AiPD: Autoinhibited Protein Database

Q9NWM0

Gene name	SMOX (C20orf16, SMO, UNQ3039/PRO9854)
Protein name	Spermine oxidase
Names	Polyamine oxidase 1, PAO-1, PAOh1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54498
EC number	1.5.3.16: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-49 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9NWM0

Entry ID	Method	Resolution	Source
7OXL	X-ray	240 A	PDB
7OY0	X-ray	209 A	PDB
AF-Q9NWM0-F1	Predicted		AlphaFoldDB

418 variants for Q9NWM0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs776144691 CA9751192	3	S>N		No	ClinGen ExAC gnomAD
rs759132180 CA9751193	6	S>P		No	ClinGen ExAC gnomAD
rs759132180 CA408138796	6	S>T		No	ClinGen ExAC gnomAD
rs755980359 CA408138813	7	S>C		No	ClinGen gnomAD
rs755980359 CA311052392	7	S>R		No	ClinGen gnomAD
CA9751194 rs138030828	7	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1481846199 CA408138879	9	D>H		No	ClinGen TOPMed
CA9751195 rs200004139	10	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408138900 rs200004139	10	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1158362889 CA408138921	11	A>G		No	ClinGen TOPMed gnomAD
CA408138918 rs1210830438	11	A>S		No	ClinGen TOPMed
rs1158362889 CA408138922	11	A>V		No	ClinGen TOPMed gnomAD
rs1600816398 CA408138960	13	D>A		No	ClinGen Ensembl
rs751519671 CA9751198	15	L>F		No	ClinGen ExAC gnomAD
CA408139058 rs1445629481	17	R>C		No	ClinGen gnomAD
rs138666566 CA9751199	17	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408139065 rs138666566	17	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763892702 CA311052496	18	G>C		No	ClinGen ExAC TOPMed gnomAD
rs763892702 CA9751202	18	G>S		No	ClinGen ExAC TOPMed gnomAD
COSM3963580 CA408139115 COSM3963579 rs1240159183	20	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
COSM1734501 CA408139110 rs1199337500 COSM1734502	20	R>W	pancreas Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	21	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs568692615 CA9751205	21	R>T		No	ClinGen 1000Genomes ExAC gnomAD
rs778043303 CA9751206	24	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs747481916 CA9751207	26	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9751208 rs771415602	26	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs777240060 CA311052581	28	V>L		No	ClinGen Ensembl
rs1600816483 CA408139351	29	V>G		No	ClinGen Ensembl
CA9751211 COSM3707773 COSM3707774 rs1555815236	32	A>T	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
CA311052633 rs954631668	34	L>F		No	ClinGen Ensembl
rs1253028821 CA408139621	39	A>V		No	ClinGen TOPMed
CA9751215 rs368649029	41	K>E		No	ClinGen ESP ExAC gnomAD
CA9751216 rs763986370	43	L>F		No	ClinGen ExAC gnomAD
CA9751217 rs763986370	43	L>I		No	ClinGen ExAC gnomAD
TCGA novel	44	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	47	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	49	T>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408139864 rs1380262910	49	T>M		No	ClinGen gnomAD
CA9751219 rs370952502	50	D>N		No	ClinGen ESP ExAC gnomAD
CA9751220 rs750300184	52	T>I		No	ClinGen ExAC gnomAD
CA9751221 rs755101351	55	E>G		No	ClinGen ExAC
CA408140031 rs1260031190	57	S>F		No	ClinGen gnomAD
rs765294854 CA9751222	57	S>P		No	ClinGen ExAC gnomAD
CA311052697 rs886262843	58	S>N		No	ClinGen Ensembl
CA408140064 rs1316172739	58	S>R		No	ClinGen gnomAD
CA9751223 rs139112875	60	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408140156 rs1179876191	63	R>C		No	ClinGen gnomAD
CA408140158 rs1179876191	63	R>G		No	ClinGen gnomAD
CA408140164 rs1255260823	63	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1478082284 CA408140175	64	V>M		No	ClinGen gnomAD
rs1195778914 CA408140206	65	Q>R		No	ClinGen gnomAD
