Q86YV6
SS
Gene name |
MYLK4 (SGK085) |
Protein name |
Myosin light chain kinase family member 4 |
Names |
EC 2.7.11.1 , Sugen kinase 85 , SgK085 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:340156 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Myosin light chain kinase family member 4 (MYLK4) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of MYLK4.
Autoinhibitory domains (AIDs)
Accessory elements
246-268 (Activation loop from InterPro)
Target domain |
106-361 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
2 structures for Q86YV6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2X4F | X-ray | 267 A | A/B | 40-388 | PDB |
| AF-Q86YV6-F1 | Predicted | AlphaFoldDB |
457 variants for Q86YV6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs796052168 RCV000190165 COSM4927097 CA204132 COSM4927099 COSM4927098 |
151 | E>K | Variant assessed as Somatic; MODERATE impact. Long QT syndrome [NCI-TCGA, ClinVar] | Yes |
ClinGen NCI-TCGA Cosmic ClinVar NCI-TCGA dbSNP gnomAD |
| rs1764203248 | 4 | V>A | No | TOPMed | |
|
rs924230351 COSM461832 COSM4821569 COSM461833 |
5 | K>N | cervix Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA |
| rs1235753273 | 5 | K>R | No |
TOPMed gnomAD |
|
| rs1764202932 | 6 | R>K | No | Ensembl | |
| rs1764202932 | 6 | R>T | No | Ensembl | |
| rs978754045 | 7 | L>M | No | Ensembl | |
| rs201558182 | 7 | L>P | No |
ExAC gnomAD |
|
| rs1582134078 | 8 | E>G | No | Ensembl | |
| TCGA novel | 9 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1254074609 | 9 | E>V | No | gnomAD | |
| rs1283069837 | 10 | F>L | No |
TOPMed gnomAD |
|
| rs771330368 | 12 | T>M | No |
ExAC gnomAD |
|
| rs1448904783 | 13 | C>* | No |
TOPMed gnomAD |
|
| rs1764202001 | 13 | C>R | No | TOPMed | |
| rs778408302 | 13 | C>Y | No |
ExAC gnomAD |
|
| rs770129366 | 14 | Y>C | No |
ExAC TOPMed gnomAD |
|
| rs968293672 | 16 | S>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs968293672 | 16 | S>T | No |
TOPMed gnomAD |
|
| rs1764201220 | 17 | N>D | No | TOPMed | |
|
COSM3727069 COSM3727068 COSM3727070 rs757954497 |
17 | N>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs750154004 | 18 | Q>E | No |
ExAC TOPMed gnomAD |
|
| rs1344221119 | 18 | Q>H | No | gnomAD | |
| rs1266764263 | 19 | L>P | No | TOPMed | |
| rs1454755086 | 22 | M>I | No |
TOPMed gnomAD |
|
| rs1764200356 | 23 | A>T | No | Ensembl | |
| rs1554134085 | 23 | A>V | No | gnomAD | |
| rs778695139 | 25 | F>L | No |
ExAC gnomAD |
|
| rs990812447 | 25 | F>L | No | Ensembl | |
| rs778695139 | 25 | F>V | No |
ExAC gnomAD |
|
| rs1428984001 | 26 | Q>H | No | TOPMed | |
|
rs762913642 COSM5076959 COSM1442702 COSM1442701 TCGA novel |
26 | Q>S | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
NCI-TCGA NCI-TCGA Cosmic |
| rs1277147349 | 28 | R>K | No |
TOPMed gnomAD |
|
| rs1277147349 | 28 | R>T | No |
TOPMed gnomAD |
|
| rs1415075449 | 29 | E>* | No | gnomAD | |
| VAR_040864 | 30 | E>Q | a breast infiltrating ductal carcinoma sample; somatic mutation [UniProt] | No | UniProt |
| rs1582133900 | 31 | V>G | No | Ensembl | |
|
rs1561887589 COSM3623631 COSM3623633 COSM3623632 |
32 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic Ensembl NCI-TCGA |
| rs1310618298 | 34 | V>A | No | gnomAD | |
|
VAR_051650 rs7770402 |
39 | E>A | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 41 | N>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs760479278 | 41 | N>I | No |
ExAC gnomAD |
|
| rs745705002 | 41 | N>K | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs760479278 | 41 | N>S | No |
ExAC gnomAD |
|
| TCGA novel | 42 | S>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1582133815 | 43 | G>E | No | TOPMed | |
| rs1764197477 | 45 | Q>E | No | Ensembl | |
|
COSM3623629 COSM3623628 COSM3623630 |
47 | S>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs2113382352 | 48 | R>* | No | Ensembl | |
|
VAR_040865 rs2296356 |
50 | G>R | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| rs868621077 | 51 | H>L | No |
TOPMed gnomAD |
|
| rs868621077 | 51 | H>R | No |
TOPMed gnomAD |
|
| rs1475695763 | 51 | H>Y | No |
TOPMed gnomAD |
|
| rs759590608 | 52 | N>S | No |
ExAC gnomAD |
|
| rs767623307 | 52 | N>Y | No |
ExAC gnomAD |
|
| rs142911273 | 54 | A>G | No |
ESP ExAC TOPMed gnomAD |
|
| rs767424888 | 54 | A>P | No |
ExAC TOPMed gnomAD |
|
| rs767424888 | 54 | A>S | No |
