Q9M9L7
PR
Gene name |
LON4 (At3g05790, F10A16.8) |
Protein name |
Lon protease homolog 4, chloroplastic/mitochondrial |
Names |
AtLon4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G05790 |
EC number |
3.4.21.53: Serine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M9L7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M9L7-F1 | Predicted | AlphaFoldDB |
111 variants for Q9M9L7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_1725173_A_G | 4 | F>L | No | 1000Genomes | |
| ENSVATH00308084 | 15 | V>L | No | 1000Genomes | |
| ENSVATH02116728 | 16 | T>N | No | 1000Genomes | |
| ENSVATH05778711 | 17 | P>L | No | 1000Genomes | |
| tmp_3_1725134_G_A | 17 | P>S | No | 1000Genomes | |
| tmp_3_1725101_T_C | 28 | N>D | No | 1000Genomes | |
| tmp_3_1725091_A_G | 31 | F>S | No | 1000Genomes | |
| tmp_3_1725058_C_T | 42 | R>Q | No | 1000Genomes | |
| ENSVATH10512839 | 43 | S>R | No | 1000Genomes | |
| ENSVATH05778708 | 52 | F>V | No | 1000Genomes | |
| tmp_3_1725018_G_C | 55 | D>E | No | 1000Genomes | |
| tmp_3_1725001_T_C | 61 | K>R | No | 1000Genomes | |
| ENSVATH00308083 | 69 | A>T | No | 1000Genomes | |
| tmp_3_1724960_C_T,G | 75 | D>H | No | 1000Genomes | |
| tmp_3_1724960_C_T,G | 75 | D>N | No | 1000Genomes | |
| tmp_3_1724956_C_T | 76 | C>Y | No | 1000Genomes | |
| ENSVATH02116723 | 79 | V>I | No | 1000Genomes | |
| tmp_3_1724528_G_T | 83 | P>T | No | 1000Genomes | |
| tmp_3_1724522_G_A | 85 | P>S | No | 1000Genomes | |
| ENSVATH10512835 | 92 | G>S | No | 1000Genomes | |
| ENSVATH02116721 | 96 | P>Q | No | 1000Genomes | |
| ENSVATH02116722 | 96 | P>T | No | 1000Genomes | |
| tmp_3_1724484_T_C | 97 | I>M | No | 1000Genomes | |
| tmp_3_1724480_C_T | 99 | V>I | No | 1000Genomes | |
| tmp_3_1724292_G_A | 128 | A>V | No | 1000Genomes | |
| ENSVATH02116719 | 151 | I>L | No | 1000Genomes | |
| tmp_3_1724218_G_C | 153 | R>G | No | 1000Genomes | |
| tmp_3_1724057_G_C | 176 | H>D | No | 1000Genomes | |
| ENSVATH00308080 | 178 | Q>R | No | 1000Genomes | |
| ENSVATH10512796 | 203 | P>S | No | 1000Genomes | |
| tmp_3_1723688_A_G | 204 | Y>H | No | 1000Genomes | |
| ENSVATH00308079 | 214 | T>I | No | 1000Genomes | |
| ENSVATH05778682 | 217 | Q>K | No | 1000Genomes | |
| ENSVATH05778681 | 224 | D>H | No | 1000Genomes | |
| ENSVATH05778680 | 229 | T>S | No | 1000Genomes | |
| ENSVATH02116700 | 241 | Q>L | No | 1000Genomes | |
| tmp_3_1723573_G_C | 242 | A>G | No | 1000Genomes | |
| ENSVATH05778679 | 246 | H>Y | No | 1000Genomes | |
| ENSVATH10512795 | 250 | C>G | No | 1000Genomes | |
| ENSVATH02116698 | 253 | H>L | No | 1000Genomes | |
| tmp_3_1723454_A_T | 265 | F>I | No | 1000Genomes | |
| ENSVATH05778676 | 273 | N>Y | No | 1000Genomes | |
| tmp_3_1723424_G_T | 275 | H>N | No | 1000Genomes | |
| tmp_3_1723418_T_C | 277 | N>D | No | 1000Genomes | |
| ENSVATH02116694 | 298 | K>N | No | 1000Genomes | |
| ENSVATH05778668 | 330 | Q>* | No | 1000Genomes | |
| ENSVATH10512760 | 339 | G>C | No | 1000Genomes | |
| ENSVATH02116691 | 341 | E>D | No | 1000Genomes | |
| ENSVATH05778660 | 350 | E>G | No | 1000Genomes | |
| ENSVATH02116690 | 357 | D>E | No | 1000Genomes | |
| tmp_3_1722751_T_C | 360 | K>E | No | 1000Genomes | |
