AiPD: Autoinhibited Protein Database

Q9P1W8

Gene name	SIRPG (SIRPB2)
Protein name	Signal-regulatory protein gamma
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55423
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-289 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

58-289 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9P1W8

Entry ID	Method	Resolution	Chain	Position	Source
2JJW	X-ray	170 A	A	29-147	PDB
4I2X	X-ray	248 A	E/F	29-347	PDB
AF-Q9P1W8-F1	Predicted				AlphaFoldDB

392 variants for Q9P1W8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs768767170 CA9729647	2	P>L		No	ClinGen ExAC gnomAD
rs1275372380 CA408001563	2	P>S		No	ClinGen TOPMed
CA310813524 rs371896459	4	P>R		No	ClinGen Ensembl
CA9729646 rs201306847	4	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs6074959 CA9729645	5	A>S		No	ClinGen ExAC gnomAD
rs1281567353 CA408001540 COSM1307170	6	S>F	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA9729643 rs375442919	7	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs202030267 CA9729644	7	W>*		No	ClinGen 1000Genomes ExAC gnomAD
rs199556654 CA310813487	8	P>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA408001532 rs199556654	8	P>T		No	ClinGen 1000Genomes TOPMed gnomAD
rs781714804 CA9729642	9	H>L		No	ClinGen ExAC TOPMed gnomAD
rs144234748 CA9729641	9	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747567133 CA9729640	11	P>R		No	ClinGen ExAC TOPMed gnomAD
rs778205397 CA9729639	12	G>C		No	ClinGen ExAC gnomAD
rs371163922 CA9729638	13	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA408001493 rs867272459	14	F>L		No	ClinGen gnomAD
TCGA novel	19	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752193069 CA9729637	19	L>V		No	ClinGen ExAC gnomAD
rs1230063434 CA408001463	20	L>P		No	ClinGen gnomAD
rs764816031 CA9729636	22	G>E		No	ClinGen ExAC gnomAD
rs139502650 CA9729635	23	L>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753560324 CA9729634	24	T>R		No	ClinGen ExAC gnomAD
CA9729632 rs760442783	25	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA408001354 rs1183850080	26	V>A		No	ClinGen gnomAD
CA408001356 rs1183850080	26	V>E		No	ClinGen gnomAD
CA408001353 rs1183850080	26	V>G		No	ClinGen gnomAD
rs368139177 CA9729616	26	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs750234705 CA9729615	27	A>S		No	ClinGen ExAC TOPMed gnomAD
rs750234705 CA9729614	27	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9729611 rs752758859	28	G>D		No	ClinGen ExAC TOPMed gnomAD
CA9729612 rs761688818	28	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9729609 rs759749841	29	E>G		No	ClinGen ExAC gnomAD
CA9729605 rs201954358	30	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA9729606 rs771321985	30	E>G		No	ClinGen ExAC
CA9729607 rs776991507	30	E>Q		No	ClinGen ExAC
CA9729603 rs772559713	31	E>G		No	ClinGen ExAC
rs779451925 CA9729601	32	L>I		No	ClinGen ExAC
CA310807013 rs903588441	33	Q>*		No	ClinGen TOPMed
CA310806996 rs576810342 CA408001270	33	Q>H		No	ClinGen gnomAD
CA408001258 rs375060745 CA9729600	34	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs960986801 CA310806993	34	M>V		No	ClinGen TOPMed gnomAD
CA9729598 rs202224518	36	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1568735963 CA408001232	37	P>L		No	ClinGen Ensembl
CA9729595 rs780854234	40	L>I		No	ClinGen ExAC gnomAD
CA9729594 rs757162144	42	L>F		No	ClinGen ExAC TOPMed gnomAD
CA310806951 rs770579012	43	V>A		No	ClinGen Ensembl
CA408001147 rs1188935483	44	T>K		No	ClinGen TOPMed gnomAD
rs751532170 CA9729593	44	T>P		No	ClinGen ExAC gnomAD
CA9729592 rs775245375	45	V>A		No	ClinGen ExAC TOPMed gnomAD
CA9729590 rs754024064	47	K>N		No	ClinGen ExAC gnomAD
rs78831862 CA9729589	48	T>P		No	ClinGen ExAC gnomAD
CA9729588 rs760807673	49	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1410500857 CA408001098	49	A>T		No	ClinGen TOPMed
CA310806905 rs760807673	49	A>V		No	ClinGen ExAC TOPMed gnomAD
rs773564663 CA9729587	50	T>S		No	ClinGen ExAC gnomAD
