B0BN28

PR
Gene name
Ska1
Protein name
Spindle and kinetochore-associated protein 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:291441
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

75-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B0BN28

Entry ID Method Resolution Chain Position Source
AF-B0BN28-F1 Predicted AlphaFoldDB

No variants for B0BN28

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B0BN28

No associated diseases with B0BN28

No regional properties for B0BN28

Type Name Position InterPro Accession
No domain, repeats, and functional sites for B0BN28

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, spindle
  • Chromosome, centromere, kinetochore
  • Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner
  • Localizes to both the mitotic spindle and kinetochore-associated proteins
  • Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
outer kinetochore The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

1 GO annotations of molecular function

Name Definition
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

4 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
regulation of microtubule polymerization or depolymerization Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9LZZ7 At3g60660 Spindle and kinetochore-associated protein 1 homolog Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASDLEQLCS YVNEKIENIK KILSLRKLGQ DPTLKTTLSK IGDEIITVNE LLNQFELEIQ
70 80 90 100 110 120
YQEQTNSSLK ELCKSLEEEF KDVEHLKEHI PSHLPQVTVT QSSTHKPDLD PKESVKAEEP
130 140 150 160 170 180
VLPKKPPKEQ RVIKEMHFIT TDEFSGVPAY MKSRLTYCQI NDVIKEINKA VVSKYKIIHQ
190 200 210 220 230 240
PKASMSSVKR NLYQRFINEE TKDTKGRHFI VEADIKEFTT LKVDKKFHVI MNILRHCQRL
250
SEVRGGGLTR YVIT