| ENSVATH05778659 | 377 | K>N | No | 1000Genomes | |
| ENSVATH00308077 | 391 | T>I | No | 1000Genomes | |
| tmp_3_1722622_A_G | 403 | W>R | No | 1000Genomes | |
| ENSVATH10512758 | 404 | G>E | No | 1000Genomes | |
| ENSVATH05778658 | 406 | F>I | No | 1000Genomes | |
| tmp_3_1722411_C_G | 433 | R>T | No | 1000Genomes | |
| ENSVATH02116687 | 458 | T>P | No | 1000Genomes | |
| ENSVATH10512742 | 493 | G>R | No | 1000Genomes | |
| tmp_3_1722065_G_A | 495 | R>C | No | 1000Genomes | |
| ENSVATH10512741 | 498 | Y>* | No | 1000Genomes | |
| ENSVATH13875453 | 504 | G>E | No | 1000Genomes | |
| tmp_3_1721837_C_T | 531 | R>K | No | 1000Genomes | |
| ENSVATH10512739 | 545 | L>M | No | 1000Genomes | |
| ENSVATH05778648 | 550 | N>Y | No | 1000Genomes | |
| ENSVATH05778647 | 561 | P>L | No | 1000Genomes | |
| ENSVATH05778644 | 585 | D>V | No | 1000Genomes | |
| tmp_3_1721487_A_T | 593 | S>T | No | 1000Genomes | |
| ENSVATH10512736 | 597 | T>S | No | 1000Genomes | |
| ENSVATH05778643 | 604 | A>S | No | 1000Genomes | |
| tmp_3_1721435_T_C | 610 | K>R | No | 1000Genomes | |
| ENSVATH02116684 | 615 | D>N | No | 1000Genomes | |
| ENSVATH10512735 | 622 | Q>H | No | 1000Genomes | |
| tmp_3_1721283_A_T | 630 | F>Y | No | 1000Genomes | |
| ENSVATH10512714 | 639 | R>* | No | 1000Genomes | |
| tmp_3_1721256_C_T | 639 | R>K | No | 1000Genomes | |
| ENSVATH10512713 | 643 | V>I | No | 1000Genomes | |
| ENSVATH05778638 | 665 | A>V | No | 1000Genomes | |
| tmp_3_1721087_G_A | 668 | T>I | No | 1000Genomes | |
| tmp_3_1721076_T_C | 672 | R>G | No | 1000Genomes | |
| tmp_3_1721075_C_G | 672 | R>T | No | 1000Genomes | |
| tmp_3_1721064_C_T | 676 | D>N | No | 1000Genomes | |
| ENSVATH05778636 | 678 | T>S | No | 1000Genomes | |
| tmp_3_1720958_G_C | 711 | T>S | No | 1000Genomes | |
| tmp_3_1720952_T_C | 713 | D>G | No | 1000Genomes | |
| tmp_3_1720934_G_T | 719 | T>N | No | 1000Genomes | |
| tmp_3_1720922_C_G | 723 | G>A | No | 1000Genomes | |
| ENSVATH05778635 | 729 | V>A | No | 1000Genomes | |
| ENSVATH02116683 | 769 | S>A | No | 1000Genomes | |
| tmp_3_1720779_C_A | 771 | G>W | No | 1000Genomes | |
| ENSVATH13875451 | 777 | I>M | No | 1000Genomes | |
| ENSVATH05778633 | 780 | T>S | No | 1000Genomes | |
| ENSVATH05778632 | 783 | E>Q | No | 1000Genomes | |
| tmp_3_1720740_C_T | 784 | E>K | No | 1000Genomes | |
| tmp_3_1720712_A_C | 793 | I>R | No | 1000Genomes | |
| tmp_3_1720694_T_C | 799 | D>G | No | 1000Genomes | |
| ENSVATH02116682 | 809 | H>Q | No | 1000Genomes | |
| tmp_3_1720662_T_A | 810 | T>S | No | 1000Genomes | |
| ENSVATH05778631 | 819 | K>R | No | 1000Genomes | |
| tmp_3_1720629_G_A | 821 | P>S | No | 1000Genomes | |
| tmp_3_1720607_T_C | 828 | N>S | No | 1000Genomes | |
| ENSVATH00308075 | 833 | L>P | No | 1000Genomes | |
| tmp_3_1720526_A_G | 855 | L>S | No | 1000Genomes | |
| ENSVATH10512711 | 864 | V>A | No | 1000Genomes | |
| ENSVATH05778627 | 888 | E>* | No | 1000Genomes | |
| ENSVATH13875449 | 905 | E>D | No | 1000Genomes | |
| ENSVATH10512710 | 905 | E>G | No | 1000Genomes | |
| ENSVATH10512709 | 919 | K>N | No | 1000Genomes | |
| ENSVATH05778625 | 922 | L>F | No | 1000Genomes | |
| ENSVATH05778624 | 939 | G>S | No | 1000Genomes | |