rs772308141 CA9729586	51	L>P		No	ClinGen ExAC gnomAD
rs143978848 CA9729585	54	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1368351044 CA408001024	56	T>A		No	ClinGen gnomAD
TCGA novel	60	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9729581 rs138452343	61	V>M		No	ClinGen ESP ExAC gnomAD
rs200917950 CA310806829	63	P>A		No	ClinGen 1000Genomes
rs62641738 CA9729579	64	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729578 rs368412754	65	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA310806798 rs368412754	65	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs148010539 CA9729576	66	W>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143474967 CA9729577	66	W>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1278147153 CA408000909	67	F>L		No	ClinGen TOPMed
CA9729573 rs185871223	70	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9729574 rs185871223	70	V>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408000870 rs1209729465	70	V>F		No	ClinGen gnomAD
CA9729572 rs376352368	72	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA408000847 rs1243589287	72	P>Q		No	ClinGen TOPMed
CA310806766 rs376352368	72	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA310806746 rs143441100	73	G>S		No	ClinGen ESP
rs750582002 COSM1532803 CA9729570	74	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs201956131 CA9729571	74	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774712730 COSM1024708 CA408000825	75	E>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA408000818 rs1362929974	75	E>D		No	ClinGen gnomAD
rs774712730 CA9729567	75	E>K		No	ClinGen ExAC TOPMed gnomAD
rs774712730 COSM3840461 CA9729568	75	E>Q	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs138635169 CA9729566	80	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408000742 rs1195538425	81	K>Q		No	ClinGen gnomAD
rs763481309 CA9729565	81	K>R		No	ClinGen ExAC gnomAD
TCGA novel	86	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9729564 rs775015713	88	V>I		No	ClinGen ExAC TOPMed gnomAD
CA310806710 rs770723293	90	T>A		No	ClinGen Ensembl
rs745421325 CA9729562	91	V>I		No	ClinGen ExAC gnomAD
CA310806697 rs917125051	93	D>E		No	ClinGen TOPMed
CA9729560 rs1555815213	94	L>P		No	ClinGen Ensembl
rs1392532853 CA408000566	95	T>I		No	ClinGen gnomAD
TCGA novel	96	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA310806679 rs527643862	100	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA408000503 rs1254431356	100	M>V		No	ClinGen gnomAD
CA9729558 rs770761854	101	D>G		No	ClinGen ExAC gnomAD
CA9729559 rs575352199	101	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs746738813 CA9729557	103	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA408000450 rs1203086520	104	I>N		No	ClinGen gnomAD
rs1203086520 CA408000448	104	I>T		No	ClinGen gnomAD
CA310806676 rs747816100	104	I>V		No	ClinGen Ensembl
rs777710856 COSM175890 CA9729556	105	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs200001337 CA9729555	105	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA310806662 rs200001337	105	R>L		No	ClinGen ExAC TOPMed gnomAD
rs777710856 CA408000443	105	R>S		No	ClinGen ExAC TOPMed gnomAD
rs748079541 CA9729554	106	I>T		No	ClinGen ExAC gnomAD
rs370269730 CA9729553	107	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs62641735 CA9729552	108	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA310806637 rs983489368	111	P>S		No	ClinGen TOPMed gnomAD
rs535216502 CA310806630	112	A>E		No	ClinGen 1000Genomes
CA408000345 rs1339573943	114	V>A		No	ClinGen TOPMed gnomAD
CA408000340 rs1201647688	115	G>C		No	ClinGen TOPMed
rs1201647688 CA408000342	115	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1307066876 CA408000331	116	T>I		No	ClinGen gnomAD
rs1371812118 CA408000329	117	Y>H		No	ClinGen TOPMed gnomAD
CA9729548 rs751880933	119	C>R		No	ClinGen ExAC TOPMed gnomAD
CA310806610 rs751880933	119	C>S		No	ClinGen ExAC TOPMed gnomAD
