AiPD: Autoinhibited Protein Database

Gene name	Sars2 (Sarsm)
Protein name	Serine--tRNA ligase, mitochondrial
Names	SerRSmt, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71984
EC number	6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

80-155 (Predicted disordered autoinhibitory region) PR

80-155 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JJL8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388885653	12	F>V	No	EVA
rs223730991	25	V>M	No	EVA
rs3388882545	27	S>I	No	EVA
rs3388896802	32	R>W	No	EVA
rs246256556	60	M>L	No	EVA
rs3388893002	73	S>Y	No	EVA
rs212438917	116	A>S	No	EVA
rs3388898047	130	Q>*	No	EVA
rs3388890312	138	L>M	No	EVA
rs3388898834	148	Q>*	No	EVA
rs3388885707	182	D>N	No	EVA
rs3388854120	188	V>M	No	EVA
rs3388895194	191	V>L	No	EVA
rs3388873857	211	K>I	No	EVA
rs47185959	253	R>K	No	EVA
rs3397634389	262	D>V	No	EVA
rs3397305352	264	L>Q	No	EVA
rs3397724550	265	R>G	No	EVA
rs3388890452	267	A>V	No	EVA
rs244040233	274	M>I	No	EVA
rs3388892933	314	A>G	No	EVA
rs3388896706	336	G>V	No	EVA
rs3388898848	360	G>E	No	EVA
rs3388892983	362	E>G	No	EVA
rs3388885633	385	H>Y	No	EVA
rs3388876647	508	K>M	No	EVA

Type	Name	Position	InterPro Accession
domain	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	291 - 468	IPR002314
domain	Aminoacyl-tRNA synthetase, class II	202 - 478	IPR006195
domain	Serine-tRNA synthetase, type1, N-terminal	59 - 172	IPR015866
domain	Serine-tRNA ligase catalytic core domain	185 - 485	IPR033729

		Description
EC Number	6.1.1.11	Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization	Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity	Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
tRNA binding	Binding to a transfer RNA.

Name	Definition
mitochondrial seryl-tRNA aminoacylation	The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.
selenocysteinyl-tRNA(Sec) biosynthetic process	The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation	The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9N0F3	SARS2	Serine--tRNA ligase, mitochondrial	Bos taurus (Bovine)	PR
Q9NP81	SARS2	Serine--tRNA ligase, mitochondrial	Homo sapiens (Human)	PR