Q9UEE5
SS
Gene name |
STK17A (DRAK1) |
Protein name |
Serine/threonine-protein kinase 17A |
Names |
EC 2.7.11.1 , DAP kinase-related apoptosis-inducing protein kinase 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9263 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The family of death-associated protein kinases (DAPKs) comprises five enzymes that exhibit a high degree of sequence homology in their catalytic domains. These enzymes function in the triggering of cellular apoptosis. DAPK2 is a CaM-dependent protein kinase (CaMK) that is kept in an inactive state by a double-locking mechanism. This mechanism requires dephosphorylation of an autophosphorylated residue within the CaM-binding domain, and is disrupted by CaM in response to Ca2+ stimuli. The autoinhibitory domain is a structural feature that regulates DAPK2, a pro-apoptotic serine/threonine kinase that controls the kinase’s activity through autoinhibition. This autoinhibition is released by CaM binding to its CaM-binding domain.
Autoinhibitory domains (AIDs)
Target domain |
59-321 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
206-228 (Activation loop from InterPro)
Target domain |
61-321 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
3 structures for Q9UEE5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7QUE | X-ray | 240 A | A/B | 50-322 | PDB |
| 7QUF | X-ray | 260 A | A/B | 50-322 | PDB |
| AF-Q9UEE5-F1 | Predicted | AlphaFoldDB |
318 variants for Q9UEE5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA4233389 rs781708885 |
3 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1363584808 CA367328995 |
5 | E>G | No |
ClinGen TOPMed |
|
|
rs1265103393 CA367329022 |
7 | P>L | No |
ClinGen gnomAD |
|
|
CA4233390 rs746329668 |
8 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1471760916 CA367329025 |
8 | G>S | No |
ClinGen gnomAD |
|
|
CA367329049 rs904358428 |
10 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
CA156936752 rs904358428 |
10 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4233392 rs775932894 |
10 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs934466219 CA156936758 |
11 | G>D | No |
ClinGen Ensembl |
|
|
CA156936767 rs907075219 |
12 | S>Y | No |
ClinGen TOPMed |
|
|
rs768916742 CA4233394 |
13 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768916742 CA367329079 |
13 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767442965 CA4233397 |
14 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs761929838 CA4233396 |
14 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs760537161 CA4233400 |
15 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs773161840 CA4233399 |
15 | G>R | No |
ClinGen ExAC |
|
|
rs1299637684 CA367329100 |
16 | A>S | No |
ClinGen gnomAD |
|
|
CA367329103 rs1299637684 |
16 | A>T | No |
ClinGen gnomAD |
|
|
CA4233401 rs766177555 |
16 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA4233402 rs753619917 |
17 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233403 rs754657235 |
18 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs764915684 CA4233404 |
19 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA4233407 rs752198996 |
20 | S>A | No |
ClinGen ExAC TOPMed |
|
|
rs757949442 CA4233408 |
20 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367329137 rs1052869241 |
22 | R>P | No |
ClinGen TOPMed |
|
|
rs1052869241 CA156936827 |
22 | R>Q | No |
ClinGen TOPMed |
|
|
CA367329144 rs1189295199 |
23 | A>V | No |
ClinGen gnomAD |
|
|
rs1160539162 CA367329145 |
24 | G>S | No |
ClinGen gnomAD |
|
|
CA367329160 rs1002737015 |
26 | G>A | No |
ClinGen TOPMed |
|
|
rs1002737015 CA156936830 |
26 | G>D | No |
ClinGen TOPMed |
|
|
rs1047675415 CA156936840 |
28 | S>R | No |
ClinGen TOPMed |
|
|
CA367329170 rs1563141159 |
28 | S>T | No |
ClinGen Ensembl |
|
|
CA4233411 rs200156727 |
29 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4233412 rs549741084 |
30 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367329205 rs749633332 |
32 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1292195983 CA367329222 |
33 | P>Q | No |
ClinGen gnomAD |
|
|
rs1444118710 CA367329231 |
34 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA4233415 rs768808965 |
38 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1220135769 CA367329273 |
39 | A>T | No |
ClinGen gnomAD |
|
|
CA367329278 rs1297515930 |
39 | A>V | No |
ClinGen gnomAD |
|
|
rs568833473 CA4233416 |
40 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367329281 rs568833473 |
40 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4233417 rs748275189 |