CA408000308 rs1410520246	120	V>M		No	ClinGen TOPMed
CA408000302 rs1167335814	121	K>Q		No	ClinGen gnomAD
rs1424811521 CA408000298	121	K>R		No	ClinGen gnomAD
CA408000292 rs1251323533	122	F>V		No	ClinGen gnomAD
CA9729546 rs763356667	123	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9729545 rs202204320 COSM1024706	123	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1355539089 CA408000271	125	G>E		No	ClinGen gnomAD
rs200195769 CA9729543	126	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1329941693 CA408000264	126	S>R		No	ClinGen TOPMed
rs897044300 CA310806558	127	P>H		No	ClinGen Ensembl
rs1335190516 CA408000260	127	P>S		No	ClinGen gnomAD
rs1335190516 CA408000262	127	P>T		No	ClinGen gnomAD
rs746685702 CA408000251 CA9729540	128	E>D		No	ClinGen ExAC TOPMed gnomAD
CA9729538 rs773052108	129	N>D		No	ClinGen ExAC TOPMed gnomAD
CA9729537 rs146471324	129	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	129	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408000244 rs1385794032	130	V>M		No	ClinGen TOPMed gnomAD
rs62641733 CA310806525	131	E>*		No	ClinGen Ensembl
rs778704272 CA9729535	132	F>L		No	ClinGen ExAC gnomAD
CA9729534 rs570107389	133	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA9729533 rs745869898 COSM3404949	133	K>N	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA408000220 rs1568735266	133	K>T		No	ClinGen Ensembl
CA9729531 rs757421982	135	G>A		No	ClinGen ExAC gnomAD
CA408000211 rs1436050511	135	G>R		No	ClinGen gnomAD
rs895636620 CA310806504	136	P>A		No	ClinGen TOPMed gnomAD
rs778009753 CA9729528	137	G>D		No	ClinGen ExAC gnomAD
CA408000175 COSM576761 rs1211510692	140	M>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA408000170 rs370649250	141	A>G		No	ClinGen ESP TOPMed gnomAD
rs370649250 CA310806472	141	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs1468867126 CA408000159	143	G>D		No	ClinGen gnomAD
CA9729511 rs777955269	145	K>T		No	ClinGen ExAC TOPMed gnomAD
CA9729509 rs752934849	146	P>L	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758657511 CA9729510	146	P>S		No	ClinGen ExAC gnomAD
rs758657511 CA408000002	146	P>T		No	ClinGen ExAC gnomAD
TCGA novel	147	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs61738503 CA9729506	148	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61738503 CA9729507	148	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA407999985 rs1568726383	149	P>H		No	ClinGen Ensembl
CA407999982 rs373555109	150	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373555109 COSM443482 CA9729503	150	V>M	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs144100952 CA9729502	152	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729500 rs773968801	153	G>D		No	ClinGen ExAC gnomAD
CA9729501 rs191856632	153	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9729499 rs768475171	154	P>L		No	ClinGen ExAC gnomAD
rs1290175888 CA407999951	155	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9729497 rs775400271	156	A>T		No	ClinGen ExAC gnomAD
rs769779237 CA9729496	156	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA407999946 rs1242428697	157	R>G		No	ClinGen gnomAD
rs368883967 CA9729494	157	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA407999943 rs1600200069	157	R>T		No	ClinGen Ensembl
rs1440335373 CA407999929	159	T>I		No	ClinGen gnomAD
CA310798159 rs750722835	161	E>K		No	ClinGen Ensembl
CA407999906 rs1282079267	163	T>A		No	ClinGen gnomAD
rs748421244 CA9729492	164	V>M		No	ClinGen ExAC gnomAD
rs779049465 CA9729491	165	S>R		No	ClinGen ExAC gnomAD
rs1600199998 CA407999878 COSM1532804	167	T>N	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1568726273 CA407999871	168	C>S		No	ClinGen Ensembl
TCGA novel	170	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs2277761 CA9729489	171	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729490 rs755370269	171	H>R		No	ClinGen ExAC TOPMed gnomAD
rs749913117 CA9729486	172	G>A		No	ClinGen ExAC gnomAD
