Q99JP6
Gene name |
Homer3 |
Protein name |
Homer protein homolog 3 |
Names |
Homer-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26558 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99JP6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99JP6-F1 | Predicted | AlphaFoldDB |
13 variants for Q99JP6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388957101 | 48 | Y>H | No | EVA | |
| rs3388984668 | 56 | A>D | No | EVA | |
| rs3388939763 | 63 | T>P | No | EVA | |
| rs3388991830 | 83 | S>N | No | EVA | |
| rs3388991622 | 127 | T>I | No | EVA | |
| rs3388969236 | 143 | L>* | No | EVA | |
| rs3388987764 | 191 | A>V | No | EVA | |
| rs224143750 | 257 | Q>E | No | EVA | |
| rs33368143 | 308 | S>A | No | EVA | |
| rs3388981100 | 310 | E>K | No | EVA | |
| rs3388975306 | 327 | V>M | No | EVA | |
| rs3388987794 | 334 | L>Q | No | EVA | |
| rs3388988090 | 349 | A>V | No | EVA |
No associated diseases with Q99JP6
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| basal part of cell | The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled glutamate receptor binding | Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). |
| identical protein binding | Binding to an identical protein or proteins. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein domain specific binding | Binding to a specific domain of a protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled glutamate receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| negative regulation of calcineurin-NFAT signaling cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
| negative regulation of interleukin-2 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. |
| regulation of postsynaptic neurotransmitter receptor activity | Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. |
| regulation of store-operated calcium entry | Any process that modulates the frequency, rate or extent of store-operated calcium entry. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTAREQPIF | STRAHVFQID | PTTKRNWIPA | GKHALTVSYF | YDATRNVYRI | ISIGGAKAII |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSTVTPNMTF | TKTSQKFGQW | ADSRANTVYG | LGFASEQQLT | QFAEKFQEVK | EAARLAREKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QDGGEFTSTG | LALASHQVPP | SPLVSTNGPG | EEKLFRSQSA | DTPGPTERER | LKKMLSEGSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEVQWEAEFF | ALQDSNQRLA | GALREANAAA | TQWRQQLEVQ | RAEAELLRQR | VAELEAQVAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPVRAGEKEA | TSQSVEQLEA | RVQTKDQTLK | NQSTGTREAP | DTAEREETQQ | QVQDLETRNA |
| 310 | 320 | 330 | 340 | 350 | |
| ELEQQLRSME | CNLEEARAER | ERARAEVGRA | AQLLDVRLFE | LSELREGLAR | LAEAAP |