AiPD: Autoinhibited Protein Database

Q9NZ01

Gene name	TECR (GPSN2, SC2)
Protein name	Very-long-chain enoyl-CoA reductase
Names	Synaptic glycoprotein SC2, Trans-2,3-enoyl-CoA reductase, TER
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9524
EC number	1.3.1.93: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-93 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

21-93 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9NZ01

Entry ID	Method	Resolution	Chain	Position	Source
2DZJ	NMR	-	A	1-81	PDB
AF-Q9NZ01-F1	Predicted				AlphaFoldDB

215 variants for Q9NZ01

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA9255043 rs772297819 RCV001330353	54	P>R	Intellectual disability, autosomal recessive 14 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000437833 RCV001335398 RCV002524710 CA9255075 rs753690636	88	V>L	Inborn genetic diseases Intellectual disability, autosomal recessive 14 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
VAR_065918 RCV000023795 CA129481 rs199469705	182	P>L	Intellectual disability, autosomal recessive 14 MRT14; reduced enzyme activity; reduced protein stability; no effect on subcellular localization [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
CA9254929 rs746471139	3	H>D		No	ClinGen ExAC gnomAD
rs761583185 CA9254930	5	E>Q		No	ClinGen ExAC gnomAD
rs760969845 CA9254961	11	A>G		No	ClinGen ExAC gnomAD
CA9254960 rs750439728	11	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9254962 rs574359444	16	K>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	17	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404435120 rs1599498505	23	V>A		No	ClinGen Ensembl
CA404435139 rs1462233750	26	H>P		No	ClinGen TOPMed gnomAD
COSM1390963 rs763449006 CA9255003	27	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs764495966 CA9255004	28	T>I		No	ClinGen ExAC gnomAD
rs752066182 CA9255005	29	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA404435180 rs757780004	32	I>M		No	ClinGen ExAC gnomAD
rs949207756 CA305679805	34	N>K		No	ClinGen gnomAD
rs765812213 CA9255007	35	L>F		No	ClinGen ExAC TOPMed gnomAD
CA9255008 rs765812213	35	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	39	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305679811 rs768569087	40	H>Y		No	ClinGen gnomAD
CA9255030 rs757998419	41	P>L		No	ClinGen ExAC TOPMed gnomAD
rs757998419 CA404435249	41	P>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1189909 rs752410543 CA9255029	41	P>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA404435270 rs746765941	44	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA9255031 rs777440115	44	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA9255032 rs746765941	44	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA9255033 rs757170936	45	P>S		No	ClinGen ExAC TOPMed gnomAD
rs745777166 CA305680248	46	A>P		No	ClinGen ExAC gnomAD
CA9255035 rs745777166	46	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1214757084 CA404435283	47	R>C		No	ClinGen TOPMed gnomAD
rs1462315926 CA404435286	47	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	49	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9255038 rs11539238	50	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA305680271 rs774492919	50	L>H		No	ClinGen Ensembl
CA305680262 rs11539238	50	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9255039 rs768867355	51	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9255040 COSM1228869 rs774603707	51	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1285860324 CA404435347	56	G>S		No	ClinGen gnomAD
rs761179115 CA404435360	57	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1568430090 CA404435380	61	D>N		No	ClinGen Ensembl
rs1474985924 CA404435396	63	D>N		No	ClinGen gnomAD
CA404435406 rs1343363113	64	V>I		No	ClinGen TOPMed
TCGA novel	70	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305680443 rs367952165	70	V>M		No	ClinGen ESP TOPMed gnomAD
rs763488501 CA9255067	72	T>I		No	ClinGen ExAC
CA9255069 rs761366209	73	T>M		No	ClinGen ExAC gnomAD
CA404435567 rs1191862746	74	A>V		No	ClinGen TOPMed
rs767425463 CA9255070	75	T>A		No	ClinGen ExAC gnomAD
CA404435667 rs1391607537	78	F>L		No	ClinGen gnomAD
CA404435672 rs200985373	79	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9255072 COSM991919 rs200985373	79	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA404435756 rs1237249707	83	A>S		No	ClinGen gnomAD
TCGA novel	84	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9255074 rs780101287	85	I>V		No	ClinGen ExAC gnomAD
CA404435886 rs1599500836	88	V>G		No	ClinGen Ensembl
rs575237431 CA9255076	89	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA404435905 rs545666123	89	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545666123 CA9255077	89	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA305680648 rs200657884	93	T>I		No	ClinGen Ensembl