ExAC TOPMed gnomAD |
|
| rs767424888 | 54 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs142911273 | 54 | A>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs766599341 | 55 | K>M | No |
ExAC TOPMed gnomAD |
|
| rs763048546 | 56 | E>K | No |
ExAC TOPMed gnomAD |
|
| rs773454223 | 57 | V>E | No |
ExAC gnomAD |
|
| rs1190493543 | 57 | V>M | No | TOPMed | |
| rs765570585 | 58 | W>* | No |
ExAC TOPMed gnomAD |
|
| rs1761863089 | 58 | W>C | No | Ensembl | |
| rs1761863509 | 58 | W>R | No | gnomAD | |
| rs1761862888 | 59 | S>* | No | TOPMed | |
| TCGA novel | 60 | N>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs769222286 | 61 | A>P | No |
ExAC TOPMed gnomAD |
|
| rs769222286 | 61 | A>S | No |
ExAC TOPMed gnomAD |
|
| rs769222286 | 61 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs748929539 | 62 | D>E | No |
ExAC TOPMed gnomAD |
|
| rs568713317 | 62 | D>N | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs114356072 | 64 | T>M | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs747931547 | 65 | E>* | No |
ExAC TOPMed gnomAD |
|
| rs747931547 | 65 | E>K | No |
ExAC TOPMed gnomAD |
|
| rs1761861484 | 66 | R>K | No | Ensembl | |
| rs1561844476 | 67 | M>I | No | Ensembl | |
| rs866285749 | 68 | P>S | No | Ensembl | |
|
COSM6173360 COSM6173361 COSM6173362 |
69 | V>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs766411254 | 69 | V>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs766411254 | 69 | V>L | No |
ExAC TOPMed gnomAD |
|
| rs374236301 | 71 | S>R | No |
TOPMed gnomAD |
|
| rs1761860523 | 72 | K>E | No | Ensembl | |
| rs1761860403 | 72 | K>T | No |
TOPMed gnomAD |
|
| rs1194225186 | 73 | R>M | No | gnomAD | |
| rs1761860036 | 76 | A>T | No | gnomAD | |
| rs1761859844 | 76 | A>V | No | gnomAD | |
| rs758483569 | 77 | L>F | No |
ExAC gnomAD |
|
| rs758483569 | 77 | L>I | No |
ExAC gnomAD |
|
|
VAR_040866 rs762093504 COSM50707 |
78 | A>S | breast a breast infiltrating ductal carcinoma sample; somatic mutation [Cosmic, UniProt] | No |
cosmic curated UniProt ExAC TOPMed dbSNP gnomAD |
|
COSM1076869 COSM1076870 COSM3248893 rs762093504 |
78 | A>T | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs777081435 | 79 | V>I | No |
ExAC gnomAD |
|
| rs1761671282 | 80 | D>G | No | gnomAD | |
| rs1761671391 | 80 | D>N | No | Ensembl | |
| rs757508603 | 82 | P>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs1761670474 | 83 | A>D | No | gnomAD | |
| rs541283627 | 83 | A>T | No |
1000Genomes ExAC gnomAD |
|
| rs1761670474 | 83 | A>V | No | gnomAD | |
| rs1175039221 | 84 | P>S | No | gnomAD | |
|
COSM1471891 rs768060086 COSM4814788 COSM1471892 |
85 | P>L | Variant assessed as Somatic; MODERATE impact. prostate breast [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs1761669465 | 89 | D>G | No | Ensembl | |
| rs372119475 | 89 | D>Y | No |
ESP ExAC TOPMed gnomAD |
|
| rs1761669294 | 90 | H>N | No |
TOPMed gnomAD |
|
| rs967872954 | 90 | H>R | No | Ensembl | |
| rs183151380 | 91 | R>C | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM1076868 COSM4874967 COSM1076867 rs1312872346 |
91 | R>H | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA |
| rs183151380 | 91 | R>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1022161712 | 92 | I>M | No | TOPMed | |
|
COSM1076866 rs1582047387 COSM1076865 COSM4864799 |
93 | V>M | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated Ensembl |
| rs1210089220 | 94 | T>I | No |
TOPMed gnomAD |
|
| rs1011990482 | 94 | T>S | No | Ensembl | |
| rs768498723 | 95 | A>G | No |
ExAC gnomAD |
|
| rs771991937 | 99 | A>E | No |
ExAC TOPMed gnomAD |
|
|
COSM71754 rs771991937 |
99 | A>V | ovary [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs1226621626 | 100 | V>F | No |
TOPMed gnomAD |
|
| rs779013525 | 101 | N>K | No |
ExAC TOPMed gnomAD |
|
| rs974834398 | 103 | F>L | No |
TOPMed gnomAD |
|
| rs1029077948 | 103 | F>S | No | TOPMed | |
| rs1761665416 | 105 | T>A | No | TOPMed | |
| rs757383820 | 105 | T>I | No |
ExAC gnomAD |
|
| rs754159123 | 107 | S>N | No |
ExAC gnomAD |
|
| rs1464730253 | 109 | T>A | No | gnomAD | |
| rs756609971 | 113 | G>R | No |
ExAC gnomAD |
|
|
rs753037954 COSM6173364 COSM6173365 COSM1545729 COSM6173363 |
114 | G>R | Variant assessed as Somatic; MODERATE impact. lung [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC gnomAD |
