Q9N0F3

PR
Gene name
SARS2 (SARSM)
Protein name
Serine--tRNA ligase, mitochondrial
Names
SerRSmt, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282060
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

80-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9N0F3

Entry ID Method Resolution Chain Position Source
1WLE X-ray 165 A A/B 35-518 PDB
AF-Q9N0F3-F1 Predicted AlphaFoldDB

170 variants for Q9N0F3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs459199866 16 R>P No EVA
rs443961474 18 L>P No EVA
rs461572558 19 R>W No EVA
rs441679494 21 R>* No EVA
rs474769341 21 R>P No EVA
rs434617891 25 V>D No EVA
rs434332642 26 C>W No EVA
rs209793152 28 Q>K No EVA
rs452262859 29 S>G No EVA
rs437086099 30 F>I No EVA
rs469792785 31 K>E No EVA
rs459208757 35 A>S No EVA
rs448231119 47 H>P No EVA
rs436482679 53 S>R No EVA
rs717192464 62 S>P No EVA
rs477406880 63 L>M No EVA
rs718020075 65 A>T No EVA
rs458956155 69 D>E No EVA
rs450397686 72 R>P No EVA
rs442963633 75 D>E No EVA
rs461537505 75 D>N No EVA
rs472783780 76 L>I No EVA
rs459411431 76 L>P No EVA
rs440914239 79 G>A No EVA
rs452025106 80 E>D No EVA
rs437050294 81 L>V No EVA
rs476361916 81 L>W No EVA
rs436152064 82 R>L No EVA
rs447727775 84 K>* No EVA
rs465352594 85 D>E No EVA
rs432476517 85 D>V No EVA
rs450149654 86 L>P No EVA
rs483017740 87 P>A No EVA
rs468026172 87 P>R No EVA
rs449514955 89 I>V No EVA
rs800440596 118 R>G No EVA
rs209240957 119 A>V No EVA
rs133133920 121 V>G No EVA
rs447252527 125 D>N No EVA
rs440808979 179 P>H No EVA
rs470395282 180 V>F No EVA
rs470395282 180 V>L No EVA
rs452318260 191 V>G No EVA
rs474225610 198 F>C No EVA
rs440667979 201 Q>H No EVA
rs455681482 201 Q>P No EVA
rs473549607 211 K>N No EVA
rs451881731 212 L>P No EVA
rs433383844 214 I>T No EVA
rs469578528 216 R>G No EVA
rs437655492 218 K>M No EVA
rs442264442 236 A>G No EVA
rs459897679 239 Q>K No EVA
rs801032502 256 T>I No EVA
rs441036034 258 M>R No EVA
rs470819139 267 V>F No EVA
rs455415343 270 E>G No EVA
rs440059505 273 G>W No EVA
rs451598958 274 M>I No EVA
rs472947283 274 M>R No EVA
rs433037781 275 T>P No EVA
rs457020308 281 S>Y No EVA
rs435346603 282 Q>K No EVA
rs468541752 284 Y>* No EVA
rs479874779 295 N>T No EVA
rs523280322 300 A>E No EVA
rs446333145 302 V>E No EVA
rs446333145 302 V>G No EVA
rs482633886 304 L>R No EVA
rs458049463 306 G>V No EVA
rs454970967 307 Y>S No EVA
rs436367178 308 F>V No EVA
rs466457933 309 M>R No EVA
rs447936639 310 D>A No EVA
rs432597587 311 H>P No EVA
rs465541104 312 S>A No EVA
rs465541104 312 S>P No EVA
rs445701210 314 A>S No EVA
rs481677169 317 D>A No EVA
rs481677169 317 D>G No EVA
rs469737444 345 V>G No EVA
rs448064813 346 H>N No EVA
rs438182361 351 V>G No EVA
rs454486560 352 E>G No EVA
rs436045923 356 V>G No EVA
rs465289583 364 S>G No EVA
rs449973917 373 S>P No EVA
rs482828755 380 T>A No EVA
rs449403150 385 H>R No EVA
rs479202543 387 R>Q No EVA
rs461765126 390 D>E No EVA
rs473831187 390 D>G No EVA
rs439981564 393 T>P No EVA
rs451562209 395 E>Q No EVA
rs432971128 397 G>A No EVA
rs475371766 398 L>Q No EVA
rs435605801 399 P>A No EVA
rs434762760 400 A>D No EVA
rs446846231 400 A>S No EVA
rs446332025 403 K>T No EVA
rs482425875 407 E>* No EVA
rs463905829 407 E>A No EVA
rs448696330 411 P>Q No EVA
rs480415388 413 R>L No EVA
rs461843744 416 F>L No EVA
rs440024861 416 F>L No EVA
rs461843744 416 F>V No EVA
rs470511820 419 V>A No EVA
rs455200787 420 T>S No EVA
rs436599761 421 S>R No EVA
rs466346623 422 A>D No EVA
rs446507015 423 S>F No EVA
rs479602994 425 C>W No EVA
rs464081173 427 D>A No EVA
rs445637413 438 Q>H No EVA
rs463505444 440 E>D No EVA
rs441873107 442 G>W No EVA
rs481284372 446 F>S No EVA
rs440985601 449 T>P No EVA
rs447551021 450 V>L No EVA
rs477210755 451 N>Y No EVA
rs449898192 453 T>P No EVA
rs461389023 456 A>S No EVA
rs442837312 457 V>A No EVA
rs472550332 458 P>L No EVA
rs460865520 460 L>F No EVA
rs439021308 460 L>P No EVA
rs471810246 462 I>L No EVA
rs456613692 465 L>R No EVA
rs438143474 466 E>* No EVA
rs476377423 467 S>C No EVA
rs436007104 467 S>R No EVA
rs454515440 467 S>T No EVA
rs465686841 469 Q>R No EVA
rs447589680 471 K>N No EVA
rs477981529 473 G>R No EVA
rs444652829 478 P>R No EVA
rs480856215 479 P>T No EVA
rs440582333 482 Q>E No EVA
rs472312428 482 Q>H No EVA
rs453800807 484 Y>S No EVA
rs722654519 486 G>S No EVA
rs438436406 487 T>S No EVA
rs456438142 489 R>P No EVA
rs437838143 490 I>L No EVA
rs467687573 490 I>M No EVA
rs455490639 491 T>P No EVA
rs466926040 492 T>P No EVA
rs466926040 492 T>S No EVA
rs445267743 492 T>S No EVA
rs433157875 493 P>L No EVA
rs469164323 494 T>P No EVA
rs469164323 494 T>S No EVA
rs450868719 496 V>G No EVA
rs447027607 498 L>H No EVA
rs447027607 498 L>R No EVA
rs479980212 500 Y>S No EVA
rs460248298 501 I>T No EVA
rs471393041 504 N>H No EVA
rs462592942 505 Q>P No EVA
rs474137282 506 P>H No EVA
rs444007700 506 P>S No EVA
rs433787532 507 Q>R No EVA
rs472969391 510 R>S No EVA
rs451696512 511 L>P No EVA
rs433297447 512 P>A No EVA
rs435551800 518 S>G No EVA
rs435551800 518 S>R No EVA
rs468870499 519 S>L No EVA
rs447099965 519 S>W No EVA

