AiPD: Autoinhibited Protein Database

Q9NR21

Gene name	PARP11
Protein name	Protein mono-ADP-ribosyltransferase PARP11
Names	ADP-ribosyltransferase diphtheria toxin-like 11, ARTD11, Poly [ADP-ribose] polymerase 11, PARP-11
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57097
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-92 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9NR21

Entry ID	Method	Resolution	Chain	Position	Source
2DK6	NMR	-	A	22-110	PDB
AF-Q9NR21-F1	Predicted				AlphaFoldDB

258 variants for Q9NR21

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA383659837 rs1232777786	4	A>V		No	ClinGen gnomAD
rs972436066 CA232077245	6	P>T		No	ClinGen TOPMed gnomAD
rs781743199 CA383659428	7	E>K		No	ClinGen ExAC TOPMed gnomAD
rs781743199 CA6395110	7	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs769023310 CA6395109	8	M>L		No	ClinGen ExAC gnomAD
rs1228339459 CA383659404	10	H>N		No	ClinGen gnomAD
rs200615337 CA6395107	12	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA383659385 rs1212636965	12	A>V		No	ClinGen gnomAD
rs75962260 CA232072320	13	E>D		No	ClinGen Ensembl
rs142910026 CA6395105	14	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs148563477 CA6395104	14	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1001268814 CA232072319	16	F>L		No	ClinGen Ensembl
rs752123367 CA6395102	18	K>R		No	ClinGen ExAC gnomAD
CA232072318 rs756510557	20	T>R		No	ClinGen TOPMed gnomAD
TCGA novel	21	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759354996 CA6395100	22	N>H		No	ClinGen ExAC gnomAD
CA383659316 rs1365351473	23	E>Q		No	ClinGen TOPMed
rs751363235 CA6395099	25	D>G		No	ClinGen ExAC TOPMed gnomAD
CA383659291 rs1467529318	26	D>Y		No	ClinGen gnomAD
rs762727764 CA6395097	27	M>I		No	ClinGen ExAC gnomAD
rs766107782 CA6395098	27	M>V		No	ClinGen ExAC gnomAD
CA6395095 rs769972983	29	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769972983 CA383659264	29	T>R		No	ClinGen ExAC TOPMed gnomAD
rs747414834 CA232072317	35	G>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	35	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395091 rs747414834	35	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1308459762 CA383659186	38	Y>*		No	ClinGen gnomAD
rs1391515321 CA383659170	40	A>V		No	ClinGen gnomAD
rs1565537050 CA383659162	41	E>G		No	ClinGen Ensembl
rs1391355847 CA383659165	41	E>Q		No	ClinGen TOPMed
CA232072314 rs1035961475	43	G>E		No	ClinGen TOPMed gnomAD
rs1045176424 CA232072315	43	G>R		No	ClinGen Ensembl
rs780692222 CA6395090	44	K>R		No	ClinGen ExAC gnomAD
TCGA novel	46	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1173439584 CA383659095	49	Q>*		No	ClinGen gnomAD
CA6395086 rs149437678	49	Q>H		No	ClinGen ESP ExAC gnomAD
rs772632316 CA6395088	49	Q>L		No	ClinGen ExAC gnomAD
rs746254129 CA6395070	50	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1205573428 CA383659072	51	D>Y		No	ClinGen gnomAD
CA383659064 rs1349904476	52	T>A		No	ClinGen gnomAD
rs1234643789 CA383659057	53	N>D		No	ClinGen gnomAD
CA383659046 rs1188644419	54	S>N		No	ClinGen TOPMed
rs780885271 CA6395066	55	Q>K		No	ClinGen ExAC gnomAD
CA383659037 rs1242389841	55	Q>R		No	ClinGen TOPMed
rs1027830967 CA232072226	56	C>R		No	ClinGen TOPMed gnomAD
CA232072225 rs999690812	57	S>*		No	ClinGen TOPMed
rs1001175802 CA232072224	58	V>G		No	ClinGen TOPMed
CA6395065 rs754513051	59	S>N		No	ClinGen ExAC gnomAD
TCGA novel	61	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395062 rs968649802	63	I>M		No	ClinGen TOPMed gnomAD
CA6395064 rs137886893	63	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1382118309 CA383658966	64	E>A		No	ClinGen gnomAD
CA6395061 rs776066856	64	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1383467710 CA383658956	65	K>T		No	ClinGen gnomAD
CA383658932 rs1162558686	68	K>E		No	ClinGen gnomAD
rs1167168072 CA383658920	69	T>I		No	ClinGen gnomAD
rs1321318263 CA383658919	70	N>H		No	ClinGen TOPMed
