Q9M9L8
PR
Gene name |
LON3 (At3g05780, F10A16.7) |
Protein name |
Lon protease homolog 3, mitochondrial |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G05780 |
EC number |
3.4.21.53: Serine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M9L8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M9L8-F1 | Predicted | AlphaFoldDB |
103 variants for Q9M9L8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_1719428_G_A | 16 | R>C | No | 1000Genomes | |
| ENSVATH10512671 | 24 | L>W | No | 1000Genomes | |
| ENSVATH02116676 | 29 | S>N | No | 1000Genomes | |
| tmp_3_1719382_G_A | 31 | T>I | No | 1000Genomes | |
| ENSVATH10512669 | 32 | L>P | No | 1000Genomes | |
| tmp_3_1719360_G_C | 38 | Y>* | No | 1000Genomes | |
| tmp_3_1719362_A_C | 38 | Y>D | No | 1000Genomes | |
| tmp_3_1719356_C_G | 40 | A>P | No | 1000Genomes | |
| tmp_3_1719341_G_A | 45 | P>S | No | 1000Genomes | |
| ENSVATH00308072 | 50 | I>V | No | 1000Genomes | |
| ENSVATH05778604 | 59 | L>Q | No | 1000Genomes | |
| ENSVATH13875445 | 64 | P>R | No | 1000Genomes | |
| ENSVATH05778603 | 71 | N>S | No | 1000Genomes | |
| ENSVATH10512667 | 79 | G>S | No | 1000Genomes | |
| ENSVATH05778602 | 80 | R>L | No | 1000Genomes | |
| ENSVATH00308071 | 81 | R>P | No | 1000Genomes | |
| ENSVATH13875384 | 87 | R>L | No | 1000Genomes | |
| tmp_3_1719176_G_A | 100 | L>F | No | 1000Genomes | |
| tmp_3_1718977_G_T | 119 | H>Q | No | 1000Genomes | |
| ENSVATH00308070 | 128 | M>I | No | 1000Genomes | |
| ENSVATH00308069 | 131 | H>Q | No | 1000Genomes | |
| ENSVATH02116665 | 147 | Q>K | No | 1000Genomes | |
| ENSVATH13875382 | 151 | Y>H | No | 1000Genomes | |
| ENSVATH02116664 | 160 | C>G | No | 1000Genomes | |
| tmp_3_1718734_T_G | 172 | E>D | No | 1000Genomes | |
| ENSVATH05778597 | 223 | I>T | No | 1000Genomes | |
| ENSVATH02116656 | 225 | E>K | No | 1000Genomes | |
| ENSVATH02116653 | 236 | R>K | No | 1000Genomes | |
| ENSVATH00308068 | 248 | D>E | No | 1000Genomes | |
| ENSVATH05778591 | 250 | A>T | No | 1000Genomes | |
| ENSVATH05778590 | 253 | K>T | No | 1000Genomes | |
| ENSVATH02116645 | 265 | E>D | No | 1000Genomes | |
| ENSVATH05778589 | 273 | W>R | No | 1000Genomes | |
| ENSVATH02116644 | 275 | D>G | No | 1000Genomes | |
| ENSVATH05778588 | 292 | G>R | No | 1000Genomes | |
| ENSVATH02116643 | 299 | H>D | No | 1000Genomes | |
| ENSVATH02116642 | 315 | E>A | No | 1000Genomes | |
| ENSVATH05778586 | 331 | K>E | No | 1000Genomes | |
| ENSVATH05778586 | 331 | K>Q | No | 1000Genomes | |
| tmp_3_1717415_C_T | 345 | V>I | No | 1000Genomes | |
| tmp_3_1717392_G_C | 352 | D>E | No | 1000Genomes | |
| ENSVATH02116633 | 359 | I>L | No | 1000Genomes | |
| ENSVATH02116632 | 387 | H>D | No | 1000Genomes | |
| ENSVATH10512573 | 392 | L>P | No | 1000Genomes | |
| ENSVATH05778584 | 394 | W>* | No | 1000Genomes | |
| tmp_3_1717133_T_G | 401 | N>H | No | 1000Genomes | |
| ENSVATH05778579 | 408 | K>E | No | 1000Genomes | |
| tmp_3_1717081_A_C | 418 | L>* | No | 1000Genomes | |
