Q9LNJ9

PR
Gene name
FKGP (At1g01220, F6F3.3)
Protein name
Bifunctional fucokinase/fucose pyrophosphorylase
Names
AtFKGP
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G01220
EC number
2.7.1.52: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

608-736 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LNJ9

Entry ID Method Resolution Chain Position Source
AF-Q9LNJ9-F1 Predicted AlphaFoldDB

45 variants for Q9LNJ9

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_91792_C_T 15 R>C No 1000Genomes
tmp_1_91944_C_G 65 S>R No 1000Genomes
ENSVATH04501376 108 M>V No 1000Genomes
ENSVATH01001033 109 E>K No 1000Genomes
ENSVATH10440474 177 A>G No 1000Genomes
ENSVATH09375261 182 Q>K No 1000Genomes
tmp_1_92640_G_T 209 A>S No 1000Genomes
ENSVATH04501382 212 I>V No 1000Genomes
tmp_1_92808_C_T 265 H>Y No 1000Genomes
ENSVATH00000355 284 S>L No 1000Genomes
ENSVATH13847976 287 V>I No 1000Genomes
tmp_1_92877_G_A 288 A>T No 1000Genomes
tmp_1_92887_G_A 291 C>Y No 1000Genomes
ENSVATH10440476 294 Q>K No 1000Genomes
ENSVATH04501386 298 L>V No 1000Genomes
ENSVATH04501392 317 W>L No 1000Genomes
tmp_1_93095_T_A 323 D>E No 1000Genomes
tmp_1_93114_T_G 330 L>V No 1000Genomes
tmp_1_93152_G_C 342 K>N No 1000Genomes
ENSVATH10440480 430 V>L No 1000Genomes
ENSVATH04501402 436 P>L No 1000Genomes
tmp_1_93542_T_G 439 D>E No 1000Genomes
ENSVATH10440481 444 E>K No 1000Genomes
ENSVATH00000358 446 F>C No 1000Genomes
ENSVATH04501405 501 G>S No 1000Genomes
tmp_1_93730_T_G 502 I>S No 1000Genomes
tmp_1_93866_C_A 547 N>K No 1000Genomes
ENSVATH00000363 587 G>A No 1000Genomes
ENSVATH00000364 629 P>H No 1000Genomes
ENSVATH04501411 662 I>V No 1000Genomes
ENSVATH13847980 712 R>M No 1000Genomes
tmp_1_94584_A_T 762 N>Y No 1000Genomes
tmp_1_94727_A_T 809 E>D No 1000Genomes
ENSVATH10440484 814 S>C No 1000Genomes
ENSVATH01001046 847 Q>K No 1000Genomes
tmp_1_94873_T_C 858 I>T No 1000Genomes
ENSVATH04501415 858 I>V No 1000Genomes
ENSVATH04501416 905 L>I No 1000Genomes
ENSVATH04501417 916 Q>H No 1000Genomes
ENSVATH10440486 969 E>D No 1000Genomes
ENSVATH04501421 972 E>Q No 1000Genomes
ENSVATH00000371 973 V>I No 1000Genomes
ENSVATH00000372 1001 E>A No 1000Genomes
ENSVATH00000372 1001 E>V No 1000Genomes
ENSVATH10440487 1005 P>R No 1000Genomes

No associated diseases with Q9LNJ9

1 regional properties for Q9LNJ9

Type Name Position InterPro Accession
domain GRAM domain 138 - 259 IPR004182

Functions

Description
EC Number 2.7.1.52 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fucokinase activity Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+).
fucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
GDP-L-fucose salvage The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N0W3 FCSK L-fucose kinase Homo sapiens (Human) PR
10 20 30 40 50 60
MSKQRKKADL ATVLRKSWYH LRLSVRHPTR VPTWDAIVLT AASPEQAELY DWQLRRAKRM
70 80 90 100 110 120
GRIASSTVTL AVPDPDGKRI GSGAATLNAI YALARHYEKL GFDLGPEMEV ANGACKWVRF
130 140 150 160 170 180
ISAKHVLMLH AGGDSKRVPW ANPMGKVFLP LPYLAADDPD GPVPLLFDHI LAIASCARQA
190 200 210 220 230 240
FQDQGGLFIM TGDVLPCFDA FKMTLPEDAA SIVTVPITLD IASNHGVIVT SKSESLAESY
250 260 270 280 290 300
TVSLVNDLLQ KPTVEDLVKK DAILHDGRTL LDTGIISARG RAWSDLVALG CSCQPMILEL
310 320 330 340 350 360
IGSKKEMSLY EDLVAAWVPS RHDWLRTRPL GELLVNSLGR QKMYSYCTYD LQFLHFGTSS
370 380 390 400 410 420
EVLDHLSGDA SGIVGRRHLC SIPATTVSDI AASSVILSSE IAPGVSIGED SLIYDSTVSG
430 440 450 460 470 480
AVQIGSQSIV VGIHIPSEDL GTPESFRFML PDRHCLWEVP LVGHKGRVIV YCGLHDNPKN
490 500 510 520 530 540
SIHKDGTFCG KPLEKVLFDL GIEESDLWSS YVAQDRCLWN AKLFPILTYS EMLKLASWLM
550 560 570 580 590 600
GLDDSRNKEK IKLWRSSQRV SLEELHGSIN FPEMCNGSSN HQADLAGGIA KACMNYGMLG
610 620 630 640 650 660
RNLSQLCHEI LQKESLGLEI CKNFLDQCPK FQEQNSKILP KSRAYQVEVD LLRACGDEAK
670 680 690 700 710 720
AIELEHKVWG AVAEETASAV RYGFREHLLE SSGKSHSENH ISHPDRVFQP RRTKVELPVR
730 740 750 760 770 780
VDFVGGWSDT PPWSLERAGY VLNMAITLEG SLPIGTIIET TNQMGISIQD DAGNELHIED
790 800 810 820 830 840
PISIKTPFEV NDPFRLVKSA LLVTGIVQEN FVDSTGLAIK TWANVPRGSG LGTSSILAAA
850 860 870 880 890 900
VVKGLLQISN GDESNENIAR LVLVLEQLMG TGGGWQDQIG GLYPGIKFTS SFPGIPMRLQ
910 920 930 940 950 960
VVPLLASPQL ISELEQRLLV VFTGQVRLAH QVLHKVVTRY LQRDNLLISS IKRLTELAKS
970 980 990 1000 1010 1020
GREALMNCEV DEVGDIMSEA WRLHQELDPY CSNEFVDKLF EFSQPYSSGF KLVGAGGGGF
1030 1040 1050
SLILAKDAEK AKELRQRLEE HAEFDVKVYN WSICI