rs757674268 CA9255101	94	E>K		No	ClinGen ExAC gnomAD
rs781406708 CA9255102	95	Y>C		No	ClinGen ExAC gnomAD
rs1426987679 CA404436083	96	A>P		No	ClinGen TOPMed
rs1426987679 CA404436085	96	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA404436091 rs1211545696 COSM1228870	96	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	98	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs865898754 CA305680692	99	L>F		No	ClinGen Ensembl
CA305680697 rs977191003	101	I>L		No	ClinGen TOPMed
CA305680710 rs773934673	103	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA404436176 rs1256092718	105	F>I		No	ClinGen TOPMed
rs1259041440 CA404436203	108	R>P		No	ClinGen gnomAD
rs1568430685 CA404436205	109	V>M		No	ClinGen Ensembl
rs1419523763 CA404436236	113	Y>C		No	ClinGen gnomAD
rs1568430717 CA404436242	114	G>C		No	ClinGen Ensembl
CA404436253 rs1305435732	115	H>Q		No	ClinGen TOPMed
CA404436250 rs1599501543	115	H>R		No	ClinGen Ensembl
rs1294543685 CA404436258	116	K>R		No	ClinGen TOPMed
CA404436267 rs1463368913	117	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA404436287 rs1334957118	118	D>E		No	ClinGen TOPMed gnomAD
rs929927050 CA305680734	118	D>V		No	ClinGen Ensembl
CA404436310 rs1349847583	120	T>M		No	ClinGen TOPMed gnomAD
rs1007090986 CA305680737	123	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA404436344 rs1239428852	123	R>W		No	ClinGen TOPMed gnomAD
CA9255110 rs766346435	124	H>L		No	ClinGen ExAC gnomAD
rs1402929106 CA404436367	125	T>A		No	ClinGen TOPMed
CA404436463 rs1281830928	130	A>S		No	ClinGen TOPMed gnomAD
rs1484517668 CA404436472	131	C>Y		No	ClinGen gnomAD
rs1599502275 CA404436482	132	I>M		No	ClinGen Ensembl
rs762871593 CA9255135	132	I>V		No	ClinGen ExAC gnomAD
CA9255136 rs764161947	135	S>L		No	ClinGen ExAC gnomAD
rs762045530 CA9255138	136	F>L		No	ClinGen ExAC gnomAD
rs1379053363 CA404436518 CA404436517	137	H>Q		No	ClinGen TOPMed gnomAD
CA404436529 rs1439618990	139	I>F		No	ClinGen gnomAD
rs1370748911 CA404436538	140	K>R		No	ClinGen TOPMed
rs767595944 CA9255139	141	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750628073 CA9255140	141	R>L		No	ClinGen ExAC gnomAD
CA9255144 rs755480303	144	E>D		No	ClinGen ExAC gnomAD
rs11539235 CA305680966	145	T>A		No	ClinGen Ensembl
TCGA novel	145	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1436591621 CA404436571	146	L>I		No	ClinGen gnomAD
rs1458829550 CA404436593	148	V>A		No	ClinGen TOPMed
rs370937224 CA404436590	148	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9255146 rs370937224	148	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1166383411 CA404436606	150	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9255147 rs770440447	151	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1218087242 CA404436627	152	S>F		No	ClinGen gnomAD
rs1356949234 CA404436636	153	H>L		No	ClinGen TOPMed
CA404436633 rs1273298187	153	H>Y		No	ClinGen gnomAD
CA404436640 rs1207148364	154	G>S		No	ClinGen gnomAD
CA404436658 rs1457554025	156	M>L		No	ClinGen gnomAD
rs1457554025 CA404436657	156	M>V		No	ClinGen gnomAD
CA9255149 rs769542618	157	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9255150 rs775199162	159	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775199162 CA404436681	159	R>G		No	ClinGen ExAC gnomAD
COSM117144 CA9255151 rs367816943	159	R>H	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA404436684 rs367816943	159	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1802169 CA9255152	162	F>L		No	ClinGen ExAC TOPMed gnomAD
CA404436714 rs1411858922	163	K>E		No	ClinGen TOPMed gnomAD
CA404436713 rs1411858922	163	K>Q		No	ClinGen TOPMed gnomAD
rs761840297 CA9255154	163	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1599505622 CA404438243	164	N>H		No	ClinGen Ensembl
rs773191627 CA9255196	166	T>I		No	ClinGen ExAC gnomAD
CA9255197 rs747148593	167	Y>H		No	ClinGen ExAC gnomAD
CA404438342 rs1285391667	168	Y>C		No	ClinGen gnomAD
rs986505550 CA305681479	168	Y>N		No	ClinGen TOPMed
CA9255199 rs777048560	170	G>C		No	ClinGen ExAC TOPMed gnomAD
rs765698953 CA9255201	172	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1254293613 CA404438391	173	A>T		No	ClinGen gnomAD
rs1441657130 CA404438396	173	A>V		No	ClinGen gnomAD
rs1395169379 CA404438485	184	Y>D		No	ClinGen gnomAD
rs1158826581 CA404438497	185	T>I		No	ClinGen TOPMed
CA9255207 rs760228540	186	P>S		No	ClinGen ExAC TOPMed gnomAD
CA404438501 rs760228540	186	P>T		No	ClinGen ExAC TOPMed gnomAD
rs765862753 CA9255208	187	P>H		No	ClinGen ExAC TOPMed gnomAD
rs765862753 CA404438513	187	P>L		No	ClinGen ExAC TOPMed gnomAD
