Q9LDW3
Gene name |
APUM11 (At4g08840, T32A17.150) |
Protein name |
Pumilio homolog 11 |
Names |
APUM-11, AtPUM11 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G08840 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LDW3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LDW3-F1 | Predicted | AlphaFoldDB |
125 variants for Q9LDW3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02751758 | 8 | G>S | No | 1000Genomes | |
| ENSVATH00480626 | 14 | G>S | No | 1000Genomes | |
| ENSVATH11323965 | 17 | T>I | No | 1000Genomes | |
| tmp_4_5631371_C_T | 25 | P>L | No | 1000Genomes | |
| ENSVATH02751759 | 27 | T>I | No | 1000Genomes | |
| tmp_4_5631404_T_A | 36 | F>Y | No | 1000Genomes | |
| tmp_4_5631409_G_A | 38 | G>S | No | 1000Genomes | |
| ENSVATH14096949 | 41 | T>R | No | 1000Genomes | |
| ENSVATH14096950 | 49 | R>Q | No | 1000Genomes | |
| ENSVATH11323966 | 52 | D>V | No | 1000Genomes | |
| ENSVATH06579109 | 58 | A>S | No | 1000Genomes | |
| ENSVATH02751761 | 60 | G>S | No | 1000Genomes | |
| ENSVATH02751762 | 60 | G>V | No | 1000Genomes | |
| ENSVATH06579110 | 62 | D>G | No | 1000Genomes | |
| ENSVATH11323967 | 63 | M>L | No | 1000Genomes | |
| ENSVATH00480630 | 70 | S>A | No | 1000Genomes | |
| ENSVATH11323968 | 73 | S>R | No | 1000Genomes | |
| tmp_4_5631523_G_A,T | 76 | D>N | No | 1000Genomes | |
| tmp_4_5631523_G_A,T | 76 | D>Y | No | 1000Genomes | |
| ENSVATH11323969 | 77 | E>V | No | 1000Genomes | |
| ENSVATH06579112 | 79 | S>R | No | 1000Genomes | |
| ENSVATH02751764 | 80 | N>I | No | 1000Genomes | |
| ENSVATH02751764 | 80 | N>S | No | 1000Genomes | |
| ENSVATH02751765 | 82 | F>L | No | 1000Genomes | |
| ENSVATH00480631 | 86 | S>C | No | 1000Genomes | |
| ENSVATH00480631 | 86 | S>G | No | 1000Genomes | |
| ENSVATH00480631 | 86 | S>R | No | 1000Genomes | |
| tmp_4_5631559_T_A | 88 | S>T | No | 1000Genomes | |
| tmp_4_5631584_G_A | 96 | R>H | No | 1000Genomes | |
| ENSVATH06579113 | 107 | S>C | No | 1000Genomes | |
| ENSVATH11323971 | 120 | F>L | No | 1000Genomes | |
| tmp_4_5631660_A_C | 121 | E>D | No | 1000Genomes | |
| ENSVATH06579114 | 122 | Q>H | No | 1000Genomes | |
| ENSVATH00480633 | 125 | R>S | No | 1000Genomes | |
| ENSVATH06579115 | 128 | A>V | No | 1000Genomes | |
| ENSVATH00480635 | 138 | S>G | No | 1000Genomes | |
| tmp_4_5631716_T_A | 140 | V>D | No | 1000Genomes | |
| tmp_4_5631718_G_A | 141 | G>S | No | 1000Genomes | |
| ENSVATH02751767 | 142 | D>E | No | 1000Genomes | |
| ENSVATH02751766 | 142 | D>Y | No | 1000Genomes | |
| ENSVATH11323972 | 143 | G>S | No | 1000Genomes | |
| ENSVATH00480636 | 147 | H>L | No | 1000Genomes | |
| ENSVATH00480636 | 147 | H>R | No | 1000Genomes | |
| tmp_4_5631755_C_T | 153 | A>V | No | 1000Genomes | |
| ENSVATH11323973 | 155 | Q>* | No | 1000Genomes | |
| ENSVATH06579116 | 156 | E>D | No | 1000Genomes | |
| ENSVATH02751768 | 158 | S>F | No | 1000Genomes | |
