClinGen TOPMed gnomAD
rs1201998344 CA399600766	57	C>F		No	ClinGen gnomAD
rs955652468 CA290773678	60	D>V		No	ClinGen gnomAD
CA399600812 rs1248163438	61	S>G		No	ClinGen Ensembl
rs367550767 CA8578489	61	S>N		No	ClinGen ESP ExAC gnomAD
CA290773684 rs535621745	62	S>C		No	ClinGen Ensembl
CA399600857 rs1240889169	64	P>L		No	ClinGen gnomAD
CA399600851 rs1192877324	64	P>S		No	ClinGen TOPMed gnomAD
rs1007102021 CA290773688	65	A>T		No	ClinGen Ensembl
rs1367200651 CA399600955	69	V>A		No	ClinGen gnomAD
rs1367200651 CA399600957	69	V>G		No	ClinGen gnomAD
rs1156632613 CA399600948	69	V>M		No	ClinGen gnomAD
rs763760312 CA8578506	72	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8578505 rs763760312	72	A>T		No	ClinGen ExAC TOPMed gnomAD
CA399601011 rs1597717790	74	S>R		No	ClinGen Ensembl
TCGA novel	75	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399601020 rs1433297005	75	D>G		No	ClinGen TOPMed
rs780677107 CA8578509	76	N>S		No	ClinGen ExAC
rs1385186210 CA399601031	76	N>Y		No	ClinGen gnomAD
rs1336621949 CA399601044	77	S>C		No	ClinGen gnomAD
CA399601042 rs1336621949	77	S>G		No	ClinGen gnomAD
rs1278207268 CA399601057	78	L>Q		No	ClinGen gnomAD
rs1278207268 CA399601060	78	L>R		No	ClinGen gnomAD
rs1238599049 CA399601056	78	L>V		No	ClinGen gnomAD
CA8578513 rs749073467	80	P>S		No	ClinGen ExAC TOPMed gnomAD
rs547233193 CA399602059	81	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs547233193 CA8578537	81	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA8578538 rs770227149	82	L>F		No	ClinGen ExAC gnomAD
CA8578539 rs776114176	82	L>H		No	ClinGen ExAC TOPMed gnomAD
rs769122835 CA8578541	85	E>G		No	ClinGen ExAC TOPMed gnomAD
CA399602112 rs769122835	85	E>V		No	ClinGen ExAC TOPMed gnomAD
CA8578542 rs774639334	86	S>G		No	ClinGen ExAC gnomAD
rs1264426750 CA399602143	87	T>I		No	ClinGen gnomAD
rs1264426750 CA399602140	87	T>S		No	ClinGen gnomAD
rs547490527 CA290775116	87	T>S		No	ClinGen Ensembl
rs761458396 CA8578543	88	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8578544 rs761458396	88	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8578545 rs142766491	88	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8578546 rs142766491	88	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8578547 rs765771374	93	V>A		No	ClinGen ExAC gnomAD
CA399602207 rs1434971115	94	S>P		No	ClinGen TOPMed
rs754861601 CA8578549	95	R>G		No	ClinGen ExAC TOPMed gnomAD
rs765097681 CA8578550	96	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1420205474 CA399602240	96	A>V		No	ClinGen TOPMed
rs1260989720 CA399602261	97	N>K		No	ClinGen TOPMed gnomAD
CA399602271 rs1484955354	98	S>N		No	ClinGen TOPMed
CA8578551 rs752476588	99	I>M		No	ClinGen ExAC TOPMed gnomAD
rs201079657 CA8578553	100	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	100	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1038225340 CA290775168	102	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	103	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746067080 CA8578554	103	S>R		No	ClinGen ExAC gnomAD
CA8578555 rs756258939	105	S>F	Variant assessed as Somatic; 9.239e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA399602384 rs1384929856	106	S>A		No	ClinGen gnomAD
rs1398690350 CA399602400	107	V>I		No	ClinGen gnomAD
rs147400711 CA8578556	109	N>S		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs749814079 CA8578557	111	D>H		No	ClinGen ExAC gnomAD
CA399602454 rs749814079	111	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	113	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs982349429 CA290775337	114	D>E		No	ClinGen TOPMed gnomAD
CA8578595 rs766460362	114	D>H		No	ClinGen ExAC gnomAD
rs374345141 CA8578596	115	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8578597 rs755087009	116	D>E		No	ClinGen ExAC gnomAD
CA8578598 rs778956968	118	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1397726183 CA399602585	119	Q>*		No	ClinGen gnomAD
rs753256987 CA8578599	120	E>G		No	ClinGen ExAC gnomAD