| rs2113140225 | 115 | G>R | No | Ensembl | |
| rs913944946 | 115 | G>V | No | Ensembl | |
|
rs755265191 COSM4878141 COSM4878140 COSM4878139 |
116 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD |
| rs755265191 | 116 | R>G | No |
ExAC gnomAD |
|
| rs922725069 | 116 | R>H | No |
TOPMed gnomAD |
|
| rs922725069 | 116 | R>L | No |
TOPMed gnomAD |
|
| rs755265191 | 116 | R>S | No |
ExAC gnomAD |
|
| rs752168911 | 117 | F>L | No |
ExAC gnomAD |
|
| rs766868889 | 117 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs759016773 | 118 | G>C | No |
ExAC TOPMed gnomAD |
|
| rs759016773 | 118 | G>R | No |
ExAC TOPMed gnomAD |
|
|
COSM1442628 rs759016773 COSM1442629 COSM4948869 |
118 | G>S | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs1761503822 | 118 | G>V | No | TOPMed | |
| rs763762722 | 119 | Q>R | No |
ExAC TOPMed gnomAD |
|
| rs1644790506 | 120 | V>F | No | TOPMed | |
| rs1644790506 | 120 | V>I | No | TOPMed | |
| rs373477505 | 121 | H>Q | No | Ensembl | |
| TCGA novel | 121 | H>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1177320149 | 122 | K>E | No | TOPMed | |
| rs774977645 | 123 | C>F | No |
ExAC gnomAD |
|
| rs760339327 | 123 | C>R | No |
ExAC TOPMed gnomAD |
|
|
VAR_040867 rs34953021 |
126 | T>M | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| rs34953021 | 126 | T>R | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1761501895 | 127 | A>T | No | TOPMed | |
| rs774493792 | 128 | T>K | No |
ExAC gnomAD |
|
| rs1761501593 | 129 | G>S | No | Ensembl | |
| rs770921467 | 132 | L>P | No |
ExAC gnomAD |
|
| rs749392555 | 133 | A>S | No |
ExAC TOPMed gnomAD |
|
| rs2113139744 | 133 | A>V | No | Ensembl | |
| rs2113139707 | 134 | A>P | No | Ensembl | |
| rs2113139707 | 134 | A>S | No | Ensembl | |
| TCGA novel | 134 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1076863 COSM1076864 COSM4871748 |
135 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1761501152 | 135 | K>R | No | Ensembl | |
| TCGA novel | 136 | I>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 137 | I>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1761500506 | 139 | T>S | No |
TOPMed gnomAD |
|
| rs1346107824 | 140 | R>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs773377431 | 140 | R>T | No |
ExAC gnomAD |
|
| rs770170824 | 141 | G>S | No |
ExAC TOPMed gnomAD |
|
| rs1370448125 | 142 | M>I | No |
TOPMed gnomAD |
|
| rs1268868625 | 142 | M>K | No | TOPMed | |
| rs1268868625 | 142 | M>T | No | TOPMed | |
| rs781259251 | 144 | D>A | No |
ExAC TOPMed gnomAD |
|
| rs781259251 | 144 | D>G | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 144 | D>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1761499391 | 145 | K>E | No | gnomAD | |
| rs1464835613 | 147 | E>K | No |
TOPMed gnomAD |
|
| rs1761494761 | 148 | V>L | No | Ensembl | |
| rs1761494761 | 148 | V>M | No | Ensembl | |
| rs1761494507 | 150 | N>D | No | TOPMed | |
| rs369334810 | 150 | N>K | No |
ESP ExAC gnomAD |
|
| rs979776423 | 150 | N>S | No |
TOPMed gnomAD |
|
| rs1761493853 | 152 | I>V | No | Ensembl | |
| rs1261045203 | 153 | S>C | No | gnomAD | |
| rs1261045203 | 153 | S>R | No | gnomAD | |
| rs138344110 | 154 | V>I | No |
1000Genomes ExAC gnomAD |
|
|
COSM4948178 COSM1442625 COSM1442626 |
155 | M>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs747424240 | 155 | M>R | No |
ExAC TOPMed gnomAD |
|
| rs747424240 | 155 | M>T | No |
ExAC TOPMed gnomAD |
|
| rs1221167162 | 155 | M>V | No | gnomAD | |
| rs1761492406 | 156 | N>K | No | Ensembl | |
| rs1761492520 | 156 | N>S | No | TOPMed | |
| rs1761492520 | 156 | N>T | No | TOPMed | |
| rs1280610650 | 157 | Q>L | No | gnomAD | |
|
COSM3948899 rs1761492182 |
159 | D>Y | lung [Cosmic] | No |
cosmic curated Ensembl |
| rs1761491944 | 160 | H>D | No | TOPMed | |
| rs780360412 | 161 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs772399027 | 161 | A>V | No |
ExAC TOPMed gnomAD |
|
| rs1761491318 | 162 | N>I | No |
TOPMed gnomAD |
|
| rs779382759 | 162 | N>K | No |
ExAC gnomAD |
|
| rs1561838387 | 163 | L>V | No | Ensembl | |
| rs201667067 | 164 | I>T | No |
ExAC TOPMed gnomAD |
|
| rs1761490972 | 164 | I>V | No | gnomAD | |
| rs1268117865 | 165 | Q>* | No |
TOPMed gnomAD |
|
| rs1341791123 | 166 | L>M | No | gnomAD | |
| rs1336698257 | 167 | Y>* | No |
TOPMed gnomAD |
|
|
rs752078679 COSM3366422 |