| ENSVATH05778578 | 418 | L>F | No | 1000Genomes | |
| tmp_3_1717061_T_A | 425 | I>L | No | 1000Genomes | |
| ENSVATH10512569 | 426 | L>S | No | 1000Genomes | |
| tmp_3_1717021_G_A | 438 | S>L | No | 1000Genomes | |
| ENSVATH05778573 | 475 | G>V | No | 1000Genomes | |
| ENSVATH00308064 | 489 | Y>C | No | 1000Genomes | |
| tmp_3_1716624_T_A | 511 | I>F | No | 1000Genomes | |
| ENSVATH13875378 | 515 | E>Q | No | 1000Genomes | |
| tmp_3_1716604_A_T | 517 | D>E | No | 1000Genomes | |
| ENSVATH05778567 | 527 | P>S | No | 1000Genomes | |
| tmp_3_1716462_G_A | 530 | A>V | No | 1000Genomes | |
| ENSVATH02116621 | 542 | K>N | No | 1000Genomes | |
| ENSVATH02116620 | 548 | L>I | No | 1000Genomes | |
| tmp_3_1716226_T_A | 562 | T>S | No | 1000Genomes | |
| tmp_3_1716213_A_G | 566 | I>T | No | 1000Genomes | |
| tmp_3_1716126_C_T | 595 | R>K | No | 1000Genomes | |
| ENSVATH05778566 | 603 | C>Y | No | 1000Genomes | |
| ENSVATH02116617 | 604 | R>* | No | 1000Genomes | |
| ENSVATH05778565 | 612 | H>Q | No | 1000Genomes | |
| ENSVATH05778564 | 618 | A>S | No | 1000Genomes | |
| ENSVATH10512566 | 621 | L>F | No | 1000Genomes | |
| ENSVATH05778562 | 629 | R>T | No | 1000Genomes | |
| ENSVATH05778561 | 634 | R>S | No | 1000Genomes | |
| ENSVATH10512565 | 645 | R>C | No | 1000Genomes | |
| ENSVATH05778558 | 648 | A>S | No | 1000Genomes | |
| ENSVATH02116616 | 650 | E>G | No | 1000Genomes | |
| ENSVATH05778557 | 660 | D>E | No | 1000Genomes | |
| ENSVATH05778556 | 661 | V>G | No | 1000Genomes | |
| ENSVATH02116615 | 661 | V>I | No | 1000Genomes | |
| ENSVATH10512534 | 679 | R>K | No | 1000Genomes | |
| tmp_3_1715703_C_G | 704 | S>T | No | 1000Genomes | |
| ENSVATH05778554 | 710 | T>I | No | 1000Genomes | |
| ENSVATH05778554 | 710 | T>N | No | 1000Genomes | |
| ENSVATH05778553 | 713 | K>R | No | 1000Genomes | |
| tmp_3_1715616_T_C | 733 | E>G | No | 1000Genomes | |
| tmp_3_1715554_C_G | 754 | G>R | No | 1000Genomes | |
| ENSVATH10512532 | 761 | T>I | No | 1000Genomes | |
| ENSVATH02116613 | 768 | L>* | No | 1000Genomes | |
| ENSVATH02116614 | 768 | L>V | No | 1000Genomes | |
| tmp_3_1715475_C_G | 780 | G>A | No | 1000Genomes | |
| ENSVATH05778551 | 788 | Q>E | No | 1000Genomes | |
| ENSVATH00308061 | 792 | T>I | No | 1000Genomes | |
| ENSVATH00308061 | 792 | T>K | No | 1000Genomes | |
| tmp_3_1715420_C_T | 798 | M>I | No | 1000Genomes | |
| tmp_3_1715407_G_A | 803 | P>S | No | 1000Genomes | |
| ENSVATH05778549 | 808 | F>S | No | 1000Genomes | |
| tmp_3_1715370_A_C | 815 | L>* | No | 1000Genomes | |
| tmp_3_1715356_C_T | 820 | G>R | No | 1000Genomes | |
| tmp_3_1715341_C_A | 825 | D>Y | No | 1000Genomes | |
| tmp_3_1715338_C_G | 826 | G>R | No | 1000Genomes | |
| tmp_3_1715334_G_A | 827 | P>L | No | 1000Genomes | |
| tmp_3_1715289_A_T | 842 | M>K | No | 1000Genomes | |
| ENSVATH05778547 | 861 | R>S | No | 1000Genomes | |
| ENSVATH00308059 | 910 | D>A | No | 1000Genomes | |
| ENSVATH05778544 | 923 | D>G | No | 1000Genomes |
No associated diseases with Q9M9L8
