Q9SWG0
PR
Gene name |
IVD (At3g45300, F18N11.6) |
Protein name |
Isovaleryl-CoA dehydrogenase, mitochondrial |
Names |
IVD |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G45300 |
EC number |
1.3.8.4: With a flavin as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SWG0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SWG0-F1 | Predicted | AlphaFoldDB |
49 variants for Q9SWG0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_16624835_A_T | 5 | F>Y | No | 1000Genomes | |
| ENSVATH12513870 | 9 | S>P | No | 1000Genomes | |
| tmp_3_16624818_G_A | 11 | L>F | No | 1000Genomes | |
| ENSVATH12513869 | 13 | Y>F | No | 1000Genomes | |
| ENSVATH06229226 | 15 | V>I | No | 1000Genomes | |
| ENSVATH06229223 | 21 | S>F | No | 1000Genomes | |
| ENSVATH06229224 | 21 | S>P | No | 1000Genomes | |
| tmp_3_16624783_G_T | 22 | F>L | No | 1000Genomes | |
| tmp_3_16624781_G_T | 23 | S>Y | No | 1000Genomes | |
| tmp_3_16624748_G_C | 34 | T>S | No | 1000Genomes | |
| tmp_3_16624744_C_A | 35 | Q>H | No | 1000Genomes | |
| tmp_3_16624377_C_T | 41 | S>N | No | 1000Genomes | |
| tmp_3_16624371_G_A | 43 | S>F | No | 1000Genomes | |
| ENSVATH14367469 | 44 | K>M | No | 1000Genomes | |
| ENSVATH06229206 | 44 | K>Q | No | 1000Genomes | |
| tmp_3_16624357_C_T | 48 | D>N | No | 1000Genomes | |
| ENSVATH00399929 | 49 | N>I | No | 1000Genomes | |
| ENSVATH02434199 | 49 | N>K | No | 1000Genomes | |
| tmp_3_16624348_C_T | 51 | A>T | No | 1000Genomes | |
| ENSVATH14367468 | 59 | K>N | No | 1000Genomes | |
| tmp_3_16624320_G_A | 60 | T>I | No | 1000Genomes | |
| ENSVATH00399927 | 83 | A>V | No | 1000Genomes | |
| tmp_3_16624166_G_A | 84 | P>S | No | 1000Genomes | |
| tmp_3_16624052_T_G | 86 | E>D | No | 1000Genomes | |
| tmp_3_16624033_C_T | 93 | G>S | No | 1000Genomes | |
| ENSVATH14367444 | 141 | K>N | No | 1000Genomes | |
| tmp_3_16623809_T_G | 141 | K>T | No | 1000Genomes | |
| tmp_3_16623398_C_T | 164 | G>S | No | 1000Genomes | |
| tmp_3_16623362_A_G | 176 | Y>H | No | 1000Genomes | |
| ENSVATH12513674 | 177 | I>V | No | 1000Genomes | |
| ENSVATH12513668 | 204 | A>E | No | 1000Genomes | |
| ENSVATH00399923 | 204 | A>S | No | 1000Genomes | |
| ENSVATH06229176 | 207 | K>N | No | 1000Genomes | |
| tmp_3_16623155_T_A | 214 | I>L | No | 1000Genomes | |
| ENSVATH02434155 | 219 | T>A | No | 1000Genomes | |
| ENSVATH06229164 | 243 | E>D | No | 1000Genomes | |
| ENSVATH06229163 | 250 | E>K | No | 1000Genomes | |
| ENSVATH14367441 | 254 | D>G | No | 1000Genomes | |
| ENSVATH02434129 | 288 | N>T | No | 1000Genomes | |
| tmp_3_16622495_C_G | 295 | Q>H | No | 1000Genomes | |
| ENSVATH06229152 | 317 | Y>F | No | 1000Genomes | |
| tmp_3_16622340_T_A | 318 | T>S | No | 1000Genomes | |
| ENSVATH02434113 | 359 | A>S | No | 1000Genomes | |
| ENSVATH02434113 | 359 | A>T | No | 1000Genomes | |
| ENSVATH06229122 | 394 | S>N | No | 1000Genomes | |
| tmp_3_16621684_C_G | 402 | G>A | No | 1000Genomes | |
| ENSVATH12513511 | 402 | G>S | No | 1000Genomes | |
| ENSVATH12513510 | 404 | E>K | No | 1000Genomes | |
| ENSVATH06229120 | 406 | F>L | No | 1000Genomes |
No associated diseases with Q9SWG0
5 regional properties for Q9SWG0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Acyl-CoA dehydrogenase, conserved site | 152 - 164 | IPR006089-1 |
| conserved_site | Acyl-CoA dehydrogenase, conserved site | 364 - 383 | IPR006089-2 |
| domain | Acyl-CoA oxidase/dehydrogenase, middle domain | 150 - 245 | IPR006091 |
| domain | Acyl-CoA dehydrogenase/oxidase C-terminal | 257 - 405 | IPR009075 |
| domain | Acyl-CoA dehydrogenase/oxidase, N-terminal | 33 - 146 | IPR013786 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.8.4 | With a flavin as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + oxidized |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| isovaleryl-CoA dehydrogenase activity | Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized = 3-methyl-(2E)-butenoyl-CoA + reduced |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| alternative respiration | Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa. |
| branched-chain amino acid catabolic process | The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. |
| leucine catabolic process | The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9FS87 | IVD | Isovaleryl-CoA dehydrogenase, mitochondrial | Solanum tuberosum (Potato) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRFFSARSI | LGYAVKTRRR | SFSSRSSSLL | FDDTQLQFKE | SVSKFAQDNI | APHAERIDKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSFPKDVNLW | KLMGEFNLHG | ITAPEEYGGL | GLGYLYHCIA | MEEISRASGS | VALSYGAHSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LCINQLVRNG | TAAQKEKYLP | KLISGEHVGA | LAMSEPNAGS | DVVGMKCKAE | KVDGGYILNG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKMWCTNGPS | AETLVVYAKT | DTKAGSKGIT | AFIIEKGMTG | FSTAQKLDKL | GMRGSDTCEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFENCFVPEE | NILDKEGKGV | YVLMSGLDLE | RLVLAAGPLG | IMQACLDNVL | PYIRQREQFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RPVGEFQFIQ | GKVADMYTAL | QSSRSYVYSV | ARDCDNGKVD | PKDCAGTILC | AAERATQVAL |
| 370 | 380 | 390 | 400 | ||
| QAIQCLGGNG | YINEYATGRL | LRDAKLYEIG | AGTSEIRRIV | IGRELFKEE |