167 | Y>C | kidney [Cosmic] | No |
cosmic curated ExAC |
| rs1184161288 | 167 | Y>H | No | TOPMed | |
| rs752078679 | 167 | Y>S | No | ExAC | |
| rs953094849 | 168 | D>N | No |
TOPMed gnomAD |
|
|
COSM3410854 COSM3410856 rs953094849 COSM3410855 |
168 | D>Y | Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD |
| rs780907454 | 169 | A>D | No |
ExAC gnomAD |
|
| rs780907454 | 169 | A>V | No |
ExAC gnomAD |
|
| rs371252859 | 171 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 173 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs901376374 | 173 | K>Q | No |
TOPMed gnomAD |
|
| rs1761487528 | 173 | K>T | No | TOPMed | |
|
COSM3623576 COSM3623577 rs750454547 COSM3623578 |
175 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs765019702 | 176 | I>T | No |
ExAC gnomAD |
|
| TCGA novel | 179 | V>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1761486464 | 180 | M>L | No | gnomAD | |
| rs1185324281 | 180 | M>R | No | gnomAD | |
| rs1185324281 | 180 | M>T | No | gnomAD | |
| rs1384652136 | 182 | Y>C | No | TOPMed | |
| rs745707113 | 183 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs560347293 | 184 | D>G | No |
ExAC gnomAD |
|
| rs914969070 | 184 | D>N | No |
TOPMed gnomAD |
|
| rs560347293 | 184 | D>V | No |
ExAC gnomAD |
|
| rs1342031929 | 185 | G>S | No | TOPMed | |
| rs1582037846 | 187 | E>G | No | Ensembl | |
| rs753780621 | 187 | E>K | No |
ExAC gnomAD |
|
| rs1283944809 | 188 | L>M | No | gnomAD | |
| rs1220210340 | 188 | L>P | No |
TOPMed gnomAD |
|
| rs1227482054 | 191 | R>C | No |
TOPMed gnomAD |
|
| rs202140204 | 191 | R>H | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1227482054 | 191 | R>S | No |
TOPMed gnomAD |
|
| rs2113127793 | 192 | I>L | No | Ensembl | |
| rs923571064 | 193 | I>V | No | TOPMed | |
|
COSM3623575 COSM3623573 COSM3623574 rs147055313 |
194 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ESP ExAC NCI-TCGA gnomAD |
|
COSM4874930 COSM1076860 COSM1076859 |
195 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1300125455 | 195 | E>Q | No | gnomAD | |
| rs1582037764 | 196 | S>N | No | Ensembl | |
|
rs767744025 COSM595512 COSM6106104 COSM6106106 COSM6106105 |
197 | Y>C | lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs577269576 | 200 | T>M | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs577269576 | 200 | T>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1761376186 | 201 | E>D | No | Ensembl | |
| rs763361432 | 201 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs773658080 | 202 | L>F | No |
ExAC TOPMed gnomAD |
|
| rs773658080 | 202 | L>I | No |
ExAC TOPMed gnomAD |
|
| rs375360627 | 203 | D>Y | No |
ESP ExAC gnomAD |
|
| rs1761375819 | 204 | T>I | No | Ensembl | |
| rs370291605 | 206 | L>Q | No |
ESP ExAC TOPMed gnomAD |
|
| rs778618915 | 207 | F>L | No |
ExAC gnomAD |
|
| rs148235992 | 208 | M>I | No |
ESP ExAC TOPMed gnomAD |
|
| rs1368318126 | 208 | M>T | No |
TOPMed gnomAD |
|
| rs1004733187 | 208 | M>V | No |
TOPMed gnomAD |
|
| rs1761374487 | 209 | K>R | No | gnomAD | |
| rs367822894 | 210 | Q>H | No |
ESP TOPMed gnomAD |
|
| rs1410958127 | 211 | I>M | No | gnomAD | |
| rs777698905 | 211 | I>R | No |
ExAC gnomAD |
|
| rs777698905 | 211 | I>T | No |
ExAC gnomAD |
|
| rs1761374152 | 211 | I>V | No | gnomAD | |
| rs755994419 | 212 | C>G | No |
ExAC TOPMed gnomAD |
|
| rs755994419 | 212 | C>R | No |
ExAC TOPMed gnomAD |
|
| rs375944212 | 212 | C>Y | No |
ESP TOPMed |
|
| rs1003724653 | 214 | G>R | No | Ensembl | |
| rs1280125923 | 216 | R>G | No |
TOPMed gnomAD |
|
| rs1761372816 | 216 | R>K | No |
TOPMed gnomAD |
|
| rs1761372691 | 216 | R>S | No | gnomAD | |
| VAR_040868 | 217 | H>L | a lung squamous cell carcinoma sample; somatic mutation [UniProt] | No | UniProt |
| rs752801207 | 217 | H>P | No |
ExAC gnomAD |
|
| rs1301862623 | 218 | M>I | No |
TOPMed gnomAD |
|
| rs950968963 | 218 | M>T | No | Ensembl | |
| rs755027478 | 220 | Q>H | No | ExAC | |
| rs767621139 | 220 | Q>R | No |
ExAC TOPMed gnomAD |
|
| rs1232036392 | 221 | M>I | No |
TOPMed gnomAD |
|
| rs766618649 | 224 | L>F | No |
ExAC TOPMed gnomAD |
|
| rs766618649 | 224 | L>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs763242236 | 225 | H>P | No |
ExAC TOPMed gnomAD |
|
| rs763242236 | 225 | H>R | No |
ExAC TOPMed gnomAD |
|
| rs1761370933 | 227 | D>A | No | TOPMed | |