rs749913117 CA9729487	172	G>D		No	ClinGen ExAC gnomAD
CA310798138 rs937565446	172	G>R		No	ClinGen Ensembl
COSM285003 rs1208182683 CA407999843	173	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs986816973 CA310798131	173	F>S		No	ClinGen TOPMed
CA9729484 rs756766017	174	S>F		No	ClinGen ExAC TOPMed gnomAD
rs767157809 CA9729485	174	S>P		No	ClinGen ExAC TOPMed gnomAD
rs756766017 CA407999835	174	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA407999828 rs1383846293	175	P>L		No	ClinGen TOPMed
rs763718809 CA9729482	177	D>N		No	ClinGen ExAC gnomAD
CA9729480 rs775275224	178	I>N		No	ClinGen ExAC gnomAD
rs374688687 CA9729481	178	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	179	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766150112 CA9729479	179	T>N		No	ClinGen ExAC TOPMed gnomAD
CA407999794 rs1215156919	181	K>R		No	ClinGen TOPMed gnomAD
rs980811811 CA310798111	182	W>C		No	ClinGen Ensembl
CA9729478 rs759496846	183	F>L		No	ClinGen ExAC TOPMed gnomAD
rs970408736 CA310798106	183	F>Y		No	ClinGen Ensembl
rs1568726146 CA407999772	184	K>R		No	ClinGen Ensembl
TCGA novel	185	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9729477 rs773223492	188	E>K		No	ClinGen ExAC gnomAD
CA9729476 rs772163644	190	S>*		No	ClinGen ExAC TOPMed gnomAD
CA407999729 rs772163644	190	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1482530255 CA407999708	193	Q>P		No	ClinGen gnomAD
rs917611496 CA310798100	194	T>N		No	ClinGen gnomAD
CA407999700 COSM1225794 rs917611496	194	T>S	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA407999693 rs768776233 CA310798093	195	N>K		No	ClinGen ExAC TOPMed gnomAD
rs982508134 CA310798097	195	N>S		No	ClinGen TOPMed gnomAD
CA310798090 rs749599207	197	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9729471 rs780598194	198	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1449884872 CA407999673	198	P>S		No	ClinGen TOPMed
rs1417353190 CA407999666	199	T>A		No	ClinGen TOPMed
rs142262583 CA9729470	199	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA310798073 rs200354721	201	Q>*		No	ClinGen 1000Genomes TOPMed
rs995344303 CA310798069	201	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA407999628 rs1294317660	202	S>T		No	ClinGen gnomAD
rs746356323 CA9729469	203	V>E		No	ClinGen ExAC TOPMed gnomAD
rs1348870294 CA407999609	204	A>S		No	ClinGen TOPMed gnomAD
CA407999612 rs1348870294	204	A>T		No	ClinGen TOPMed gnomAD
rs1334973840 CA407999603	204	A>V		No	ClinGen TOPMed
rs781588891 CA9729468 COSM576763	205	Y>*	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs756787375 CA9729467	206	S>R		No	ClinGen ExAC gnomAD
COSM443480 CA9729466 rs534699318	208	R>C	Variant assessed as Somatic; 0.0001848 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs570506979 CA9729465	208	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9729464 rs758047919	211	A>G		No	ClinGen ExAC gnomAD
rs758047919 CA407999536	211	A>V		No	ClinGen ExAC gnomAD
CA407999522 rs1281713774	214	V>I		No	ClinGen gnomAD
rs200104645 CA9729461	215	L>V		No	ClinGen ExAC gnomAD
rs768885801 CA9729457	216	D>E		No	ClinGen ExAC gnomAD
rs761896989 CA9729459	216	D>G		No	ClinGen ExAC TOPMed gnomAD
rs761896989 CA9729458	216	D>V		No	ClinGen ExAC TOPMed gnomAD
CA407999510 rs1263158236	216	D>Y		No	ClinGen TOPMed
CA9729454 rs775904582	217	P>H		No	ClinGen ExAC TOPMed gnomAD
CA9729455 rs775904582	217	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1219947167 CA407999507	217	P>T		No	ClinGen gnomAD
CA9729453 rs755894803	218	W>*		No	ClinGen ExAC gnomAD
CA407999500 rs1274128865	218	W>*		No	ClinGen gnomAD
CA9729452 rs746301292	219	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
rs746459913 CA9729449	220	V>A		No	ClinGen ExAC TOPMed gnomAD