| ENSVATH11323974 | 159 | N>S | No | 1000Genomes | |
| ENSVATH00480637 | 164 | C>G | No | 1000Genomes | |
| ENSVATH00480638 | 172 | L>H | No | 1000Genomes | |
| ENSVATH00480638 | 172 | L>R | No | 1000Genomes | |
| tmp_4_5631836_T_C | 180 | L>S | No | 1000Genomes | |
| ENSVATH00480639 | 187 | I>M | No | 1000Genomes | |
| ENSVATH06579117 | 188 | R>Q | No | 1000Genomes | |
| tmp_4_5631863_G_A | 189 | R>Q | No | 1000Genomes | |
| ENSVATH06579118 | 195 | P>S | No | 1000Genomes | |
| tmp_4_5631910_G_A | 205 | E>K | No | 1000Genomes | |
| ENSVATH06579119 | 211 | F>L | No | 1000Genomes | |
| tmp_4_5631946_T_C | 217 | S>P | No | 1000Genomes | |
| ENSVATH00480641 | 227 | M>T | No | 1000Genomes | |
| ENSVATH06579120 | 231 | E>K | No | 1000Genomes | |
| tmp_4_5632028_G_A | 244 | G>D | No | 1000Genomes | |
| ENSVATH06579122 | 246 | V>G | No | 1000Genomes | |
| tmp_4_5632048_A_G | 251 | K>E | No | 1000Genomes | |
| tmp_4_5632060_G_C | 255 | G>R | No | 1000Genomes | |
| ENSVATH06579123 | 257 | R>* | No | 1000Genomes | |
| ENSVATH06579124 | 262 | F>S | No | 1000Genomes | |
| ENSVATH02751770 | 263 | V>I | No | 1000Genomes | |
| tmp_4_5632093_G_C | 266 | G>R | No | 1000Genomes | |
| ENSVATH02751771 | 267 | N>S | No | 1000Genomes | |
| ENSVATH02751772 | 270 | D>N | No | 1000Genomes | |
| tmp_4_5632113_G_T | 272 | M>I | No | 1000Genomes | |
| ENSVATH11324026 | 274 | I>V | No | 1000Genomes | |
| ENSVATH02751773 | 278 | V>M | No | 1000Genomes | |
| ENSVATH14096951 | 283 | I>T | No | 1000Genomes | |
| tmp_4_5632168_G_A | 291 | G>S | No | 1000Genomes | |
| tmp_4_5632186_A_G | 297 | K>E | No | 1000Genomes | |
| ENSVATH00480643 | 299 | I>N | No | 1000Genomes | |
| ENSVATH00480643 | 299 | I>T | No | 1000Genomes | |
| tmp_4_5632210_G_A | 305 | E>K | No | 1000Genomes | |
| tmp_4_5632222_C_A,G | 309 | Q>E | No | 1000Genomes | |
| tmp_4_5632222_C_A,G | 309 | Q>K | No | 1000Genomes | |
| tmp_4_5632235_G_A | 313 | R>K | No | 1000Genomes | |
| tmp_4_5632278_C_A | 327 | N>K | No | 1000Genomes | |
| tmp_4_5632737_G_T | 332 | R>L | No | 1000Genomes | |
| tmp_4_5632740_T_C | 333 | V>A | No | 1000Genomes | |
| tmp_4_5632749_A_T | 336 | K>M | No | 1000Genomes | |
| ENSVATH06579141 | 341 | V>M | No | 1000Genomes | |
| ENSVATH06579142 | 342 | T>P | No | 1000Genomes | |
| tmp_4_5632796_T_A | 352 | S>T | No | 1000Genomes | |
| ENSVATH06579143 | 361 | L>F | No | 1000Genomes | |
| ENSVATH06579144 | 368 | N>S | No | 1000Genomes | |
| ENSVATH00480647 | 392 | K>N | No | 1000Genomes | |
| ENSVATH02751790 | 399 | T>S | No | 1000Genomes | |
| tmp_4_5633035_G_A | 401 | R>H | No | 1000Genomes | |
| tmp_4_5633047_G_C | 405 | C>S | No | 1000Genomes | |
| tmp_4_5633064_G_A,T | 411 | V>F | No | 1000Genomes | |
| tmp_4_5633064_G_A,T | 411 | V>I | No | 1000Genomes | |
| tmp_4_5633076_G_A | 415 | V>I | No | 1000Genomes | |
| ENSVATH02751793 | 418 | Q>P | No | 1000Genomes | |