| rs1215252115 | 227 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed |
| TCGA novel | 230 | P>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1400499343 | 231 | E>G | No | TOPMed | |
| rs1761243391 | 231 | E>K | No | Ensembl | |
| TCGA novel | 234 | L>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1223908185 | 234 | L>P | No |
TOPMed gnomAD |
|
| rs1223908185 | 234 | L>Q | No |
TOPMed gnomAD |
|
| rs758984976 | 235 | C>R | No |
ExAC gnomAD |
|
| rs1314267672 | 236 | V>A | No | gnomAD | |
| rs770517389 | 238 | R>P | No |
ExAC TOPMed gnomAD |
|
| rs770517389 | 238 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs773858936 | 238 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs1049777329 | 239 | D>N | No | gnomAD | |
| rs1390406500 | 240 | A>T | No | gnomAD | |
| TCGA novel | 243 | I>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1442612 COSM1442611 |
244 | K>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| TCGA novel | 245 | I>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1332326301 | 245 | I>S | No | TOPMed | |
| rs1561834279 | 245 | I>V | No | Ensembl | |
| rs1761240459 | 247 | D>V | No | TOPMed | |
| rs1391037353 | 247 | D>Y | No | gnomAD | |
|
COSM740829 COSM740828 |
249 | G>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1294963712 | 251 | A>S | No | gnomAD | |
| rs1294963712 | 251 | A>T | No | gnomAD | |
| rs762703990 | 252 | R>G | No |
ExAC gnomAD |
|
| rs1761239518 | 252 | R>K | No | TOPMed | |
| TCGA novel | 253 | R>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs772825765 | 253 | R>K | No |
ExAC TOPMed gnomAD |
|
|
COSM1186930 rs112149614 |
253 | R>S | lung [Cosmic] | No |
cosmic curated ESP ExAC TOPMed gnomAD |
| rs2113112920 | 254 | Y>C | No | Ensembl | |
| rs764891380 | 255 | K>N | No |
ExAC gnomAD |
|
| rs1407045616 | 256 | P>A | No |
TOPMed gnomAD |
|
| rs1407045616 | 256 | P>S | No |
TOPMed gnomAD |
|
| TCGA novel | 257 | R>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM6173371 COSM6173370 COSM6173369 |
258 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs545014932 | 258 | E>A | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs979849619 | 258 | E>D | No |
TOPMed gnomAD |
|
| rs927046007 | 258 | E>K | No | TOPMed | |
| rs927046007 | 258 | E>Q | No | TOPMed | |
| rs1371414709 | 262 | V>A | No |
TOPMed gnomAD |
|
| TCGA novel | 262 | V>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1761209545 | 264 | F>Y | No | Ensembl | |
| rs1442994593 | 267 | P>S | No | gnomAD | |
| TCGA novel | 268 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1372881677 | 268 | E>D | No | TOPMed | |
| rs1582032520 | 270 | L>F | No | Ensembl | |
| rs760385501 | 271 | A>D | No |
ExAC TOPMed gnomAD |
|
| rs146436167 | 271 | A>P | No |
ESP ExAC TOPMed gnomAD |
|
| rs146436167 | 271 | A>T | No |
ESP ExAC TOPMed gnomAD |
|
| rs140266941 | 272 | P>A | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs771850352 | 272 | P>H | No |
ExAC gnomAD |
|
| rs771850352 | 272 | P>L | No |
ExAC gnomAD |
|
| rs140266941 | 272 | P>S | No |
1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 274 | V>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1009204576 | 275 | V>G | No | TOPMed | |
|
COSM356182 rs745971493 |
275 | V>M | lung [Cosmic] | No |
cosmic curated ExAC gnomAD |
|
rs1269145570 COSM50710 |
276 | N>S | large_intestine breast [Cosmic] | No |
cosmic curated TOPMed gnomAD |
| rs771099192 | 278 | D>E | No |
ExAC gnomAD |
|
| rs145224022 | 278 | D>V | No |
ESP ExAC gnomAD |
|
| rs1229411877 | 279 | F>S | No |
TOPMed gnomAD |
|
| rs749568483 | 283 | P>R | No |
ExAC TOPMed gnomAD |
|
|
TCGA novel rs1761207456 |
285 | D>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1320666044 | 286 | M>I | No |
TOPMed gnomAD |
|
| rs1332222618 | 287 | W>C | No | gnomAD | |
| rs1405830641 | 287 | W>G | No |
TOPMed gnomAD |
|
| rs1405830641 | 287 | W>R | No |
TOPMed gnomAD |
|
| rs756567595 | 288 | S>I | No |
ExAC TOPMed gnomAD |
|
| rs756567595 | 288 | S>N | No |
ExAC TOPMed gnomAD |
|
| rs1761206568 | 290 | G>R | No | Ensembl | |
| rs1473068398 | 291 | V>D | No |
TOPMed gnomAD |
|
| rs781728937 | 291 | V>F | No |
ExAC gnomAD |
|
| rs755428233 | 292 | I>N | No |
ExAC gnomAD |
|
| rs778444097 | 293 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs1200133647 | 294 | Y>C | No | gnomAD | |
| rs1200133647 | 294 | Y>S | No | gnomAD | |