rs186182902 CA9729450	220	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM723584 rs375274090 CA9729448	221	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA407999481 rs148726891	221	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9729447 rs148726891	221	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs867426310 COSM1713071 CA310797995	222	S>F	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA9729446 rs372433614	222	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs754758888 CA9729445	226	C>*		No	ClinGen ExAC TOPMed gnomAD
rs147250447 CA9729443	227	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs766277023 CA9729442	228	V>M		No	ClinGen ExAC gnomAD
CA9729441 rs760563124	229	A>S		No	ClinGen ExAC gnomAD
CA9729438 rs763166687	231	V>I		No	ClinGen ExAC gnomAD
rs147498898 CA9729437	233	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs569541055 CA9729436	234	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA407999405 rs1439146809	234	Q>K		No	ClinGen TOPMed
CA310797954 rs917574984	235	G>R		No	ClinGen TOPMed
CA407999393 rs1316345736	236	D>N		No	ClinGen TOPMed
CA407999391 rs1316345736	236	D>Y		No	ClinGen TOPMed
rs982455872 CA310797950	238	L>F		No	ClinGen Ensembl
rs776862353 CA9729434	238	L>H		No	ClinGen ExAC gnomAD
CA9729433 COSM2703714 rs771425697	239	R>C	Variant assessed as Somatic; 4.62e-05 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs771425697 CA407999374	239	R>G		No	ClinGen ExAC TOPMed gnomAD
rs370463374 CA9729432	239	R>H	Variant assessed as Somatic; 0.0001848 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs370463374 CA407999373	239	R>P		No	ClinGen ExAC TOPMed gnomAD
rs941997415 CA310797926	241	T>A		No	ClinGen TOPMed
CA407999362 rs1262888704	241	T>S		No	ClinGen gnomAD
rs951073014 CA310797924	243	N>K		No	ClinGen Ensembl
CA407999339 rs1311830350	245	S>P		No	ClinGen gnomAD
CA407999317 rs1241097052	248	I>T		No	ClinGen gnomAD
rs778389847 CA9729431	248	I>V		No	ClinGen ExAC gnomAD
CA9729430 rs771536811 COSM3404947	249	R>*	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs771536811 CA407999314	249	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9729429 rs747718268	249	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778483181 CA407999310	250	V>F		No	ClinGen ExAC TOPMed gnomAD
rs778483181 CA9729428	250	V>I		No	ClinGen ExAC TOPMed gnomAD
rs768249416 CA9729409	253	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1423634389 CA407999276	254	L>W		No	ClinGen gnomAD
rs1290244218 CA407999261	256	V>F		No	ClinGen TOPMed
TCGA novel	257	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370231533 CA310797533	258	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370231533 CA9729406	258	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs781217864 CA9729404	260	P>S		No	ClinGen ExAC gnomAD
rs548420665 CA9729403	261	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA310797522 rs1032983737	262	R>K		No	ClinGen TOPMed
CA9729401 rs6043409 VAR_049936	263	V>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA407999215 rs6043409	263	V>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200055053 CA9729402	263	V>M		No	ClinGen ExAC TOPMed gnomAD
rs753971956 CA9729399	264	G>E		No	ClinGen ExAC TOPMed gnomAD
rs970135212 CA310797501	265	N>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1389223302 CA407999198	266	Q>R		No	ClinGen gnomAD
rs1354029029 CA407999190	267	V>A		No	ClinGen TOPMed
rs760893584 CA9729397	268	N>H		No	ClinGen ExAC gnomAD
rs767975166 CA9729395	269	V>I		No	ClinGen ExAC gnomAD
rs1475658105 CA407999156	272	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1024803591 CA310797479	272	Q>R		No	ClinGen TOPMed gnomAD
CA407999119 rs1407233643	277	Y>*		No	ClinGen TOPMed
rs1421002880 CA407999125	277	Y>H		No	ClinGen gnomAD
CA407999115 rs1251377665	278	P>H		No	ClinGen gnomAD
TCGA novel	279	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1196245641 CA407999101	280	S>N		No	ClinGen gnomAD
CA407999089 rs1271032197	282	Q>*		No	ClinGen gnomAD
CA407999086 rs1319116368	282	Q>L		No	ClinGen gnomAD
rs547549347 CA9729391	284	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA9729390 rs748895752	285	W>*		No	ClinGen ExAC gnomAD