TCGA novel	121	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8578601 rs778119116	122	Y>F		No	ClinGen ExAC gnomAD
CA8578600 rs758848942	122	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs747300000 CA399602612	123	K>E		No	ClinGen ExAC gnomAD
CA399602614 rs1362515516	123	K>M		No	ClinGen gnomAD
rs747300000 CA8578602	123	K>Q		No	ClinGen ExAC gnomAD
CA290775344 rs139677858	125	S>F		No	ClinGen ESP TOPMed
rs1316361565 CA399602636	126	Y>C		No	ClinGen gnomAD
rs143700523 CA8578604	129	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1263926960 CA399602657	129	R>W		No	ClinGen gnomAD
rs745504523 CA399602661	130	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs769496179 CA8578606	131	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8578607 rs775127202	132	R>H		No	ClinGen ExAC TOPMed gnomAD
rs775127202 CA399602673	132	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8578609 rs371444407	133	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs769263207 CA8578611	140	K>Q		No	ClinGen ExAC gnomAD
CA8578612 rs568777376	143	D>E		No	ClinGen 1000Genomes ExAC gnomAD
COSM269601 rs759737992 CA8578614	144	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1320015483 CA399602757	145	I>V		No	ClinGen gnomAD
CA399602799 rs1329976607	149	Y>S		No	ClinGen TOPMed
rs765407614 CA8578633	150	D>G		No	ClinGen ExAC gnomAD
CA290775430 rs570620164	155	I>T		No	ClinGen Ensembl
rs148497001 CA8578636	156	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8578637 rs752074528	158	T>S		No	ClinGen ExAC gnomAD
CA8578638 rs757769608	160	Q>R		No	ClinGen ExAC gnomAD
CA399602882 rs767788086	161	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1222632361 CA399602884	162	Q>K		No	ClinGen TOPMed gnomAD
CA399602913 rs1266046244	165	S>F		No	ClinGen gnomAD
CA8578640 rs750775768	166	I>T		No	ClinGen ExAC
CA399602931 rs1449568993	168	S>F		No	ClinGen gnomAD
rs1015383378 CA290775446	169	Q>H		No	ClinGen gnomAD
CA399602969 rs1166401759	174	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8578641 rs755852891	175	I>V		No	ClinGen ExAC gnomAD
CA399602983 rs1156557930	176	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1419149105 CA399603004	179	K>R		No	ClinGen gnomAD
rs779900314 CA8578642	180	T>A		No	ClinGen ExAC TOPMed gnomAD
CA8578669 rs780954981	181	I>V		No	ClinGen ExAC gnomAD
rs768857309 CA8578671	185	Q>H		No	ClinGen ExAC TOPMed
rs1285266902 CA399603077	188	H>D		No	ClinGen TOPMed
rs1054095958 CA290775542	188	H>P		No	ClinGen TOPMed
rs201470982 CA290775549	189	K>R		No	ClinGen 1000Genomes
CA399603108 rs1199620026	190	E>G		No	ClinGen gnomAD
rs772011845 CA8578674	194	Q>R		No	ClinGen ExAC gnomAD
rs1424407318 CA399603176	195	E>D		No	ClinGen gnomAD
CA399603172 rs1195508352	195	E>G		No	ClinGen gnomAD
rs528569258 CA8578675	195	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399603197 rs761247919	197	E>A		No	ClinGen ExAC TOPMed gnomAD
CA8578676 rs761247919	197	E>G		No	ClinGen ExAC TOPMed gnomAD
CA290775558 rs1048805920	200	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766861331 CA8578677	200	T>P		No	ClinGen ExAC gnomAD
COSM1257812 rs759146238 CA8578679	202	R>C	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs759146238 CA8578680	202	R>G		No	ClinGen ExAC TOPMed gnomAD
rs774834596 CA8578681 COSM1215245	202	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA290775563 rs1009349298	203	K>T		No	ClinGen TOPMed gnomAD
rs757969851 CA8578682	206	T>I		No	ClinGen ExAC gnomAD
CA399603296 rs751557461	207	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8578684 rs751557461	207	A>T		No	ClinGen ExAC TOPMed gnomAD
rs562122560 CA8578686	209	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750296353 CA8578706	215	Y>C		No	ClinGen ExAC gnomAD
CA8578707 rs756002887	216	E>K		No	ClinGen ExAC gnomAD
TCGA novel	218	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748411344 CA8578709	222	H>R		No	ClinGen ExAC
rs1165000260 CA399603521	223	Q>*		No	ClinGen TOPMed gnomAD