| rs1761205078 | 295 | M>I | No | gnomAD | |
| rs763589941 | 295 | M>T | No |
ExAC gnomAD |
|
| rs753594803 | 295 | M>V | No | ExAC | |
| rs755686453 | 297 | L>H | No |
ExAC TOPMed gnomAD |
|
| rs1278333544 | 297 | L>I | No | TOPMed | |
| rs752359294 | 298 | S>N | No |
ExAC gnomAD |
|
| rs146700839 | 298 | S>R | No |
ESP ExAC TOPMed gnomAD |
|
| rs371937683 | 299 | G>C | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs766350396 | 299 | G>D | No |
ExAC gnomAD |
|
| rs371937683 | 299 | G>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs766350396 | 299 | G>V | No |
ExAC gnomAD |
|
| rs563674644 | 300 | L>S | No |
1000Genomes ExAC TOPMed gnomAD |
|
|
COSM3727410 rs780121652 COSM3727408 COSM3727409 |
301 | S>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs149683135 | 302 | P>S | No |
ESP ExAC TOPMed gnomAD |
|
| rs149683135 | 302 | P>T | No |
ESP ExAC TOPMed gnomAD |
|
| rs139362604 | 303 | F>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1761162025 | 304 | L>V | No | gnomAD | |
| rs747309392 | 305 | G>C | No |
ExAC gnomAD |
|
| rs1761161690 | 305 | G>D | No | Ensembl | |
| TCGA novel | 305 | G>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1488350344 | 306 | D>E | No |
TOPMed gnomAD |
|
| rs1561832451 | 306 | D>V | No | Ensembl | |
| rs1761161215 | 307 | N>D | No | Ensembl | |
| rs543599676 | 308 | D>G | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1582030670 | 311 | T>A | No | Ensembl | |
| rs151300027 | 311 | T>M | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1170788778 | 313 | N>K | No |
TOPMed gnomAD |
|
| rs755624244 | 315 | I>F | No |
ExAC TOPMed gnomAD |
|
| rs1404364485 | 315 | I>M | No | gnomAD | |
| rs755624244 | 315 | I>V | No |
ExAC TOPMed gnomAD |
|
|
COSM3861027 COSM3861028 COSM3861029 |
318 | C>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
VAR_040869 rs35609073 |
318 | C>Y | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 319 | R>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1361341218 | 320 | W>* | No |
TOPMed gnomAD |
|
| rs1761158371 | 320 | W>G | No | TOPMed | |
| rs754823062 | 323 | E>Q | No |
ExAC gnomAD |
|
| rs1426725425 | 324 | D>N | No | gnomAD | |
| rs1175296096 | 324 | D>V | No | gnomAD | |
| TCGA novel | 325 | E>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs200299518 | 329 | D>G | No |
1000Genomes TOPMed gnomAD |
|
| rs369914977 | 329 | D>Y | No | TOPMed | |
| rs758804991 | 330 | I>N | No | TOPMed | |
| rs758804991 | 330 | I>T | No | TOPMed | |
| rs1449975628 | 330 | I>V | No | TOPMed | |
|
COSM1442606 COSM1442607 rs758227194 COSM4396252 |
331 | S>L | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs1582030495 | 332 | E>G | No | Ensembl | |
| rs1761156097 | 332 | E>K | No |
TOPMed gnomAD |
|
| rs376817677 | 333 | E>K | No |
ESP ExAC TOPMed gnomAD |
|
| rs1211309964 | 335 | K>E | No |
TOPMed gnomAD |
|
| rs1462958612 | 335 | K>R | No | gnomAD | |
| rs1318612856 | 340 | K>M | No | gnomAD | |
|
COSM5895851 COSM5895852 COSM5895850 |
341 | L>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs764245515 | 342 | L>P | No |
ExAC TOPMed gnomAD |
|
| rs764245515 | 342 | L>Q | No |
ExAC TOPMed gnomAD |
|
| rs2113107415 | 342 | L>V | No | Ensembl | |
| rs761054112 | 343 | I>M | No |
ExAC gnomAD |
|
| rs775796428 | 344 | K>* | No |
ExAC gnomAD |
|
| rs1582030399 | 346 | K>R | No | Ensembl | |
| rs1237338521 | 347 | S>R | No | TOPMed | |
| rs2113107302 | 347 | S>R | No | Ensembl | |
| rs771770248 | 348 | W>* | No |
ExAC gnomAD |
|
| rs779753653 | 348 | W>R | No |
ExAC gnomAD |
|
|
rs368261756 COSM343722 |
349 | R>* | lung [Cosmic] | No |
cosmic curated ESP ExAC TOPMed gnomAD |
| rs759563113 | 349 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs1264561247 | 350 | I>K | No |
TOPMed gnomAD |
|
| rs753747585 | 350 | I>V | No |
ExAC gnomAD |
|
| rs777883295 | 351 | S>R | No |
ExAC gnomAD |
|
| rs1166814937 | 353 | S>N | No | TOPMed | |
| rs1761036583 | 354 | E>G | No | Ensembl | |
|
COSM1076855 COSM1076856 rs752979205 COSM4865983 |
354 | E>K | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs752979205 | 354 | E>Q | No |
ExAC TOPMed gnomAD |
|
| rs767708255 | 355 | A>V | No |
ExAC gnomAD |
|
| rs2113095542 | 356 | L>P | No | Ensembl | |
| rs143856526 | 358 | H>Y | No |
ESP ExAC TOPMed gnomAD |
|
| rs1761036176 | 360 | W>S | No | TOPMed | |