CA9729389 rs367852522	285	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA407999064 rs6034239	286	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs6034239 CA9729387 VAR_049937	286	S>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9729388 rs142972068	286	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA310797417 rs6034239	286	S>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757208638 CA9729385	287	E>G		No	ClinGen ExAC gnomAD
rs1454498399 CA407999061	287	E>K		No	ClinGen gnomAD
rs1460681957 CA407999033	291	V>E		No	ClinGen TOPMed
rs141069067 CA9729381	291	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729382 rs141069067	291	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729378 rs145447195	298	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs756394138 CA9729377	299	T>I		No	ClinGen ExAC gnomAD
CA9729376 rs148883600	300	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs148883600 CA310797361	300	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA407998971 rs1471293832	301	T>P		No	ClinGen gnomAD
rs1430296364 CA407998963	302	E>G		No	ClinGen TOPMed
rs1469609571 CA407998950	304	K>E		No	ClinGen TOPMed
rs762205668 CA9729374	304	K>M		No	ClinGen ExAC gnomAD
CA9729373 rs542506528	305	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA407998944 rs542506528	305	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764721660 CA9729372	307	T>I		No	ClinGen ExAC TOPMed gnomAD
CA9729371 rs370713827	310	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA407998897 rs1288820175	311	T>I		No	ClinGen TOPMed
CA310797326 rs937488425	313	W>*		No	ClinGen TOPMed
CA9729369 rs775068837	313	W>R		No	ClinGen ExAC gnomAD
rs574972022 CA9729368	314	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs200982024 CA9729367	315	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs41275436 CA9729364	316	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA407998847 rs1316683956	319	S>F		No	ClinGen gnomAD
CA407998842 rs1322463631	320	D>Y		No	ClinGen TOPMed
rs1217126513 CA407998836	321	Q>K		No	ClinGen TOPMed
TCGA novel	322	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9729362 rs201051307	323	D>G		No	ClinGen ExAC TOPMed gnomAD
CA9729363 rs777554720	323	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA9729361 rs749290871	324	D>E		No	ClinGen ExAC TOPMed gnomAD
CA407998811 rs1172046249	324	D>G		No	ClinGen gnomAD
rs780208812 CA9729360	326	V>F		No	ClinGen ExAC gnomAD
rs780208812 CA407998802	326	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9729356 rs757606654	329	C>*		No	ClinGen ExAC TOPMed gnomAD
CA9729357 rs781459773	329	C>R		No	ClinGen ExAC gnomAD
rs576944150 CA9729354	333	H>L		No	ClinGen 1000Genomes ExAC gnomAD
CA9729355 rs751933850	333	H>Y		No	ClinGen ExAC gnomAD
CA9729353 rs373199508	334	D>Y		No	ClinGen ESP ExAC gnomAD
CA407998744 rs1281873519	335	G>R		No	ClinGen gnomAD
CA9729352 rs145754609	335	G>V		No	ClinGen ESP ExAC gnomAD
CA9729349 rs776416912	337	L>P		No	ClinGen ExAC gnomAD
CA9729347 rs41275434	338	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1377290844 CA407998710	340	S>R		No	ClinGen gnomAD
rs148596804 CA9729345	342	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729344 rs748098905	342	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA310797149 rs369760423	344	A>S		No	ClinGen Ensembl
CA407998680 rs1344323115	346	E>K		No	ClinGen TOPMed
CA407998667 rs1476293856	347	V>A		No	ClinGen gnomAD
TCGA novel	347	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9729339 rs746007484	353	D>G		No	ClinGen ExAC gnomAD
rs78053816 CA407998623	354	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs78053816 CA9729338	354	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs78053816 CA9729337	354	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9729336 rs751880612	354	Q>P		No	ClinGen ExAC gnomAD
CA9729335 rs778222328	355	S>N		No	ClinGen ExAC TOPMed gnomAD