CA399603523 rs1165000260	223	Q>K		No	ClinGen TOPMed gnomAD
rs665268 CA399603527	223	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399603525 rs665268	223	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs665268 CA8578710 VAR_049547	223	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs984039391 CA290775690	225	N>S		No	ClinGen gnomAD
CA399603562 rs747033129	226	P>A		No	ClinGen ExAC gnomAD
TCGA novel	226	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399603564 rs747033129	226	P>S		No	ClinGen ExAC gnomAD
rs747033129 CA8578712	226	P>T		No	ClinGen ExAC gnomAD
CA399603577 rs1447306646	227	H>R		No	ClinGen TOPMed gnomAD
CA399603592 rs1374660839	228	E>D		No	ClinGen TOPMed gnomAD
rs771115404 CA8578713	228	E>Q		No	ClinGen ExAC gnomAD
CA399603600 rs1290426197	229	G>E		No	ClinGen gnomAD
rs1008625060 CA290775708	229	G>W		No	ClinGen TOPMed gnomAD
rs370455047 CA290775712	230	E>D		No	ClinGen TOPMed gnomAD
rs777239344 CA8578714	231	D>Y		No	ClinGen ExAC gnomAD
CA8578716 rs770252469	232	Q>H		No	ClinGen ExAC gnomAD
rs775660549 CA8578717	238	K>R		No	ClinGen ExAC TOPMed gnomAD
rs143736694 CA290775746	240	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs143736694 CA8578718	240	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1185964649 CA399603733	241	V>M		No	ClinGen gnomAD
rs761350836 CA8578721	243	Q>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs761350836 CA290775751	243	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1162062759 CA399604430	247	D>E		No	ClinGen gnomAD
rs1254111230 CA399604418	247	D>N		No	ClinGen TOPMed
CA399604468 rs1213833738	250	F>L		No	ClinGen TOPMed
TCGA novel	250	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	251	Q>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755944141 CA8578724	254	N>S		No	ClinGen ExAC TOPMed gnomAD
CA8578725 rs199695342	255	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8578726 rs199695342	255	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs111260159 CA290775769	256	S>P		No	ClinGen Ensembl
CA8578730 rs757483745	260	A>V		No	ClinGen ExAC gnomAD
CA8578731 rs781122018	262	F>L		No	ClinGen ExAC gnomAD
rs1320351365 CA399604637	263	Q>*		No	ClinGen TOPMed gnomAD
rs1248932634 CA399604695	267	A>G		No	ClinGen TOPMed
CA399604688 rs1199525755	267	A>S		No	ClinGen gnomAD
COSM282826 rs1248932634 CA399604697	267	A>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1212623144 CA399604708	268	C>Y		No	ClinGen gnomAD
rs775956555 COSM417512 CA8578735	273	I>M	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA399604782 rs1388644291	273	I>V		No	ClinGen TOPMed
rs780372140 CA290775803	275	E>A		No	ClinGen TOPMed gnomAD
rs780372140 CA290775807	275	E>G		No	ClinGen TOPMed gnomAD
CA8578736 rs201627294	275	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA8578737 rs768975531	276	H>Q		No	ClinGen ExAC gnomAD
rs1420960638 CA399604891	280	Q>H		No	ClinGen gnomAD
CA290776709 rs140676383	282	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed
CA399605108 rs1597720539	282	L>V		No	ClinGen Ensembl
CA8578763 rs759537997	283	R>P		No	ClinGen ExAC gnomAD
CA8578762 rs759537997	283	R>Q		No	ClinGen ExAC gnomAD
rs150470672 CA290776721	284	E>K		No	ClinGen ESP
rs1245733780 CA399605163	285	I>M		No	ClinGen gnomAD
rs752474682 CA8578764	285	I>T		No	ClinGen ExAC TOPMed gnomAD
CA8578765 rs762127321	287	I>S		No	ClinGen ExAC TOPMed gnomAD
rs767588014 CA8578766	288	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8578768 rs756214487	289	V>I		No	ClinGen ExAC TOPMed gnomAD
rs756214487 CA399605205	289	V>L		No	ClinGen ExAC TOPMed gnomAD
CA399605241 rs1419289573	291	H>L		No	ClinGen TOPMed
CA8578769 rs780167658	291	H>Y		No	ClinGen ExAC gnomAD
rs543511292 CA290776770	292	Q>E		No	ClinGen 1000Genomes TOPMed gnomAD
CA399605320 rs1460465255	296	Q>R		No	ClinGen TOPMed
rs200600765 CA290776786	297	L>P		No	ClinGen 1000Genomes
TCGA novel	299	Y>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q9UH92

