Q9LF10
PR
Gene name |
At5g16180 (T21H19.100) |
Protein name |
Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic |
Names |
Chloroplastic RNA splicing factor 1, Protein CHLOROPLAST RNA SPLICING 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G16180 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LF10
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LF10-F1 | Predicted | AlphaFoldDB |
61 variants for Q9LF10
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_5279896_A_G | 5 | I>V | No | 1000Genomes | |
| ENSVATH03061877 | 6 | N>Y | No | 1000Genomes | |
| ENSVATH14911502 | 7 | I>T | No | 1000Genomes | |
| ENSVATH06975089 | 13 | F>I | No | 1000Genomes | |
| ENSVATH03061879 | 25 | C>G | No | 1000Genomes | |
| ENSVATH00624771 | 31 | P>T | No | 1000Genomes | |
| tmp_5_5279989_T_C | 36 | F>L | No | 1000Genomes | |
| tmp_5_5280020_C_T | 46 | S>L | No | 1000Genomes | |
| ENSVATH10777925 | 53 | L>M | No | 1000Genomes | |
| ENSVATH10268872 | 59 | S>Y | No | 1000Genomes | |
| tmp_5_5280077_C_G | 65 | S>C | No | 1000Genomes | |
| ENSVATH06975090 | 67 | F>V | No | 1000Genomes | |
| ENSVATH10777929 | 71 | R>S | No | 1000Genomes | |
| ENSVATH10777930 | 78 | D>N | No | 1000Genomes | |
| ENSVATH00624773 | 84 | P>R | No | 1000Genomes | |
| ENSVATH03061880 | 104 | K>E | No | 1000Genomes | |
| ENSVATH06975092 | 107 | N>Y | No | 1000Genomes | |
| ENSVATH10777932 | 141 | E>K | No | 1000Genomes | |
| ENSVATH03061881 | 144 | D>N | No | 1000Genomes | |
| ENSVATH00624774 | 145 | E>G | No | 1000Genomes | |
| ENSVATH06975093 | 148 | D>Y | No | 1000Genomes | |
| ENSVATH14046409 | 154 | M>L | No | 1000Genomes | |
| ENSVATH06975094 | 158 | S>R | No | 1000Genomes | |
| ENSVATH06975095 | 158 | S>T | No | 1000Genomes | |
| tmp_5_5280373_G_T | 164 | G>C | No | 1000Genomes | |
| tmp_5_5280560_T_C | 226 | V>A | No | 1000Genomes | |
| ENSVATH10777933 | 242 | K>R | No | 1000Genomes | |
| tmp_5_5280817_T_G | 285 | F>C | No | 1000Genomes | |
| ENSVATH10777958 | 294 | S>N | No | 1000Genomes | |
| ENSVATH06975099 | 334 | V>A | No | 1000Genomes | |
| ENSVATH10777975 | 347 | M>R | No | 1000Genomes | |
| tmp_5_5281045_T_G | 361 | L>R | No | 1000Genomes | |
| ENSVATH10777977 | 362 | T>S | No | 1000Genomes | |
| ENSVATH10778029 | 417 | N>S | No | 1000Genomes | |
| ENSVATH10778032 | 433 | L>M | No | 1000Genomes | |
| tmp_5_5281806_A_T | 453 | E>V | No | 1000Genomes | |
| ENSVATH10778034 | 459 | E>D | No | 1000Genomes | |
| ENSVATH03061887 | 463 | R>K | No | 1000Genomes | |
| tmp_5_5281845_G_T | 466 | S>I | No | 1000Genomes | |
| tmp_5_5281885_T_G | 479 | D>E | No | 1000Genomes | |
| ENSVATH00624779 | 481 | E>G | No | 1000Genomes | |
| ENSVATH00624780 | 482 | L>I | No | 1000Genomes | |
| tmp_5_5281907_A_G | 487 | T>A | No | 1000Genomes | |
| ENSVATH00624781 | 496 | N>S | No | 1000Genomes | |
| ENSVATH06975110 | 506 | E>D | No | 1000Genomes | |
| ENSVATH03061888 | 524 | E>D | No | 1000Genomes | |
| ENSVATH10778036 | 534 | S>I | No | 1000Genomes | |
| ENSVATH06975115 | 562 | P>S | No | 1000Genomes | |
| tmp_5_5282239_A_G | 567 | D>G | No | 1000Genomes | |