40 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 45 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA156936867 rs1028481524 |
46 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1451245116 CA367329366 |
48 | A>V | No |
ClinGen gnomAD |
|
|
rs1210403435 CA367329369 |
49 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1412413897 CA367329378 |
50 | V>A | No |
ClinGen gnomAD |
|
|
CA156936875 rs1008606192 |
50 | V>L | No |
ClinGen gnomAD |
|
|
rs1403046096 CA367329380 |
51 | R>C | No |
ClinGen gnomAD |
|
|
rs1166510455 CA367329387 |
51 | R>H | No |
ClinGen gnomAD |
|
|
rs1350039982 CA367329406 |
53 | E>D | No |
ClinGen gnomAD |
|
|
rs1228300837 CA367329417 |
54 | P>L | No |
ClinGen TOPMed |
|
|
rs1442116720 CA367329412 |
54 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA367329425 rs1320290164 |
55 | F>S | No |
ClinGen gnomAD |
|
|
rs1583542532 CA367329432 |
56 | Q>* | No |
ClinGen Ensembl |
|
|
CA156936879 rs1017273652 |
56 | Q>R | No |
ClinGen TOPMed |
|
|
rs1363695932 CA367329457 |
58 | G>C | No |
ClinGen gnomAD |
|
|
rs1437874047 CA367329460 |
58 | G>D | No |
ClinGen gnomAD |
|
| TCGA novel | 59 | Y>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1355772300 CA367329492 |
61 | L>P | No |
ClinGen gnomAD |
|
|
rs773216966 CA4233419 |
62 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367329497 rs1226614191 |
62 | C>R | No |
ClinGen gnomAD |
|
|
rs760666031 CA4233420 |
63 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1189161611 CA367329529 |
65 | R>L | No |
ClinGen gnomAD |
|
|
CA4233423 rs759357000 |
65 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 66 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1366843016 CA367329552 |
68 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1183040884 CA367329564 |
69 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1183040884 CA367329567 |
69 | R>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1336294762 CA367331105 |
71 | K>I | No |
ClinGen gnomAD |
|
|
rs1336294762 CA367331103 |
71 | K>R | No |
ClinGen gnomAD |
|
| TCGA novel | 75 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4233438 rs747064066 |
79 | I>R | No |
ClinGen ExAC gnomAD |
|
|
CA156941794 rs928020340 |
79 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA367331270 rs1352494963 |
81 | K>I | No |
ClinGen gnomAD |
|
|
CA367331276 rs1239574949 CA367331273 |
81 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs994911657 CA156941807 |
82 | D>E | No |
ClinGen Ensembl |
|
|
CA367331279 rs770909237 |
82 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233439 rs770909237 |
82 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs568389865 CA156941811 |
83 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA4233441 rs759352972 |
85 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs909666267 CA156941824 |
87 | F>I | No |
ClinGen TOPMed |
|
|
CA367331391 rs1482445748 |
88 | A>P | No |
ClinGen gnomAD |
|
|
CA4233442 rs769637860 |
89 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA4233444 rs762732276 |
91 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA4233446 rs751162547 |
92 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA4233445 rs763807404 |
92 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1563144662 CA367331467 |
93 | R>G | No |
ClinGen Ensembl |
|
|
CA4233447 rs200968580 |
94 | K>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 94 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367331515 rs1583550381 |
96 | R>I | No |
ClinGen Ensembl |
|
|
rs138232263 CA4233449 |
97 | K>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4233450 rs149595482 |
98 | G>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367331535 rs1372713934 |
98 | G>D | No |
ClinGen gnomAD |
|
|
rs1323087699 CA367331555 |
100 | D>H | No |
ClinGen gnomAD |
|
|
CA4233453 rs143280410 |
101 | C>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs771565115 CA4233456 |
102 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777953142 CA4233454 |
102 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4233458 rs565475401 |
103 | M>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1276123444 CA367331592 |
103 | M>T | No |
ClinGen gnomAD |
|
|
CA4233457 rs781066809 |
103 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA367331638 rs1264775404 |
108 | E>D | No |
ClinGen gnomAD |
|
|
CA156941875 rs777075015 |
108 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA367331656 rs1450239470 |
111 | V>A | No |
ClinGen gnomAD |
|
|
CA4233460 rs775394314 |
115 | A>E | No |
ClinGen ExAC gnomAD |
|
|
CA367331680 rs775394314 |
115 | A>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 117 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367331702 rs1254241079 |