| rs773713096 | 363 | D>E | No |
ExAC TOPMed gnomAD |
|
| rs1407267677 | 363 | D>Y | No | gnomAD | |
| rs1299914279 | 365 | K>Q | No | Ensembl | |
|
COSM3623562 COSM3623564 COSM3623563 |
368 | S>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1163536595 | 369 | R>G | No | gnomAD | |
| rs2113095413 | 371 | N>S | No | Ensembl | |
| rs144915326 | 373 | Q>* | No |
1000Genomes ExAC gnomAD |
|
|
VAR_040870 rs35211631 |
373 | Q>R | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| rs982542540 | 374 | K>N | No | TOPMed | |
| COSM116927 | 374 | K>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1760887974 | 375 | K>E | No | Ensembl | |
|
COSM4875646 rs760282729 COSM1076854 |
376 | K>N | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs1416360836 | 377 | N>D | No | TOPMed | |
| rs952501044 | 377 | N>K | No | TOPMed | |
|
COSM3623561 COSM3623560 rs369735779 |
378 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs199960114 | 378 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs199960114 | 378 | R>P | No |
ExAC TOPMed gnomAD |
|
| rs369735779 | 378 | R>S | No |
ESP ExAC TOPMed gnomAD |
|
| rs1201391743 | 379 | G>S | No | gnomAD | |
| rs1760886417 | 380 | S>T | No | TOPMed | |
| rs773858303 | 382 | A>T | No |
ExAC gnomAD |
|
| rs770782965 | 383 | Q>* | No |
ExAC gnomAD |
|
| rs1760885770 | 384 | D>E | No | TOPMed | |
| rs1228767320 | 384 | D>H | No |
TOPMed gnomAD |
|
| rs1228767320 | 384 | D>N | No |
TOPMed gnomAD |
|
| rs1328746657 | 384 | D>V | No | gnomAD | |
| rs1760885656 | 385 | F>L | No | Ensembl | |
| rs749020563 | 387 | T>I | No | ExAC | |
| rs773149809 | 388 | K>* | No |
ExAC gnomAD |
No associated diseases with Q86YV6
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| myosin light chain kinase activity | Catalysis of the reaction |
| protein serine kinase activity | Catalysis of the reactions |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
105 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q0VD22 | STK33 | Serine/threonine-protein kinase 33 | Bos taurus (Bovine) | PR |
| O15075 | DCLK1 | Serine/threonine-protein kinase DCLK1 | Homo sapiens (Human) | EV |
| Q9UIK4 | DAPK2 | Death-associated protein kinase 2 | Homo sapiens (Human) | EV |
| O94768 | STK17B | Serine/threonine-protein kinase 17B | Homo sapiens (Human) | PR |
| Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens (Human) | SS |
| Q8N568 | DCLK2 | Serine/threonine-protein kinase DCLK2 | Homo sapiens (Human) | PR |
| Q9UEE5 | STK17A | Serine/threonine-protein kinase 17A | Homo sapiens (Human) | SS |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| Q8WWF8 | CAPSL | Calcyphosin-like protein | Homo sapiens (Human) | PR |
| P53355 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens (Human) | EV |
| Q9BYT3 | STK33 | Serine/threonine-protein kinase 33 | Homo sapiens (Human) | PR |
| O43293 | DAPK3 | Death-associated protein kinase 3 | Homo sapiens (Human) | PR |
| Q16816 | PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | Homo sapiens (Human) | PR |
| P15735 | PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | Homo sapiens (Human) | PR |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Homo sapiens (Human) | SS |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| Q14012 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | Homo sapiens (Human) | EV |
| Q9QYK9 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Mus musculus (Mouse) | PR |
| Q91VB2 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Mus musculus (Mouse) | SS |
| Q8BG48 | Stk17b | Serine/threonine-protein kinase 17B | Mus musculus (Mouse) | PR |
| Q8VCR8 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Mus musculus (Mouse) | SS |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| Q91YS8 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Mus musculus (Mouse) | SS |
| Q3UIZ8 | Mylk3 | Myosin light chain kinase 3 | Mus musculus (Mouse) | SS |
| Q8VDF3 | Dapk2 | Death-associated protein kinase 2 | Mus musculus (Mouse) | EV |
| Q6P8Y1 | Capsl | Calcyphosin-like protein | Mus musculus (Mouse) | PR |
| Q8BW96 | Camk1d | Calcium/calmodulin-dependent protein kinase type 1D | Mus musculus (Mouse) | SS |
| Q3UHL1 | Camkv | CaM kinase-like vesicle-associated protein | Mus musculus (Mouse) | SS |