CA6395060 rs758287056	70	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1163127614 CA383658908	71	P>L		No	ClinGen gnomAD
CA383658912 rs1341425830	71	P>S		No	ClinGen TOPMed
CA383658910 rs1341425830	71	P>T		No	ClinGen TOPMed
rs1476523526 CA383658896	73	G>R		No	ClinGen gnomAD
rs1052914196 CA232072221	74	S>T		No	ClinGen TOPMed
rs1591769520 CA383658886	75	I>L		No	ClinGen Ensembl
rs374976574 CA6395056	77	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1246157737 CA383658855	79	T>N		No	ClinGen gnomAD
CA232072220 rs890055563	80	S>T		No	ClinGen Ensembl
rs1272004036 CA383658834	82	F>L		No	ClinGen gnomAD
CA383658832 rs1226193361	83	S>G		No	ClinGen gnomAD
rs1341078870 CA383658829	83	S>T		No	ClinGen gnomAD
CA383658822 rs1591769466	84	Y>C		No	ClinGen Ensembl
CA6395055 rs754070697	85	K>T		No	ClinGen ExAC gnomAD
CA232072218 rs142750141	86	I>M		No	ClinGen ESP
TCGA novel	87	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA232072217 rs1051059747	88	F>L		No	ClinGen Ensembl
CA6395022 rs775107533	92	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1309869955 CA383658459	93	Q>H		No	ClinGen TOPMed
CA6395021 rs771634874	95	N>K		No	ClinGen ExAC gnomAD
TCGA novel	96	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233089064 CA383658406	101	Q>R		No	ClinGen gnomAD
CA6395019 rs778761342	102	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6395018 rs770853161	102	R>H		No	ClinGen ExAC TOPMed gnomAD
CA383658392 rs1282848269	103	L>F		No	ClinGen gnomAD
rs749068267 CA6395017	104	I>V		No	ClinGen ExAC gnomAD
rs777556914 CA6395016	106	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1178807249 CA383658361	108	P>R		No	ClinGen TOPMed
TCGA novel	109	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753028518 CA6395014	115	S>T		No	ClinGen ExAC gnomAD
CA383657782 rs1316997811	116	Y>*		No	ClinGen gnomAD
CA6394993 rs781614028	116	Y>C		No	ClinGen ExAC gnomAD
rs534914792 CA6394992	117	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs187071509 CA6394991	121	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780118516 CA6394990	122	A>G		No	ClinGen ExAC gnomAD
CA232071470 rs956054384	124	P>L		No	ClinGen TOPMed
CA16434717 rs1412012690	125	M>V		No	ClinGen TOPMed gnomAD
CA383657653 rs1242095146	127	P>L		No	ClinGen gnomAD
CA6394988 rs751003046	127	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	129	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA232071469 rs865826135	130	E>V		No	ClinGen Ensembl
CA6394987 rs765698455	133	N>H		No	ClinGen ExAC gnomAD
rs762209914 CA6394986	134	T>A		No	ClinGen ExAC gnomAD
CA383657567 rs1232837447	135	Q>*		No	ClinGen gnomAD
rs1159483719 CA383657538	137	P>A		No	ClinGen TOPMed
CA6394982 rs759160235	138	Y>C		No	ClinGen ExAC gnomAD
CA383657528 rs1405173786	138	Y>H		No	ClinGen TOPMed
CA6394981 rs773746009	139	Q>R		No	ClinGen ExAC gnomAD
CA6394970 rs745922688	140	L>F		No	ClinGen ExAC TOPMed gnomAD
rs779411527 CA6394969	140	L>H		No	ClinGen ExAC gnomAD
CA383657463 rs1226022041	141	I>M		No	ClinGen gnomAD
CA383657456 rs1591762691	142	P>R		No	ClinGen Ensembl
rs1373139996 CA383657458	142	P>S		No	ClinGen gnomAD
rs757717146 CA6394968	143	L>V		No	ClinGen ExAC TOPMed gnomAD
rs754206396 CA6394967	144	H>R		No	ClinGen ExAC gnomAD
rs1299593681 CA383657437	145	N>H		No	ClinGen TOPMed gnomAD
CA383657433 rs1370274803	145	N>K		No	ClinGen gnomAD
rs145879477 CA6394966	145	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA383657425 rs1167120178	146	Q>H		No	ClinGen gnomAD
rs765592829 CA232071462	147	T>A		No	ClinGen Ensembl
CA6394965 rs142135252	148	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6394964 rs142135252	148	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA383657410 rs1396248877	149	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA232071461 rs376223375	152	E>K		No	ClinGen ESP TOPMed gnomAD
rs765917945 CA6394963	153	V>L		No	ClinGen ExAC gnomAD
TCGA novel	156	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762575037 CA6394962	156	L>V		No	ClinGen ExAC gnomAD