CA404438512 rs765862753	187	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1271051567 CA404438518	188	T>A		No	ClinGen TOPMed
CA9255229 rs753329257	188	T>N		No	ClinGen ExAC
rs764909052 CA9255231	189	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs758229620 CA9255233	190	G>E		No	ClinGen ExAC gnomAD
CA404438541 rs1315867683	190	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA404438549 rs1478197074	191	A>D		No	ClinGen TOPMed
CA305681739 rs777367114	196	L>M		No	ClinGen ExAC gnomAD
CA404438598 rs1189016830 COSM1228868	199	A>T	Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9255237 rs781472725	200	I>S		No	ClinGen ExAC gnomAD
CA404438605 rs1470198351	200	I>V		No	ClinGen gnomAD
CA404438622 rs1203523753	202	V>A		No	ClinGen gnomAD
CA404438650 rs1165336013	204	C>W		No	ClinGen TOPMed gnomAD
CA404438653 rs1407972406	205	Q>*		No	ClinGen TOPMed
CA9255248 COSM3772518 rs775216128	208	N>S	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9255249 rs775216128	208	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1264753206 CA404438684	209	F>L		No	ClinGen gnomAD
CA9255250 rs764010266	213	M>V		No	ClinGen ExAC gnomAD
rs1385061666 CA404438719	214	A>V		No	ClinGen TOPMed gnomAD
rs1016800878 CA305681910	216	R>Q		No	ClinGen TOPMed
rs1383359863 CA404438748	217	D>E		No	ClinGen gnomAD
rs1236990027 CA404438763	219	R>Q		No	ClinGen TOPMed
rs369073436 CA9255252	221	A>D		No	ClinGen ESP ExAC gnomAD
TCGA novel	224	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	224	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378564126 CA404438811	225	T>M		No	ClinGen gnomAD
CA9255273 rs750389418	226	R>W		No	ClinGen ExAC gnomAD
CA9255275 rs766536818	229	P>S		No	ClinGen ExAC gnomAD
rs1599507591 CA404438841	230	Y>S		No	ClinGen Ensembl
CA404438847 rs1374040102	231	P>A		No	ClinGen gnomAD
CA404438857 rs1172373426	232	T>S		No	ClinGen TOPMed
TCGA novel	233	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404438862 rs1448918355	233	K>R		No	ClinGen gnomAD
CA404438871 rs1599507618	234	N>T		No	ClinGen Ensembl
CA404438886 rs1599507639	236	F>L		No	ClinGen Ensembl
rs1352371127 CA404438892	237	T>M		No	ClinGen gnomAD
rs1310046574 CA404438928	243	V>L		No	ClinGen gnomAD
TCGA novel	243	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404438938 rs1163959161	244	S>Y		No	ClinGen TOPMed
rs1354387493 CA404438965	248	Y>C		No	ClinGen gnomAD
rs758771173 CA9255280	249	T>A		No	ClinGen ExAC gnomAD
rs1188461250 CA404439035	257	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1449958806 CA404439050	259	A>T		No	ClinGen gnomAD
CA9255311 rs760415972	259	A>V		No	ClinGen ExAC gnomAD
rs1417017101 CA404439056	260	I>V		No	ClinGen gnomAD
rs1264225416 CA404439086	264	C>R		No	ClinGen gnomAD
rs1185059852 CA404439089	264	C>S		No	ClinGen TOPMed
CA404439093 rs1489393529	265	L>F		No	ClinGen gnomAD
CA404439146 rs1276260764	271	S>C		No	ClinGen gnomAD
CA404439145 rs1276260764	271	S>F		No	ClinGen gnomAD
CA404439147 rs1276260764	271	S>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1179209770 CA404439152	272	L>R		No	ClinGen gnomAD
CA404439163 rs1329720150	274	G>A		No	ClinGen TOPMed
CA305682700 rs928402871	275	F>I		No	ClinGen TOPMed gnomAD
rs1377915473 CA404439177	276	T>I		No	ClinGen gnomAD
rs1467252503 CA404439193	278	M>I		No	ClinGen gnomAD
CA305682706 rs959803672	278	M>L		No	ClinGen TOPMed
rs757991417 CA9255341	280	I>S		No	ClinGen ExAC TOPMed gnomAD
rs1332658610 CA404439214	281	W>C		No	ClinGen gnomAD
CA305682735 rs964867376	282	A>V		No	ClinGen Ensembl
TCGA novel	284	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404439228 rs1158790131	284	G>S		No	ClinGen TOPMed
rs1306368190 CA404439234	285	K>E		No	ClinGen gnomAD
CA9255344 rs539503764	287	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA9255343 rs539503764	287	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA404439251 rs1235700606	287	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs745697598 CA9255347	288	S>R		No	ClinGen ExAC TOPMed gnomAD
rs780892632 CA9255345	288	S>T		No	ClinGen ExAC gnomAD
rs1199013603 CA404439264	289	Y>F		No	ClinGen gnomAD
rs566728357 CA9255349	294	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs749158547 CA9255348	294	R>W		No	ClinGen ExAC gnomAD
rs371148869 CA305682801	298	P>L		No	ClinGen gnomAD
CA404439331 rs1376668265	298	P>S		No	ClinGen gnomAD
CA9255352 rs767746955	299	L>P		No	ClinGen ExAC gnomAD
CA404439344 rs1171794910	299	L>V		No	ClinGen gnomAD
CA9255353 rs773524852	300	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9255354 rs761141551	301	M>T		No	ClinGen ExAC gnomAD
CA404439397 rs1388541153	302	P>H		No	ClinGen gnomAD
rs1391581665 CA404439391	302	P>S		No	ClinGen gnomAD
TCGA novel	303	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404439456 rs1568434752	305	P>L		No	ClinGen Ensembl

