Q9M9X7
SS
Gene name |
IMPA7 (At3g05720, F18C1.1) |
Protein name |
Importin subunit alpha-7 |
Names |
IMPa-7 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G05720 |
EC number |
|
Protein Class |
|
Descriptions
Importin-α is a nuclear import receptor that facilitates the transport of proteins with nuclear localization sequences (NLSs) into the nucleus. It is autoinhibited by its N-terminal region, which occupies the NLS-binding site, preventing unnecessary binding and import activity. Importin-α is autoinhibited in the absence of importin-β and the binding of importin-β alleviates this autoinhibition, which displaces the autoinhibitory sequence.
Autoinhibitory domains (AIDs)
Target domain |
126-218 (Major NLS-binding site);294-383 (Minor NLS-binding site) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Fontes MR et al. (2000) "Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha", Journal of molecular biology, 297, 1183-94
- Fontes MR et al. (2003) "Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha", The Journal of biological chemistry, 278, 27981-7
- Catimel B et al. (2001) "Biophysical characterization of interactions involving importin-alpha during nuclear import", The Journal of biological chemistry, 276, 34189-98
- Pumroy RA et al. (2015) "Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7", Structure (London, England : 1993), 23, 374-84
Autoinhibited structure
Activated structure
1 structures for Q9M9X7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M9X7-F1 | Predicted | AlphaFoldDB |
33 variants for Q9M9X7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05778086 | 21 | V>I | No | 1000Genomes | |
| ENSVATH10511562 | 30 | D>N | No | 1000Genomes | |
| ENSVATH13875030 | 50 | A>T | No | 1000Genomes | |
| ENSVATH02116471 | 50 | A>V | No | 1000Genomes | |
| tmp_3_1690933_T_C | 74 | D>G | No | 1000Genomes | |
| ENSVATH00307955 | 89 | G>A | No | 1000Genomes | |
| tmp_3_1690485_G_A | 124 | A>V | No | 1000Genomes | |
| tmp_3_1690452_G_A | 135 | T>I | No | 1000Genomes | |
| ENSVATH05778056 | 182 | D>N | No | 1000Genomes | |
| tmp_3_1689980_C_T | 200 | G>E | No | 1000Genomes | |
| tmp_3_1689962_A_T | 206 | L>H | No | 1000Genomes | |
| tmp_3_1689399_G_A | 246 | L>F | No | 1000Genomes | |
| ENSVATH05778049 | 251 | C>S | No | 1000Genomes | |
| tmp_3_1689351_T_G | 262 | N>H | No | 1000Genomes | |
| tmp_3_1689339_G_T | 266 | Q>K | No | 1000Genomes | |
| ENSVATH10511524 | 271 | A>V | No | 1000Genomes | |
| ENSVATH00307951 | 287 | S>A | No | 1000Genomes | |
| ENSVATH05778042 | 347 | Q>P | No | 1000Genomes | |
| ENSVATH05778041 | 354 | F>C | No | 1000Genomes | |
| tmp_3_1688633_T_A | 381 | I>F | No | 1000Genomes | |
| tmp_3_1688395_A_G | 395 | F>S | No | 1000Genomes | |
| ENSVATH05778035 | 397 | V>L | No | 1000Genomes | |
| ENSVATH00307948 | 404 | P>L | No | 1000Genomes | |
| tmp_3_1688340_A_T | 413 | D>E | No | 1000Genomes | |
| ENSVATH05778033 | 435 | S>R | No | 1000Genomes | |
| ENSVATH13874984 | 437 | R>K | No | 1000Genomes | |
| tmp_3_1688245_C_A | 445 | C>F | No | 1000Genomes | |
| ENSVATH10511520 | 460 | A>T | No | 1000Genomes | |
| ENSVATH05778032 | 461 | E>A | No | 1000Genomes | |
| ENSVATH10511519 | 467 | E>G | No | 1000Genomes | |
| ENSVATH05778031 | 481 | A>V | No | 1000Genomes | |
| ENSVATH09432301 | 494 | E>Q | No | 1000Genomes | |
| tmp_3_1688081_G_A | 500 | Q>* | No | 1000Genomes |
No associated diseases with Q9M9X7
9 regional properties for Q9M9X7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 92 - 175 | IPR000225-1 |
| repeat | Armadillo | 176 - 218 | IPR000225-2 |
| repeat | Armadillo | 220 - 259 | IPR000225-3 |
| repeat | Armadillo | 261 - 301 | IPR000225-4 |
| repeat | Armadillo | 303 - 344 | IPR000225-5 |
| repeat | Armadillo | 346 - 386 | IPR000225-6 |
| repeat | Armadillo | 389 - 429 | IPR000225-7 |
