Q9QXY4

PR
Gene name
Ogfr
Protein name
Opioid growth factor receptor
Names
OGFr, Zeta-type opioid receptor
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

264-580 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QXY4

Entry ID Method Resolution Chain Position Source
AF-Q9QXY4-F1 Predicted AlphaFoldDB

No variants for Q9QXY4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9QXY4

No associated diseases with Q9QXY4

1 regional properties for Q9QXY4

Type Name Position InterPro Accession
domain Opioid growth factor receptor (OGFr) conserved domain 78 - 282 IPR006757

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Nucleus
  • The OGF/OGFR complex is probably translocated to the nucleus
  • Colocalized with OGF in the perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

1 GO annotations of molecular function

Name Definition
opioid growth factor receptor activity Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99PG2 Ogfr Opioid growth factor receptor Mus musculus (Mouse) PR
10 20 30 40 50 60
MDDPDCDSTW EEESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM TGYRNWRAMQ
70 80 90 100 110 120
DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGALI EDILQNWKDN YDLLEENHSY
130 140 150 160 170 180
IQWLFPLREP GVNWHAKPLT LKEVEAFKSS KEVRERLVRA YELMLGFYGF HLEDRGTGAV
190 200 210 220 230 240
CRAQNFQPRF HNLNSHSHNN LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR
250 260 270 280 290 300
QSALDYFLFA VRCRHQRREL VYFAWEHFKP RREFVWGPRD KLRRFKPQTI PQPLTGPGQA
310 320 330 340 350 360
DKDEGSRDPS QEAGTQGRTC GSGRDLSGDS GTAEDPSLLN TKPSDGGTLD GNQRDEAKSL
370 380 390 400 410 420
SPKESKKRKL EGNRQEQVPG EADPQGVSEV EKIALNLEEC ALSPISQEPR EAEPPCPVAR
430 440 450 460 470 480
VANEVRKRRK VEEGAEGDGV VSNTQMQASA LPPTPSECPE AQKDGNGPED SNSQVGAEDS
490 500 510 520 530 540
KSQVGPEDPN SQVGLEDPNS QVGPEDPNSQ VGPEDPNSQV GPEDPNSQVG PEDPNSQVVG
550 560 570
PEQAASKSPV EDPDSDTMGT SVDESEELAR IEASAEPPKP