rs1600816658 CA408140237	66	S>R		No	ClinGen Ensembl
CA311052728 rs768213792	69	L>R		No	ClinGen Ensembl
rs370365021 CA408141227 CA408141223	71	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141615452 CA408141235	72	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs141615452 CA9751246	72	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs141615452 CA9751245	72	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA311054734 rs374652818	72	A>V		No	ClinGen ESP TOPMed gnomAD
CA408141269 rs1366232539	73	T>I		No	ClinGen TOPMed
rs1466325645 CA408141347	75	E>D		No	ClinGen gnomAD
CA311054755 rs972488683	76	L>V		No	ClinGen Ensembl
CA408141568 rs1354770777	85	H>N		No	ClinGen gnomAD
rs150504374 CA311054766	85	H>R		No	ClinGen ESP gnomAD
rs750973072 CA9751249	89	I>V		No	ClinGen ExAC TOPMed gnomAD
CA311054815 rs867676554	90	Y>C		No	ClinGen Ensembl
CA408141733 rs1247897099	91	H>N		No	ClinGen gnomAD
CA9751250 rs756632480	92	L>V		No	ClinGen ExAC gnomAD
rs1190209335 CA408141841	95	A>T		No	ClinGen gnomAD
rs779734758 CA9751251	96	N>S		No	ClinGen ExAC TOPMed gnomAD
rs377708564 CA9751252	97	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1600819302 CA408141873	98	L>I		No	ClinGen Ensembl
CA311054890 rs764802450	100	E>K		No	ClinGen Ensembl
rs938873488 CA311054898	101	E>Q		No	ClinGen Ensembl
rs1015596749 CA311054915	104	D>N		No	ClinGen TOPMed gnomAD
CA9751254 rs564856867	105	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA9751255 rs747745458	107	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1325373749 CA408142138	107	R>H		No	ClinGen TOPMed gnomAD
rs371076115 CA9751256	108	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs186455590 CA9751257	109	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA408142158 rs1228757533	110	G>D		No	ClinGen gnomAD
CA408142154 rs1349718677	110	G>S		No	ClinGen gnomAD
CA9751258 rs760624917	111	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA311054950 rs949008536	111	R>H		No	ClinGen gnomAD
CA9751259 rs770811543	114	L>F		No	ClinGen ExAC gnomAD
rs776517863 CA9751260	117	K>N		No	ClinGen ExAC gnomAD
CA9751261 rs763069710	118	N>S		No	ClinGen ExAC gnomAD
CA408142216 rs1469948535	119	G>D		No	ClinGen gnomAD
CA311055003 rs375716040	120	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs375716040 CA9751262	120	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9751263 rs753048218	121	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1600819485 CA408142229	122	C>S		No	ClinGen Ensembl
rs1385610213 CA408142235	123	Y>H		No	ClinGen TOPMed
CA311055052 rs948889338	124	L>I		No	ClinGen TOPMed
rs767939611 CA9751265	125	T>S		No	ClinGen ExAC gnomAD
rs1448480627 CA408142254	126	N>D		No	ClinGen gnomAD
CA408142256 rs1285798823	126	N>S		No	ClinGen gnomAD
CA9751268 rs780749483	128	G>S		No	ClinGen ExAC TOPMed gnomAD
rs147730753 CA9751269	129	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs147730753 CA9751270	129	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA9751271 COSM1026921 COSM1026922 rs370515510	129	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA311055123 rs370515510	129	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370515510 CA408142274	129	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	130	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408142283 rs1442701128	131	I>V		No	ClinGen gnomAD
rs747846684 CA9751273	132	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9751272 rs747846684	132	P>R		No	ClinGen ExAC TOPMed gnomAD
CA9751275 rs746843739	135	V>M		No	ClinGen ExAC gnomAD
rs1187896378 CA408142314	136	V>I		No	ClinGen gnomAD
CA408142335 rs1424354310	138	E>D		No	ClinGen TOPMed gnomAD
rs770690584 CA9751276	140	S>G		No	ClinGen ExAC TOPMed gnomAD