| tmp_4_5633101_T_G | 423 | V>G | No | 1000Genomes | |
| tmp_4_5633115_A_C,G | 428 | R>G | No | 1000Genomes | |
| tmp_4_5633133_G_T | 434 | A>S | No | 1000Genomes | |
| ENSVATH00480651 | 437 | P>R | No | 1000Genomes | |
| ENSVATH11324083 | 442 | L>M | No | 1000Genomes | |
| tmp_4_5633364_G_A | 443 | V>M | No | 1000Genomes | |
| tmp_4_5633414_G_A,C | 459 | E>D | No | 1000Genomes | |
| ENSVATH14096998 | 463 | N>Y | No | 1000Genomes | |
| ENSVATH11324105 | 468 | A>T | No | 1000Genomes | |
| tmp_4_5633497_G_A | 487 | S>N | No | 1000Genomes | |
| ENSVATH14096999 | 487 | S>R | No | 1000Genomes | |
| ENSVATH11324106 | 490 | Q>L | No | 1000Genomes | |
| ENSVATH00480653 | 499 | L>P | No | 1000Genomes | |
| ENSVATH02751796 | 500 | N>T | No | 1000Genomes | |
| ENSVATH02751798 | 502 | G>R | No | 1000Genomes | |
| ENSVATH06579148 | 507 | D>H | No | 1000Genomes | |
| ENSVATH06579149 | 509 | Y>* | No | 1000Genomes | |
| ENSVATH06579150 | 515 | Q>H | No | 1000Genomes | |
| ENSVATH00480654 | 519 | S>A | No | 1000Genomes | |
| ENSVATH02751799 | 519 | S>L | No | 1000Genomes | |
| ENSVATH02751800 | 521 | T>S | No | 1000Genomes | |
| tmp_4_5633681_G_T | 525 | V>F | No | 1000Genomes | |
| tmp_4_5633728_G_T | 540 | K>N | No | 1000Genomes | |
| ENSVATH11324112 | 541 | M>T | No | 1000Genomes | |
| ENSVATH00480656 | 542 | T>S | No | 1000Genomes |
2 associated diseases with Q9LDW3
[MIM: 137750]: Glaucoma 1, open angle, A (GLC1A)
A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269|PubMed:10196380, ECO:0000269|PubMed:10330365, ECO:0000269|PubMed:10340788, ECO:0000269|PubMed:10644174, ECO:0000269|PubMed:10798654, ECO:0000269|PubMed:10819638, ECO:0000269|PubMed:10873982, ECO:0000269|PubMed:10916185, ECO:0000269|PubMed:10980537, ECO:0000269|PubMed:11004290, ECO:0000269|PubMed:11774072, ECO:0000269|PubMed:12189160, ECO:0000269|PubMed:12356829, ECO:0000269|PubMed:12362081, ECO:0000269|PubMed:12442283, ECO:0000269|PubMed:12860809, ECO:0000269|PubMed:12872267, ECO:0000269|PubMed:15025728, ECO:0000269|PubMed:15255110, ECO:0000269|PubMed:15534471, ECO:0000269|PubMed:15795224, ECO:0000269|PubMed:16401791, ECO:0000269|PubMed:17210859, ECO:0000269|PubMed:17499207, ECO:0000269|PubMed:25524706, ECO:0000269|PubMed:9005853, ECO:0000269|PubMed:9328473, ECO:0000269|PubMed:9345106, ECO:0000269|PubMed:9361308, ECO:0000269|PubMed:9490287, ECO:0000269|PubMed:9510647, ECO:0000269|PubMed:9521427, ECO:0000269|PubMed:9535666, ECO:0000269|PubMed:9697688, ECO:0000269|PubMed:9792882, ECO:0000269|PubMed:9863594}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 231300]: Glaucoma 3, primary congenital, A (GLC3A)
An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. {ECO:0000269|PubMed:15733270}. Note=The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. MYOC mutations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locus associated with the disease (PubMed:15733270). {ECO:0000269|PubMed:15733270}.