5 regional properties for Q9UH92

Type	Name	Position	InterPro Accession
conserved_site	MoaA/NifB/PqqE, iron-sulphur binding, conserved site	73 - 84	IPR000385
domain	Molybdopterin cofactor biosynthesis C (MoaC) domain	490 - 625	IPR002820
domain	Elp3/MiaA/NifB-like, radical SAM core domain	67 - 270	IPR006638
domain	Radical SAM	56 - 380	IPR007197
domain	Molybdenum cofactor biosynthesis protein A-like, twitch domain	239 - 373	IPR010505

Functions

		Description
EC Number
Subcellular Localization	[Isoform Alpha]: Cytoplasm	Found predominantly in the cytoplasm (PubMed:10918583)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

10 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

5 GO annotations of biological process

Name	Definition
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O08609	Mlx	Max-like protein X	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MTEPGASPED	PWVKASPVGA	HAGEGRAGRA	RARRGAGRRG	ASLLSPKSPT	LSVPRGCRED
70	80	90	100	110	120
SSHPACAKVE	YAYSDNSLDP	GLFVESTRKG	SVVSRANSIG	STSASSVPNT	DDEDSDYHQE
130	140	150	160	170	180
AYKESYKDRR	RRAHTQAEQK	RRDAIKRGYD	DLQTIVPTCQ	QQDFSIGSQK	LSKAIVLQKT
190	200	210	220	230	240
IDYIQFLHKE	KKKQEEEVST	LRKDVTALKI	MKVNYEQIVK	AHQDNPHEGE	DQVSDQVKFN
250	260	270	280	290
VFQGIMDSLF	QSFNASISVA	SFQELSACVF	SWIEEHCKPQ	TLREIVIGVL	HQLKNQLY