Q9LHQ7

PR
Gene name
At3g20650 (F3H11.3)
Protein name
mRNA cap guanine-N7 methyltransferase 1
Names
mRNA (guanine-N(7))-methyltransferase 1, mRNA cap methyltransferase 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G20650
EC number
2.1.1.56: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LHQ7

Entry ID Method Resolution Chain Position Source
AF-Q9LHQ7-F1 Predicted AlphaFoldDB

13 variants for Q9LHQ7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05870925 9 P>S No 1000Genomes
ENSVATH05870924 23 N>Y No 1000Genomes
ENSVATH13954207 24 P>H No 1000Genomes
ENSVATH05870923 24 P>S No 1000Genomes
tmp_3_7223291_C_A 76 V>F No 1000Genomes
tmp_3_7223089_C_T 117 E>K No 1000Genomes
tmp_3_7222767_C_T 155 E>K No 1000Genomes
tmp_3_7221995_A_G 250 I>T No 1000Genomes
ENSVATH13954150 257 E>K No 1000Genomes
ENSVATH00336526 296 Y>F No 1000Genomes
tmp_3_7221392_C_T 324 A>T No 1000Genomes
tmp_3_7221230_C_T 351 G>R No 1000Genomes
ENSVATH05870832 363 D>N No 1000Genomes

No associated diseases with Q9LHQ7

1 regional properties for Q9LHQ7

Type Name Position InterPro Accession
domain mRNA (guanine-N(7))-methyltransferase domain 22 - 347 IPR004971

Functions

Description
EC Number 2.1.1.56 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mRNA cap binding complex Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43148 RNMT mRNA cap guanine-N7 methyltransferase Homo sapiens (Human) PR
10 20 30 40 50 60
MKRGFSDSPS SSAPPPSSRF KSNPEGDSQF LEDETTKNFA RKVADHYSRR TNQTLEEREA
70 80 90 100 110 120
SPIIHLKKLN NWIKSVLIQL YARPDDAVLD LACGKGGDLI KWDKARIGYY VGIDIAEGSI
130 140 150 160 170 180
EDCRTRYNGD ADHHQRRKKF SFPSRLLCGD CFEVELDKIL EEDAPFDICS CQFAMHYSWT
190 200 210 220 230 240
TEARARRALA NVSALLRPGG VFIGTMPDAN VIIKKLREAE GLEIGNSVYW IRFGEEYSQK
250 260 270 280 290 300
KFKSSSPFGI EYVFHLEDAV DCPEWIVPFN VFKSLAEEYD LELVFVKNSH EFVHEYMKKP
310 320 330 340 350 360
EFVELMRRLG ALGDGSNDQS TLSADEWEAA YLYLSFVLRK RGESDGARRS GRRKNGKMNL
SKDDVLYIDS