CA6394961 rs373508149	157	F>I		No	ClinGen ESP ExAC
rs371221825 CA6394960	158	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1202810871 CA383657323	161	M>I		No	ClinGen gnomAD
rs776584439 CA6394958	162	D>N		No	ClinGen ExAC gnomAD
rs776584439 CA383657321	162	D>Y		No	ClinGen ExAC gnomAD
rs377497123 CA6394957	163	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6394956 rs746746559	163	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA383657307 rs775827919	164	N>S		No	ClinGen ExAC gnomAD
rs775827919 CA6394955	164	N>T		No	ClinGen ExAC gnomAD
rs886703518 CA232071460	165	R>*		No	ClinGen TOPMed gnomAD
CA232071459 rs762146923	165	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383657292 rs1345471568	167	K>*		No	ClinGen TOPMed
CA383657293 rs1345471568	167	K>E		No	ClinGen TOPMed
CA6394953 rs745974844	167	K>R		No	ClinGen ExAC TOPMed gnomAD
CA383657283 rs1417077072	168	R>I		No	ClinGen TOPMed gnomAD
CA383657284 rs1417077072	168	R>K		No	ClinGen TOPMed gnomAD
rs1376592827 CA383657276	169	I>T		No	ClinGen gnomAD
CA383657265 rs1278403229	171	R>G		No	ClinGen gnomAD
TCGA novel	171	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383657226 rs1464998067	176	D>G		No	ClinGen gnomAD
CA6394951 rs757774355	179	E>*		No	ClinGen ExAC gnomAD
rs1323721200 CA383657186	181	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA383658281 rs759695271	186	A>P		No	ClinGen ExAC gnomAD
rs759695271 CA6394932	186	A>T		No	ClinGen ExAC gnomAD
CA6394931 rs774543070	187	Q>R		No	ClinGen ExAC gnomAD
CA6394929 rs749334415	189	K>N		No	ClinGen ExAC gnomAD
rs887119577 CA232070641	189	K>R		No	ClinGen Ensembl
CA383658250 rs1363681386	190	K>N		No	ClinGen gnomAD
rs1417311474 CA383658253	190	K>R		No	ClinGen TOPMed
rs778394236 CA6394928	192	R>K		No	ClinGen ExAC
TCGA novel	192	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383658230 rs1441792761	193	G>D		No	ClinGen gnomAD
rs1305679184 CA383658235	193	G>S		No	ClinGen gnomAD
rs1441792761 CA383658232	193	G>V		No	ClinGen gnomAD
rs1362074219 CA383658221	195	P>S		No	ClinGen TOPMed
rs1321757583 CA383658197	198	N>I		No	ClinGen gnomAD
rs1395346450 CA383658194	199	E>*		No	ClinGen TOPMed
CA383658184 rs1411884149	200	Q>*		No	ClinGen gnomAD
rs1388302257 CA383658137	206	T>N		No	ClinGen gnomAD
CA383658116 rs1194943874	208	S>N		No	ClinGen gnomAD
rs1384657005 CA383658080	211	V>M		No	ClinGen TOPMed
CA6394923 rs201810855	212	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1245629180 CA383658073	212	E>K		No	ClinGen gnomAD
rs778707249 CA6394921	214	I>V		No	ClinGen ExAC TOPMed gnomAD
CA383658039 rs1213700923	215	C>R		No	ClinGen TOPMed
rs1252939337 CA383658032	215	C>Y		No	ClinGen TOPMed gnomAD
CA6394919 rs764119678	216	I>F		No	ClinGen ExAC gnomAD
CA6394918 rs764119678	216	I>V		No	ClinGen ExAC gnomAD
rs760459094 CA6394917	217	H>R		No	ClinGen ExAC gnomAD
CA383657999 rs1159173179	218	N>I		No	ClinGen gnomAD
rs1455553173 CA383657940	223	I>M		No	ClinGen gnomAD
rs752549212 CA6394916	224	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1039958043 CA232070637	227	H>R		No	ClinGen TOPMed gnomAD
CA232070638 rs894277353	227	H>Y		No	ClinGen Ensembl
CA6394915 rs767357669	228	G>D		No	ClinGen ExAC TOPMed gnomAD
CA383657898 rs1565529349	229	A>T		No	ClinGen Ensembl
CA6394914 rs775879028	230	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1331594125 CA383657146	236	Y>C		No	ClinGen TOPMed gnomAD
CA383657129 rs1565528722	238	A>V		No	ClinGen Ensembl
rs942477203 CA232070490	239	R>K		No	ClinGen TOPMed
rs1401993347 CA383657124	239	R>S		No	ClinGen gnomAD
rs752642991 CA6394896	240	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1157867431 CA383657115	241	A>T		No	ClinGen gnomAD
TCGA novel	245	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA232070489 rs866467165	246	R>C		No	ClinGen TOPMed
CA6394895 rs767408832	246	R>H		No	ClinGen ExAC gnomAD
CA383657066 rs1293268422	248	C>Y		No	ClinGen TOPMed
