P54767
Gene name |
|
Protein name |
Glutamate decarboxylase |
Names |
GAD, ERT D1 |
Species |
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) |
KEGG Pathway |
|
EC number |
4.1.1.15: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P54767
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54767-F1 | Predicted | AlphaFoldDB |
No variants for P54767
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P54767 | |||||
No associated diseases with P54767
No regional properties for P54767
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P54767 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.15 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| glutamate decarboxylase activity | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutamate catabolic process | The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04792 | GAD1 | Glutamate decarboxylase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P69908 | gadA | Glutamate decarboxylase alpha | Escherichia coli (strain K12) | PR |
| P69910 | gadB | Glutamate decarboxylase beta | Escherichia coli (strain K12) | EV |
| Q9ZPS3 | GAD4 | Glutamate decarboxylase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42521 | GAD1 | Glutamate decarboxylase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LSH2 | GAD5 | Glutamate decarboxylase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLTTTSIRD | SEESLHCTFA | SRYVQEPLPK | FKMPKKSMPK | EAAYQIVNDE | LMLDGNPRLN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LASFVSTWME | PECDKLIMSS | INKNYVDMDE | YPVTTELQNR | CVNMLAHLFH | APVGDDETAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVGTVGSSEA | IMLAGLAFKR | KWQSKRKAEG | KPFDKPNIVT | GANVQVCWEK | FARYFEVELK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVKLKEGYYV | MDPAKAVEIV | DENTICVAAI | LGSTLTGEFE | DVKLLNELLT | KKNKETGWET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PIHVDAASGG | FIAPFLWPDL | EWDFRLPLVK | SINVSGHKYG | LVYAGVGWVI | WRSKEDLPDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVFHINYLGS | DQPTFTLNFS | KGSYQIIAQY | YQLIRLGFEG | YKNVMKNCLS | NAKVLTEGIT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KMGRFDIVSK | DVGVPVVAFS | LRDSSKYTVF | EVSEHLRRFG | WIVPAYTMPP | DAEHIAVLRV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VIREDFSHSL | AERLVSDIEK | ILSELDTQPP | RLPTKAVRVT | AEEVRDDKGD | GLHHFHMDTV |
| 490 | 500 | ||||
| ETQKDIIKHW | RKIAGKKTSG | VC |