rs140869535 CA311055207	140	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9751279 rs768785503	145	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs144934870 CA9751298	155	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9751297 rs542965046	155	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408143274 rs140225529	156	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9751299 rs772260115	156	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA9751301 COSM167013 COSM167014 rs760977109	157	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA9751303 rs377195026	161	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	163	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9751304 rs760116878	164	S>C		No	ClinGen ExAC gnomAD
rs1454036102 CA408143356	168	V>M		No	ClinGen gnomAD
rs753221843 CA9751306	169	G>W		No	ClinGen ExAC gnomAD
TCGA novel	170	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408143368 rs1443730574	170	V>L		No	ClinGen TOPMed
CA408143373 rs1157944535	171	F>V		No	ClinGen gnomAD
rs763589123 CA9751309	173	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1388006201 CA408143387	173	R>Q		No	ClinGen gnomAD
CA9751310 rs756844158	175	E>K		No	ClinGen ExAC gnomAD
CA408143409 rs1369765812	176	V>A		No	ClinGen gnomAD
rs750147048 COSM3405094 COSM3405093 CA9751312	177	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs562326806 CA9751313	177	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1026926 COSM1026925 CA408143449 rs1461074065	179	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs779907818 COSM178881 COSM178880 CA9751314	179	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA311060029 rs991090030	180	I>L		No	ClinGen TOPMed gnomAD
rs991090030 CA408143459	180	I>V		No	ClinGen TOPMed gnomAD
CA408143512 rs1600824735	183	D>A		No	ClinGen Ensembl
rs370313611 CA9751316	184	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs749239484 CA9751315	184	P>T		No	ClinGen ExAC
rs747253706 CA9751318	186	D>H		No	ClinGen ExAC gnomAD
CA9751319 rs747253706	186	D>N		No	ClinGen ExAC gnomAD
TCGA novel	187	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468170400 CA408143611	190	T>A		No	ClinGen gnomAD
CA311060088 rs914250918	191	K>E		No	ClinGen Ensembl
CA408143644 rs147947595	192	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201599922 CA9751321	192	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201599922 CA408143649	192	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9751320 rs147947595	192	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770180676 CA9751322	195	L>F		No	ClinGen ExAC gnomAD
COSM1740682 CA9751325 rs372589961 COSM1740681	196	A>S	thyroid haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA9751324 rs372589961	196	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA408143770 rs1160922309	198	I>F		No	ClinGen gnomAD
CA408143852 rs1170718899	201	Y>C		No	ClinGen Ensembl
CA311060270 rs981640735	207	C>Y		No	ClinGen Ensembl
rs766104598 CA9751348	208	E>D		No	ClinGen ExAC gnomAD
rs1260547374 CA408144120	209	S>G		No	ClinGen TOPMed
rs1305957463 CA408144209	212	H>Q		No	ClinGen gnomAD
CA408144234 rs1227011365	214	M>T		No	ClinGen gnomAD
CA9751352 rs752664921	216	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA408144287 rs1488603338	218	S>F		No	ClinGen gnomAD
COSM1026928 CA408144315 rs1427502871 COSM1026927	221	A>T	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA408144345 rs1378502623	223	G>R		No	ClinGen gnomAD
rs749693796 CA9751358	227	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs987012222 CA311060299	229	P>A		No	ClinGen TOPMed
CA408144460 rs1401191212	230	G>D		No	ClinGen gnomAD
CA311060303 rs912776055	230	G>S		No	ClinGen TOPMed gnomAD