CA383657061 rs1182851082	249	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383657051 rs1591754674	250	D>Y		No	ClinGen Ensembl
CA6394894 rs754815849	251	D>G		No	ClinGen ExAC TOPMed gnomAD
rs751307986 CA383657037	252	I>L		No	ClinGen ExAC gnomAD
rs751307986 CA6394893	252	I>V		No	ClinGen ExAC gnomAD
CA383656991 rs1207003391	257	T>K		No	ClinGen gnomAD
TCGA novel	260	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773356131 CA6394890	261	H>R		No	ClinGen ExAC gnomAD
TCGA novel	262	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376430479 CA6394889	262	G>V		No	ClinGen ESP ExAC gnomAD
rs964634885 CA232070487	264	S>R		No	ClinGen Ensembl
rs1228720017 CA383656942	264	S>R		No	ClinGen gnomAD
CA6394888 rs761950257	268	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA383656916 rs1378325609	268	R>W		No	ClinGen TOPMed gnomAD
CA383656909 rs1388669648	269	H>R		No	ClinGen gnomAD
CA383656901 rs1319343812	270	L>R		No	ClinGen gnomAD
CA6394886 rs769234197	272	R>T		No	ClinGen ExAC gnomAD
CA383656886 rs1444194292	273	T>A		No	ClinGen TOPMed
rs1406086391 CA383656877	274	Y>C		No	ClinGen TOPMed
CA6394885 rs747406907	274	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA383656845 rs1405210657	278	F>C		No	ClinGen gnomAD
rs775926730 CA6394884	280	A>V		No	ClinGen ExAC gnomAD
rs770716873 CA6394883	281	R>*		No	ClinGen ExAC gnomAD
CA6394882 rs748949914	281	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs748949914 CA232070486	281	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA383656814 rs1437702736	284	I>T		No	ClinGen TOPMed
rs1186799156 CA383656805	286	D>N		No	ClinGen gnomAD
rs1186799156 CA383656803	286	D>Y		No	ClinGen gnomAD
rs747671113 CA6394879	288	I>V		No	ClinGen ExAC gnomAD
rs1320819779 CA383656762	291	D>E		No	ClinGen gnomAD
CA6394876 rs571551050	295	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs754871412 CA6394877	295	M>T		No	ClinGen ExAC gnomAD
CA6394875 rs375575295	296	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA383656732 rs375575295	296	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1296204230 CA383656731	296	R>Q		No	ClinGen gnomAD
rs867744639 CA232070484	298	P>L		No	ClinGen TOPMed
rs886121817 CA232070483	299	S>C		No	ClinGen Ensembl
rs1047912619 CA232070482	300	K>E		No	ClinGen gnomAD
rs771753451 CA232070481	301	D>A		No	ClinGen Ensembl
rs372428384 CA383656700 CA232070480	301	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6394873 rs747777856	302	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6394871 rs765469745	303	S>R		No	ClinGen ExAC gnomAD
CA383656682 rs1170909158	304	Y>F		No	ClinGen TOPMed gnomAD
CA6394867 rs761201225	308	Y>C		No	ClinGen ExAC gnomAD
rs538035117 CA6394868	308	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
CA6394866 rs368758168	311	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1473151020 CA383656625	312	V>A		No	ClinGen TOPMed
CA383656620 rs1487647947	313	D>G		No	ClinGen gnomAD
rs898631920 CA232070479	313	D>N		No	ClinGen Ensembl
CA6394865 rs772384248	314	D>N		No	ClinGen ExAC gnomAD
CA6394863 rs201874770	316	W>C		No	ClinGen 1000Genomes ExAC gnomAD
rs958800544 CA232070478	319	K>E		No	ClinGen TOPMed
CA6394860 rs747643710	321	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1160555238 CA383656566	321	F>L		No	ClinGen TOPMed
rs1385836174 CA383656552	323	V>F		No	ClinGen gnomAD
TCGA novel	325	D>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383656537 rs1565528386	325	D>G		No	ClinGen Ensembl
CA6394859 rs780613912	327	N>H		No	ClinGen ExAC TOPMed gnomAD
rs754923500 CA6394858	327	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1370477086 CA383656502	330	Y>C		No	ClinGen gnomAD
CA6394857 rs747008753	330	Y>N		No	ClinGen ExAC gnomAD
CA232070476 rs937574433	333	Y>C		No	ClinGen gnomAD
rs758169815 CA6394855	334	L>*		No	ClinGen ExAC gnomAD
CA6394854 rs750214060	336	D>N		No	ClinGen ExAC gnomAD
CA6394853 rs779031373	337	F>L		No	ClinGen ExAC gnomAD
CA383656447 rs1184079868	338	H>R		No	ClinGen gnomAD