| ENSVATH13875448 | 943 | H>K | No | 1000Genomes |
No associated diseases with Q9M9L7
5 regional properties for Q9M9L7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Lon protease, N-terminal domain | 78 - 299 | IPR003111 |
| domain | AAA+ ATPase domain | 448 - 594 | IPR003593 |
| domain | ATPase, AAA-type, core | 452 - 591 | IPR003959 |
| active_site | Peptidase S16, active site | 843 - 851 | IPR008268 |
| domain | Peptidase S16, Lon proteolytic domain | 734 - 940 | IPR008269 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.21.53 | Serine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast thylakoid membrane | The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent peptidase activity | Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| single-stranded DNA binding | Binding to single-stranded DNA. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to oxidative stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| chaperone-mediated protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| oxidation-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein. |
| protein quality control for misfolded or incompletely synthesized proteins | The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKFLTPTAY | ASHHVTPATR | FRSTPVKNLL | FKQLTLLTGW | NRSSYELGRR | SFSSDLDSDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSSTTTVSAK | PHLDDCLTVI | ALPLPHKPLI | PGFYMPIYVK | DPKVLAALQE | SRRQQAPYAG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFLLKDDASS | DSSSSSETEN | ILEKLKGKEL | INRIHEVGTL | AQISSIQGEQ | VILIGHRQLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ITEMVSESED | PLTVKVDHLK | DKPYDKDDDV | IKATYFQVMS | TLRDVLKTTS | LWRDHVRTYT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QACSLHIWHC | LRHIGEFNYP | KLADFGAGIS | GANKHQNQGV | LEELDVHKRL | ELTLELVKKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEINKIQESI | AKAVEEKFSG | DRRRIILKEQ | INAIKKELGG | ETDSKSALSE | KFRGRIDPIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DKIPGHVLKV | IEEELKKLQL | LETSSSEFDV | TCNYLDWLTV | LPWGNFSDEN | FNVLRAEKIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DEDHYGLSDV | KERILEFIAV | GGLRGTSQGK | IICLSGPTGV | GKTSIGRSIA | RALDRKFFRF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SVGGLSDVAE | IKGHRRTYIG | AMPGKMVQCL | KNVGTENPLV | LIDEIDKLGV | RGHHGDPASA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MLELLDPEQN | ANFLDHYLDV | PIDLSKVLFV | CTANVTDTIP | GPLLDRMEVI | TLSGYITDEK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MHIARDYLEK | TARRDCGIKP | EQVDVSDAAF | LSLIEHYCRE | AGVRNLQKQI | EKIFRKIALK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVRKAASTEV | PRISDDVTTD | TEETKSLAKT | DLESPETSAE | GSTVLTDELA | TGDPTESTTE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QSGEVAETVE | KYMIDESNLS | DYVGKPVFQE | EKIYEQTPVG | VVMGLAWTSM | GGSTLYIETT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FVEEGEGKGG | LHITGRLGDV | MKESAEIAHT | VARRIMLEKE | PENKLFANSK | LHLHVPAGAT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PKDGPSAGCT | MITSLLSLAL | KKPVRKDLAM | TGEVTLTGRI | LAIGGVKEKT | IAARRSQVKV |
| 910 | 920 | 930 | 940 | ||
| IIFPEANRRD | FDELARNVKE | GLEVHFVDEY | EQIFELAFGY | DH |