118 | N>S | No |
ClinGen gnomAD |
|
|
rs762818321 CA4233461 |
119 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs762818321 CA367331706 |
119 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs902934302 CA156941883 |
122 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1170348793 CA367331736 |
123 | N>S | No |
ClinGen gnomAD |
|
|
CA367331752 rs1388776530 |
125 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA156941886 rs979513132 |
125 | H>R | No |
ClinGen gnomAD |
|
|
rs56286238 CA4233465 VAR_041145 |
126 | E>D | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA4233464 rs148044065 |
126 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 130 | T>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367331792 rs1364429004 |
131 | A>G | No |
ClinGen gnomAD |
|
|
CA4233466 rs749885971 COSM1266930 |
134 | M>I | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA4233468 rs374257441 |
140 | Y>S | No |
ClinGen ESP ExAC gnomAD |
|
|
rs763387664 CA4233490 |
141 | A>S | No |
ClinGen ExAC |
|
|
CA4233491 rs764459918 |
141 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs145372994 CA4233492 |
142 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs757545124 CA4233493 |
144 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1464180703 CA367333881 |
145 | E>A | No |
ClinGen TOPMed |
|
|
CA156946751 rs11555026 |
148 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367333905 rs1160998830 COSM3663199 |
148 | D>G | liver [Cosmic] | No |
ClinGen cosmic curated gnomAD |
| TCGA novel | 150 | C>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1047522353 CA156946761 |
150 | C>Y | No |
ClinGen Ensembl |
|
|
CA4233495 rs750607266 |
151 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA367333940 rs1307042172 |
153 | D>E | No |
ClinGen gnomAD |
|
|
rs61732519 CA4233497 |
153 | D>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367333941 rs1348229341 |
154 | R>G | No |
ClinGen gnomAD |
|
|
CA367333946 rs1227016933 |
154 | R>S | No |
ClinGen gnomAD |
|
|
CA367333959 rs1563149028 |
156 | E>A | No |
ClinGen Ensembl |
|
|
rs939081716 CA156946765 |
156 | E>D | No |
ClinGen Ensembl |
|
|
CA367333968 rs1388223267 |
157 | A>D | No |
ClinGen TOPMed |
|
|
rs1187796946 CA367333974 |
158 | F>C | No |
ClinGen TOPMed |
|
|
CA156946767 rs146830422 COSM108418 |
164 | Q>* | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs35940029 CA367334039 |
167 | M>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233498 VAR_041146 rs35940029 |
167 | M>T | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
|
|
CA4233499 rs754951190 |
168 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
RCV000890709 CA4233500 rs77026432 |
168 | R>Q | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs771807800 CA4233502 |
169 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233501 rs747923492 |
169 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA367334056 rs1344351458 |
170 | I>T | No |
ClinGen TOPMed |
|
|
rs371239772 CA4233503 |
170 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1251432655 CA367334075 |
173 | G>S | No |
ClinGen gnomAD |
|
|
CA4233504 rs746632915 |
174 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs770356144 CA367334122 |
180 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4233506 rs770356144 |
180 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776064671 CA4233507 |
180 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367334121 rs770356144 |
180 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233508 rs374240387 |
181 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367334126 rs374240387 |
181 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4233509 rs764582897 |
182 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs762103940 CA4233511 |
183 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA367334147 rs1193662801 |
184 | H>L | No |
ClinGen gnomAD |
|
|
rs1377947776 CA367334152 |
185 | L>F | No |
ClinGen TOPMed |
|
|
rs1368362464 CA367334154 |
185 | L>P | No |
ClinGen gnomAD |
|
|
rs766676359 CA4233536 |
190 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367336431 rs111947320 |
197 | E>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1351673777 CA367336419 |
197 | E>K | No |
ClinGen TOPMed |
|
| TCGA novel | 199 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367336473 rs1298795666 |
201 | G>V | No |
ClinGen gnomAD |
|
|
rs1246041326 CA367336481 |
202 | D>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1476118736 CA367336490 |
203 | I>V | No |
ClinGen gnomAD |
|
|
CA4233540 rs139022225 |