Without disease ID
- A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269|PubMed:10196380, ECO:0000269|PubMed:10330365, ECO:0000269|PubMed:10340788, ECO:0000269|PubMed:10644174, ECO:0000269|PubMed:10798654, ECO:0000269|PubMed:10819638, ECO:0000269|PubMed:10873982, ECO:0000269|PubMed:10916185, ECO:0000269|PubMed:10980537, ECO:0000269|PubMed:11004290, ECO:0000269|PubMed:11774072, ECO:0000269|PubMed:12189160, ECO:0000269|PubMed:12356829, ECO:0000269|PubMed:12362081, ECO:0000269|PubMed:12442283, ECO:0000269|PubMed:12860809, ECO:0000269|PubMed:12872267, ECO:0000269|PubMed:15025728, ECO:0000269|PubMed:15255110, ECO:0000269|PubMed:15534471, ECO:0000269|PubMed:15795224, ECO:0000269|PubMed:16401791, ECO:0000269|PubMed:17210859, ECO:0000269|PubMed:17499207, ECO:0000269|PubMed:25524706, ECO:0000269|PubMed:9005853, ECO:0000269|PubMed:9328473, ECO:0000269|PubMed:9345106, ECO:0000269|PubMed:9361308, ECO:0000269|PubMed:9490287, ECO:0000269|PubMed:9510647, ECO:0000269|PubMed:9521427, ECO:0000269|PubMed:9535666, ECO:0000269|PubMed:9697688, ECO:0000269|PubMed:9792882, ECO:0000269|PubMed:9863594}. Note=The disease is caused by variants affecting the gene represented in this entry.
- An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. {ECO:0000269|PubMed:15733270}. Note=The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. MYOC mutations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locus associated with the disease (PubMed:15733270). {ECO:0000269|PubMed:15733270}.
1 regional properties for Q9LDW3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Serine dehydratase-like, alpha subunit | 90 - 422 | IPR005130 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| post-transcriptional regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9C9R6 | APUM7 | Putative pumilio homolog 7, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFGFFPGDL | RQRGSFTDLG | FNGFPLTSSV | SNGFHFSGDR | TTNPFLNLRK | LDTTSLMADG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDMGLCQNLS | KMSISDERSN | FFNHSSFSGY | GCYQGRESSF | HGEASSSMRG | FVGYGDVHRF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQDLRVRASF | HGESAMSSYV | GDGSDYHRLR | FLALQEASNP | NPRCFTENMS | LLNRDYMLEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EHFNQQIRRD | FSLVPQKSPL | AFHEERILPP | FSAMGGSREL | DGSAKCMKNK | EDSLDLASMV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSYGSVYLMA | KDQLGCRLLQ | KFVDEGNFVD | VMIIFKEVIN | NVIELGTDPF | GNYLIQKLIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VCNEEQRTQI | LIRLTSKPGL | LVKISINNYG | TRVVQKLIET | VTTKEQISLV | KSALVPGFLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFRELNGNHV | ILNCLKFFSP | NDNKFILEAA | TKFCIEIATT | RHGCCVLQRC | VSYSVGEQHE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KLVDEISRNS | LLLAQDPFGN | YLVQYIIEKK | VGGVNVLFEL | RGNYVKLATQ | KFGSHVVEKC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LRYYPESRSQ | IVNELVSVLN | FGYLLQDPYA | NYVIQCALSK | TKGFVRASLV | EKVRRYENLK |
| 550 | |||||
| MTPYCKRIFS | KNLWKK |