CA408144470 rs1159877938	231	A>G		No	ClinGen TOPMed
rs748652848 CA9751361	231	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9751363 rs771490241	234	I>V		No	ClinGen ExAC TOPMed gnomAD
CA9751365 rs760271089	237	S>L		No	ClinGen ExAC TOPMed gnomAD
rs759460337 CA9751368	240	M>T		No	ClinGen ExAC gnomAD
rs1485261503 CA408144547	241	R>Q		No	ClinGen gnomAD
rs765116817 CA9751369	241	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767516409 CA9751372	247	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1343445337 CA408144595	249	G>A		No	ClinGen gnomAD
rs1343445337 CA408144596	249	G>V		No	ClinGen gnomAD
CA311060385 rs968828254	250	I>V		No	ClinGen TOPMed
rs756116715 CA9751374	251	P>S		No	ClinGen ExAC gnomAD
rs1373427554 CA408144610	252	A>D		No	ClinGen gnomAD
CA9751375 rs202222150	252	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1373427554 CA408144612	252	A>V		No	ClinGen gnomAD
CA9751378 rs374161474	253	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs749501428 CA9751376	253	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs748671422 CA9751379	254	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1316327990 CA408144627	255	I>T		No	ClinGen gnomAD
rs45622731 CA9751380	255	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9751382 rs141015711	262	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs776490148 CA9751384	262	R>H		No	ClinGen ExAC gnomAD
CA9751383 COSM4134562 COSM4134561 rs141015711	262	R>S	thyroid [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1252703582 CA408144677	263	C>F		No	ClinGen gnomAD
rs752255111 CA311060483	270	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA9751387 rs775375295	272	R>C		No	ClinGen ExAC gnomAD
CA9751388 rs145030123 COSM419391 COSM419392	272	R>H	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs145030123 CA408144773	272	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408144828 rs1462111747	277	E>K		No	ClinGen TOPMed
CA9751392 rs766443432	280	P>L		No	ClinGen ExAC TOPMed gnomAD
rs766443432 CA408144881	280	P>R		No	ClinGen ExAC TOPMed gnomAD
rs754067325 CA408144883	281	R>G		No	ClinGen ExAC TOPMed gnomAD
rs755137940 CA9751394	281	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs754067325 CA9751393	281	R>W		No	ClinGen ExAC TOPMed gnomAD
rs757930768 CA311060586	282	G>A		No	ClinGen TOPMed gnomAD
rs757930768 CA408144897	282	G>D		No	ClinGen TOPMed gnomAD
CA408144892 rs896377132	282	G>R		No	ClinGen TOPMed gnomAD
rs896377132 CA311060582	282	G>S		No	ClinGen TOPMed gnomAD
rs753023945 CA9751396	285	D>G		No	ClinGen ExAC gnomAD
rs887784765 CA408144941	285	D>H		No	ClinGen TOPMed gnomAD
CA311060615 rs887784765	285	D>N		No	ClinGen TOPMed gnomAD
rs1250439572 CA408144957	286	H>Y		No	ClinGen TOPMed
rs778398126 CA9751398	289	D>N		No	ClinGen ExAC TOPMed gnomAD
CA408145009 rs778398126	289	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs770476968 CA9751400	290	T>I		No	ClinGen ExAC gnomAD
CA408145028 rs770476968	290	T>N		No	ClinGen ExAC gnomAD
rs747463944 CA9751399	290	T>S		No	ClinGen ExAC gnomAD
CA311060661 rs747298185	292	E>K		No	ClinGen Ensembl
rs1006599301 CA311060662	293	G>D		No	ClinGen Ensembl
CA408145078 rs1568746924	294	G>D		No	ClinGen Ensembl
CA408145098 rs1470027651	297	G>E		No	ClinGen gnomAD
CA9751403 rs769530935	298	E>D		No	ClinGen ExAC gnomAD
CA9751402 rs371088693	298	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371088693 CA9751401	298	E>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408145122 rs6084654	301	R>L		No	ClinGen ExAC TOPMed gnomAD
CA311060714 rs6084654 VAR_059114	301	R>P		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