No associated diseases with Q9NR21

2 regional properties for Q9NR21

Type	Name	Position	InterPro Accession
domain	WWE domain	22 - 106	IPR004170
domain	Poly(ADP-ribose) polymerase, catalytic domain	123 - 338	IPR012317

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nuclear pore complex	Colocalizes with NUP153 at nuclear pores
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
NAD+ ADP-ribosyltransferase activity	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
NAD+- protein-cysteine ADP-ribosyltransferase activity	Catalysis of the reaction: L-cysteinyl- + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-
NAD+- protein-lysine ADP-ribosyltransferase activity	Catalysis of the reaction: L-lysyl- + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-
NAD+-protein ADP-ribosyltransferase activity	Catalysis of the reaction: amino acyl- + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-

7 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nuclear envelope organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
protein auto-ADP-ribosylation	The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
protein mono-ADP-ribosylation	The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q7Z2W4	ZC3HAV1	Zinc finger CCCH-type antiviral protein 1	Homo sapiens (Human)	PR
Q3UPF5	Zc3hav1	Zinc finger CCCH-type antiviral protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MWEANPEMFH	KAEELFSKTT	NNEVDDMDTS	DTQWGWFYLA	ECGKWHMFQP	DTNSQCSVSS
70	80	90	100	110	120
EDIEKSFKTN	PCGSISFTTS	KFSYKIDFAE	MKQMNLTTGK	QRLIKRAPFS	ISAFSYICEN
130	140	150	160	170	180
EAIPMPPHWE	NVNTQVPYQL	IPLHNQTHEY	NEVANLFGKT	MDRNRIKRIQ	RIQNLDLWEF
190	200	210	220	230	240
FCRKKAQLKK	KRGVPQINEQ	MLFHGTSSEF	VEAICIHNFD	WRINGIHGAV	FGKGTYFARD
250	260	270	280	290	300
AAYSSRFCKD	DIKHGNTFQI	HGVSLQQRHL	FRTYKSMFLA	RVLIGDYING	DSKYMRPPSK
310	320	330
DGSYVNLYDS	CVDDTWNPKI	FVVFDANQIY	PEYLIDFH