Q9N425
Gene name |
csn-3 (Y38C1AA.2) |
Protein name |
COP9 signalosome complex subunit 3 |
Names |
Signalosome subunit 3 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_Y38C1AA.2 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9N425
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9N425-F1 | Predicted | AlphaFoldDB |
No variants for Q9N425
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9N425 | |||||
No associated diseases with Q9N425
1 regional properties for Q9N425
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Proteasome component (PCI) domain | 275 - 445 | IPR000717 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle switching | The process in which a cell switches cell cycle mode. |
| establishment of mitotic spindle localization | The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| negative regulation of ubiquitin protein ligase activity | Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. |
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
| regulation of oogenesis | Any process that modulates the frequency, rate or extent of oogenesis. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8W575 | CSN3 | COP9 signalosome complex subunit 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTFFNKLFT | GASSSSSAAA | SSGMDLGSME | SLCAAINELC | SEKHVSENVG | ELAAGIVRKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KELFEKKSND | VEAFLLHCSP | NVGSAAMVAA | IKGMFDTSAA | KNNETGTDRA | VELLNHYVDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNFVGGHLKL | VPEIIFPLLR | DVGLYCLEKK | NKPEIGQRII | MKALGSMFPR | NGSNAPNVLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAHGVLFACA | LETKDYASVE | PFIDLHVDEI | ANENCIQDQE | KSDNRERDFG | DVFLGRMKKG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAFGSQPVAH | NPHLHPKYVL | DYLYNGACIL | IELKRFEDAL | FLLEICVGMP | AFSVQDQHLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SFKKYVLISL | ILKGKVDVTE | NGDKSAIRHF | KTKSPEYKQF | SEIRFSRSSN | THSAVESLVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SAKDRLRKDG | NTEIAKYLVV | EMKKKTIMSL | TRMFTSIRIS | EIEELAFLKS | RDQVTELIGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVEEQRITVR | IDGDMVFWTE | LSPVPSKNDV | ENKIRIVDHL | NTLLHEKNTT | MKAGSGRMRP |
| 490 | 500 | ||||
| SVMYNEDEGL | SMPPTESKFF | S |