5 regional properties for Q9M9L8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Lon protease, N-terminal domain | 111 - 323 | IPR003111 |
| domain | AAA+ ATPase domain | 439 - 584 | IPR003593 |
| domain | ATPase, AAA-type, core | 443 - 579 | IPR003959 |
| active_site | Peptidase S16, active site | 825 - 833 | IPR008268 |
| domain | Peptidase S16, Lon proteolytic domain | 716 - 922 | IPR008269 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.21.53 | Serine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent peptidase activity | Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| single-stranded DNA binding | Binding to single-stranded DNA. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to oxidative stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| chaperone-mediated protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| oxidation-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein. |
| protein quality control for misfolded or incompletely synthesized proteins | The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMPKRFNTSG | FDTTLRLPSY | YGFLHLTQSL | TLNSRVFYGA | RHVTPPAIRI | GSNPVQSLLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FRAPTQLTGW | NRSSRDLLGR | RVSFSDRSDG | VDLLSSSPIL | STNPNLDDSL | TVIALPLPHK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLIPGFYMPI | HVKDPKVLAA | LQESTRQQSP | YVGAFLLKDC | ASTDSSSRSE | TEDNVVEKFK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VKGKPKKKRR | KELLNRIHQV | GTLAQISSIQ | GEQVILVGRR | RLIIEEMVSE | DPLTVRVDHL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDKPYDKDNA | VIKASYVEVI | STLREVLKTN | SLWRDQDIGD | FSYQHLADFG | AGISGANKHK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NQGVLTELDV | HKRLELTLEL | VKKQVEINKI | KETDDGSSLS | AKIRVRIDTK | RDKIPKHVIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VMEEEFTKLE | MLEENYSDFD | LTYNYLHWLT | VLPWGNFSYE | NFDVLRAKKI | LDEDHYGLSD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VKERILEFIA | VGRLRGTSQG | KIICLSGPPG | VGKTSIGRSI | ARALDRKFFR | FSVGGLSDVA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EIKGHCQTYV | GAMPGKMVQC | LKSVGTANPL | ILFDEIDKLG | RCHTGDPASA | LLEVMDPEQN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKFLDHFLNV | TIDLSKVLFV | CTANVIEMIP | GPLLDRMEVI | DLSGYVTDEK | MHIARDYLVK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KTCRDCGIKP | EHVDLSDAAL | LSLIENYCRE | AGVRNLQKQI | EKIYRKVALE | LVRQGAVSFD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VTDTKDTKSL | AKTDSEVKRM | KVADIMKILE | SATGDSTESK | TKQSGLVAKT | FEKVMIDESN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LADYVGKPVF | QEEKIYEQTP | VGVVMGLAWT | SMGGSTLYIE | TTFVEEGLGK | GGLHITGQLG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DVMKESAQIA | HTVARRIMFE | KEPENLFFAN | SKLHLHVPEG | ATPKDGPSAG | CTMITSFLSL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AMKKLVRKDL | AMTGEVTLTG | RILPIGGVKE | KTIAARRSQI | KTIIFPEANR | RDFEELAENM |
| 910 | 920 | ||||
| KEGLDVHFVD | EYEKIFDLAF | NYDH |