Q8W575
Gene name |
CSN3 (FUS11, At5g14250, F18O22.40) |
Protein name |
COP9 signalosome complex subunit 3 |
Names |
Signalosome subunit 3, Protein FUSCA 11 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G14250 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W575
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W575-F1 | Predicted | AlphaFoldDB |
28 variants for Q8W575
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03055372 | 15 | I>T | No | 1000Genomes | |
| ENSVATH06965457 | 25 | L>S | No | 1000Genomes | |
| tmp_5_4598049_C_T | 27 | A>V | No | 1000Genomes | |
| tmp_5_4598066_A_G | 33 | R>G | No | 1000Genomes | |
| tmp_5_4598106_A_G | 46 | N>S | No | 1000Genomes | |
| tmp_5_4598114_A_G | 49 | T>A | No | 1000Genomes | |
| tmp_5_4598130_A_G | 54 | D>G | No | 1000Genomes | |
| ENSVATH14024216 | 55 | A>T | No | 1000Genomes | |
| ENSVATH14024217 | 66 | L>I | No | 1000Genomes | |
| ENSVATH10742030 | 81 | Y>H | No | 1000Genomes | |
| tmp_5_4598402_C_G | 84 | P>R | No | 1000Genomes | |
| tmp_5_4598453_C_T | 101 | A>V | No | 1000Genomes | |
| ENSVATH06965463 | 102 | S>N | No | 1000Genomes | |
| tmp_5_4598600_A_T | 117 | I>L | No | 1000Genomes | |
| tmp_5_4598631_G_A | 127 | G>E | No | 1000Genomes | |
| ENSVATH00621557 | 131 | N>K | No | 1000Genomes | |
| ENSVATH00621558 | 138 | V>I | No | 1000Genomes | |
| tmp_5_4598694_C_T | 148 | P>L | No | 1000Genomes | |
| tmp_5_4598736_C_T | 162 | S>F | No | 1000Genomes | |
| ENSVATH06965467 | 170 | D>A | No | 1000Genomes | |
| tmp_5_4598802_G_C | 184 | S>T | No | 1000Genomes | |
| ENSVATH06965470 | 203 | L>H | No | 1000Genomes | |
| ENSVATH06965474 | 217 | A>G | No | 1000Genomes | |
| tmp_5_4599873_C_A | 320 | Q>K | No | 1000Genomes | |
| ENSVATH03055381 | 324 | N>S | No | 1000Genomes | |
| ENSVATH06965478 | 330 | N>S | No | 1000Genomes | |
| tmp_5_4599906_G_T | 331 | A>S | No | 1000Genomes | |
| tmp_5_4600374_A_T | 396 | S>C | No | 1000Genomes |
No associated diseases with Q8W575
1 regional properties for Q8W575
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Proteasome component (PCI) domain | 196 - 383 | IPR000717 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of G2/M transition of mitotic cell cycle | Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. |
| protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
| red, far-red light phototransduction | The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9N425 | csn-3 | COP9 signalosome complex subunit 3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIGAVNSVEA | VITSIQGLSG | SPEDLSALHD | LLRGAQDSLR | AEPGVNFSTL | DQLDASKHSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GYLYFLEVLT | CGPVSKEKAA | YEIPIIARFI | NSCDAGQIRL | ASYKFVSLCK | ILKDHVIALG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPLRGVGPLL | NAVQKLQVSS | KRLTALHPDV | LQLCLQAKSY | KSGFSILSDD | IVEIDQPRDF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLYSYYGGMI | CIGLKRFQKA | LELLYNVVTA | PMHQVNAIAL | EAYKKYILVS | LIHNGQFTNT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPKCASTAAQ | RSFKNYTGPY | IELGNCYNDG | KIGELEALVV | ARNAEFEEDK | NLGLVKQAVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLYKRNILRL | TQKYLTLSLQ | DIANMVQLGN | AKEAEMHVLQ | MIQDGQIHAL | INQKDGMVRF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LEDPEQYKSS | EMIEIMDSVI | QRTIGLSKNL | LAMDESLSCD | PLYLGKVGRE | RQRYDFGDDF |
| DTVPQKFSM |