AiPD: Autoinhibited Protein Database

Gene name	TS1 (MTO2, At4g29840, F27B13.80)
Protein name	Threonine synthase 1, chloroplastic
Names	Protein METHIONINE OVER-ACCUMULATOR 2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G29840
EC number	4.2.3.1: Acting on phosphates
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-105 (Predicted disordered autoinhibitory region) PR

1-105 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1E5X	X-ray	225 A	A/B	41-526	PDB
2C2B	X-ray	260 A	A/B/C/D/E/F	41-526	PDB
2C2G	X-ray	261 A	A/B	41-526	PDB
AF-Q9S7B5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_4_14600999_G_A	6	L>F	No	1000Genomes
tmp_4_14600970_G_T	15	N>K	No	1000Genomes
tmp_4_14600951_G_A	22	R>C	No	1000Genomes
tmp_4_14600929_A_G	29	L>P	No	1000Genomes
ENSVATH14312444	30	L>P	No	1000Genomes
tmp_4_14600917_C_T	33	R>H	No	1000Genomes
tmp_4_14600902_G_C	38	S>C	No	1000Genomes
tmp_4_14600869_G_A	49	P>L	No	1000Genomes
ENSVATH00544628	53	A>V	No	1000Genomes
ENSVATH14312443	54	V>I	No	1000Genomes
tmp_4_14600762_G_A	85	P>S	No	1000Genomes
ENSVATH06799715	116	D>N	No	1000Genomes
tmp_4_14600664_C_A	117	M>I	No	1000Genomes
ENSVATH00544627	118	E>D	No	1000Genomes
ENSVATH02941819	340	I>V	No	1000Genomes
ENSVATH06799709	379	S>C	No	1000Genomes
tmp_4_14599854_C_A	387	M>I	No	1000Genomes
tmp_4_14599531_C_G	495	C>S	No	1000Genomes
ENSVATH06799707	505	K>I	No	1000Genomes
tmp_4_14599453_C_T	521	S>N	No	1000Genomes

Type	Name	Position	InterPro Accession
binding_site	Serine/threonine dehydratase, pyridoxal-phosphate-binding site	193 - 207	IPR000634
domain	Tryptophan synthase beta chain-like, PALP domain	166 - 472	IPR001926

		Description
EC Number	4.2.3.1	Acting on phosphates
Subcellular Localization	Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast stroma	The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
threonine synthase activity	Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Name	Definition
cysteine biosynthetic process	The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
threonine biosynthetic process	The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9MT28		Threonine synthase, chloroplastic	Solanum tuberosum (Potato)	PR
Q9SSP5	TS2	Threonine synthase 2, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR