Q17QN2

PR
Gene name
TOE1
Protein name
Target of EGR1 protein 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513052
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

314-419 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17QN2

Entry ID Method Resolution Chain Position Source
AF-Q17QN2-F1 Predicted AlphaFoldDB

78 variants for Q17QN2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs437798317 7 D>E No EVA
rs445976717 12 A>P No EVA
rs477272190 15 V>G No EVA
rs447574871 17 D>A No EVA
rs479204462 18 D>N No EVA
rs448378474 29 E>* No EVA
rs482969708 29 E>A No EVA
rs469309558 29 E>D No EVA
rs446055024 46 E>* No EVA
rs477661751 56 K>Q No EVA
rs137661618 63 V>G No EVA
rs134872857 64 D>G No EVA
rs444034744 81 I>S No EVA
rs519683373 107 Q>* No EVA
rs473207045 145 G>D No EVA
rs436323231 146 F>I No EVA
rs474119800 147 N>D No EVA
rs443289491 149 N>T No EVA
rs481815173 168 S>R No EVA
rs451177974 174 R>G No EVA
rs481832388 174 R>S No EVA
rs458501282 175 T>P No EVA
rs458501282 175 T>S No EVA
rs473119882 176 L>R No EVA
rs459522718 179 E>G No EVA
rs442610453 187 L>P No EVA
rs473965539 194 I>M No EVA
rs437022547 196 L>S No EVA
rs385390463 196 L>V No EVA
rs475629341 197 V>G No EVA
rs452367155 202 N>K No EVA
rs432509666 206 H>R No EVA
rs436592407 213 T>P No EVA
rs482495166 248 F>I No EVA
rs465659424 256 G>V No EVA
rs445441554 258 Q>L No EVA
rs445441554 258 Q>P No EVA
rs479466070 259 R>P No EVA
rs448994775 265 H>Y No EVA
rs480099628 268 L>M No EVA
rs463421526 270 F>V No EVA
rs443376728 270 F>Y No EVA
rs441052999 271 C>F No EVA
rs458046206 271 C>G No EVA
rs458046206 271 C>R No EVA
rs453214800 281 I>L No EVA
rs442978988 284 R>L No EVA
rs474285324 285 C>W No EVA
rs457574831 287 A>G No EVA
rs465520591 288 P>A No EVA
rs465520591 288 P>T No EVA
rs451993736 291 T>P No EVA
rs451993736 291 T>S No EVA
rs435053482 292 Y>F No EVA
rs465809174 294 T>S No EVA
rs448768707 297 T>P No EVA
rs480162865 298 S>I No EVA
rs469705086 298 S>R No EVA
rs449645879 299 I>F No EVA
rs445838855 309 C>G No EVA
rs445838855 309 C>S No EVA
rs442840241 314 Q>H No EVA
rs459788248 314 Q>P No EVA
rs474143998 318 S>A No EVA
rs463860584 328 D>G No EVA
rs443706698 332 L>M No EVA
rs721040082 372 K>E No EVA
rs435110483 442 S>R No EVA
rs472867602 448 G>V No EVA
rs455220759 471 S>N No EVA
rs481069360 475 H>Y No EVA
rs435158778 487 H>P No EVA
rs469570010 497 V>L No EVA
rs449708455 506 F>V No EVA
rs1115750385 508 R>H No EVA
rs432824515 516 K>E No EVA
rs473705956 522 G>C No EVA
rs479000255 524 S>R No EVA

No associated diseases with Q17QN2

1 regional properties for Q17QN2

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 294 - 322 IPR000571

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus speckle
  • Localizes to nuclear speckles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

5 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
metal ion binding Binding to a metal ion.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
RNA binding Binding to an RNA molecule or a portion thereof.
snRNA binding Binding to a small nuclear RNA (snRNA).

1 GO annotations of biological process

Name Definition
snRNA 3'-end processing Any process involved in forming the mature 3' end of an snRNA molecule.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95453 PARN Poly(A)-specific ribonuclease PARN Homo sapiens (Human) PR
Q96GM8 TOE1 Target of EGR1 protein 1 Homo sapiens (Human) PR
Q6YYA3 Os08g0360100 Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9LF10 At5g16180 Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAADSDDGAA SAPTVSDDGV RQSTKSGEEL VVQVPVVDVQ SDNFKEMWPS LLLAIKTANF
70 80 90 100 110 120
VAVDTELSGL GDRKCLLNQC IEERYKAVCH AARTRSILSL GLACFKQQPD KGEHSYLAQV
130 140 150 160 170 180
FNLTLLCMEE YVIEPKSVQF LVQHGFNFNR QYAQGIPYHK GNDKGDESQR QSVRTLFLEL
190 200 210 220 230 240
IRARRPLVLH NGLIDLVFLY QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFL
250 260 270 280 290 300
ASYLEYAFRK CERENGKQRA AGSPHLTLEF CSYPSSMRAH IDYRCCAPPP TYRTHSTSIC
310 320 330 340 350 360
DNFSAYGWCP LGPQCPRSHD IDLIIDTDEA ALEDKRRRRR RKEKRRRALL GLPGKQPSRE
370 380 390 400 410 420
AEDSPPTKQV CKDNRKPEET EQEVAEDETG TQPGSEQGHT NDLEMEPKAT SAETTDTATS
430 440 450 460 470 480
EAPERQVTTD MATSEAPERQ VSPNPVPGDG LHRAGFDAFM TGYVMAYVGV SQGSHPCSSE
490 500 510 520
PWLPECHNKV YLSGKAVPLT VVKSQFSRSS KAHNQKMKLA WGSS