| domain | Importin-alpha, importin-beta-binding domain | 1 - 70 | IPR002652 |
| repeat | Atypical Arm repeat | 451 - 500 | IPR032413 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
| nuclear localization sequence binding | Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| NLS-bearing protein import into nucleus | The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope. |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02821 | SRP1 | Importin subunit alpha | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A2VE08 | KPNA1 | Importin subunit alpha-5 | Bos taurus (Bovine) | SS |
| C1JZ66 | KPNA7 | Importin subunit alpha-8 | Bos taurus (Bovine) | PR |
| Q0V7M0 | KPNA6 | Importin subunit alpha-7 | Bos taurus (Bovine) | SS |
| Q5ZML1 | KPNA1 | Importin subunit alpha-5 | Gallus gallus (Chicken) | SS |
| P52295 | Pen | Importin subunit alpha | Drosophila melanogaster (Fruit fly) | SS |
| A9QM74 | KPNA7 | Importin subunit alpha-8 | Homo sapiens (Human) | EV |
| O00505 | KPNA3 | Importin subunit alpha-4 | Homo sapiens (Human) | SS |
| O00629 | KPNA4 | Importin subunit alpha-3 | Homo sapiens (Human) | SS |
| O15131 | KPNA5 | Importin subunit alpha-6 | Homo sapiens (Human) | SS |
| O60684 | KPNA6 | Importin subunit alpha-7 | Homo sapiens (Human) | SS |
| P52292 | KPNA2 | Importin subunit alpha-1 | Homo sapiens (Human) | EV |
| P52294 | KPNA1 | Importin subunit alpha-5 | Homo sapiens (Human) | SS |
| P52293 | Kpna2 | Importin subunit alpha-1 | Mus musculus (Mouse) | EV |
| O35343 | Kpna4 | Importin subunit alpha-3 | Mus musculus (Mouse) | SS |
| O35344 | Kpna3 | Importin subunit alpha-4 | Mus musculus (Mouse) | SS |
| O35345 | Kpna6 | Importin subunit alpha-7 | Mus musculus (Mouse) | PR |
| Q60960 | Kpna1 | Importin subunit alpha-5 | Mus musculus (Mouse) | SS |
| C0LLJ0 | Kpna7 | Importin subunit alpha-8 | Mus musculus (Mouse) | SS |
| C6K7I2 | KPNA7 | Importin subunit alpha-8 | Sus scrofa (Pig) | SS |
| Q56R16 | Kpna5 | Importin subunit alpha-6 | Rattus norvegicus (Rat) | SS |
| P83953 | Kpna1 | Importin subunit alpha-5 | Rattus norvegicus (Rat) | SS |
| Q71VM4 | Os01g0253300 | Importin subunit alpha-1a | Oryza sativa subsp. japonica (Rice) | SS |
| P91276 | ima-2 | Importin subunit alpha-2 | Caenorhabditis elegans | SS |
| Q19969 | ima-3 | Importin subunit alpha-3 | Caenorhabditis elegans | SS |
| O04294 | IMPA3 | Importin subunit alpha-3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ09 | IMPA5 | Importin subunit alpha-5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FWY7 | IMPA6 | Importin subunit alpha-6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22478 | Importin subunit alpha | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | SS | |
| Q503E9 | kpna5 | Importin subunit alpha-6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKGGETMSVR | RSGYKAVVDG | VGGRRRREDD | MVEIRKAKRE | ESLLKKRREA | LPHSPSADSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQKLISCIWS | DERDLLIEAT | TQIRTLLCGE | MFNVRVEEVI | QAGLVPRFVE | FLTWDDSPQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QFEAAWALTN | IASGTSENTE | VVIDHGAVAI | LVRLLNSPYD | VVREQVVWAL | GNISGDSPRC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDIVLGHAAL | PSLLLQLNHG | AKLSMLVNAA | WTLSNLCRGK | PQPPFDQVSA | ALPALAQLIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDDKELLAYT | CWALVYLSDG | SNEKIQAVIE | ANVCARLIGL | SIHRSPSVIT | PALRTIGNIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGNDSQTQHI | IDLQALPCLV | NLLRGSYNKT | IRKEACWTVS | NITAGCQSQI | QAVFDADICP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALVNLLQNSE | GDVKKEAAWA | ICNAIAGGSY | KQIMFLVKQE | CIKPLCDLLT | CSDTQLVMVC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEALKKILKV | GEVFSSRHAE | GIYQCPQTNV | NPHAQLIEEA | EGLEKIEGLQ | SHENNDIYET |
| 490 | 500 | 510 | 520 | ||
| AVKILETYWM | EEEEEEDQEQ | QDMIYFPVDN | FANMPTSSGT | LSEMHCGP |