| ENSVATH14046413 | 571 | I>M | No | 1000Genomes | |
| ENSVATH10778039 | 588 | N>K | No | 1000Genomes | |
| tmp_5_5282313_G_A | 592 | V>I | No | 1000Genomes | |
| tmp_5_5282460_C_T | 607 | H>Y | No | 1000Genomes | |
| ENSVATH03061891 | 631 | T>I | No | 1000Genomes | |
| ENSVATH00624782 | 637 | T>A | No | 1000Genomes | |
| ENSVATH00624783 | 640 | N>S | No | 1000Genomes | |
| ENSVATH00624784 | 649 | L>I | No | 1000Genomes | |
| tmp_5_5282705_G_A | 688 | M>I | No | 1000Genomes | |
| ENSVATH00624786 | 688 | M>L | No | 1000Genomes | |
| tmp_5_5282845_G_T | 704 | A>S | No | 1000Genomes | |
| ENSVATH14046414 | 717 | D>H | No | 1000Genomes |
No associated diseases with Q9LF10
6 regional properties for Q9LF10
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SNF2, N-terminal | 243 - 715 | IPR000330 |
| domain | Helicase, C-terminal | 831 - 990 | IPR001650 |
| domain | Zinc finger, RING-type | 754 - 795 | IPR001841 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 236 - 608 | IPR014001 |
| domain | HIRAN domain | 60 - 154 | IPR014905 |
| conserved_site | Zinc finger, RING-type, conserved site | 769 - 778 | IPR017907 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| Group II intron splicing | The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QN2 | TOE1 | Target of EGR1 protein 1 | Bos taurus (Bovine) | PR |
| Q96GM8 | TOE1 | Target of EGR1 protein 1 | Homo sapiens (Human) | PR |
| O95453 | PARN | Poly(A)-specific ribonuclease PARN | Homo sapiens (Human) | PR |
| Q6YYA3 | Os08g0360100 | Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRNGINILSY | PRFLSFCEVF | VLLLCNFSDN | PKLQTFTQML | NSLFLSARAF | PSLITNSSSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAKSSQFDQF | RENRGVSDAA | IKVPTAPWMK | GPLLLRPDEI | LDTKKRNKPR | KVEEKTFKAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NRRESGVRGK | KAMKKIVRNV | EKLDEDSDSE | ETQMDDLSEF | EYLGRIEEKV | ESKDRFGGKM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PWEREEERFI | LRRMKKESVP | TTAELILDEG | LLNRLRREAS | KMRKWVNVRK | AGVTELVVNK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKSMWKLNEL | AMVRFDVPLC | RNMERAQEII | EMKTGGLVVL | SKKEFLVVYR | GGPSYSSEGQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DEISSSLYER | EADRLLDGLG | PRYMDWWMRR | PFPVDADLLP | EVVNGYMTPS | RRCPPNTRAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LTDEELTYLR | NIAQPLPFHF | VLGRNYGLQG | LASAIVKLWE | KCIIAKIAIK | WGALNTNNEE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MADELRYLTG | GVLILRNKYL | IVLYRGKDFL | SDEVADLVED | RERLLSRYQH | FEETKRESDI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ELLEVVTNGK | QLKETNKSGT | LLEFQELQRK | FGEMDPRNLE | TEAEKARLEK | ELKSQEHKLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILKSKIEKSN | MELFKLNSLW | KPSEGDDDIE | ILTNEERECL | RRIGLKMNSS | LVLGRRGVFF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GVMEGLHQHW | KHREVAKVIT | MQKLFSRVVY | TAKALETESN | GVLISIEKLK | EGHAILIYRG |
| 670 | 680 | 690 | 700 | 710 | |
| KNYKRPSSKL | MAQNLLTKRK | ALQRSVVMQR | LGSLKFFAYQ | RERAIEDLKV | SLVNLQDSAF |