204 | K>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367336508 rs139022225 |
204 | K>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs566758223 CA4233541 |
205 | I>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1403216482 CA367336521 |
205 | I>T | No |
ClinGen gnomAD |
|
| TCGA novel | 208 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367336552 rs1163289455 |
208 | F>V | No |
ClinGen gnomAD |
|
|
CA367336582 rs1462257064 |
211 | S>P | No |
ClinGen gnomAD |
|
|
rs1343934361 CA367336610 |
213 | I>K | No |
ClinGen gnomAD |
|
|
rs777491002 CA367336631 |
215 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1131575 rs149915695 CA4233545 |
221 | R>* | Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA4233546 rs144946086 |
221 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1266230649 CA367336739 |
223 | I>T | No |
ClinGen gnomAD |
|
|
CA367336776 rs1448660444 CA367336777 |
224 | M>I | No |
ClinGen gnomAD |
|
|
rs902851827 CA156953612 |
224 | M>T | No |
ClinGen TOPMed |
|
|
CA4233547 rs780842727 |
225 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1471496373 CA367336857 |
227 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA367336869 rs1447405572 |
228 | E>K | No |
ClinGen TOPMed |
|
|
rs201447491 CA4233549 |
230 | V>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA367336999 rs1475772186 |
231 | A>S | No |
ClinGen gnomAD |
|
|
rs1307179906 CA367338690 |
232 | P>L | No |
ClinGen TOPMed |
|
|
CA156956071 rs773653788 |
239 | P>S | No |
ClinGen TOPMed |
|
|
CA4233568 rs757073046 |
240 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233569 rs757073046 |
240 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367338762 rs1367441437 |
242 | M>I | No |
ClinGen TOPMed |
|
|
rs114472894 CA156956075 |
242 | M>L | No |
ClinGen 1000Genomes |
|
|
CA367338760 rs1433380430 |
242 | M>T | No |
ClinGen gnomAD |
|
|
rs114472894 CA156956081 |
242 | M>V | No |
ClinGen 1000Genomes |
|
|
CA367338771 rs1432997375 |
244 | T>P | No |
ClinGen gnomAD |
|
|
CA367338789 rs1457163011 |
246 | M>I | No |
ClinGen TOPMed |
|
|
CA4233571 rs144785063 |
246 | M>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4233570 rs144785063 |
246 | M>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1261697884 CA367338815 |
248 | S>C | No |
ClinGen TOPMed |
|
| TCGA novel | 248 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4233587 rs774347943 |
249 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1326681930 CA367338847 |
253 | T>A | No |
ClinGen TOPMed |
|
|
CA4233589 rs537023294 |
254 | Y>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1410381522 CA367338861 |
255 | V>F | No |
ClinGen gnomAD |
|
|
rs750213145 CA4233591 |
258 | T>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 259 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367338891 rs1292707660 |
260 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
CA367338893 rs1292707660 |
260 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs755803806 CA4233593 |
262 | P>S | No |
ClinGen ExAC TOPMed |
|
|
CA4233594 rs559296227 |
266 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367338942 rs1368086715 |
267 | D>G | No |
ClinGen gnomAD |
|
|
rs754549690 CA4233596 |
269 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA367338975 rs1339648808 |
272 | F>L | No |
ClinGen gnomAD |
|
|
rs376734546 CA4233599 |
278 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367339027 rs1386801634 |
279 | N>D | No |
ClinGen TOPMed |
|
|
COSM109476 rs139281234 CA156956216 |
280 | L>I | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs1044103574 CA156956220 |
282 | Y>D | No |
ClinGen TOPMed gnomAD |
|
|
rs3779062 CA4233600 VAR_032823 |
286 | E>Q | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 287 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1563168650 CA367339086 |
287 | F>V | No |
ClinGen Ensembl |
|
|
rs1583817957 CA367339104 |
289 | V>A | No |
ClinGen Ensembl |
|
|
CA367339110 rs1191098206 |
290 | L>S | No |
ClinGen gnomAD |
|
|
rs770191727 CA4233603 |
293 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 295 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA156956242 rs1044326727 |
296 | D>E | No |
ClinGen Ensembl |
|
| TCGA novel | 297 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1190957296 CA367339155 |
297 | F>S | No |
ClinGen TOPMed |
|
|
rs749400528 CA4233605 |
298 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374135927 CA156956245 |
299 | R>K | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs553652334 CA4233606 |
300 | T>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1297061625 CA367339211 |
306 | P>T | No |
ClinGen gnomAD |
