Q9LNH6
Gene name |
NPSN12 (At1g48240, F11A17.20, F21D18.4) |
Protein name |
Novel plant SNARE 12 |
Names |
AtNPSN12 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G48240 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LNH6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LNH6-F1 | Predicted | AlphaFoldDB |
22 variants for Q9LNH6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_17811593_A_T | 22 | F>I | No | 1000Genomes | |
| ENSVATH01319234 | 24 | A>T | No | 1000Genomes | |
| ENSVATH04902372 | 39 | S>T | No | 1000Genomes | |
| tmp_1_17811335_G_C | 41 | Q>E | No | 1000Genomes | |
| tmp_1_17811331_C_T | 42 | S>N | No | 1000Genomes | |
| tmp_1_17811051_T_C | 60 | K>R | No | 1000Genomes | |
| ENSVATH01319228 | 75 | P>R | No | 1000Genomes | |
| ENSVATH13437272 | 110 | K>N | No | 1000Genomes | |
| ENSVATH13437271 | 125 | T>I | No | 1000Genomes | |
| ENSVATH00086750 | 126 | A>S | No | 1000Genomes | |
| ENSVATH00086750 | 126 | A>T | No | 1000Genomes | |
| tmp_1_17809954_C_T | 142 | V>I | No | 1000Genomes | |
| tmp_1_17809791_T_G | 171 | T>P | No | 1000Genomes | |
| tmp_1_17809784_G_C | 173 | T>S | No | 1000Genomes | |
| tmp_1_17809667_G_A | 186 | R>C | No | 1000Genomes | |
| ENSVATH04902333 | 198 | L>I | No | 1000Genomes | |
| tmp_1_17809471_C_T | 215 | D>N | No | 1000Genomes | |
| tmp_1_17809455_G_A | 220 | A>V | No | 1000Genomes | |
| ENSVATH04902325 | 245 | I>V | No | 1000Genomes | |
| ENSVATH01319221 | 246 | R>K | No | 1000Genomes | |
| tmp_1_17809239_A_C | 261 | L>W | No | 1000Genomes | |
| tmp_1_17809228_C_G | 265 | E>Q | No | 1000Genomes |
No associated diseases with Q9LNH6
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| ER to Golgi transport vesicle membrane | The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9LRP1 | NPSN13 | Novel plant SNARE 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASELPMSPH | LEQIHGEIRD | HFRALANGFQ | RLDKIKDSSR | QSKQLEELAE | KMRDCKRLVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFDRELKDGE | ARNSPQVNKQ | LNDEKQSMIK | ELNSYVALRK | TYLNTLGNKK | VELFDTGAGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGEPTAEENV | QMASTMSNQE | LVDAGMKRMD | ETDQAIERSK | QVVHQTLEVG | TQTASNLKGQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDQMGRVVND | LDTIQFSLKK | ASQLVKEIGR | QVATDKCIMA | FLFLIVCGVI | AIIIVKIVNP |
| 250 | 260 | ||||
| NNKDIRDIPG | LAPPAQSRKL | LYFRE |