CA9729334 rs147969759	355	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1283794975 CA407998587	359	T>I		No	ClinGen TOPMed
rs547634798 CA9729332	360	P>H		No	ClinGen 1000Genomes ExAC gnomAD
rs547634798 CA407998582	360	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs777894070 CA9729317	362	P>L		No	ClinGen ExAC TOPMed gnomAD
rs777894070 CA407998561	362	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs777894070 CA407998560	362	P>R		No	ClinGen ExAC TOPMed gnomAD
rs747232069 CA9729318	362	P>S		No	ClinGen ExAC TOPMed gnomAD
rs748516544 CA9729315	363	A>S		No	ClinGen ExAC gnomAD
rs748516544 CA310791201	363	A>T		No	ClinGen ExAC gnomAD
rs1405074917 CA407998550	364	S>*		No	ClinGen gnomAD
CA407998554 rs1399764109	364	S>T		No	ClinGen gnomAD
TCGA novel	365	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407998544 rs1178495642	365	S>F		No	ClinGen TOPMed gnomAD
CA407998528 rs35062363	368	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA9729313 rs35062363	368	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA407998505 rs1465470091	372	I>T		No	ClinGen TOPMed
CA407998493 rs1224452521	374	V>D		No	ClinGen gnomAD
rs1286427526 CA407998494	374	V>I		No	ClinGen gnomAD
rs767134003 CA9729308	375	L>F		No	ClinGen ExAC gnomAD
rs868456979 CA310791171	378	P>H		No	ClinGen TOPMed
CA407998471 rs868456979	378	P>R		No	ClinGen TOPMed
rs561280167 CA9729306	380	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs761612919 CA9729307	380	Y>H		No	ClinGen ExAC gnomAD
CA9729304 rs762898132	381	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1400827235 CA407998437	383	W>C		No	ClinGen gnomAD
CA407998443 rs1160630685	383	W>G		No	ClinGen gnomAD
rs1213068429 CA407998442	383	W>L		No	ClinGen TOPMed
rs117221203 CA9729302	384	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9729303 rs775455306	384	K>R		No	ClinGen ExAC gnomAD
rs773466471 CA407998430	385	Q>*		No	ClinGen ExAC gnomAD
CA407998429 rs773466471	385	Q>E		No	ClinGen ExAC gnomAD
CA9729300 rs773466471	385	Q>K		No	ClinGen ExAC gnomAD
CA407998419 rs1313223752	386	K>R		No	ClinGen TOPMed
CA310791083 rs868485581	388	T>L		No	ClinGen Ensembl

No associated diseases with Q9P1W8

8 regional properties for Q9P1W8

Type	Name	Position	InterPro Accession
domain	Immunoglobulin C1-set	157 - 236	IPR003597-1
domain	Immunoglobulin C1-set	261 - 339	IPR003597-2
domain	Immunoglobulin subtype	38 - 133	IPR003599-1
domain	Immunoglobulin subtype	256 - 348	IPR003599-2
domain	Immunoglobulin-like domain	13 - 119	IPR007110-1
domain	Immunoglobulin-like domain	146 - 245	IPR007110-2
domain	Immunoglobulin-like domain	252 - 340	IPR007110-3
domain	Immunoglobulin V-set domain	36 - 126	IPR013106

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

8 GO annotations of biological process

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cell-cell adhesion	Any process that activates or increases the rate or extent of cell adhesion to another cell.
positive regulation of phagocytosis	Any process that activates or increases the frequency, rate or extent of phagocytosis.
positive regulation of T cell activation	Any process that activates or increases the frequency, rate or extent of T cell activation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O00241	SIRPB1	Signal-regulatory protein beta-1	Homo sapiens (Human)	PR
P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	Homo sapiens (Human)	PR

10	20	30	40	50	60
MPVPASWPHP	PGPFLLLTLL	LGLTEVAGEE	ELQMIQPEKL	LLVTVGKTAT	LHCTVTSLLP
70	80	90	100	110	120
VGPVLWFRGV	GPGRELIYNQ	KEGHFPRVTT	VSDLTKRNNM	DFSIRISSIT	PADVGTYYCV
130	140	150	160	170	180
KFRKGSPENV	EFKSGPGTEM	ALGAKPSAPV	VLGPAARTTP	EHTVSFTCES	HGFSPRDITL
190	200	210	220	230	240
KWFKNGNELS	DFQTNVDPTG	QSVAYSIRST	ARVVLDPWDV	RSQVICEVAH	VTLQGDPLRG
250	260	270	280	290	300
TANLSEAIRV	PPTLEVTQQP	MRVGNQVNVT	CQVRKFYPQS	LQLTWSENGN	VCQRETASTL
310	320	330	340	350	360
TENKDGTYNW	TSWFLVNISD	QRDDVVLTCQ	VKHDGQLAVS	KRLALEVTVH	QKDQSSDATP
370	380
GPASSLTALL	LIAVLLGPIY	VPWKQKT