COSM380525 rs6084654 CA9751407	301	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9751406 COSM1026935 rs145014650	301	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs376767598 CA9751408	302	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs376767598 CA408145124	302	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs746816975	303	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761590852 CA9751409	303	G>D		No	ClinGen ExAC TOPMed gnomAD
CA9751410 rs201267857	304	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs746816975	304	R>Q	Variant assessed as Somatic; 4.899e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs1326562803 CA408145147	305	W>C		No	ClinGen gnomAD
CA408145176 rs1173416133	309	E>G		No	ClinGen TOPMed
CA9751412 rs759789277	311	W>C		No	ClinGen ExAC gnomAD
CA9751411 rs753870066	311	W>R		No	ClinGen ExAC gnomAD
CA9751413 rs765487941	312	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs74994690 CA311060770	317	C>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	318	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9751416 rs777931094	318	E>K		No	ClinGen ExAC gnomAD
rs1451656008 CA408145275	320	C>G		No	ClinGen TOPMed
rs1271249488 CA408145277	320	C>Y		No	ClinGen gnomAD
COSM1495082 rs199631589 CA9751417	322	L>P	kidney Variant assessed as Somatic; 4.781e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA9751418 rs757789023	324	P>A		No	ClinGen ExAC gnomAD
CA9751419 rs138153642	324	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs138153642 CA9751420	324	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs757789023 CA408145329	324	P>S		No	ClinGen ExAC gnomAD
rs769406294 CA9751421	325	A>V		No	ClinGen ExAC TOPMed gnomAD
CA408145360 rs920072700 CA311060831	326	D>E		No	ClinGen TOPMed gnomAD
rs768504967 CA9751424	332	V>M		No	ClinGen ExAC gnomAD
rs761835699 CA9751426 COSM1226883	333	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA408145466 rs1393298773	334	L>P		No	ClinGen TOPMed
VAR_036546	340	Q>K	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
rs1433268013 CA408145592	343	S>G		No	ClinGen TOPMed
rs976528719 CA408145640	346	R>G		No	ClinGen TOPMed gnomAD
rs143899175 CA9751431	346	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9751430 rs143899175	346	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs976528719 CA311060923	346	R>W		No	ClinGen TOPMed gnomAD
TCGA novel	347	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA311060943 rs1056120663	352	E>D		No	ClinGen TOPMed gnomAD
rs917615923 CA311060951	353	K>N		No	ClinGen TOPMed
rs751828784 CA9751434	353	K>R		No	ClinGen ExAC gnomAD
rs947941287 CA311060957	358	H>R		No	ClinGen TOPMed
CA9751436 rs376713573	359	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1026938 CA9751437 COSM1026939 rs148610229	359	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs148610229 CA408145812	359	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9751435 rs376713573	359	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408145867 rs1195217785	363	G>D		No	ClinGen gnomAD
CA9751443 rs747982196	366	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1398438150 CA408145938	368	I>V		No	ClinGen gnomAD
CA408145965 rs1317081399	369	F>L		No	ClinGen TOPMed gnomAD
rs147367771 CA9751446	373	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs769873295 CA9751447	375	P>S		No	ClinGen ExAC gnomAD
rs1400576613 CA408146090	377	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs77612978 CA311061118	377	W>G		No	ClinGen Ensembl
rs1156266405 CA408146106	379	P>A		No	ClinGen TOPMed
TCGA novel	380	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763266369 CA9751449	382	N>K		No	ClinGen ExAC gnomAD
CA408146170 rs1473301125	383	S>G		No	ClinGen TOPMed
CA408146189 rs1412116831	384	L>V		No	ClinGen TOPMed
