Q8BFZ1

PR
Gene name
Tecrl (Srd5a2l2)
Protein name
Trans-2,3-enoyl-CoA reductase-like
Names
Steroid 5-alpha-reductase 2-like 2 protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:243078
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BFZ1

Entry ID Method Resolution Chain Position Source
AF-Q8BFZ1-F1 Predicted AlphaFoldDB

15 variants for Q8BFZ1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3395828676 9 E>* No EVA
rs258032798 28 A>T No EVA
rs31631993 28 A>V No EVA
rs3388768334 107 E>D No EVA
rs260586578 114 R>K No EVA
rs3388755849 163 S>N No EVA
rs251787298 173 T>S No EVA
rs31632835 185 F>C No EVA
rs3395750824 185 F>E No EVA
rs233887638 195 L>V No EVA
rs3395837350 197 L>M No EVA
rs3388760844 229 M>L No EVA
rs3388753094 243 F>I No EVA
rs235069512 253 I>L No EVA
rs225352053 340 K>N No EVA

No associated diseases with Q8BFZ1

1 regional properties for Q8BFZ1

Type Name Position InterPro Accession
domain 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal 210 - 361 IPR001104

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

1 GO annotations of biological process

Name Definition
very long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NZ01 TECR Very-long-chain enoyl-CoA reductase Homo sapiens (Human) PR
10 20 30 40 50 60
MFKRHKSLER KRELLFQGLP QSTMKNNARN FHSLSQLVLS AGPLKTTTAV KHSKTTHFEI
70 80 90 100 110 120
EILDAHTRKQ ICIVDKVTQT STIHDVKQKF HKACPKWYPS RIGLQLEYGG PYLRDYITVQ
130 140 150 160 170 180
SVAASSIITL YFTDLGQQVG WTTVFLAEYS GPLLIYLLFY LRSSYIYDVK ESTRWPRHPV
190 200 210 220 230 240
VHLAFFCHCI HYIRLLLETL FVHKVSTGHS PMKNLIKGCA FYWGFTSWMA YYINHPRYTP
250 260 270 280 290 300
PSFGNRQVIV SAINFLFCEA GNHFINTVLA HPNHTGSNAC FPSPNYNPFT WLFFLVSCPN
310 320 330 340 350 360
YTYEIGSWIS FTVMTQTLPV GIFTILMTIQ MSLWARKKHK IYRKKFNSYV HRKSAIIPLI
L