AiPD: Autoinhibited Protein Database

Gene name	TS2 (At1g72810, F3N23.1)
Protein name	Threonine synthase 2, chloroplastic
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G72810
EC number	4.2.3.1: Acting on phosphates
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-84 (Predicted disordered autoinhibitory region) PR

1-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9SSP5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_1_27400344_G_C	17	S>C	No	1000Genomes
tmp_1_27400342_C_T	18	E>K	No	1000Genomes
tmp_1_27400332_A_C	21	L>R	No	1000Genomes
ENSVATH05134417	27	A>T	No	1000Genomes
tmp_1_27400293_G_A	34	T>I	No	1000Genomes
tmp_1_27400288_C_A	36	A>S	No	1000Genomes
ENSVATH05134414	48	P>S	No	1000Genomes
ENSVATH01527088	53	D>H	No	1000Genomes
tmp_1_27400177_G_C	73	R>G	No	1000Genomes
tmp_1_27400101_G_A	98	S>F	No	1000Genomes
ENSVATH05134412	107	D>E	No	1000Genomes
ENSVATH05134413	107	D>Y	No	1000Genomes
ENSVATH01527086	109	A>T	No	1000Genomes
ENSVATH14474238	113	R>P	No	1000Genomes
ENSVATH01527085	122	L>F	No	1000Genomes
ENSVATH01527084	182	V>M	No	1000Genomes
ENSVATH14474237	200	V>L	No	1000Genomes
ENSVATH01527079	211	M>K	No	1000Genomes
tmp_1_27399640_C_T	224	G>E	No	1000Genomes
ENSVATH05134407	247	A>S	No	1000Genomes
ENSVATH14474233	320	W>C	No	1000Genomes
ENSVATH00139916	350	I>V	No	1000Genomes
tmp_1_27399130_G_A	394	P>L	No	1000Genomes
tmp_1_27398948_C_G	455	A>P	No	1000Genomes
tmp_1_27398888_T_C	475	I>V	No	1000Genomes
tmp_1_27398825_C_T	496	V>I	No	1000Genomes
ENSVATH13798876	502	S>P	No	1000Genomes

Type	Name	Position	InterPro Accession
binding_site	Serine/threonine dehydratase, pyridoxal-phosphate-binding site	184 - 198	IPR000634
domain	Tryptophan synthase beta chain-like, PALP domain	157 - 464	IPR001926

		Description
EC Number	4.2.3.1	Acting on phosphates
Subcellular Localization	Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
threonine synthase activity	Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Name	Definition
cysteine biosynthetic process	The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
threonine biosynthetic process	The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9MT28		Threonine synthase, chloroplastic	Solanum tuberosum (Potato)	PR
Q9S7B5	TS1	Threonine synthase 1, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR