Q9QWW1
PR
Gene name |
Homer2 |
Protein name |
Homer protein homolog 2 |
Names |
Homer-2, Cupidin, VASP/Ena-related gene up-regulated during seizure and LTP 2, Vesl-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26557 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q9QWW1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1I7A | X-ray | 224 A | A/B/C/D | 1-111 | PDB |
| 5ZZ9 | X-ray | 230 A | A/B/C | 1-115 | PDB |
| AF-Q9QWW1-F1 | Predicted | AlphaFoldDB |
14 variants for Q9QWW1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388921699 | 40 | V>F | No | EVA | |
| rs3397775016 | 41 | T>S | No | EVA | |
| rs3388915811 | 63 | P>S | No | EVA | |
| rs3388916655 | 108 | E>K | No | EVA | |
| rs3388919200 | 148 | D>E | No | EVA | |
| rs212238530 | 157 | P>L | No | EVA | |
| rs3388921693 | 173 | L>M | No | EVA | |
| rs3388915790 | 176 | S>I | No | EVA | |
| rs3388922816 | 216 | S>Y | No | EVA | |
| rs36395798 | 223 | D>N | No | EVA | |
| rs3388915819 | 253 | I>T | No | EVA | |
| rs3398083538 | 281 | M>I | No | EVA | |
| rs3398155862 | 282 | S>F | No | EVA | |
| rs3388895002 | 307 | S>P | No | EVA |
No associated diseases with Q9QWW1
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| apical part of cell | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| intracellular organelle | Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| stereocilium tip | A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| G protein-coupled glutamate receptor binding | Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). |
| glutamate receptor binding | Binding to a glutamate receptor. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| synaptic receptor adaptor activity | The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| behavioral response to cocaine | Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. |
| calcium-mediated signaling using intracellular calcium source | The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. |
| chemical homeostasis within a tissue | Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. |
| G protein-coupled glutamate receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| negative regulation of calcineurin-NFAT signaling cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
| negative regulation of interleukin-2 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
| regulation of store-operated calcium entry | Any process that modulates the frequency, rate or extent of store-operated calcium entry. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGEQPIFTTR | AHVFQIDPST | KKNWVPASKQ | AVTVSYFYDV | TRNSYRIISV | DGAKVIINST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITPNMTFTKT | SQKFGQWADS | RANTVFGLGF | SSELQLTKFA | EKFQEVREAA | RLARDKSQEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TETSSNHSQE | SGCETPSSTQ | ASSVNGTDDE | KASHASPADT | HLKSENDKLK | IALTQSAANV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKWEMELQTL | RESNARLTTA | LQESAASVEQ | WKRQFSICRD | ENDRLRSKIE | ELEEQCSEIN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| REKEKNTQLK | RRIEELESEV | RDKEMELKDL | RKQSEIIPQL | MSECEYVSEK | LEAAERDNQN |
| 310 | 320 | 330 | 340 | 350 | |
| LEDKVRSLKT | DIEESKYRQR | HLKGELKSFL | EVLDGKIDDL | HDFRRGLSKL | GTDN |