Q99PG2
Gene name |
Ogfr |
Protein name |
Opioid growth factor receptor |
Names |
OGFr, Zeta-type opioid receptor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72075 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99PG2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99PG2-F1 | Predicted | AlphaFoldDB |
32 variants for Q99PG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388614742 | 4 | P>S | No | EVA | |
| rs13475605 | 19 | E>D | No | EVA | |
| rs3388617685 | 28 | D>E | No | EVA | |
| rs3388620892 | 149 | S>G | No | EVA | |
| rs3388620460 | 149 | S>N | No | EVA | |
| rs3388619362 | 157 | L>F | No | EVA | |
| rs3388621635 | 224 | R>C | No | EVA | |
| rs3392606447 | 243 | A>T | No | EVA | |
| rs233903603 | 317 | G>S | No | EVA | |
| rs257472146 | 318 | R>W | No | EVA | |
| rs223208139 | 329 | D>H | No | EVA | |
| rs241234198 | 341 | A>T | No | EVA | |
| rs261618806 | 345 | D>G | No | EVA | |
| rs3388611398 | 398 | E>D | No | EVA | |
| rs3388611482 | 400 | C>Y | No | EVA | |
| rs3388613219 | 431 | V>M | No | EVA | |
| rs3388613187 | 446 | V>M | No | EVA | |
| rs3388617580 | 473 | S>G | No | EVA | |
| rs581334174 | 493 | V>L | No | EVA | |
| rs33112008 | 503 | G>E | No | EVA | |
| rs29566060 | 512 | E>G | No | EVA | |
| rs586685919 | 514 | E>K | No | EVA | |
| rs578493699 | 545 | S>G | No | EVA | |
| rs581940754 | 554 | S>G | No | EVA | |
| rs1135188801 | 560 | D>N | No | EVA | |
| rs584459126 | 566 | E>G | No | EVA | |
| rs578686672 | 575 | E>G | No | EVA | |
| rs581949979 | 584 | G>E | No | EVA | |
| rs1134575378 | 587 | D>N | No | EVA | |
| rs258970331 | 589 | Q>K | No | EVA | |
| rs3388614693 | 625 | E>K | No | EVA | |
| rs3388608184 | 629 | E>G | No | EVA |
No associated diseases with Q99PG2
1 regional properties for Q99PG2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Opioid growth factor receptor (OGFr) conserved domain | 78 - 282 | IPR006757 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| opioid growth factor receptor activity | Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9QXY4 | Ogfr | Opioid growth factor receptor | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDDPECDSTW | EDESEEDGED | GQADDTTDED | TGDDDGDAEE | ARPSLFQSRM | TRYRNWRAMQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DMQRYRHNYP | DLTDQDCNGD | MCNLSFYKNE | ICFQPNGFLI | EDILQNWKDN | YDLLEENHSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQWLFPLREP | GVNWHAKPLT | LKEVEAFKSS | KEVRERLVRA | YELMLGFYGI | QLEDRNTGAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CRAQNFQPRF | HNLNSHSHNN | LRITRILKSL | GELGLEHYQA | PLVRFFLEET | LVQHKLPSVR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QSALDYFLFA | VRCRHQRREL | VHFAWEHFKP | RREFVWGPRD | KLRRFRPQTI | SRPLMGLGQA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKDEGPGDPS | QEAGTQGRTC | GSGRDLSGDS | GTAEDLSLLS | AKPQDVGTLD | GDQRHEAKSP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPKESKKRKL | EGNRQEQVPG | EPDPQGVSEV | EKIALNLEGC | ALSPTSQEPR | EAEQPCLVAR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VANEVRKRRK | VEEGAEGDGV | ASNTQVQASA | LSPTPSECPE | SQKDGNGPED | PKSQVGPEDP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KSQVGPEDPK | SQVGPEDPKS | QVGPEDPKGQ | VEPEDPKGQV | GPEDPKGQVG | PEDPKGQVGP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EDPKSQVGPE | DPKSQVEPED | PKSQVEPEDP | KSQVEPEDPK | SQVGPEDPQS | QVGPEQAASK |
| 610 | 620 | 630 | |||
| SLGEDPDSDT | TGTSMSESEE | LARIEASVEP | PKP |