rs1186776645 CA408146201	385	Q>*		No	ClinGen TOPMed
CA408146207 rs1261824433	385	Q>R		No	ClinGen gnomAD
CA9751450 rs764263169	387	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	390	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	391	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408146330 rs942313750	392	A>E		No	ClinGen TOPMed gnomAD
CA311061160 rs942313750	392	A>V		No	ClinGen TOPMed gnomAD
CA311061176 rs897854422	394	S>R		No	ClinGen Ensembl
rs767990257 CA9751453	395	H>Y		No	ClinGen ExAC gnomAD
rs1453568958 CA408146392	396	T>A		No	ClinGen TOPMed gnomAD
rs1365442931 CA408146406	397	L>V		No	ClinGen gnomAD
rs1157442346 CA408146454	400	P>A		No	ClinGen gnomAD
CA408146470 rs1462641508	401	P>S		No	ClinGen gnomAD
TCGA novel	404	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA311061225 rs997497140	406	R>C		No	ClinGen TOPMed
CA9751459 rs778483532	408	I>T		No	ClinGen ExAC gnomAD
CA408146580 rs1232868800	408	I>V		No	ClinGen gnomAD
CA9751461 rs558532128	410	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1338006030 CA408146662	412	D>G		No	ClinGen gnomAD
rs144794871 CA9751465	416	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9751464 rs770732127	416	P>S		No	ClinGen ExAC gnomAD
CA408146753 rs1468243315	418	E>D		No	ClinGen gnomAD
COSM1026940 rs774503562 CA9751468 COSM1026941	419	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA9751469 rs762061401	419	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA408146765 rs139432235	420	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA408146767 rs1417875745	421	G>S		No	ClinGen gnomAD
CA408146777 rs1475893481	422	H>R		No	ClinGen gnomAD
rs1021460925 CA311061282	427	W>*		No	ClinGen Ensembl
rs754351934 CA9751474	430	G>E		No	ClinGen ExAC gnomAD
rs764734071 CA9751476	434	L>F		No	ClinGen ExAC gnomAD
CA9751477 rs150061281	435	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs150061281 CA9751478	435	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA408146872 rs1228468849	436	M>I		No	ClinGen gnomAD
CA9751480 CA408146865 rs751394002	436	M>L		No	ClinGen ExAC gnomAD
rs751394002 CA408146866	436	M>V		No	ClinGen ExAC gnomAD
rs1337217116 CA408146883	438	K>*		No	ClinGen gnomAD
rs1600826540 CA408146886	438	K>M		No	ClinGen Ensembl
CA408146887 rs757052740 CA9751481	438	K>N		No	ClinGen ExAC gnomAD
CA408146892 rs781048374	439	C>F		No	ClinGen ExAC gnomAD
rs1600826572 CA408146894	439	C>W		No	ClinGen Ensembl
rs781048374 CA9751482	439	C>Y		No	ClinGen ExAC gnomAD
rs745813389 CA9751483	440	D>H		No	ClinGen ExAC gnomAD
rs745813389 CA408146895	440	D>N		No	ClinGen ExAC gnomAD
rs1600826608 CA408146913	442	E>A		No	ClinGen Ensembl
CA408146910 rs1428678929	442	E>K		No	ClinGen gnomAD
rs1172110586 CA408146919	443	A>P		No	ClinGen gnomAD
CA9751485 rs779079367	445	A>S		No	ClinGen ExAC
rs965098133 CA311061364	447	I>M		No	ClinGen Ensembl
CA9751487 rs145064074	447	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs773539301 CA9751488	448	C>S		No	ClinGen ExAC
rs1376570567 CA408146950	448	C>Y		No	ClinGen TOPMed gnomAD
rs1353288563 CA408146956	449	T>A		No	ClinGen gnomAD
CA408146958 rs200727159	449	T>K		No	ClinGen ExAC TOPMed gnomAD
CA9751489 rs200727159	449	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs777005039 CA9751491	451	M>T		No	ClinGen ExAC gnomAD
CA9751493 rs199700652	453	R>C		No	ClinGen ExAC TOPMed gnomAD
rs752161137 CA9751494	453	R>H		No	ClinGen ExAC TOPMed gnomAD
CA9751495 rs762416365	456	T>A		No	ClinGen ExAC gnomAD
CA408147036 rs1420253080 COSM1026942 COSM1026943	459	P>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1161312789 CA408147043	460	N>S		No	ClinGen gnomAD
rs1456861734 CA408147049	461	I>V		No	ClinGen gnomAD
