Q9LSH2

PR
Gene name
GAD5 (At3g17760, MIG5.6)
Protein name
Glutamate decarboxylase 5
Names
GAD 5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G17760
EC number
4.1.1.15: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LSH2

Entry ID Method Resolution Chain Position Source
AF-Q9LSH2-F1 Predicted AlphaFoldDB

15 variants for Q9LSH2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00329840 12 H>N No 1000Genomes
tmp_3_6080232_T_A 139 K>N No 1000Genomes
ENSVATH05852780 145 K>R No 1000Genomes
tmp_3_6080030_G_A 170 A>V No 1000Genomes
ENSVATH07965148 173 F>V No 1000Genomes
ENSVATH13938090 200 E>A No 1000Genomes
tmp_3_6079826_G_A 238 T>I No 1000Genomes
ENSVATH05852774 269 S>T No 1000Genomes
tmp_3_6079701_C_G 280 V>L No 1000Genomes
tmp_3_6079261_G_A 373 P>S No 1000Genomes
ENSVATH00329837 436 I>M No 1000Genomes
ENSVATH13938088 453 L>F No 1000Genomes
tmp_3_6079012_C_T 456 A>T No 1000Genomes
tmp_3_6079005_G_C 458 A>G No 1000Genomes
tmp_3_6078975_A_G 468 V>A No 1000Genomes

No associated diseases with Q9LSH2

No regional properties for Q9LSH2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9LSH2

Functions

Description
EC Number 4.1.1.15 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

3 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04792 GAD1 Glutamate decarboxylase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P69908 gadA Glutamate decarboxylase alpha Escherichia coli (strain K12) PR
P69910 gadB Glutamate decarboxylase beta Escherichia coli (strain K12) EV
Q42521 GAD1 Glutamate decarboxylase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q9ZPS3 GAD4 Glutamate decarboxylase 4 Arabidopsis thaliana (Mouse-ear cress) PR
P54767 Glutamate decarboxylase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MVLATNSDSD EHLHSTFASR YVRAVVPRFK MPDHCMPKDA AYQVINDELM LDGNPRLNLA
70 80 90 100 110 120
SFVTTWMEPE CDKLIMDSVN KNYVDMDEYP VTTELQNRCV NMIANLFHAP VGEDEAAIGC
130 140 150 160 170 180
GTVGSSEAIM LAGLAFKRKW QHRRKAQGLP IDKPNIVTGA NVQVCWEKFA RYFEVELKEV
190 200 210 220 230 240
KLSEDYYVMD PAKAVEMVDE NTICVAAILG STLTGEFEDV KQLNDLLAEK NAETGWETPI
250 260 270 280 290 300
HVDAASGGFI APFLYPDLEW DFRLPWVKSI NVSGHKYGLV YAGVGWVVWR TKDDLPEELV
310 320 330 340 350 360
FHINYLGADQ PTFTLNFSKG SSQIIAQYYQ FIRLGFEGYK NIMENCMDNA RRLREGIEMT
370 380 390 400 410 420
GKFNIVSKDI GVPLVAFSLK DSSKHTVFEI AESLRKFGWI IPAYTMPADA QHIAVLRVVI
430 440 450 460 470 480
REDFSRGLAD RLITHIIQVL KEIEGLPSRI AHLAAAAAVS GDDEEVKVKT AKMSLEDITK
490
YWKRLVEHKR NIVC