|
|
CA367339235 rs1255750275 |
307 | E>D | No |
ClinGen gnomAD |
|
|
rs748203381 CA4233631 |
308 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1188456105 CA367339244 |
309 | R>G | No |
ClinGen gnomAD |
|
|
CA4233632 rs772088806 |
309 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4233634 rs760541089 |
312 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs770775482 CA4233635 |
314 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA367339273 COSM3832806 rs770775482 |
314 | E>Q | breast [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs759301453 CA4233637 |
315 | C>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367339288 rs1376942868 |
316 | L>V | No |
ClinGen gnomAD |
|
|
rs976300914 CA156956739 |
319 | P>S | No |
ClinGen TOPMed |
|
|
CA367339352 rs1274611622 |
321 | L>V | No |
ClinGen TOPMed |
|
|
rs1373058634 CA367339378 |
323 | Q>E | No |
ClinGen gnomAD |
|
|
CA4233639 rs371459681 |
323 | Q>H | No |
ClinGen ESP ExAC |
|
|
CA367339392 rs1389970044 |
324 | S>R | No |
ClinGen gnomAD |
|
|
rs762577905 CA4233640 |
326 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1318040752 CA367339467 |
329 | P>A | No |
ClinGen gnomAD |
|
|
rs1233707345 CA367339471 |
329 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1350086474 CA367339499 |
331 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA4233642 rs750977139 |
333 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs536016170 CA4233644 |
336 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1178714966 CA367339570 |
337 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs200980304 CA367339590 |
338 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs199987361 CA4233646 |
339 | E>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs199987361 CA367339602 |
339 | E>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4233647 rs779129137 |
340 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233648 rs747876258 |
341 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367339657 rs1434722047 |
342 | A>V | No |
ClinGen gnomAD |
|
|
CA156956789 rs896602971 |
343 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs557775841 CA156956807 |
345 | E>D | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs539535387 CA156956803 |
345 | E>G | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1043074470 CA156956791 |
345 | E>Q | No |
ClinGen gnomAD |
|
|
CA4233650 rs777774589 |
346 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 348 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367339772 rs1373295905 |
349 | V>L | No |
ClinGen gnomAD |
|
|
CA4233653 rs776533036 |
350 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs770770740 CA4233652 |
350 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs759234453 CA4233654 |
351 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA367339904 rs1211746137 |
356 | T>A | No |
ClinGen gnomAD |
|
|
rs1304075947 CA367339941 |
357 | D>E | No |
ClinGen TOPMed |
|
|
CA4233659 rs773990561 |
357 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233660 rs143807634 |
358 | K>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1044141 CA367340042 |
362 | K>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1044141 CA4233662 VAR_019991 |
362 | K>E | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs76244589 CA4233664 |
365 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs559570046 CA4233666 |
367 | T>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1388053597 CA367340189 |
368 | E>D | No |
ClinGen TOPMed |
|
|
rs202162765 CA4233668 |
368 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs747030252 CA4233669 |
371 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367340256 rs1428129528 |
372 | V>G | No |
ClinGen TOPMed |
|
|
CA4233670 rs757272252 |
374 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs781017701 CA4233671 |
377 | T>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 377 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367340364 rs1414877274 |
378 | L>I | No |
ClinGen TOPMed |
|
|
rs745780567 CA4233672 |
378 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs749011542 CA4233675 |
379 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233674 COSM1698609 CA367340389 rs775409686 |
379 | G>R | skin [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA156956941 rs889698679 |
381 | C>Y | No |
ClinGen TOPMed |
|
|
CA4233677 rs768388950 |
382 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233678 rs773957244 |
383 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs1019220298 CA156956978 |
384 | S>C | No |
ClinGen TOPMed |
|
|
rs761249710 CA4233679 |