No associated diseases with Q9N0F3

3 regional properties for Q9N0F3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 291 - 468 IPR002314
domain Aminoacyl-tRNA synthetase, class II 202 - 478 IPR006195
domain Serine-tRNA ligase catalytic core domain 185 - 485 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
tRNA binding Binding to a transfer RNA.

3 GO annotations of biological process

Name Definition
mitochondrial seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NP81 SARS2 Serine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
Q9JJL8 Sars2 Serine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MAASIVRRLG PLVAGRGLRL RGGCVCNQSF KRSFATERQD RNLLYEHARE GYSALPLLDM
70 80 90 100 110 120
ESLCAYPEDA ARALDLRKGE LRSKDLPGII STWQELRQLR EQIRSLEEEK EAVTEAVRAL
130 140 150 160 170 180
VVNQDNSQVQ QDPQYQSLRA RGREIRKQLT LLYPKEAQLE EQFYLRALRL PNQTHPDVPV
190 200 210 220 230 240
GDESQARVLH VVGDKPAFSF QPRGHLEIAE KLDIIRQKRL SHVSGHRSYY LRGAGALLQH
250 260 270 280 290 300
GLVNFTLNKL IHRGFTPMTV PDLLRGVVFE GCGMTPNAKP SQIYNIDPSR FEDLNLAGTA
310 320 330 340 350 360
EVGLAGYFMD HSVAFRDLPI RMVCSSTCYR AETDTGKEPW GLYRVHHFTK VEMFGVTGPG
370 380 390 400 410 420
LEQSSELLEE FLSLQMEILT ELGLHFRVLD MPTQELGLPA YRKFDIEAWM PGRGRFGEVT
430 440 450 460 470 480
SASNCTDFQS RRLHIMFQTE AGELQFAHTV NATGCAVPRL LIALLESYQQ KDGSVLVPPA
490 500 510
LQPYLGTDRI TTPTHVPLQY IGPNQPQKPR LPGQPASS