rs1397048412 CA408147075	465	R>Q		No	ClinGen gnomAD
rs1014534074 CA311062161	465	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs753767021 CA9751523	466	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1274081760 CA408147092	468	L>S		No	ClinGen gnomAD
rs534746380 CA311062166	469	R>C		No	ClinGen 1000Genomes TOPMed gnomAD
CA9751524 rs758552152	469	R>H		No	ClinGen ExAC gnomAD
CA9751525 rs777990952	470	S>L		No	ClinGen ExAC TOPMed gnomAD
CA9751528 rs140594899	471	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	473	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145492779 CA9751531	476	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs6037782 CA9751532	476	P>H		No	ClinGen ExAC TOPMed gnomAD
rs6037782 CA311062227	476	P>L		No	ClinGen ExAC TOPMed gnomAD
rs145492779 CA9751529	476	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145492779 CA9751530	476	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9751534 rs201219336	477	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA9751533 rs201219336	477	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
CA408147145 rs201219336	477	Y>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1246510275 CA408147155	478	F>L		No	ClinGen gnomAD
rs145519721 CA9751535	479	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767227934 CA9751536	479	R>H		No	ClinGen ExAC gnomAD
CA9751538 rs760556639	480	G>S		No	ClinGen ExAC TOPMed gnomAD
CA408147184 rs1162330172	483	S>L		No	ClinGen TOPMed
rs754948708 CA9751541	485	T>A		No	ClinGen ExAC gnomAD
CA9751542 rs764313286	485	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1188148140 CA408147213	488	G>S		No	ClinGen TOPMed
CA408147225 rs1446370390	490	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA408147224 rs1446370390	490	S>G		No	ClinGen TOPMed
TCGA novel	491	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408147231 rs1330034249	491	G>R		No	ClinGen TOPMed
CA311062306 rs1049711750	492	A>G		No	ClinGen TOPMed gnomAD
rs781491758 CA9751545	492	A>S		No	ClinGen ExAC TOPMed gnomAD
CA408147239 rs1049711750	492	A>V		No	ClinGen TOPMed gnomAD
CA408147252 rs1600827682	494	V>G		No	ClinGen Ensembl
rs1294645351 COSM478174 COSM478175 CA408147249	494	V>M	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs780383074 COSM1026947 CA9751548 COSM1026946	495	E>D	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1227412872 CA408147274	497	L>R		No	ClinGen gnomAD
rs749842121 CA9751549	499	K>R		No	ClinGen ExAC gnomAD
CA408147301 rs1430576325	502	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA311062320 rs1005183806	502	P>S		No	ClinGen Ensembl
rs779246435 CA9751551	504	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9751553 rs771422876	505	E>Q		No	ClinGen ExAC gnomAD
rs772918286 CA9751554	506	S>R		No	ClinGen ExAC
CA408147350 rs1188690027	509	T>I		No	ClinGen TOPMed gnomAD
CA408147354 rs760395151	510	A>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	510	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760395151 CA9751555	510	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780837040 CA408147587	512	M>R		No	ClinGen ExAC TOPMed gnomAD
rs780837040 CA9751609	512	M>T		No	ClinGen ExAC TOPMed gnomAD
rs745584278 CA9751610	513	Q>E		No	ClinGen ExAC gnomAD
CA311065035 rs1021263162	514	V>L		No	ClinGen TOPMed
CA408147618 rs1568750987	517	S>A		No	ClinGen Ensembl
rs779717057 CA9751612	518	G>A		No	ClinGen ExAC gnomAD
CA408147624 rs779717057	518	G>D		No	ClinGen ExAC gnomAD
COSM1411891 COSM1411892 CA311065047 rs370133256	518	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
CA408147640 rs1600831604	521	T>P		No	ClinGen Ensembl
VAR_019531	522	H>Y		No	UniProt