387 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA367340579 rs1476159862 |
387 | E>Q | No |
ClinGen gnomAD |
|
|
CA4233681 CA367340662 rs777009041 |
389 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4233680 rs201305620 |
389 | M>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4233682 rs371595934 |
391 | Q>* | No |
ClinGen ESP ExAC gnomAD |
|
|
CA4233683 rs150230872 |
391 | Q>P | No |
ClinGen ESP ExAC gnomAD |
|
|
rs753056472 CA4233684 |
393 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs753056472 CA4233685 |
393 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA4233686 rs764280193 |
395 | S>C | No |
ClinGen ExAC |
|
|
CA367340834 rs1314364327 |
396 | K>R | No |
ClinGen TOPMed |
|
|
CA4233688 rs193218605 |
397 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs781270039 CA367340866 |
397 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781270039 CA4233689 |
397 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1377758126 CA367340892 |
399 | K>Q | No |
ClinGen TOPMed |
|
|
rs963663218 CA156957064 |
401 | E>A | No |
ClinGen TOPMed gnomAD |
|
|
rs749066768 CA367341028 |
403 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA4233693 rs749066768 |
403 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs780033239 CA4233692 |
403 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs138840285 CA4233694 |
404 | L>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs375843224 CA156957085 |
406 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA367341098 rs1256454137 |
407 | E>K | No |
ClinGen gnomAD |
|
|
CA367341206 rs1260082945 |
411 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1260082945 CA367341202 |
411 | E>K | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 414 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4233696 rs142571975 |
414 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
|
CA4233697 rs747768998 |
415 | Y>R | No |
ClinGen ExAC gnomAD |
No associated diseases with Q9UEE5
4 regional properties for Q9UEE5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 61 - 321 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 182 - 194 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 67 - 90 | IPR017441 |
| domain | Serine/threonine-protein kinase 17A, catalytic domain | 51 - 321 | IPR042704 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of fibroblast apoptotic process | Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of reactive oxygen species metabolic process | Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. |
99 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q0VD22 | STK33 | Serine/threonine-protein kinase 33 | Bos taurus (Bovine) | PR |
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Homo sapiens (Human) | SS |
| O15075 | DCLK1 | Serine/threonine-protein kinase DCLK1 | Homo sapiens (Human) | EV |
| Q14012 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | Homo sapiens (Human) | EV |
| Q86YV6 | MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens (Human) | SS |
| Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens (Human) | SS |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q8N568 | DCLK2 | Serine/threonine-protein kinase DCLK2 | Homo sapiens (Human) | PR |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| Q8WWF8 | CAPSL | Calcyphosin-like protein | Homo sapiens (Human) | PR |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q9BYT3 | STK33 | Serine/threonine-protein kinase 33 | Homo sapiens (Human) | PR |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| O94768 | STK17B | Serine/threonine-protein kinase 17B | Homo sapiens (Human) | PR |
| P53355 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens (Human) | EV |
| O43293 | DAPK3 | Death-associated protein kinase 3 | Homo sapiens (Human) | PR |
| Q9UIK4 | DAPK2 | Death-associated protein kinase 2 | Homo sapiens (Human) | EV |
| Q9QYK9 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Mus musculus (Mouse) | PR |
| Q91VB2 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Mus musculus (Mouse) | SS |
| Q8BG48 | Stk17b | Serine/threonine-protein kinase 17B | Mus musculus (Mouse) | PR |
| Q8VCR8 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Mus musculus (Mouse) | SS |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| Q91YS8 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Mus musculus (Mouse) | SS |
| Q3UIZ8 | Mylk3 | Myosin light chain kinase 3 | Mus musculus (Mouse) | SS |
| Q8VDF3 | Dapk2 | Death-associated protein kinase 2 | Mus musculus (Mouse) | EV |
| Q6P8Y1 | Capsl | Calcyphosin-like protein | Mus musculus (Mouse) | PR |
