AiPD: Autoinhibited Protein Database

Gene name	At3g60660 (T4C21_70)
Protein name	Spindle and kinetochore-associated protein 1 homolog
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G60660
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

34-169 (Predicted disordered autoinhibitory region) PR

34-169 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LZZ7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH06350159	2	E>D	No	1000Genomes
tmp_3_22421502_T_G	8	S>A	No	1000Genomes
ENSVATH02531289	14	I>V	No	1000Genomes
ENSVATH02531291	47	T>I	No	1000Genomes
tmp_3_22421778_G_A	73	A>T	No	1000Genomes
tmp_3_22421947_T_G	81	L>R	No	1000Genomes
tmp_3_22421954_A_T	83	Q>H	No	1000Genomes
ENSVATH06350164	84	Q>H	No	1000Genomes
ENSVATH06350167	99	P>L	No	1000Genomes
ENSVATH06350166	99	P>T	No	1000Genomes
ENSVATH14461421	113	L>R	No	1000Genomes
tmp_3_22422180_C_T	124	H>Y	No	1000Genomes
ENSVATH06350170	137	A>V	No	1000Genomes
tmp_3_22422233_G_T	141	K>N	No	1000Genomes
tmp_3_22422383_G_A	146	R>H	No	1000Genomes
ENSVATH12854563	180	N>K	No	1000Genomes
tmp_3_22422712_T_A	205	W>R	No	1000Genomes
ENSVATH14461423	212	R>Q	No	1000Genomes
tmp_3_22422876_T_A	225	F>I	No	1000Genomes
ENSVATH06350180	255	I>L	No	1000Genomes
ENSVATH12854585	267	I>T	No	1000Genomes
ENSVATH00429740	271	P>A	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9LZZ7

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitotic spindle	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
outer kinetochore	The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
spindle microtubule	Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

Name	Definition
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
regulation of microtubule polymerization or depolymerization	Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
B0BN28	Ska1	Spindle and kinetochore-associated protein 1	Rattus norvegicus (Rat)	PR