1 associated diseases with Q9NZ01

[MIM: 614020]: Intellectual developmental disorder, autosomal recessive 14 (MRT14)

A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:21212097, ECO:0000269|PubMed:24220030}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:21212097, ECO:0000269|PubMed:24220030}. Note=The disease is caused by variants affecting the gene represented in this entry.

1 regional properties for Q9NZ01

Type	Name	Position	InterPro Accession
domain	3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal	155 - 308	IPR001104

Functions

		Description
EC Number	1.3.1.93	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
very-long-chain enoyl-CoA reductase activity	Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA.
very-long-chain-acyl-CoA dehydrogenase activity	Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized = a very-long-chain (2E)-enoyl-CoA + reduced

4 GO annotations of biological process

Name	Definition
fatty acid elongation	The elongation of a fatty acid chain by the sequential addition of two-carbon units.
long-chain fatty-acyl-CoA biosynthetic process	The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
sphingolipid metabolic process	The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
very long-chain fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BFZ1	Tecrl	Trans-2,3-enoyl-CoA reductase-like	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MKHYEVEILD	AKTREKLCFL	DKVEPHATIA	EIKNLFTKTH	PQWYPARQSL	RLDPKGKSLK
70	80	90	100	110	120
DEDVLQKLPV	GTTATLYFRD	LGAQISWVTV	FLTEYAGPLF	IYLLFYFRVP	FIYGHKYDFT
130	140	150	160	170	180
SSRHTVVHLA	CICHSFHYIK	RLLETLFVHR	FSHGTMPLRN	IFKNCTYYWG	FAAWMAYYIN
190	200	210	220	230	240
HPLYTPPTYG	AQQVKLALAI	FVICQLGNFS	IHMALRDLRP	AGSKTRKIPY	PTKNPFTWLF
250	260	270	280	290	300
LLVSCPNYTY	EVGSWIGFAI	MTQCLPVALF	SLVGFTQMTI	WAKGKHRSYL	KEFRDYPPLR

MPIIPFLL