| Q8BW96 | Camk1d | Calcium/calmodulin-dependent protein kinase type 1D | Mus musculus (Mouse) | SS |
| Q3UHL1 | Camkv | CaM kinase-like vesicle-associated protein | Mus musculus (Mouse) | SS |
| P08414 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Mus musculus (Mouse) | SS |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q91YA2 | Pskh1 | Serine/threonine-protein kinase H1 | Mus musculus (Mouse) | SS |
| Q80YE7 | Dapk1 | Death-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q924X7 | Stk33 | Serine/threonine-protein kinase 33 | Mus musculus (Mouse) | PR |
| O54784 | Dapk3 | Death-associated protein kinase 3 | Mus musculus (Mouse) | PR |
| Q7TNJ7 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Rattus norvegicus (Rat) | SS |
| P20689 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Rattus norvegicus (Rat) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q91XS8 | Stk17b | Serine/threonine-protein kinase 17B | Rattus norvegicus (Rat) | PR |
| O08875 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Rattus norvegicus (Rat) | PR |
| E9PT87 | Mylk3 | Myosin light chain kinase 3 | Rattus norvegicus (Rat) | SS |
| O70150 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Rattus norvegicus (Rat) | PR |
| Q63092 | Camkv | CaM kinase-like vesicle-associated protein | Rattus norvegicus (Rat) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| O88764 | Dapk3 | Death-associated protein kinase 3 | Rattus norvegicus (Rat) | PR |
| P13234 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Rattus norvegicus (Rat) | SS |
| Q63450 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Rattus norvegicus (Rat) | EV |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q5MPA9 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Rattus norvegicus (Rat) | PR |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6K968 | CPK6 | Calcium-dependent protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| P53684 | CPK7 | Calcium-dependent protein kinase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6AVM3 | CCAMK | Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase | Oryza sativa subsp japonica (Rice) | PR |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| P53682 | CPK23 | Calcium-dependent protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| O44997 | dapk-1 | Death-associated protein kinase dapk-1 | Caenorhabditis elegans | SS |
| Q95QC4 | zyg-8 | Serine/threonine-protein kinase zyg-8 | Caenorhabditis elegans | PR |
| P28583 | Calcium-dependent protein kinase SK5 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39016 | CPK11 | Calcium-dependent protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FX86 | CRK8 | CDPK-related kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38872 | CPK6 | Calcium-dependent protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJ61 | CPK25 | Calcium-dependent protein kinase 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZV15 | CPK20 | Calcium-dependent protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38870 | CPK2 | Calcium-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJL9 | CRK2 | CDPK-related kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SG12 | CRK6 | CDPK-related kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCS2 | CRK5 | CDPK-related kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38869 | CPK4 | Calcium-dependent protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q06850 | CPK1 | Calcium-dependent protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42438 | CPK8 | Calcium-dependent protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42396 | CPK12 | Calcium-dependent protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1LUA6 | trio | Triple functional domain protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIPLEKPGSG | GSSPGATSGS | GRAGRGLSGP | CRPPPPPQAR | GLLTEIRAVV | RTEPFQDGYS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LCPGRELGRG | KFAVVRKCIK | KDSGKEFAAK | FMRKRRKGQD | CRMEIIHEIA | VLELAQDNPW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VINLHEVYET | ASEMILVLEY | AAGGEIFDQC | VADREEAFKE | KDVQRLMRQI | LEGVHFLHTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVVHLDLKPQ | NILLTSESPL | GDIKIVDFGL | SRILKNSEEL | REIMGTPEYV | APEILSYDPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SMATDMWSIG | VLTYVMLTGI | SPFLGNDKQE | TFLNISQMNL | SYSEEEFDVL | SESAVDFIRT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLVKKPEDRA | TAEECLKHPW | LTQSSIQEPS | FRMEKALEEA | NALQEGHSVP | EINSDTDKSE |
| 370 | 380 | 390 | 400 | 410 | |
| TKESIVTEEL | IVVTSYTLGQ | CRQSEKEKME | QKAISKRFKF | EEPLLQEIPG | EFIY |