| P08414 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Mus musculus (Mouse) | SS |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q91YA2 | Pskh1 | Serine/threonine-protein kinase H1 | Mus musculus (Mouse) | SS |
| Q80YE7 | Dapk1 | Death-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q924X7 | Stk33 | Serine/threonine-protein kinase 33 | Mus musculus (Mouse) | PR |
| O54784 | Dapk3 | Death-associated protein kinase 3 | Mus musculus (Mouse) | PR |
| Q7TNJ7 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Rattus norvegicus (Rat) | SS |
| P20689 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Rattus norvegicus (Rat) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q91XS8 | Stk17b | Serine/threonine-protein kinase 17B | Rattus norvegicus (Rat) | PR |
| O08875 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Rattus norvegicus (Rat) | PR |
| E9PT87 | Mylk3 | Myosin light chain kinase 3 | Rattus norvegicus (Rat) | SS |
| O70150 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Rattus norvegicus (Rat) | PR |
| Q63092 | Camkv | CaM kinase-like vesicle-associated protein | Rattus norvegicus (Rat) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| O88764 | Dapk3 | Death-associated protein kinase 3 | Rattus norvegicus (Rat) | PR |
| P13234 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Rattus norvegicus (Rat) | SS |
| Q63450 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Rattus norvegicus (Rat) | EV |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q5MPA9 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Rattus norvegicus (Rat) | PR |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6K968 | CPK6 | Calcium-dependent protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| P53684 | CPK7 | Calcium-dependent protein kinase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6AVM3 | CCAMK | Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase | Oryza sativa subsp japonica (Rice) | PR |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| P53682 | CPK23 | Calcium-dependent protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| O44997 | dapk-1 | Death-associated protein kinase dapk-1 | Caenorhabditis elegans | SS |
| Q95QC4 | zyg-8 | Serine/threonine-protein kinase zyg-8 | Caenorhabditis elegans | PR |
| P28583 | Calcium-dependent protein kinase SK5 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39016 | CPK11 | Calcium-dependent protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FX86 | CRK8 | CDPK-related kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38872 | CPK6 | Calcium-dependent protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJ61 | CPK25 | Calcium-dependent protein kinase 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZV15 | CPK20 | Calcium-dependent protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38870 | CPK2 | Calcium-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJL9 | CRK2 | CDPK-related kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SG12 | CRK6 | CDPK-related kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCS2 | CRK5 | CDPK-related kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38869 | CPK4 | Calcium-dependent protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q06850 | CPK1 | Calcium-dependent protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42438 | CPK8 | Calcium-dependent protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42396 | CPK12 | Calcium-dependent protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1LUA6 | trio | Triple functional domain protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKVKRLEEF | NTCYNSNQLE | KMAFFQCREE | VEKVKCFLEK | NSGDQDSRSG | HNEAKEVWSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ADLTERMPVK | SKRTSALAVD | IPAPPAPFDH | RIVTAKQGAV | NSFYTVSKTE | ILGGGRFGQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HKCEETATGL | KLAAKIIKTR | GMKDKEEVKN | EISVMNQLDH | ANLIQLYDAF | ESKNDIVLVM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EYVDGGELFD | RIIDESYNLT | ELDTILFMKQ | ICEGIRHMHQ | MYILHLDLKP | ENILCVNRDA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KQIKIIDFGL | ARRYKPREKL | KVNFGTPEFL | APEVVNYDFV | SFPTDMWSVG | VIAYMLLSGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPFLGDNDAE | TLNNILACRW | DLEDEEFQDI | SEEAKEFISK | LLIKEKSWRI | SASEALKHPW |
| 370 | 380 | ||||
| LSDHKLHSRL | NAQKKKNRGS | DAQDFVTK |