COSM1026950 CA9751613 COSM1026949 rs749058005	523	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA9751614 rs768438474	523	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs774273790 CA9751615	525	Y>C		No	ClinGen ExAC gnomAD
rs748070472 CA9751616	527	S>F		No	ClinGen ExAC gnomAD
rs1162268652 CA408147702	530	H>R		No	ClinGen gnomAD
rs1457713610 CA408147706	531	G>S		No	ClinGen TOPMed gnomAD
rs1399202677 CA408147726	534	L>P		No	ClinGen gnomAD
rs1428421801 CA408147733	535	S>F		No	ClinGen gnomAD
CA408147736 COSM1226882 COSM1226881 rs1356192685	536	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs763234414 CA9751623	538	R>H		No	ClinGen ExAC gnomAD
CA9751622 rs763234414	538	R>L		No	ClinGen ExAC gnomAD
rs138039387 CA9751624	542	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs566360232 COSM1681520 CA9751625 COSM1681521	542	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA9751627 rs749931058	546	M>R		No	ClinGen ExAC TOPMed gnomAD
CA408147811 rs1600831757	547	Y>*		No	ClinGen Ensembl
rs1486356842 CA408147809	547	Y>C		No	ClinGen gnomAD
rs755601734 CA9751628	548	R>G		No	ClinGen ExAC gnomAD
rs376839763 CA311065169	548	R>Q		No	ClinGen gnomAD
rs1555817124 CA408147821	549	D>G		No	ClinGen Ensembl
CA311065181 rs915068966	550	L>F		No	ClinGen Ensembl
rs1428773426 CA408147826	550	L>H		No	ClinGen TOPMed gnomAD
rs1448144965 CA408147860	555	T>A		No	ClinGen gnomAD
rs1448144965 CA408147859	555	T>P		No	ClinGen gnomAD
rs1376667238 CA408147866	556	T>R		No	ClinGen TOPMed gnomAD

No associated diseases with Q9NWM0

4 regional properties for Q9NWM0

Type	Name	Position	InterPro Accession
domain	K Homology domain	154 - 252	IPR004087
domain	K Homology domain, type 1	158 - 214	IPR004088
domain	Sam68, tyrosine-rich domain	366 - 415	IPR032335
domain	KHDRBS, Qua1 domain	102 - 153	IPR032571

Functions

		Description
EC Number	1.5.3.16	With oxygen as acceptor
Subcellular Localization	[Isoform 1]: Cytoplasm Nucleus ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity	Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide.
norspermine:oxygen oxidoreductase activity	Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
polyamine oxidase activity	Catalysis of the oxidative degradation or interconversion of polyamines.
spermine:oxygen oxidoreductase (spermidine-forming) activity	Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine.

4 GO annotations of biological process

Name	Definition
polyamine biosynthetic process	The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.
polyamine catabolic process	The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
spermine catabolic process	The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8NB78	KDM1B	Lysine-specific histone demethylase 2	Homo sapiens (Human)	PR
O60341	KDM1A	Lysine-specific histone demethylase 1A	Homo sapiens (Human)	PR
Q6ZQ88	Kdm1a	Lysine-specific histone demethylase 1A	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MQSCESSGDS	ADDPLSRGLR	RRGQPRVVVI	GAGLAGLAAA	KALLEQGFTD	VTVLEASSHI
70	80	90	100	110	120
GGRVQSVKLG	HATFELGATW	IHGSHGNPIY	HLAEANGLLE	ETTDGERSVG	RISLYSKNGV
130	140	150	160	170	180
ACYLTNHGRR	IPKDVVEEFS	DLYNEVYNLT	QEFFRHDKPV	NAESQNSVGV	FTREEVRNRI
190	200	210	220	230	240
RNDPDDPEAT	KRLKLAMIQQ	YLKVESCESS	SHSMDEVSLS	AFGEWTEIPG	AHHIIPSGFM
250	260	270	280	290	300
RVVELLAEGI	PAHVIQLGKP	VRCIHWDQAS	ARPRGPEIEP	RGEGDHNHDT	GEGGQGGEEP
310	320	330	340	350	360
RGGRWDEDEQ	WSVVVECEDC	ELIPADHVIV	TVSLGVLKRQ	YTSFFRPGLP	TEKVAAIHRL
370	380	390	400	410	420
GIGTTDKIFL	EFEEPFWGPE	CNSLQFVWED	EAESHTLTYP	PELWYRKICG	FDVLYPPERY
430	440	450	460	470	480
GHVLSGWICG	EEALVMEKCD	DEAVAEICTE	MLRQFTGNPN	IPKPRRILRS	AWGSNPYFRG
490	500	510	520	530	540
SYSYTQVGSS	GADVEKLAKP	LPYTESSKTA	PMQVLFSGEA	THRKYYSTTH	GALLSGQREA
550
ARLIEMYRDL	FQQGT